메뉴 건너뛰기




Volumn 60, Issue 2, 2005, Pages 193-205

Human respiratory epithelial cell culture for drug delivery applications

Author keywords

Alveolar epithelial cells; Bronchial epithelial cells; In vitro models; Pulmonary drug delivery

Indexed keywords

4 AMINOHIPPURIC ACID; ADRENALIN; ATENOLOL; BROMIDE; BUDESONIDE; CAFFEINE; CIPROFLOXACIN; COCAINE; CROMOGLYCATE DISODIUM; DEXAMETHASONE; DIAZEPAM; DIGOXIN; FLUNISOLIDE; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; IMMUNOGLOBULIN A; INULIN; LEUCINE; LUCIFER YELLOW; MACROGOL; METOPROLOL; MORPHINE; NICOTINE; PHENAZONE; PROPRANOLOL; RECOMBINANT HUMAN INSULIN; RHODAMINE 123; RITONAVIR; SALBUTAMOL; SAQUINAVIR; SUCROSE; TETRYLAMMONIUM; THEOPHYLLINE; TRIAMCINOLONE; TRIAMCINOLONE ACETONIDE; URIDINE; VERAPAMIL; ZIDOVUDINE;

EID: 20444378183     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2005.02.010     Document Type: Conference Paper
Times cited : (262)

References (130)
  • 1
    • 0033813721 scopus 로고    scopus 로고
    • The ascent of pulmonary drug delivery
    • I. Gonda The ascent of pulmonary drug delivery J. Pharm. Sci. 87 2000 940 945
    • (2000) J. Pharm. Sci. , vol.87 , pp. 940-945
    • Gonda, I.1
  • 2
    • 0035111927 scopus 로고    scopus 로고
    • Treating systemic diseases via the lung
    • S. Sanjar, and J. Matthews Treating systemic diseases via the lung J. Aerosol. Med. 14 2001 S51 S58
    • (2001) J. Aerosol. Med. , vol.14
    • Sanjar, S.1    Matthews, J.2
  • 3
    • 0029090267 scopus 로고
    • The controlled delivery of drugs to the lung
    • X.M. Zeng, G.P. Martin, and C. Marriott The controlled delivery of drugs to the lung Int. J. Pharm. 124 1995 149 164
    • (1995) Int. J. Pharm. , vol.124 , pp. 149-164
    • Zeng, X.M.1    Martin, G.P.2    Marriott, C.3
  • 6
    • 0030588714 scopus 로고    scopus 로고
    • Caco-2 monolayers in experimental and theoretical prediction of drug transport
    • P. Artursson, K. Palm, and K. Luthman Caco-2 monolayers in experimental and theoretical prediction of drug transport Adv. Drug Deliv. Rev. 22 1996 67 84
    • (1996) Adv. Drug Deliv. Rev. , vol.22 , pp. 67-84
    • Artursson, P.1    Palm, K.2    Luthman, K.3
  • 7
    • 0031413702 scopus 로고    scopus 로고
    • Intestinal drug absorption and metabolism in cell cultures: Caco-2 and beyond
    • P. Artursson, and R.T. Borchardt Intestinal drug absorption and metabolism in cell cultures: Caco-2 and beyond Pharm. Res. 14 1997 1655 1658
    • (1997) Pharm. Res. , vol.14 , pp. 1655-1658
    • Artursson, P.1    Borchardt, R.T.2
  • 8
    • 0142106303 scopus 로고    scopus 로고
    • Transporter-enzyme interactions: implications for predicting drug-drug interactions from in vitro data
    • L.Z. Benet, C.L. Cummins, and C.Y. Wu Transporter-enzyme interactions: implications for predicting drug-drug interactions from in vitro data Curr. Drug Metab. 4 2003 393 398
    • (2003) Curr. Drug Metab. , vol.4 , pp. 393-398
    • Benet, L.Z.1    Cummins, C.L.2    Wu, C.Y.3
  • 10
    • 0035313918 scopus 로고    scopus 로고
    • Methods used to assess pulmonary deposition and absorption of drugs
    • C. Mobley, and G. Hochhaus Methods used to assess pulmonary deposition and absorption of drugs Drug Discov. Today 6 2001 367 375
    • (2001) Drug Discov. Today , vol.6 , pp. 367-375
    • Mobley, C.1    Hochhaus, G.2
  • 11
    • 0017873165 scopus 로고
    • Drug absorption from the lung
    • L.S. Schanker Drug absorption from the lung Biochem. Pharmacol. 27 1978 381 385
