Diminished expression of multidrug resistance-associated protein 1 (MRP1) in bronchial epithelium of COPD patients

Virchows Archiv

Volumn 449, Issue 6, 2006, Pages 682-688

  Van Der Deen, Margaretha ^a   Marks, Hendrik ^a   Willemse, Brigitte W M ^a   Postma, Dirkje S ^a   Müller, Michael ^a   Smit, Egbert F ^b   Scheffer, George L ^b   Scheper, Rik J ^b   De Vries, Elisabeth G E ^a   Timens, Wim ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Chronic obstructive pulmonary disease; Immunohistochemistry; Lung; MDR; Pathology

Indexed keywords

GLYCOPROTEIN P; LUNG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1;

ADULT; ARTICLE; BRONCHUS BIOPSY; BRONCHUS MUCOSA; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG PARENCHYMA; MALE; METAPLASIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMOKING; SQUAMOUS CELL; SQUAMOUS EPITHELIUM;

ADULT; AGED; BRONCHI; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; P-GLYCOPROTEIN; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE;

EID: 33751511745     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00428-006-0240-3     Document Type: Article

References (24)

1. Brechot JM, Hurbain I, Fajac A, Daty N, Bernaudin JF (1998) Different pattern of MRP localization in ciliated and basal cells from human bronchial epithelium. J Histochem Cytochem 46:513-517
2. Cole SP, Bhardwaj G, Gerlach JH, Mackie JE, Grant CE, Almquist KC, Stewart AJ, Kurz EU, Duncan AM, Deeley RG (1992) Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 258:1650-1654
3. Hurbain I, Sermet-Gaudelus I, Vallee B, Feuillet MN, Lenoir G, Bernaudin JF, Edelman A, Fajac A (2003) Evaluation of MRP1-5 gene expression in cystic fibrosis patients homozygous for the delta F508 mutation. Pediatr Res 54:627-634
4. Kitazono M, Sumizawa T, Takebayashi Y, Chen ZS, Furukawa T, Nagayama S, Tani A, Takao S, Aikou T, Akiyama S (1999) Multidrug resistance and the lung resistance-related protein in human colon carcinoma SW-620 cells. J Natl Cancer Inst 91:1647-1653
5. Lechapt-Zalcman E, Hurbain I, Lacave R, Commo F, Urban T, Antoine M, Milleron B, Bernaudin JF (1997) MDR1-Pgp 170 expression in human bronchus. Eur Respir J 10:1837-1843
6. Leslie EM, Ito K, Upadhyaya P, Hecht SS, Deeley RG, Cole SP (2001) Transport of the beta-O-glucuronide conjugate of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by the multidrug resistance protein 1 (MRP1). Requirement for glutathione or a non-sulfur-containing analog. J Biol Chem 276:27846-27854
7. Muller M, Meijer C, Zaman GJ, Borst P, Scheper RJ, Mulder NH, de Vries EG, Jansen PL (1994) Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport. Proc Natl Acad Sci U S A 91:13033-13037
8. Nooter K, Westerman AM, Flens MJ, Zaman GJ, Scheper RJ, van Wingerden KE, Burger H, Oostrum R, Boersma T, Sonneveld P (1995) Expression of the multidrug resistance-associated protein (MRP) gene in human cancers. Clin Cancer Res 1:1301-1310
9. Pastan I, Gottesman MM, Ueda K, Lovelace E, Rutherford AV, Willingham MC (1988) A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells. Proc Natl Acad Sci U S A 85:4486-4490
10. Pauwels RA, Buist AS, Calverley PM, Jenkins CR, Hurd SS (2001) Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary. Am J Respir Crit Care Med 163:1256-1276
11. Pryor WA, Stone K (1993) Oxidants in cigarette smoke. Radicals, hydrogen peroxide, peroxynitrate, and peroxynitrite. Ann NY Acad Sci 686:12-27
12. Rahman I, MacNee W (1999) Lung glutathione and oxidative stress: implications in cigarette smoke-induced airway disease. Am J Physiol 277:L1067-L1088
13. Rahman I, Morrison D, Donaldson K, MacNee W (1996) Systemic oxidative stress in asthma, COPD, and smokers. Am J Respir Crit Care Med 154:1055-1060
14. Repine JE, Bast A, Lankhorst I (1997) Oxidative stress in chronic obstructive pulmonary disease. Oxidative stress study group. Am J Respir Crit Care Med 156:341-357
15. Rutgers SR, Timens W, Kaufmann HF, van der Mark TW, Koeter GH, Postma DS (2000) Comparison of induced sputum with bronchial wash, bronchoalveolar lavage and bronchial biopsies in COPD. Eur Respir J 15:109-115
16. Scheffer GL, Kool M, Heijn M, de Haas M, Pijnenborg AC, Wijnholds J, van Helvoort A, de Jong MC, Hooijberg JH, Mol CA, van der Linden M, de Vree JM, van der Valk P, Elferink RP, Borst P, Scheper RJ (2000) Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies. Cancer Res 60:5269-5277
17. Scheffer GL, Pijnenborg AC, Smit EF, Muller M, Postma DS, Timens W, van der Valk P, de Vries EG, Scheper RJ (2002) Multidrug resistance related molecules in human and murine lung. J Clin Pathol 55:332-339
18. Scheffer GL, Schroeijers AB, Izquierdo MA, Wiemer EA, Scheper RJ (2000) Lung resistance-related protein/major vault protein and vaults in multidrug-resistant cancer. Curr Opin Oncol 12:550-556
19. Scheffer GL, Wijngaard PL, Flens MJ, Izquierdo MA, Slovak ML, Pinedo HM, Meijer CJ, Clevers HC, Scheper RJ (1995) The drug resistance-related protein LRP is the human major vault protein. Nat Med 1:578-582
20. Schroeijers AB, Scheffer GL, Reurs AW, Pijnenborg AC, Abbondanza C, Wiemer EA, Scheper RJ (2001) Detection of the Mr 110,000 lung resistance-related protein LRP/MVP with monoclonal antibodies. J Histochem Cytochem 49:1379-1385
21. Thomas GA, Barrand MA, Stewart S, Rabbitts PH, Williams ED, Twentyman PR (1994) Expression of themultidrug resistance-associated protein (MRP) gene in human lung tumours and normal tissue as determined by in situ hybridisation. Eur J Cancer 30A:1705-1709
22. van der Deen M, de Vries EG, Timens W, Scheper RJ, Timmer-Bosscha H, Postma DS (2005) ATP-binding cassette (ABC) transporters in normal and pathological lung. Respir Res 6:59
23. van Straaten JF, Coers W, Noordhoek JA, Huitema S, Flipsen JT, Kauffman HF, Timens W, Postma DS (1999) Proteoglycan changes in the extracellular matrix of lung tissue from patients with pulmonary emphysema. Mod Pathol 12:697-705
24. Wright SR, Boag AH, Valdimarsson G, Hipfner DR, Campling BG, Cole SP, Deeley RG (1998) Immunohistochemical detection of multidrug resistance protein in human lung cancer and normal lung. Clin Cancer Res 4:2279-2289