메뉴 건너뛰기




Volumn 10, Issue 9, 2013, Pages 1287-1302

Pharmaceutical applications of the Calu-3 lung epithelia cell line

Author keywords

Calu 3; Drug deposition; Drug transport; Metabolism; Pulmonary delivery

Indexed keywords

BUDESONIDE; CIPROFLOXACIN; FLUTICASONE PROPIONATE; SALBUTAMOL; SECRETORY COMPONENT;

EID: 84882395942     PISSN: 17425247     EISSN: 17447593     Source Type: Journal    
DOI: 10.1517/17425247.2013.805743     Document Type: Review
Times cited : (70)

References (96)
  • 1
    • 0344513087 scopus 로고    scopus 로고
    • Pulmonary drug delivery. Part I: Physiological factors affecting therapeutic effectiveness of aerosolized medications
    • DOI 10.1046/j.1365-2125.2003.01892.x
    • Labiris N, Dolovich M. Pulmonary drug delivery. Part I: Physiological factors affecting therapeutic effectiveness of aerosolized medications. Br J Clin Pharmacol 2003;56(6):588-99 (Pubitemid 37491710)
    • (2003) British Journal of Clinical Pharmacology , vol.56 , Issue.6 , pp. 588-599
    • Labiris, N.R.1    Dolovich, M.B.2
  • 2
    • 0033959120 scopus 로고    scopus 로고
    • Human airway epithelial cell lines for in vitro drug transport and metabolism studies
    • DOI 10.1016/S1461-5347(99)00231-X, PII S146153479900231X
    • Forbes B. Human airway epithelial cell lines for in vitro drug transport and metabolism studies. Pharm Sci Technol Today 2000;3(1):18-27 (Pubitemid 30066491)
    • (2000) Pharmaceutical Science and Technology Today , vol.3 , Issue.1 , pp. 18-27
    • Forbes, B.1
  • 3
    • 51049107647 scopus 로고    scopus 로고
    • In vitro models of the human epithelial airway barrier to study the toxic potential of particulate matter
    • Rothen-Rutishauser B, Blank F, Muhlfeld C, Gehr P. In vitro models of the human epithelial airway barrier to study the toxic potential of particulate matter. Expert Opin Drug Metab Toxicol 2008;4(8):1075-89
    • (2008) Expert Opin Drug Metab Toxicol , vol.4 , Issue.8 , pp. 1075-1089
    • Rothen-Rutishauser, B.1    Blank, F.2    Muhlfeld, C.3    Gehr, P.4
  • 4
    • 36249017868 scopus 로고    scopus 로고
    • Nanoparticles for drug delivery to the lungs
    • DOI 10.1016/j.tibtech.2007.09.005, PII S0167779907002703
    • Sung JC, Pulliam BL, Edwards DA. Nanoparticles for drug delivery to the lungs. Trends Biotechnol 2007;25(12):563-70 (Pubitemid 350138179)
    • (2007) Trends in Biotechnology , vol.25 , Issue.12 , pp. 563-570
    • Sung, J.C.1    Pulliam, B.L.2    Edwards, D.A.3
  • 5
    • 0028933682 scopus 로고
    • Culture and transformation of human airway epithelial cells
    • Gruenert DC, Finkbeiner WE, Widdicombe JH. Culture and transformation of human airway epithelial cells. Am J Physiol 1995;268(3):L347-60
    • (1995) Am J Physiol , vol.268 , Issue.3
    • Gruenert, D.C.1    Finkbeiner, W.E.2    Widdicombe, J.H.3
  • 6
    • 0002909708 scopus 로고
    • Epihelial cells of trachea and bronchi. In: Parent R, editor. Comparative biology of the normal lung
    • CRC Press
    • Mariassy AT. Epihelial cells of trachea and bronchi. In: Parent R, editor. Comparative biology of the normal lung. CRC Press; London: 1992. p. 63-76
    • (1992) London , pp. 63-76
    • Mariassy, A.T.1
  • 7
    • 33750845387 scopus 로고    scopus 로고
    • In vivo, in vitro and ex vivo models to assess pulmonary absorption and disposition of inhaled therapeutics for systemic delivery
    • DOI 10.1016/j.addr.2006.07.012, PII S0169409X06001463
    • Sakagami M. In vivo, in vitro and ex vivo models to assess pulmonary absorption and disposition of inhaled therapeutics for systemic delivery. Adv Drug Deliv Rev 2006;58(9):1030-60 (Pubitemid 44712023)
    • (2006) Advanced Drug Delivery Reviews , vol.58 , Issue.9-10 , pp. 1030-1060
    • Sakagami, M.1
  • 8
    • 0028307695 scopus 로고
    • Calu-3: A human airway epithelial cell line that shows cAMP-dependent Cl-secretion
    • Shen B, Finkbeiner W, Wine J, et al. Calu-3: A human airway epithelial cell line that shows cAMP-dependent Cl-secretion. Am J Physiol 1994;266(5): L493-501
    • (1994) Am J Physiol , vol.266 , Issue.5
    • Shen, B.1    Finkbeiner, W.2    Wine, J.3
  • 9
    • 0017412603 scopus 로고
    • One hundred and twenty seven cultured human tumor cell lines producing tumors in nude mice
    • Fogh J, Fogh JM, Orfeo T. One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice. J Natl Cancer Inst 1977;59(1):221-6 (Pubitemid 8144854)
    • (1977) Journal of the National Cancer Institute , vol.59 , Issue.1 , pp. 221-226
    • Fogh, J.1    Fogh, J.M.2    Orfeo, T.3
  • 10
    • 33745630072 scopus 로고    scopus 로고
    • Culture of Calu-3 cells at the air interface provides a representative model of the airway epithelial barrier
    • DOI 10.1007/s11095-006-0255-0
    • Grainger CI, Greenwell LL, Lockley DJ, et al. Culture of Calu-3 cells at the air interface provides a representative model of the airway epithelial barrier. Pharm Res 2006;23(7):1482-90 (Pubitemid 43993811)
    • (2006) Pharmaceutical Research , vol.23 , Issue.7 , pp. 1482-1490
    • Grainger, C.I.1    Greenwell, L.L.2    Lockley, D.J.3    Martin, G.P.4    Forbes, B.5
