Evaluation of air-interfaced Calu-3 cell layers for investigation of inhaled drug interactions with organic cation transporters in vitro

International Journal of Pharmaceutics

Volumn 426, Issue 1-2, 2012, Pages 7-14

  Mukherjee, M ^a   Pritchard, D I ^a   Bosquillon, C ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Bronchial epithelium; Calu 3 cells; Carrier mediated transport; In vitro models; Organic cation transporters; Permeability; Pulmonary absorption

Indexed keywords

BUDESONIDE; FORMOTEROL; IPRATROPIUM BROMIDE; OCTN1 PROTEIN; OCTN2 PROTEIN; ORGANIC CATION TRANSPORTER; ORGANIC CATION TRANSPORTER 1; ORGANIC CATION TRANSPORTER 3; SALBUTAMOL; TETRYLAMMONIUM; UNCLASSIFIED DRUG;

ARTICLE; BRONCHUS MUCOSA; CELL STRAIN CALU 3; CONTROLLED STUDY; DRUG ABSORPTION; DRUG PENETRATION; DRUG PROTEIN BINDING; DRUG TRANSPORT; DRUG UPTAKE; EPITHELIUM CELL; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; INHIBITION KINETICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS INHIBITION; QUANTITATIVE ANALYSIS;

ADMINISTRATION, INHALATION; ALBUTEROL; BIOLOGICAL TRANSPORT; BRONCHODILATOR AGENTS; BUDESONIDE; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; ETHANOLAMINES; FLUORESCENT DYES; GENE EXPRESSION REGULATION; HUMANS; IPRATROPIUM; ORGANIC CATION TRANSPORT PROTEINS; ORGANIC CATION TRANSPORTER 1; PERMEABILITY; PYRIDINIUM COMPOUNDS; RESPIRATORY MUCOSA;

EID: 84857792529     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.12.036     Document Type: Article

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