    • (1978) Biochem. Pharmacol. , vol.27 , pp. 381-385
    • Schanker, L.S.1
  • 12
    • 0031026464 scopus 로고    scopus 로고
    • Airway permeability and alveolar permeability and surface liquid thickness: theory
    • J. Widdecombe Airway permeability and alveolar permeability and surface liquid thickness: theory J. Appl. Physiol. 82 1997 3 12
    • (1997) J. Appl. Physiol. , vol.82 , pp. 3-12
    • Widdecombe, J.1
  • 13
    • 0036046741 scopus 로고    scopus 로고
    • Replacement, reduction, refinement
    • P. Flecknell Replacement, reduction, refinement ALTEX 19 2002 73 78
    • (2002) ALTEX , vol.19 , pp. 73-78
    • Flecknell, P.1
  • 16
    • 0037607679 scopus 로고    scopus 로고
    • Pulmonary absorption rate and bioavailability of drugs in vivo in rats: structure-absorption relationships and physicochemical profiling of inhaled drugs
    • A. Tronde, B. Norden, H. Marchner, A.K. Wendel, H. Lennernas, and U.H. Bengtsson Pulmonary absorption rate and bioavailability of drugs in vivo in rats: structure-absorption relationships and physicochemical profiling of inhaled drugs J. Pharm. Sci. 92 2003 1216 1233
    • (2003) J. Pharm. Sci. , vol.92 , pp. 1216-1233
    • Tronde, A.1    Norden, B.2    Marchner, H.3    Wendel, A.K.4    Lennernas, H.5    Bengtsson, U.H.6
  • 17
    • 0033959120 scopus 로고    scopus 로고
    • Human airway epithelial cell lines for in vitro drug transport and metabolism studies
    • B. Forbes Human airway epithelial cell lines for in vitro drug transport and metabolism studies Pharm. Sci. Technol. Today 3 2000 18 27
    • (2000) Pharm. Sci. Technol. Today , vol.3 , pp. 18-27
    • Forbes, B.1
  • 18
    • 0030588581 scopus 로고    scopus 로고
    • Respiratory epithelial cell culture models for evaluation of ion and drug transport
    • N.R. Mathias, F. Yamashita, and V.H.L. Lee Respiratory epithelial cell culture models for evaluation of ion and drug transport Adv. Drug Deliv. Rev. 22 1996 215 249
    • (1996) Adv. Drug Deliv. Rev. , vol.22 , pp. 215-249
    • Mathias, N.R.1    Yamashita, F.2    Lee, V.H.L.3
  • 20
    • 0343171768 scopus 로고    scopus 로고
    • Expression of metallothionein protein in the lungs of Wistar rats and C57 and DBA mice exposed to cadmium oxide fumes
    • I.M. McKenna, T. Gordon, L.C. Chen, M.R. Anver, and M.P. Waalkes Expression of metallothionein protein in the lungs of Wistar rats and C57 and DBA mice exposed to cadmium oxide fumes Toxicol. Appl. Pharmacol. 153 1998 169 178
    • (1998) Toxicol. Appl. Pharmacol. , vol.153 , pp. 169-178
    • McKenna, I.M.1    Gordon, T.2    Chen, L.C.3    Anver, M.R.4    Waalkes, M.P.5
  • 21
    • 0033073433 scopus 로고    scopus 로고
    • Endothelin receptor distribution and function in the airways
    • P.J. Henry Endothelin receptor distribution and function in the airways Clin. Exp. Pharmacol. Physiol. 26 1999 16216 16217
    • (1999) Clin. Exp. Pharmacol. Physiol. , vol.26 , pp. 16216-16217
    • Henry, P.J.1
  • 22
    • 0035719828 scopus 로고    scopus 로고
    • The lung as a route for systemic delivery of therapeutic proteins and peptides
    • R.U. Agu, M.I. Ugwoke, M. Armand, R. Kinget, and N. Verbeke The lung as a route for systemic delivery of therapeutic proteins and peptides Respir. Res. 2 2001 198 209
    • (2001) Respir. Res. , vol.2 , pp. 198-209
    • Agu, R.U.1    Ugwoke, M.I.2    Armand, M.3    Kinget, R.4    Verbeke, N.5
  • 23
    • 0028087664 scopus 로고