  • 12
    • 0242584998 scopus 로고    scopus 로고
    • Large porous particle impingement on lung epithelial cell monolayers - Toward improved particle characterization in the lung
    • DOI 10.1023/A:1023441804464
    • Fiegel J, Ehrhardt C, Schaefer UF, et al. Large porous particle impingement on lung epithelial cell monolayers-toward improved particle characterization in the lung. Pharm Res 2003;20(5):788-96 (Pubitemid 36515312)
    • (2003) Pharmaceutical Research , vol.20 , Issue.5 , pp. 788-796
    • Fiegel, J.1    Ehrhardt, C.2    Schaefer, U.F.3    Lehr, C.-M.4    Hanes, J.5
  • 14
    • 20444378183 scopus 로고    scopus 로고
    • Human respiratory epithelial cell culture for drug delivery applications
    • Forbes B, Ehrhardt C. Human respiratory epithelial cell culture for drug delivery applications. Eur J Pharm Biopharm 2005;60(2):193
    • (2005) Eur J Pharm Biopharm , vol.60 , Issue.2 , pp. 193
    • Forbes, B.1    Ehrhardt, C.2
  • 15
    • 77956419131 scopus 로고    scopus 로고
    • Time-and passage-dependent characteristics of a calu-3 respiratory epithelial cell model
    • Haghi M, Young PM, Traini D, et al. Time-and passage-dependent characteristics of a Calu-3 respiratory epithelial cell model. Drug Dev Ind Pharm 2010;36(10):1207-14
    • (2010) Drug Dev Ind Pharm , vol.36 , Issue.10 , pp. 1207-1214
    • Haghi, M.1    Young, P.M.2    Traini, D.3
  • 16
    • 59649090204 scopus 로고    scopus 로고
    • Chitosan/cyclodextrin nanoparticles can efficiently transfect the airway epithelium in vitro
    • Teijeiro-Osorio D, Remunán-López C, Alonso MJ. Chitosan/cyclodextrin nanoparticles can efficiently transfect the airway epithelium in vitro. Eur J Pharm Biopharm 2009;71(2):257-63
    • (2009) Eur J Pharm Biopharm , vol.71 , Issue.2 , pp. 257-263
    • Teijeiro-Osorio, D.1    Remunán-López, C.2    Alonso, M.J.3
  • 17
    • 38549180306 scopus 로고    scopus 로고
    • In vitro toxicity and permeation of cyclodextrins in Calu-3 cells
    • Matilainen L, Toropainen T, Vihola H, et al. In vitro toxicity and permeation of cyclodextrins in Calu-3 cells. J Control Release 2008;126(1):10-16
    • (2008) J Control Release , vol.126 , Issue.1 , pp. 10-16
    • Matilainen, L.1    Toropainen, T.2    Vihola, H.3
  • 18
    • 67349272759 scopus 로고    scopus 로고
    • Sparing methylation of b-cyclodextrin mitigates cytotoxicity and permeability induction in respiratory epithelial cell layers in vitro
    • Salem LB, Bosquillon C, Dailey L, et al. Sparing methylation of b-cyclodextrin mitigates cytotoxicity and permeability induction in respiratory epithelial cell layers in vitro. J Control Release 2009;136(2):110-16
    • (2009) J Control Release , vol.136 , Issue.2 , pp. 110-116
    • Salem, L.B.1    Bosquillon, C.2    Dailey, L.3
  • 19
    • 45049083552 scopus 로고    scopus 로고
    • Formulation of rifampicin-cyclodextrin complexes for lung nebulization
    • Tewes F, Brillault J, Couet W, Olivier JC. Formulation of rifampicin-cyclodextrin complexes for lung nebulization. J Control Release 2008;129(2):93-9
    • (2008) J Control Release , vol.129 , Issue.2 , pp. 93-99
    • Tewes, F.1    Brillault, J.2    Couet, W.3    Olivier, J.C.4
  • 20
    • 84860704136 scopus 로고    scopus 로고
    • Absorption-promoting effects of chitosan in airway and intestinal cell lines: A comparative study
    • Vllasaliu D, Casettari L, Fowler R, et al. Absorption-promoting effects of chitosan in airway and intestinal cell lines: A comparative study. Int J Pharm 2012;430(1-2):151-60
    • (2012) Int J Pharm , vol.430 , Issue.1-2 , pp. 151-160
    • Vllasaliu, D.1    Casettari, L.2    Fowler, R.3
  • 22
    • 64149091646 scopus 로고    scopus 로고
    • New generation of hybrid poly/oligosaccharide nanoparticles as carriers for the nasal delivery of macromolecules
    • Teijeiro-Osorio D, Remun?án-López C, Alonso MJ. New generation of hybrid poly/oligosaccharide nanoparticles as carriers for the nasal delivery of macromolecules. Biomacromolecules 2008;10(2):243-9
    • (2008) Biomacromolecules , vol.10 , Issue.2 , pp. 243-249
    • Teijeiro-Osorio, D.1    Remunán-López, C.2    Alonso, M.J.3
  • 23
    • 52449135231 scopus 로고    scopus 로고
    • Transfection efficiency and toxicity of polyethylenimine in differentiated Calu-3 and nondifferentiated COS-1 cell cultures
    • Florea BI, Meaney C, Junginger HE, Borchard G. Transfection efficiency and toxicity of polyethylenimine in differentiated Calu-3 and nondifferentiated COS-1 cell cultures. AAPS PharmSci 2002;4(3):E12
    • (2002) AAPS PharmSci , vol.4 , Issue.3
    • Florea, B.I.1    Meaney, C.2    Junginger, H.E.3    Borchard, G.4
  • 26
    • 84872118822 scopus 로고    scopus 로고
    • Liposomal nanoparticles control the uptake of ciprofloxacin across respiratory epithelia
    • 1-12
    • Ong HX, Traini D, Cipolla D, et al. Liposomal nanoparticles control the uptake of ciprofloxacin across respiratory epithelia. Pharm Res 2012;29(12):3335-46; 1-12
    • (2012) Pharm Res , vol.29 , Issue.12 , pp. 3335-3346
    • Ong, H.X.1    Traini, D.2    Cipolla, D.3
  • 27
    • 0032961328 scopus 로고    scopus 로고
