In-vitro respiratory drug absorption models possess nominal functional P-glycoprotein activity

Journal of Pharmacy and Pharmacology

Volumn 61, Issue 3, 2009, Pages 293-301

  Madlova, Michaela ^a,b   Bosquillon, Cynthia ^a,c   Asker, Dan ^a   Dolezal, Pavel ^b   Forbes, Ben ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b Charles University in Prague Faculty of Pharmacy   (Czech Republic)

^c UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Airways; Drug disposition; Normal human bronchial epithelium; P gp; Transport

Indexed keywords

DIGOXIN; GF 120918A; GLYCOPROTEIN P; GLYCOPROTEIN P INHIBITOR; UNCLASSIFIED DRUG; ACRIDINE DERIVATIVE; ELACRIDAR; TETRAHYDROISOQUINOLINE DERIVATIVE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRONCHUS MUCOSA; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DISPOSITION; DRUG PROTEIN BINDING; DRUG TRANSPORT; HUMAN; HUMAN CELL; MALE; NONHUMAN; PROTEIN FUNCTION; RAT; ANIMAL; BIOLOGICAL MODEL; BRONCHUS; CELL CULTURE; CYTOLOGY; DRUG ANTAGONISM; EPITHELIUM CELL; INHALATIONAL DRUG ADMINISTRATION; LUNG; METABOLISM; TRANSPORT AT THE CELLULAR LEVEL; WISTAR RAT;

ACRIDINES; ADMINISTRATION, INHALATION; ANIMALS; BIOLOGICAL TRANSPORT; BRONCHI; CACO-2 CELLS; CELLS, CULTURED; DIGOXIN; EPITHELIAL CELLS; HUMANS; LUNG; MALE; MODELS, BIOLOGICAL; P-GLYCOPROTEIN; RATS; RATS, WISTAR; TETRAHYDROISOQUINOLINES;

EID: 85047685633     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.61.03.0003     Document Type: Article

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