    • Drug delivery via the respiratory tract
    • P.R. Byron, and J.S. Patton Drug delivery via the respiratory tract J. Aerosol. Med. 7 1994 49 75
    • (1994) J. Aerosol. Med. , vol.7 , pp. 49-75
    • Byron, P.R.1    Patton, J.S.2
  • 25
    • 0035963943 scopus 로고    scopus 로고
    • Caveolae as potential macromolecule trafficking compartments within alveolar epithelium
    • M. Gumbleton Caveolae as potential macromolecule trafficking compartments within alveolar epithelium Adv. Drug Deliv. Rev. 49 2001 281 300
    • (2001) Adv. Drug Deliv. Rev. , vol.49 , pp. 281-300
    • Gumbleton, M.1
  • 26
    • 0033925098 scopus 로고    scopus 로고
    • Sustained release drug delivery to the lungs - an option for the future
    • J.G. Hardy, and T.S. Chadwick Sustained release drug delivery to the lungs - an option for the future Clin. Pharmacokinet. 39 2000 1 4
    • (2000) Clin. Pharmacokinet. , vol.39 , pp. 1-4
    • Hardy, J.G.1    Chadwick, T.S.2
  • 27
    • 0344513087 scopus 로고    scopus 로고
    • Pulmonary drug delivery. Part I. Physiological factors affecting therapeutic effectiveness of aerosolized medications
    • N.R. Labiris, and M.B. Dolovich Pulmonary drug delivery. Part I. Physiological factors affecting therapeutic effectiveness of aerosolized medications Br. J. Clin. Pharmacol. 56 2003 588 599
    • (2003) Br. J. Clin. Pharmacol. , vol.56 , pp. 588-599
    • Labiris, N.R.1    Dolovich, M.B.2
  • 28
    • 0027670013 scopus 로고
    • Mucociliary clearance and drug-delivery via the respiratory tract
    • A.B. Lansley Mucociliary clearance and drug-delivery via the respiratory tract Adv. Drug Deliv. Rev. 11 1993 299 327
    • (1993) Adv. Drug Deliv. Rev. , vol.11 , pp. 299-327
    • Lansley, A.B.1
  • 29
    • 0343058935 scopus 로고    scopus 로고
    • Mechanisms of macromolecule absorption by the lungs
    • J.S. Patton Mechanisms of macromolecule absorption by the lungs Adv. Drug Deliv. Rev. 19 1996 3 36
    • (1996) Adv. Drug Deliv. Rev. , vol.19 , pp. 3-36
    • Patton, J.S.1
  • 30
    • 0031454495 scopus 로고    scopus 로고
    • Pulmonary drug delivery: physiologic and mechanistic aspects
    • J.W. Yu, and Y.W. Chien Pulmonary drug delivery: physiologic and mechanistic aspects Crit. Rev. Ther. Drug Carrier Syst. 14 1997 395 453
    • (1997) Crit. Rev. Ther. Drug Carrier Syst. , vol.14 , pp. 395-453
    • Yu, J.W.1    Chien, Y.W.2
  • 31
    • 0344299169 scopus 로고    scopus 로고
    • Monolayers of human alveolar epithelial cells in primary culture for pulmonary absorption and transport studies
    • K.J. Elbert, U.F. Schäfer, H.J. Schäfers, K.J. Kim, V.H.L. Lee, and C.M. Lehr Monolayers of human alveolar epithelial cells in primary culture for pulmonary absorption and transport studies Pharm. Res. 16 1999 601 608
    • (1999) Pharm. Res. , vol.16 , pp. 601-608
    • Elbert, K.J.1    Schäfer, U.F.2    Schäfers, H.J.3    Kim, K.J.4    Lee, V.H.L.5    Lehr, C.M.6
  • 32
    • 0026636673 scopus 로고
    • Differentiated structure and function of cultures from human tracheal epithelium
    • M. Yamaya, W.E. Finkbeiner, S.Y. Chun, and J.H. Widdecombe Differentiated structure and function of cultures from human tracheal epithelium Am. J. Physiol. 262 1992 L713 L724
    • (1992) Am. J. Physiol. , vol.262
    • Yamaya, M.1    Finkbeiner, W.E.2    Chun, S.Y.3    Widdecombe, J.H.4
  • 33
    • 0043125890 scopus 로고    scopus 로고
    • Effects of growth surface on differentiation of cultures of human tracheal epithelium