    • In vitro evaluation of microparticles and polymer gels for use as nasal platforms for protein delivery
    • Witschi C, Mrsny RJ. In vitro evaluation of microparticles and polymer gels for use as nasal platforms for protein delivery. Pharm Res 1999;16(3):382-90 (Pubitemid 29162095)
    • (1999) Pharmaceutical Research , vol.16 , Issue.3 , pp. 382-390
    • Witschi, C.1    Mrsny, R.J.2
  • 28
    • 58149191872 scopus 로고    scopus 로고
    • Effects of cell penetrating peptides and pegylation on transfection efficiency of polyethylenimine in mouse lungs
    • Nguyen J, Xie X, Neu M, et al. Effects of cell penetrating peptides and pegylation on transfection efficiency of polyethylenimine in mouse lungs. J Gene Med 2008;10(11):1236-46
    • (2008) J Gene Med , vol.10 , Issue.11 , pp. 1236-1246
    • Nguyen, J.1    Xie, X.2    Neu, M.3
  • 29
    • 79951700341 scopus 로고    scopus 로고
    • Modular construction of multifunctional bioresponsive cell-targeted nanoparticles For Gene Delivery
    • Saeed AO, Magnusson JP, Moradi E, et al. Modular construction of multifunctional bioresponsive cell-targeted nanoparticles for gene delivery. Bioconjugate Chem 2011;22(2):156-68
    • (2011) Bioconjugate Chem , vol.22 , Issue.2 , pp. 156-168
    • Saeed, A.O.1    Magnusson, J.P.2    Moradi, E.3
  • 30
    • 33344467489 scopus 로고    scopus 로고
    • Preparation and characterization of protein-loaded N-trimethyl chitosan nanoparticles as nasal delivery system
    • DOI 10.1016/j.jconrel.2005.11.014, PII S0168365905006528
    • Amidi M, Romeijn SG, Borchard G, et al. Preparation and characterization of protein-loaded N-trimethyl chitosan nanoparticles as nasal delivery system. J Control Release 2006;111(1-2):107-16 (Pubitemid 43290000)
    • (2006) Journal of Controlled Release , vol.111 , Issue.1-2 , pp. 107-116
    • Amidi, M.1    Romeijn, S.G.2    Borchard, G.3    Junginger, H.E.4    Hennink, W.E.5    Jiskoot, W.6
  • 31
    • 29244456136 scopus 로고    scopus 로고
    • Enhancement of bronchial octreotide absorption by chitosan and N-trimethyl chitosan shows linear in vitro/in vivo correlation
    • DOI 10.1016/j.jconrel.2005.10.001, PII S0168365905005262
    • Florea BI, Thanou M, Junginger HE, Borchard G. Enhancement of bronchial octreotide absorption by chitosan and N-trimethyl chitosan shows linear in vitro/in vivo correlation. J Controld Release 2006;110(2):353-61 (Pubitemid 41827489)
    • (2006) Journal of Controlled Release , vol.110 , Issue.2 , pp. 353-361
    • Florea, B.I.1    Thanou, M.2    Junginger, H.E.3    Borchard, G.4
  • 32
    • 0028819164 scopus 로고
    • Regulation of human airway surface liquid
    • Widdicombe JH, Widdicombe JG. Regulation of human airway surface liquid. Respir Physiol 1995;99(1):3-12
    • (1995) Respir Physiol , vol.99 , Issue.1 , pp. 3-12
    • Widdicombe, J.H.1    Widdicombe, J.G.2
  • 33
    • 0030784505 scopus 로고    scopus 로고
    • Transepithelial transport of the fluoroquinolone ciprofloxacin by human airway epithelial Calu-3 cells
    • Cavet ME, West M, Simmons NL. Transepithelial transport of the fluoroquinolone ciprofloxacin by human airway epithelial Calu-3 cells. Antimicrob Agents Chemother 1997;41(12):2693-8 (Pubitemid 27524741)
    • (1997) Antimicrobial Agents and Chemotherapy , vol.41 , Issue.12 , pp. 2693-2698
    • Cavet, M.E.1    West, M.2    Simmons, N.L.3
  • 34
    • 0034605705 scopus 로고    scopus 로고
    • Characterization of the Calu-3 cell line as a tool to screen pulmonary drug delivery
    • Foster KA, Avery ML, Yazdanian M, Audus KL. Characterization of the Calu-3 cell line as a tool to screen pulmonary drug delivery. Int J Pharm 2000;208(1):1-11
    • (2000) Int J Pharm , vol.208 , Issue.1 , pp. 1-11
    • Foster, K.A.1    Avery, M.L.2    Yazdanian, M.3    Audus, K.L.4
  • 35
    • 77949476243 scopus 로고    scopus 로고
    • Permeation of losartan across human respiratory epithelium: An in vitro study with Calu-3 cells
    • Amoako-Tuffour M, Yeung PK, Agu RU. Permeation of losartan across human respiratory epithelium: An in vitro study with Calu-3 cells. Acta Pharm 2009;59(4):395-405
    • (2009) Acta Pharm , vol.59 , Issue.4 , pp. 395-405
    • Amoako-Tuffour, M.1    Yeung, P.K.2    Agu, R.U.3
  • 36
    • 0036282759 scopus 로고    scopus 로고
    • Transport and local metabolism of budesonide and fluticasone propionate in a human bronchial epithelial cell line (Calu-3
    • Borchard G, Cassará ML, Roemelé PEH, Florea BI. Transport and local metabolism of budesonide and fluticasone propionate in a human bronchial epithelial cell line (Calu-3). J Pharm Sci 2002;91(6):1561-7
    • (2002) J Pharm Sci , vol.91 , Issue.6 , pp. 1561-1567
    • Borchard, G.1    Cassará, M.L.2    Roemelé, P.E.H.3    Florea, B.I.4
  • 37
    • 77955903375 scopus 로고    scopus 로고
    • Technosphere® insulin: Defining the role of technosphere particles at the cellular level
    • Angelo R, Rousseau K, Grant M, et al. Technosphere® insulin: Defining the role of technosphere particles at the cellular level. J Diabetes Sci Technol 2009;3(3):545
    • (2009) J Diabetes Sci Technol , vol.3 , Issue.3 , pp. 545
