Choline transporters in human lung adenocarcinoma: Expression and functional implications

Acta Biochimica et Biophysica Sinica

Volumn 39, Issue 9, 2007, Pages 668-674

  Wang, Tao ^a,b   Li, Jinjun ^b   Chen, Fei ^b   Zhao, Yingjun ^b   He, Xianghuo ^b   Wan, Dafang ^b   Gu, Jianren ^b  

^a FUDAN UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Choline transporter; CTL1; Lung adenocarcinoma; Proliferation

Indexed keywords

CHOLINE; LEUKOCYTE ANTIGEN; ORGANIC CATION TRANSPORTER; SLC44A1 PROTEIN, HUMAN; UNCLASSIFIED DRUG;

ADENOCARCINOMA; ARTICLE; BIOSYNTHESIS; CELL CULTURE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; LUNG TUMOR; METABOLISM; PHYSIOLOGY; TUMOR CELL LINE;

ADENOCARCINOMA; ANTIGENS, CD; CELL LINE, TUMOR; CHOLINE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; ORGANIC CATION TRANSPORT PROTEINS; TUMOR CELLS, CULTURED;

EID: 34548733106     PISSN: 16729145     EISSN: 17457270     Source Type: Journal    
DOI: 10.1111/j.1745-7270.2007.00323.x     Document Type: Article

References (27)

1. Zeisel SH, Da Costa KA, Franklin PD, Alexander EA, Lamont JT, Sheard NF, Beiser A. Choline, an essential nutrient for humans. FASEB J 1991, 5 : 2093 2098
2. Loffelholz K, Klein J, Koppen A. Choline, a precursor of acetylcholine and phospholipids in the brain. Prog Brain Res 1993, 98 : 197 200
3. Song P, Sekhon HS, Jia Y, Keller JA, Blusztajn JK, Mark GP, Spindle ER. Acetylcholine is synthesized by and acts as an autocrine growth factor for small cell lung carcinoma. Cancer Res 2003, 63 : 214 221
4. Zeisel SH. Choline: An essential nutrient for humans. Nutrition 2000, 16 : 669 671
5. Michel V, Yuan Z, Ramsubir S, Bakovic M. Choline transport for phospholipid synthesis. Exp Biol Med (Maywood) 2006. 231 : 490 504
6. Lockman PR, Allen DD. The transport of choline. Drug Dev Ind Pharm 2002, 28 : 749 771
7. Manyam BV, Biacobini E, Colliver JA. Cerebrospinal fluid acetyl-cholinesterase and choline measurements in Huntington's disease. J Neurol 1990, 237 : 281 284
8. Manyam BV, Giacobini E, Colliver JA. Cerebrospinal fluid choline levels are decreased in Parkinson's disease. Ann Neurol 1993, 27 : 683 685
9. Slotkin TA, Nemeroff CB, Bissette G, Seidler FJ. Overexpression of the high affinity choline transporter in cortical regions affected by Alzheimer's disease. Evidence for rapid autopsy studies. J Clin Invest 1994, 94 : 696 702
10. Yoshimoto M, Waki A, Obata A, Furukawa T, Yonekura Y, Fujibayashi Y. Radiolabeled choline as a proliferation marker: Comparison with radiolabeled acetate. Nucl Med Biol 2004, 31 : 859 865
11. Hara T, Bansal A, DeGrado TR. Choline transporter as a novel target for molecular imaging of cancer. Mol Imaging 2006, 5 : 498 509
12. Koepsell H, Schmitt BM, Gorboulev V. Organic cation transporters. Rev Physiol Biochem Pharmacol 2003, 150 : 36 90
13. Tamai I, Yabuuchi H, Nezu J, Sai Y, Oku A, Shimane M, Tsuji A. Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1. FEBS Lett 1997, 419 : 107 111
14. Wagner CA, Lukewille U, Kaltenbach S, Moschen I, Broer A, Risler T, Broer S et al. Functional and pharmacological characterization of human Na(+)-carnitine cotransporter hOCTN2. Am J Physiol Renal Physiol 2000, 279 : 584 591
15. Okuda T, Haga T, Kanai Y, Endou H, Ishihara T, Katsura I. Identification and characterization of the high-affinity choline transporter. Nature Neurosci 2000, 3 : 120 125
16. Pfeil U, Haberberger RV, Lips KS, Eberling L, Grau V, Kummer W. Expression of the high-affinity choline transporter CHT1 in epithelia. Life Sci 2003, 72 : 2087 2090
17. Lips KS, Pfeil U, Reiners K, Rimasch C, Kuchelmeister K, Braun-Dullaeus RC, Haberberger RV et al. Expression of the high-affinity choline transporter CHT1 in rat and human arteries. J Histochem Cytochem 2003, 51 : 1645 1654
18. Yuan Z, Tie A, Tarnopolsky M, Bakovic M. Genomic organization, promoter activity, and expression of the human choline transporter-like protein. Physiol Genomics 2006, 26 : 76 90
19. Fullerton MD, Wagner L, Yuan Z, Bakovic M. Impaired trafficking of choline transporter-like protein-1 at plasma membrane and inhibition of choline transport in THP-1 monocyte-derived macrophages. Am J Physiol Cell Physiol 2006, 290 : 1230 1238
20. +-independent systems of choline transport by plasma membrane vesicles of A549 cell line. Am J Physiol 1994, 267 : 1279 1287
21. Van Rossum GD, Boyd CA. Sodium-dependent and -independent choline uptake by type II epithelial cells from rat lung. J Membr Biol 1998, 162 : 147 156
22. Cetinkaya I, Ciarimboli G, Yalcinkaya G, Mehrens T, Velic A, Hirsch JR, Gorboulev V et al. Regulation of human organic cation transporter hOCT2 by PKA, PI3K, and calmodulin-dependent kinases. Am J Physiol Renal Physiol 2003, 284 : 293 302
23. Martel F, Keating E, Calhau C, Grundemann D, Schomig E, Azevedo I. Regulation of human extraneuronal monoamine transporter (hEMT) expressed in HEK293 cells by intracellular second messenger systems. Naunyn Schmiedebergs Arch Pharmacol 2001, 364 : 487 489
24. Novakova J, Mikasova L, Machova E, Lisa V, Dolezal V. Chronic treatment with amyloid â(1-42) inhibits non-cholinergic high-affinity choline transport in NG108-15 cells through protein kinase C signaling. Brain Res 2005, 1062 : 101 110
25. Qian J, Dong A, Kong M, Ma Z, Fan J, Jiang G. Suppression of type 1 insulin-like growth factor receptor expression by small interfering RNA inhibits A549 human lung cancer cell invasion in vitro and metastasis in xenograft nude mice. Acta Biochim Biophys Sin 2007, 39 : 137 147
26. Vivanco I, Sawyers CL. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2002, 2 : 489 501
27. Shaw RJ, Cantley LC. Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature 2006, 441 : 424 430