    • J.H. Widdecombe, L.A. Sachs, and W.E. Finkbeiner Effects of growth surface on differentiation of cultures of human tracheal epithelium In Vitro Cell Dev. Biol. 39 2003 51 55
    • (2003) In Vitro Cell Dev. Biol. , vol.39 , pp. 51-55
    • Widdecombe, J.H.1    Sachs, L.A.2    Finkbeiner, W.E.3
  • 34
    • 0043033102 scopus 로고    scopus 로고
    • Effects of media on differentiation of cultured human tracheal epithelium
    • L.A. Sachs, W.E. Finkbeiner, and J.H. Widdecombe Effects of media on differentiation of cultured human tracheal epithelium In Vitro Cell Dev. Biol. 39 2003 56 62
    • (2003) In Vitro Cell Dev. Biol. , vol.39 , pp. 56-62
    • Sachs, L.A.1    Finkbeiner, W.E.2    Widdecombe, J.H.3
  • 35
    • 20444377151 scopus 로고    scopus 로고
    • http://www.mattek.com/pages/products/epiairway.
  • 38
    • 0035989143 scopus 로고    scopus 로고
    • Influence of apical fluid volume on the development of functional intercellular junctions in the human epithelial cell line 16HBE14o-: implications for the use of this cell line as an in vitro model for bronchial drug absorption studies
    • C. Ehrhardt, C. Kneuer, J. Fiegel, J. Hanes, U.F. Schaefer, K.J. Kim, and C.M. Lehr Influence of apical fluid volume on the development of functional intercellular junctions in the human epithelial cell line 16HBE14o-: implications for the use of this cell line as an in vitro model for bronchial drug absorption studies Cell Tissue Res. 308 2002 391 400
    • (2002) Cell Tissue Res. , vol.308 , pp. 391-400
    • Ehrhardt, C.1    Kneuer, C.2    Fiegel, J.3    Hanes, J.4    Schaefer, U.F.5    Kim, K.J.6    Lehr, C.M.7
  • 39
    • 0037433812 scopus 로고    scopus 로고
    • The human bronchial epithelial cell line 16HBE14o- as a model system of the airways for studying drug transport
    • B. Forbes, A. Shah, G.P. Martin, and A.B. Lansley The human bronchial epithelial cell line 16HBE14o- as a model system of the airways for studying drug transport Int. J. Pharm. 257 2003 61 167
    • (2003) Int. J. Pharm. , vol.257 , pp. 61-167
    • Forbes, B.1    Shah, A.2    Martin, G.P.3    Lansley, A.B.4
  • 40
    • 0036125277 scopus 로고    scopus 로고
    • Permeability characteristics of Calu-3 human bronchial epithelial cells: in vitro-in vivo correlation to predict lung absorption in rats
    • N.R. Mathias, J. Timoszyk, P.I. Stetsko, J.R. Megill, R.L. Smith, and D.A. Wall Permeability characteristics of Calu-3 human bronchial epithelial cells: in vitro-in vivo correlation to predict lung absorption in rats J. Drug Target. 10 2002 31 40
    • (2002) J. Drug Target. , vol.10 , pp. 31-40
    • Mathias, N.R.1    Timoszyk, J.2    Stetsko, P.I.3    Megill, J.R.4    Smith, R.L.5    Wall, D.A.6
  • 42
    • 0037458930 scopus 로고    scopus 로고
    • Drug transport and metabolism characteristics of the human airway epithelial cell line Calu-3
    • B.I. Florea, M.L. Cassara, H.E. Junginger, and G. Borchard Drug transport and metabolism characteristics of the human airway epithelial cell line Calu-3 J. Control Rel. 87 2003 131 138
    • (2003) J. Control Rel. , vol.87 , pp. 131-138
    • Florea, B.I.1    Cassara, M.L.2    Junginger, H.E.3    Borchard, G.4
  • 43
    • 0036282607 scopus 로고    scopus 로고
    • Insulin aggregation and asymmetric transport across human bronchial epithelial cell monolayers (Calu-3)
    • I. Pezron, R. Mitra, D. Pal, and A.K. Mitra Insulin aggregation and asymmetric transport across human bronchial epithelial cell monolayers (Calu-3) J. Pharm. Sci. 91 2002 1135 1146