    • Angelo, R.1    Rousseau, K.2    Grant, M.3
  • 39
    • 14644421632 scopus 로고    scopus 로고
    • Development of a size-dependent aerosol deposition model utilising human airway epithelial cells for evaluating aerosol drug delivery
    • Cooney D, Kazantseva M, Hickey AJ. Development of a size-dependent aerosol deposition model utilising human airway epithelial cells for evaluating aerosol drug delivery. Altern Lab Ani 2004;32(6):581-90 (Pubitemid 40321537)
    • (2004) ATLA Alternatives to Laboratory Animals , vol.32 , Issue.6 , pp. 581-590
    • Cooney, D.1    Kazantseva, M.2    Hickey, A.J.3
  • 40
    • 67349171605 scopus 로고    scopus 로고
    • A novel cell compatible impingement system to study in vitro drug absorption from dry powder aerosol formulations
    • Bur M, Rothen-Rutishauser B, Huwer H, Lehr C-M. A novel cell compatible impingement system to study in vitro drug absorption from dry powder aerosol formulations. Eur J Pharm Biopharm 2009;72(2):350-7
    • (2009) Eur J Pharm Biopharm , vol.72 , Issue.2 , pp. 350-357
    • Bur, M.1    Rothen-Rutishauser, B.2    Huwer, H.3    Lehr, C.-M.4
  • 41
    • 59849094684 scopus 로고    scopus 로고
    • The permeability of large molecular weight solutes following particle delivery to air-interfaced cells that model the respiratory mucosa
    • Grainger C, Greenwell L, Martin G, Forbes B. The permeability of large molecular weight solutes following particle delivery to air-interfaced cells that model the respiratory mucosa. Eur J Pharm Biopharm 2009;71(2):318-24
    • (2009) Eur J Pharm Biopharm , vol.71 , Issue.2 , pp. 318-324
    • Grainger, C.1    Greenwell, L.2    Martin, G.3    Forbes, B.4
  • 42
    • 80054750314 scopus 로고    scopus 로고
    • Epithelial profiling of antibiotic controlled release respiratory formulations
    • Ong HX, Traini D, Bebawy M, Young PM. Epithelial profiling of antibiotic controlled release respiratory formulations. Pharm Res 2011;28(9):2327-38
    • (2011) Pharm Res , vol.28 , Issue.9 , pp. 2327-2338
    • Ong, H.X.1    Traini, D.2    Bebawy, M.3    Young, P.M.4
  • 43
    • 84857624965 scopus 로고    scopus 로고
    • Modification of disodium cromoglycate passage across lung epithelium in vitro via incorporation into polymeric microparticles
    • 1-8
    • Haghi M, Salama R, Traini D, et al. Modification of disodium cromoglycate passage across lung epithelium in vitro via incorporation into polymeric microparticles. AAPS J 2012;14(1):79-86; 1-8
    • AAPS J 2012 , vol.14 , Issue.1 , pp. 79-86
    • Haghi, M.1    Salama, R.2    Traini, D.3
  • 44
    • 84862001733 scopus 로고    scopus 로고
    • Deposition diffusion and transport mechanism of dry powder microparticulate salbutamol at the respiratory epithelia
    • Haghi M, Traini D, Bebawy M, Young PM. Deposition, diffusion and transport mechanism of dry powder microparticulate salbutamol, at the respiratory epithelia. Mol Pharm 2012;9(6):1717-26
    • (2012) Mol Pharm , vol.9 , Issue.6 , pp. 1717-1726
    • Haghi, M.1    Traini, D.2    Bebawy, M.3    Young, P.M.4
  • 45
    • 84858040013 scopus 로고    scopus 로고
    • Critical characteristics for corticosteroid solution metered dose inhaler bioequivalence
    • Grainger C, Saunders M, Buttini F, et al. Critical characteristics for corticosteroid solution metered dose inhaler bioequivalence. Mol Pharm 2012;9(3):563-9
    • (2012) Mol Pharm , vol.9 , Issue.3 , pp. 563-569
    • Grainger, C.1    Saunders, M.2    Buttini, F.3
  • 46
    • 77953954921 scopus 로고    scopus 로고
    • Drug transport across pulmonary epithelial cell monolayers: Effects of particle size, apical liquid volume, and deposition technique
    • Bur M, Huwer H, Muys L, Lehr C-M. Drug transport across pulmonary epithelial cell monolayers: Effects of particle size, apical liquid volume, and deposition technique. J Aerosol Med Pulm Drug Deliv 2010;23(3):119-27
    • (2010) J Aerosol Med Pulm Drug Deliv , vol.23 , Issue.3 , pp. 119-127
    • Bur, M.1    Huwer, H.2    Muys, L.3    Lehr, C.-M.4
  • 47
    • 78650715310 scopus 로고    scopus 로고
    • A new pharmaceutical aerosol deposition device on cell cultures (PADDOCC) to evaluate pulmonary drug absorption for metered dose dry powder formulations
    • Hein S, Bur M, Schaefer UF, Lehr CM. A new Pharmaceutical Aerosol Deposition Device on Cell Cultures (PADDOCC) to evaluate pulmonary drug absorption for metered dose dry powder formulations. Eur J Pharm Biopharm 2011;77(1):132-8
    • (2011) Eur J Pharm Biopharm , vol.77 , Issue.1 , pp. 132-138
    • Hein, S.1    Bur, M.2    Schaefer, U.F.3    Lehr, C.M.4
  • 48
    • 0036125277 scopus 로고    scopus 로고
    • Permeability characteristics of Calu-3 human bronchial epithelial cells: In vitro-in vitro correlation to predict lung absorption in rats
    • DOI 10.1080/10611860290007504
    • Mathias NR, Timoszyk J, Stetsko PI, et al. Permeability characteristics of calu-3 human bronchial epithelial cells: In vitro-in vivo correlation to predict lung absorption in rats. J Drug Target 2002;10(1):31-40 (Pubitemid 34223847)
