Drug transport across pulmonary epithelial cell monolayers: Effects of particle size, apical liquid volume, and deposition technique

Journal of Aerosol Medicine and Pulmonary Drug Delivery

Volumn 23, Issue 3, 2010, Pages 119-127

  Bur, Michael ^a   Huwer, Hanno ^b   Muys, Leon ^a   Lehr, Claus Michael ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b Volklingen Heart Centre   (Germany)

Author keywords

Air interface deposition; Air blood barrier; Air liquid interface cell culture; Alveolar lining fluid; Pulmonary cell culture; Pulmonary drug delivery

Indexed keywords

BUDESONIDE; SALBUTAMOL SULFATE; AEROSOL; BRONCHODILATING AGENT; EXCIPIENT; GENERIC DRUG; LACTOSE; SALBUTAMOL;

AEROSOL; AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; BRONCHUS MUCOSA; CARCINOMA CELL; CONTROLLED STUDY; DRUG ABSORPTION; DRUG FORMULATION; DRUG SOLUBILITY; DRUG TRANSPORT; DRY POWDER; EPITHELIUM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; INHALER; LIQUID; LUNG ADENOCARCINOMA; LUNG ALVEOLUS CELL; PARTICLE SIZE; BRONCHUS; CELL LINE; CHEMISTRY; COMPARATIVE STUDY; CRYSTALLIZATION; CYTOLOGY; DRUG DELIVERY SYSTEM; INHALATIONAL DRUG ADMINISTRATION; METABOLISM; NEBULIZER; SOLUBILITY; THERAPEUTIC EQUIVALENCE; TRANSPORT AT THE CELLULAR LEVEL;

ADMINISTRATION, INHALATION; AEROSOLS; ALBUTEROL; BIOLOGICAL TRANSPORT; BRONCHI; BRONCHODILATOR AGENTS; BUDESONIDE; CELL LINE; CRYSTALLIZATION; DRUG DELIVERY SYSTEMS; DRUGS, GENERIC; EPITHELIAL CELLS; EXCIPIENTS; HUMANS; LACTOSE; NEBULIZERS AND VAPORIZERS; PARTICLE SIZE; SOLUBILITY; THERAPEUTIC EQUIVALENCY;

EID: 77953954921     PISSN: 19412711     EISSN: 19412703     Source Type: Journal    
DOI: 10.1089/jamp.2009.0757     Document Type: Article

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