    • (2002) J. Pharm. Sci. , vol.91 , pp. 1135-1146
    • Pezron, I.1    Mitra, R.2    Pal, D.3    Mitra, A.K.4
  • 45
    • 0242584998 scopus 로고    scopus 로고
    • Large porous particle impingement on lung epithelial cell monolayers - toward improved particle characterization in the lung
    • J. Fiegel, C. Ehrhardt, U.F. Schaefer, C.M. Lehr, and J. Hanes Large porous particle impingement on lung epithelial cell monolayers - toward improved particle characterization in the lung Pharm. Res. 20 2003 788 796
    • (2003) Pharm. Res. , vol.20 , pp. 788-796
    • Fiegel, J.1    Ehrhardt, C.2    Schaefer, U.F.3    Lehr, C.M.4    Hanes, J.5
  • 46
    • 0043092355 scopus 로고    scopus 로고
    • Do cell culture conditions influence the carrier-mediated transport of peptides in Caco-2 cell monolayers?
    • I. Behrens, and T. Kissel Do cell culture conditions influence the carrier-mediated transport of peptides in Caco-2 cell monolayers? Eur. J. Pharm. Sci. 19 2003 433 442
    • (2003) Eur. J. Pharm. Sci. , vol.19 , pp. 433-442
    • Behrens, I.1    Kissel, T.2
  • 47
    • 0030909506 scopus 로고    scopus 로고
    • The influence of culture time and passage number on the morphological and physiological development of Caco-2 cells
    • M.J. Briske-Anderson, J.W. Finley, and S.M. Newman The influence of culture time and passage number on the morphological and physiological development of Caco-2 cells Proc. Soc. Exp. Biol. Med. 214 1997 248 257
    • (1997) Proc. Soc. Exp. Biol. Med. , vol.214 , pp. 248-257
    • Briske-Anderson, M.J.1    Finley, J.W.2    Newman, S.M.3
  • 49
    • 0035721766 scopus 로고    scopus 로고
    • Alveolar epithelial type II cell: defender of the alveolus revisited
    • H. Fehrenbach Alveolar epithelial type II cell: defender of the alveolus revisited Respir. Res. 2 2001 33 46
    • (2001) Respir. Res. , vol.2 , pp. 33-46
    • Fehrenbach, H.1
  • 50
    • 0038041946 scopus 로고    scopus 로고
    • Alveolar type I cells: molecular phenotype and development
    • M.C. Williams Alveolar type I cells: molecular phenotype and development Annu. Rev. Physiol. 65 2003 669 695
    • (2003) Annu. Rev. Physiol. , vol.65 , pp. 669-695
    • Williams, M.C.1
  • 51
    • 0034948869 scopus 로고    scopus 로고
    • A useful in vitro model for transport studies of alveolar epithelial barrier
    • K.J. Kim, Z. Borok, and E.D. Crandall A useful in vitro model for transport studies of alveolar epithelial barrier Pharm. Res. 18 2001 253 255
    • (2001) Pharm. Res. , vol.18 , pp. 253-255
    • Kim, K.J.1    Borok, Z.2    Crandall, E.D.3
  • 52
    • 0029101698 scopus 로고
    • Permeability of peptides and proteins in human cultured alveolar A549 cell monolayer
    • S. Kobayashi, S. Kondo, and K. Juni Permeability of peptides and proteins in human cultured alveolar A549 cell monolayer Pharm. Res. 12 1995 1115 1119
    • (1995) Pharm. Res. , vol.12 , pp. 1115-1119
    • Kobayashi, S.1    Kondo, S.2    Juni, K.3
  • 53
    • 0347989344 scopus 로고    scopus 로고
    • Transport of proteins and peptides across human cultured alveolar A549 cell monolayer
    • Z. Wang, and Q. Zhang Transport of proteins and peptides across human cultured alveolar A549 cell monolayer Int. J. Pharm. 269 2004 451 456
    • (2004) Int. J. Pharm. , vol.269 , pp. 451-456
    • Wang, Z.1    Zhang, Q.2
  • 54
    • 0019988614 scopus 로고