    • (2002) Journal of Drug Targeting , vol.10 , Issue.1 , pp. 31-40
    • Mathias, N.R.1    Timoszyk, J.2    Stetsko, P.I.3    Megill, J.R.4    Smith, R.L.5    Wall, D.A.6
  • 49
    • 78650545991 scopus 로고    scopus 로고
    • In vitro and in vivo testing methods for respiratory drug delivery
    • Agu RU, Ugwoke MI. In vitro and in vivo testing methods for respiratory drug delivery. Expert Opin Drug Deliv 2011;8(1):57-69
    • (2011) Expert Opin Drug Deliv , vol.8 , Issue.1 , pp. 57-69
    • Agu, R.U.1    Ugwoke, M.I.2
  • 50
    • 0036282607 scopus 로고    scopus 로고
    • Insulin aggregation and asymmetric transport across human bronchial epithelial cell monolayers (Calu-3)
    • DOI 10.1002/jps.10114
    • Pezron I, Mitra R, Pal D, Mitra AK. Insulin aggregation and asymmetric transport across human bronchial epithelial cell monolayers (Calu-3). J Pharm Sci 2002;91(4):1135-46 (Pubitemid 34640938)
    • (2002) Journal of Pharmaceutical Sciences , vol.91 , Issue.4 , pp. 1135-1146
    • Pezron, I.1    Mitra, R.2    Pal, D.3    Mitra, A.K.4
  • 51
    • 0035834190 scopus 로고    scopus 로고
    • Modulation of P-glycoprotein activity in Calu-3 cells using steroids and β-ligands
    • DOI 10.1016/S0378-5173(01)00836-5, PII S0378517301008365
    • Hamilton KO, Yazdanian MA, Audus KL. Modulation of P-glycoprotein activity in Calu-3 cells using steroids and b-ligands. Int J Pharm 2001;228(1):171-9 (Pubitemid 32905376)
    • (2001) International Journal of Pharmaceutics , vol.228 , Issue.1-2 , pp. 171-179
    • Hamilton, K.O.1    Yazdanian, M.A.2    Audus, K.L.3
  • 52
    • 73849142300 scopus 로고    scopus 로고
    • Relative contributions of active mediated transport and passive diffusion of fluoroquinolones with various lipophilicities in a calu-3 lung epithelial cell model
    • Brillault J, De Castro WV, Couet W. Relative contributions of active mediated transport and passive diffusion of fluoroquinolones with various lipophilicities in a Calu-3 lung epithelial cell model. Antimicrob Agents Chemother 2010;54(1):543-5
    • (2010) Antimicrob Agents Chemother , vol.54 , Issue.1 , pp. 543-545
    • Brillault, J.1    De Castro, W.V.2    Couet, W.3
  • 53
    • 85047683608 scopus 로고    scopus 로고
    • RT-PCR analysis of ABC, SLC and SLCO drug transporters in human lung epithelial cell models
    • Endter S, Francombe D, Ehrhardt C, Gumbleton M. RT-PCR analysis of ABC, SLC and SLCO drug transporters in human lung epithelial cell models. J Pharm Pharmacol 2010;61(5):583-91
    • (2010) J Pharm Pharmacol , vol.61 , Issue.5 , pp. 583-591
    • Endter, S.1    Francombe, D.2    Ehrhardt, C.3    Gumbleton, M.4
  • 54
    • 77951277135 scopus 로고    scopus 로고
    • Drug transporters in the lung do they play a role in the biopharmaceutics of inhaled drugs?
    • Bosquillon C. Drug transporters in the lung, do they play a role in the biopharmaceutics of inhaled drugs? J Pharm Sci 2010;99(5):2240-55
    • (2010) J Pharm Sci , vol.99 , Issue.5 , pp. 2240-2255
    • Bosquillon, C.1
  • 56
    • 0035032962 scopus 로고    scopus 로고
    • P-glycoprotein efflux pump expression and activity in calu-3 cells
    • DOI 10.1002/1520-6017(200105)90:5<647::AID-JPS1021>3.0.CO;2-G
    • Hamilton KO, Backstrom G, Yazdanian MA, Audus KL. P-glycoprotein efflux pump expression and activity in Calu-3 cells. J Pharm Sci 2001;90(5):647-58 (Pubitemid 32378386)
    • (2001) Journal of Pharmaceutical Sciences , vol.90 , Issue.5 , pp. 647-658
    • Hamilton, K.O.1    Backstrom, G.2    Yazdanian, M.A.3    Audus, K.L.4
  • 58
    • 0037458930 scopus 로고    scopus 로고
    • Drug transport and metabolism characteristics of the human airway epithelial cell line Calu-3
    • DOI 10.1016/S0168-3659(02)00356-5
    • Florea BI, Cassará ML, Junginger HE, Borchard G. Drug transport and metabolism characteristics of the human airway epithelial cell line Calu-3. J Control Release 2003;87(1):131-8 (Pubitemid 36255450)
    • (2003) Journal of Controlled Release , vol.87 , Issue.1-3 , pp. 131-138
    • Florea, B.I.1    Cassara, M.L.2    Junginger, H.E.3    Borchard, G.4
  • 59
    • 70649101231 scopus 로고    scopus 로고
    • Identification and functional characterization of breast cancer resistance protein in human bronchial epithelial cells (Calu-3
    • Paturi DK, Kwatra D, Ananthula HK, et al. Identification and functional characterization of breast cancer resistance protein in human bronchial epithelial cells (Calu-3). Int J Pharm 2010;384(1):32-8
    • (2010) Int J Pharm , vol.384 , Issue.1 , pp. 32-38
    • Paturi, D.K.1    Kwatra, D.2    Ananthula, H.K.3
  • 60
    • 43149086651 scopus 로고    scopus 로고
    • Hpept1 is responsible for uptake and transport of Gly-Sar in the human bronchial airway epithelial cell-line Calu-3
    • Søndergaard HB, Brodin B, Nielsen CU. hPEPT1 is responsible for uptake and transport of Gly-Sar in the human bronchial airway epithelial cell-line Calu-3. Pflu?gers Archiv 2008;456(3):611-22
    • (2008) Pflugers Archiv , vol.456 , Issue.3 , pp. 611-622
    • Søndergaard, H.B.1    Brodin, B.2    Nielsen, C.U.3
  • 61
    • 79953160988 scopus 로고    scopus 로고
