Digoxin net secretory transport in bronchial epithelial cell layers is not exclusively mediated by P-glycoprotein/MDR1

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 86, Issue 1, 2014, Pages 74-82

  Hutter, Victoria ^a,d   Chau, David Y S ^a   Hilgendorf, Constanze ^b   Brown, Alan ^a   Cooper, Anne ^c   Zann, Vanessa ^c   Pritchard, David I ^a   Bosquillon, Cynthia ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b ASTRAZENECA R AND D   (Sweden)

^c ASTRAZENECA   (United Kingdom)

^d UNIVERSITY OF HERTFORDSHIRE   (United Kingdom)

Author keywords

Bronchial epithelium; Calu 3; Drug transporters; In vitro models; In vitro in vivo correlation; Pulmonary absorption

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIBODY; DIGOXIN; MULTIDRUG RESISTANCE PROTEIN 1;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG DISPOSITION; DRUG TRANSPORT; EPITHELIUM CELL; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; NONHUMAN; PROTEIN DEPLETION; PROTEIN EXPRESSION;

BRONCHIAL EPITHELIUM; CALU-3; DRUG TRANSPORTERS; IN VITRO MODELS; IN VITRO/IN VIVO CORRELATION; PULMONARY ABSORPTION;

ANIMALS; BIOLOGICAL TRANSPORT; BRONCHI; CELL CULTURE TECHNIQUES; DIGOXIN; DOGS; EPITHELIAL CELLS; FLOW CYTOMETRY; HUMANS; MADIN DARBY CANINE KIDNEY CELLS; MICROSCOPY, CONFOCAL; P-GLYCOPROTEIN; PERMEABILITY; TRANSFECTION;

EID: 84896700746     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2013.06.010     Document Type: Article

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