    • Calu-3 cells grown under AIC and LCC conditions: Implications for dipeptide uptake and transepithelial transport of substances
    • Stentebjerg-Andersen A, Notlevsen IV, Brodin B, Nielsen CU. Calu-3 cells grown under AIC and LCC conditions: Implications for dipeptide uptake and transepithelial transport of substances. Eur J Pharm Biopharm 2011;78(1):19-26
    • (2011) Eur J Pharm Biopharm , vol.78 , Issue.1 , pp. 19-26
    • Stentebjerg-Andersen, A.1    Notlevsen, I.V.2    Brodin, B.3    Nielsen, C.U.4
  • 62
    • 65649129716 scopus 로고    scopus 로고
    • P-glycoprotein-mediated transport of moxifloxacin in a Calu-3 lung epithelial cell model
    • Brillault J, De Castro WV, Harnois T, et al. P-glycoprotein-mediated transport of moxifloxacin in a Calu-3 lung epithelial cell model. Antimicrob Agents Chemother 2009;53(4):1457-62
    • (2009) Antimicrob Agents Chemother , vol.53 , Issue.4 , pp. 1457-1462
    • Brillault, J.1    De Castro, W.V.2    Harnois, T.3
  • 65
    • 84876229793 scopus 로고    scopus 로고
    • Salbutamol sulfate absorption across Calu-3 bronchial epithelia cell monolayer is inhibited in the presence of common anionic NSAIDs
    • Mamlouk M, Young PM, Bebawy M, et al. Salbutamol sulfate absorption across Calu-3 bronchial epithelia cell monolayer is inhibited in the presence of common anionic NSAIDs. J Asthma 2013;50(4):334-41
    • (2013) J Asthma , vol.50 , Issue.4 , pp. 334-341
    • Mamlouk, M.1    Young, P.M.2    Bebawy, M.3
  • 67
    • 33750690503 scopus 로고    scopus 로고
    • In vitro assessment of transferrin-conjugated liposomes as drug delivery systems for inhalation therapy of lung cancer
    • DOI 10.1016/j.ejps.2006.07.004, PII S0928098706002028
    • Anabousi S, Bakowsky U, Schneider M, et al. In vitro assessment of transferrin-conjugated liposomes as drug delivery systems for inhalation therapy of lung cancer. Eur J Pharm Sci 2006;29(5):367-74 (Pubitemid 44709858)
    • (2006) European Journal of Pharmaceutical Sciences , vol.29 , Issue.5 , pp. 367-374
    • Anabousi, S.1    Bakowsky, U.2    Schneider, M.3    Huwer, H.4    Lehr, C.-M.5    Ehrhardt, C.6
  • 68
    • 34248631942 scopus 로고    scopus 로고
    • Antitumor activity of enzastaurin (LY317615.HCl) against human cancer cell lines and freshly explanted tumors investigated in vitro soft-agar cloning experiments
    • DOI 10.1007/s10637-007-9038-7
    • Hanauske A-R, Oberschmidt O, Hanauske-Abel H, et al. Antitumor activity of enzastaurin (LY317615. HCl) against human cancer cell lines and freshly explanted tumors investigated in vitro soft-agar cloning experiments. Invest New Drugs 2007;25(3):205-10 (Pubitemid 46774707)
    • (2007) Investigational New Drugs , vol.25 , Issue.3 , pp. 205-210
    • Hanauske, A.-R.1    Oberschmidt, O.2    Hanauske-Abel, H.3    Lahn, M.M.4    Eismann, U.5
  • 69
    • 76749136371 scopus 로고    scopus 로고
    • AZD8931 an equipotent reversible inhibitor of signaling by epidermal growth factor receptor ERBB2 (HER2) And ERBB3: A unique agent for simultaneous ERBB receptor blockade in cancer
    • Hickinson DM, Klinowska T, Speake G, et al. AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor, ERBB2 (HER2), and ERBB3: A unique agent for simultaneous ERBB receptor blockade in cancer. Clin Cancer Res 2010;16(4):1159-69
    • (2010) Clin Cancer Res , vol.16 , Issue.4 , pp. 1159-1169
    • Hickinson, D.M.1    Klinowska, T.2    Speake, G.3
  • 71
    • 0032788573 scopus 로고    scopus 로고
    • A novel charged trinuclear platinum complex effective against cisplatin-resistant tumours: Hypersensitivity of p53-mutant human tumour xenografts
    • Pratesi G, Perego P, Polizzi D, et al. A novel charged trinuclear platinum complex effective against cisplatin-resistant tumours: Hypersensitivity of p53-mutant human tumour xenografts. Br J Cancer 1999;80(12):1912
    • (1999) Br J Cancer , vol.80 , Issue.12 , pp. 1912
    • Pratesi, G.1    Perego, P.2    Polizzi, D.3
  • 72
    • 73649149433 scopus 로고    scopus 로고
    • Strongly enhanced antitumor activity of trastuzumab and pertuzumab combination treatment on HER2-positive human xenograft tumor models
    • Scheuer W, Friess T, Burtscher H, et al. Strongly enhanced antitumor activity of trastuzumab and pertuzumab combination treatment on HER2-positive human xenograft tumor models. Cancer Res 2009;69(24):9330-6
    • (2009) Cancer Res , vol.69 , Issue.24 , pp. 9330-9336
    • Scheuer, W.1    Friess, T.2    Burtscher, H.3
  • 73
    • 48749110809 scopus 로고    scopus 로고
    • Synergistic anti-proliferative and pro-apoptotic activity of combined therapy with bortezomib, a proteasome inhibitor, with anti-epidermal growth factor receptor (EGFR) drugs in human cancer cells
    • Cascone T, Morelli MP, Morgillo F, et al. Synergistic anti-proliferative and pro-apoptotic activity of combined therapy with bortezomib, a proteasome inhibitor, with anti-epidermal growth factor receptor (EGFR) drugs in human cancer cells. J Cell Physiol 2008;216(3):698-707
    • (2008) J Cell Physiol , vol.216 , Issue.3 , pp. 698-707
    • Cascone, T.1    Morelli, M.P.2    Morgillo, F.3
  • 74
    • 22344457603 scopus 로고    scopus 로고
    • Combination treatment with erlotinib and pertuzumab against human tumor xenografts is superior to monotherapy
    • DOI 10.1158/1078-0432.CCR-04-2642
    • Friess T, Scheuer W, Hasmann M. Combination treatment with erlotinib and pertuzumab against human tumor xenografts is superior to monotherapy. Clin Cancer Res 2005;11(14):5300-9 (Pubitemid 41003719)
    • (2005) Clinical Cancer Research , vol.11 , Issue.14 , pp. 5300-5309
    • Friess, T.1    Scheuer, W.2    Hasmann, M.3
  • 75
    • 0035866409 scopus 로고    scopus 로고
    • Drug resistance induced by ouabain via the stimulation of MDR1 gene expression in human carcinomatous pulmonary cells
    • Brouillard F, Tondelier D, Edelman A, Baudouin-Legros M. Drug resistance induced by ouabain via the stimulation of MDR1 gene expression in human carcinomatous pulmonary cells. Cancer Res 2001;61(4):1693-8 (Pubitemid 34292607)
    • (2001) Cancer Research , vol.61 , Issue.4 , pp. 1693-1698
    • Brouillard, F.1    Tondelier, D.2    Edelman, A.3    Baudouin-Legros, M.4
  • 76
    • 74949121129 scopus 로고    scopus 로고
    • Controlled release antibiotics for dry powder lung delivery
    • Adi H, Young PM, Chan H-K, et al. Controlled release antibiotics for dry powder lung delivery. Drug Dev Ind Pharm 2010;36(1):119-26
    • (2010) Drug Dev Ind Pharm , vol.36 , Issue.1 , pp. 119-126
    • Adi, H.1    Young, P.M.2    Chan, H.-K.3
  • 77
    • 50149083441 scopus 로고    scopus 로고
    • Preparation and characterisation of controlled release co-spray dried drug-polymer microparticles for inhalation 2: Evaluation of in vitro release profiling methodologies for controlled release respiratory aerosols
    • Salama RO, Traini D, Chan H-K, Young PM. Preparation and characterisation of controlled release co-spray dried drug-polymer microparticles for inhalation 2: Evaluation of in vitro release profiling methodologies for controlled release respiratory aerosols. Eur J Pharm Biopharm 2008;70(1):145-52
    • (2008) Eur J Pharm Biopharm , vol.70 , Issue.1 , pp. 145-152
    • Salama, R.O.1    Traini, D.2    Chan, H.-K.3    Young, P.M.4
  • 78
    • 73349132967 scopus 로고    scopus 로고
    • Development of an ovine dry powder inhalation model for the evaluation of conventional and controlled release microparticles
    • Salama R, Ladd L, Chan H-K, et al. Development of an ovine dry powder inhalation model for the evaluation of conventional and controlled release microparticles. AAPS J 2009;11(3):465-8
    • (2009) AAPS J , vol.11 , Issue.3 , pp. 465-468
    • Salama, R.1    Ladd, L.2    Chan, H.-K.3
  • 79
    • 37849015123 scopus 로고    scopus 로고
    • Chitosan microspheres for intrapulmonary administration of moxifloxacin: Interaction with biomembrane models and in vitro permeation studies
    • Ventura CA, Tommasini S, Crupi E. Chitosan microspheres for intrapulmonary administration of moxifloxacin: Interaction with biomembrane models and in vitro permeation studies. Eur J Pharm Biopharm 2008;68(2):235-44
    • (2008) Eur J Pharm Biopharm , vol.68 , Issue.2 , pp. 235-244
    • Ventura, C.A.1    Tommasini, S.2    Crupi, E.3
  • 80
    • 33745108769 scopus 로고    scopus 로고
    • A mucoadhesive in situ gel delivery system for paclitaxel
    • Jauhari S, Dash AK. A mucoadhesive in situ gel delivery system for paclitaxel. AAPS Pharm Sci Tech 2006;7(2):154-9
    • (2006) AAPS Pharm Sci Tech , vol.7 , Issue.2 , pp. 154-159
    • Jauhari, S.1    Dash, A.K.2
  • 81
    • 0027172392 scopus 로고
    • Regulation of tight junction permeability by calcium mediators and cell cytoskeleton in rabbit tracheal epithelium
    • DOI 10.1023/A:1018906504944
    • Bhat M, Toledo-Velasquez D, Wang L, et al. Regulation of tight junction permeability by calcium mediators and cell cytoskeleton in rabbit tracheal epithelium. Pharm Res 1993;10(7):991-7 (Pubitemid 23211421)
    • (1993) Pharmaceutical Research , vol.10 , Issue.7 , pp. 991-997
    • Bhat, M.1    Toledo-Velasquez, D.2    Wang, L.3    Malanga, C.J.4    Ma, J.K.H.5    Rojanasakul, Y.6
  • 82
    • 0026666843 scopus 로고
    • The transport barrier of epithelia: A comparative study on membrane permeability and charge selectivity in the rabbit
    • Rojanasakul Y, Wang L-Y, Bhat M, et al. The transport barrier of epithelia: A comparative study on membrane permeability and charge selectivity in the rabbit. Pharm Res 1992;9(8):1029-34
    • (1992) Pharm Res , vol.9 , Issue.8 , pp. 1029-1034
    • Rojanasakul, Y.1    Wang, L.-Y.2    Bhat, M.3
  • 84
    • 0031026464 scopus 로고    scopus 로고
    • Airway and alveolar permeability and surface liquid thickness: Theory
    • Widdicombe J. Airway and alveolar permeability and surface liquid thickness: Theory. J Appl Physiol 1997;82(1):3-12 (Pubitemid 27052036)
    • (1997) Journal of Applied Physiology , vol.82 , Issue.1 , pp. 3-12
    • Widdicombe, J.1
  • 85
    • 85047685633 scopus 로고    scopus 로고
    • In-vitro respiratory drug absorption models possess nominal functional P-glycoprotein activity
    • Madlova M, Bosquillon C, Asker D, et al. In-vitro respiratory drug absorption models possess nominal functional P-glycoprotein activity. J Pharm Pharmacol 2009;61(3):293-301
    • (2009) J Pharm Pharmacol , vol.61 , Issue.3 , pp. 293-301
    • Madlova, M.1    Bosquillon, C.2    Asker, D.3
  • 86
    • 33646740631 scopus 로고    scopus 로고
    • Airway selectivity: An update of pharmacokinetic factors affecting local and systemic disposition of inhaled steroids
    • Edsba?cker S, Johansson C-J. Airway selectivity: An update of pharmacokinetic factors affecting local and systemic disposition of inhaled steroids. Basic Clin Pharmacol Toxicol 2006;98(6):523-36
    • (2006) Basic Clin Pharmacol Toxicol , vol.98 , Issue.6 , pp. 523-536
    • Edsbacker, S.1    Johansson, C.-J.2
  • 87
    • 78650225640 scopus 로고    scopus 로고
    • The particle has landed-characterizing the fate of inhaled pharmaceuticals
    • Patton JS, Brain JD, Davies LA, et al. The particle has landed-characterizing the fate of inhaled pharmaceuticals. J Aerosol Med Pulm Drug Deliv 2010;23(S2):71-87
    • (2010) J Aerosol Med Pulm Drug Deliv , vol.23 , Issue.S2 , pp. 71-87
    • Patton, J.S.1    Brain, J.D.2    Davies, L.A.3
  • 89
    • 84857792529 scopus 로고    scopus 로고
    • Evaluation of air-interfaced Calu-3 cell layers for investigation of inhaled drug interactions with organic cation transporters in vitro
    • Mukherjee M, Pritchard D, Bosquillon C. Evaluation of air-interfaced Calu-3 cell layers for investigation of inhaled drug interactions with organic cation transporters in vitro. Int J Pharm 2012;426(1-2):7-14
    • (2012) Int J Pharm , vol.426 , Issue.1-2 , pp. 7-14
    • Mukherjee, M.1    Pritchard, D.2    Bosquillon, C.3
  • 90
    • 0032961328 scopus 로고    scopus 로고
    • In vitro evaluation of microparticles and polymer gels for use as nasal platforms for protein delivery
    • Witschi C, Mrsny RJ. In vitro evaluation of microparticles and polymer gels for use as nasal platforms for protein delivery. Pharm Res 1999;16(3):382-90 (Pubitemid 29162095)
    • (1999) Pharmaceutical Research , vol.16 , Issue.3 , pp. 382-390
    • Witschi, C.1    Mrsny, R.J.2
  • 91
    • 0036844744 scopus 로고    scopus 로고
    • 3-treated calu-3 cell monolayers: Modulation of p-glycoprotein activity
    • DOI 10.1023/A:1020761514471
    • Patel J, Pal D, Vangala V, et al. Transport of HIV-protease inhibitors across 1a, 25di-hydroxy vitamin D 3-treated Calu-3 cell monolayers: Modulation of P-glycoprotein activity. Pharm Res 2002;19(11):1696-703 (Pubitemid 35305522)
    • (2002) Pharmaceutical Research , vol.19 , Issue.11 , pp. 1696-1703
    • Patel, J.1    Pal, D.2    Vangala, V.3    Gandhi, M.4    Mitra, A.K.5
  • 92
    • 0030940316 scopus 로고    scopus 로고
    • Vectorial transcytosis of dimeric IgA by the Calu-3 human lung epithelial cell line: Upregulation by IFN-gamma
    • Loman S, Radl J, Jansen H, et al. Vectorial transcytosis of dimeric IgA by the Calu-3 human lung epithelial cell line: Upregulation by IFN-gamma. Am J Physiol 1997;272(5):L951-8
    • (1997) Am J Physiol , vol.272 , Issue.5
    • Loman, S.1    Radl, J.2    Jansen, H.3
  • 93
    • 0036282607 scopus 로고    scopus 로고
    • Insulin aggregation and asymmetric transport across human bronchial epithelial cell monolayers (Calu-3)
    • DOI 10.1002/jps.10114
    • Pezron I, Mitra R, Pal D, Mitra AK. Insulin aggregation and asymmetric transport across human bronchial epithelial cell monolayers (Calu) . J Pharm Sci 2002;91(4):1135-46 (Pubitemid 34640938)
    • (2002) Journal of Pharmaceutical Sciences , vol.91 , Issue.4 , pp. 1135-1146
    • Pezron, I.1    Mitra, R.2    Pal, D.3    Mitra, A.K.4
  • 94
    • 84879099401 scopus 로고    scopus 로고
    • Multiple dosing of simvastatin inhibits airway mucus production of epithelial cells: Implications in the treatment of chronic obstructive airway pathologies
    • doi
    • Marin L, Traini D, Bebawy M, et al. Multiple dosing of simvastatin inhibits airway mucus production of epithelial cells: Implications in the treatment of chronic obstructive airway pathologies. Eur J Pharm Biopharm 2013; doi: Http://dx.doi.org/10.1016/ j.ejpb.2013.01.021
    • (2013) Eur J Pharm Biopharm
    • Marin, L.1    Traini, D.2    Bebawy, M.3
  • 95
    • 13544250625 scopus 로고    scopus 로고
    • Salbutamol is actively absorbed across human bronchial epithelial cell layers
    • Ehrhardt C, Kneuer C, Bies C, et al. Salbutamol is actively absorbed across human bronchial epithelial cell layers. Pulm Pharmacol Ther 2005;18(3):165
    • (2005) Pulm Pharmacol Ther , vol.18 , Issue.3 , pp. 165
    • Ehrhardt, C.1    Kneuer, C.2    Bies, C.3
  • 96
    • 66549124096 scopus 로고    scopus 로고
    • Active uptake of ulifloxacin from plasma to lung that controls its concentration in epithelial lining fluid
    • Aoki M, Iguchi M, Hayashi H, et al. Active uptake of ulifloxacin from plasma to lung that controls its concentration in epithelial lining fluid. Biol Pharm Bull 2009;32(6):1095-100
    • (2009) Biol Pharm Bull , vol.32 , Issue.6 , pp. 1095-1100
    • Aoki, M.1    Iguchi, M.2    Hayashi, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.