    • Dome formation in primary cultured monolayers of alveolar epithelial cells
    • B.E. Goodman, and E.D. Crandall Dome formation in primary cultured monolayers of alveolar epithelial cells Am. J. Physiol. 243 1982 C96 C100
    • (1982) Am. J. Physiol. , vol.243
    • Goodman, B.E.1    Crandall, E.D.2
  • 55
    • 0024467703 scopus 로고
    • Type I cell-like morphology in tight alveolar epithelial monolayers
    • J.M. Cheek, M.J. Evans, and E.D. Crandall Type I cell-like morphology in tight alveolar epithelial monolayers Exp. Cell Res. 184 1989 3753 3787
    • (1989) Exp. Cell Res. , vol.184 , pp. 3753-3787
    • Cheek, J.M.1    Evans, M.J.2    Crandall, E.D.3
  • 56
    • 0028332971 scopus 로고
    • Defined medium for primary culture de novo of adult rat alveolar epithelial cells
    • Z. Borok, S.I. Danto, S.M. Zabski, and E.D. Crandall Defined medium for primary culture de novo of adult rat alveolar epithelial cells In Vitro Cell Dev. Biol. 30A 1994 99 104
    • (1994) In Vitro Cell Dev. Biol. , vol.30 , pp. 99-104
    • Borok, Z.1    Danto, S.I.2    Zabski, S.M.3    Crandall, E.D.4
  • 57
  • 59
    • 0035236614 scopus 로고    scopus 로고
    • Marker transport across biological barriers in vitro: comparison of cell culture models for the gastrointestinal barrier, the blood-brain barrier and the alveolar epithelium of the lung
    • C. Gindorf, A. Steimer, C.M. Lehr, U. Bock, S. Schmitz, and E. Haltner Marker transport across biological barriers in vitro: comparison of cell culture models for the gastrointestinal barrier, the blood-brain barrier and the alveolar epithelium of the lung ALTEX 18 2001 155 165
    • (2001) ALTEX , vol.18 , pp. 155-165
    • Gindorf, C.1    Steimer, A.2    Lehr, C.M.3    Bock, U.4    Schmitz, S.5    Haltner, E.6
  • 60
    • 0021743744 scopus 로고
    • Growth characteristics, morphology, and phospholipid composition of human type II pulmonary alveolar cells grown in a collagen-free microenvironment
    • G.E. Milo, G.A. Ackerman, and R.L. Sanders Growth characteristics, morphology, and phospholipid composition of human type II pulmonary alveolar cells grown in a collagen-free microenvironment In Vitro 20 1984 899 911
    • (1984) In Vitro , vol.20 , pp. 899-911
    • Milo, G.E.1    Ackerman, G.A.2    Sanders, R.L.3
  • 61
    • 1842858258 scopus 로고    scopus 로고
    • Differentiation of human alveolar epithelial cells in primary culture - morphological characterisation and expression of caveolin-1 and surfactant protein-C
    • S. Fuchs, A.J. Hollins, M. Laue, U.F. Schaefer, K. Roemer, M. Gumbleton, and C.M. Lehr Differentiation of human alveolar epithelial cells in primary culture - morphological characterisation and expression of caveolin-1 and surfactant protein-C Cell Tissue Res. 311 2003 31 45
    • (2003) Cell Tissue Res. , vol.311 , pp. 31-45
    • Fuchs, S.1    Hollins, A.J.2    Laue, M.3    Schaefer, U.F.4    Roemer, K.5    Gumbleton, M.6    Lehr, C.M.7
  • 63
    • 0028847496 scopus 로고
    • Epithelial lung cell marker: current tools for cell typing
    • M. Kasper, and G. Singh Epithelial lung cell marker: current tools for cell typing Histol. Histopathol. 10 1995 155 169
    • (1995) Histol. Histopathol. , vol.10 , pp. 155-169
    • Kasper, M.1    Singh, G.2
  • 65
    • 0032921302 scopus 로고    scopus 로고
    • Caveolin and its cellular and subcellular immunolocalisation in lung alveolar epithelium: implications for alveolar type I cell function
    • G.R. Newman, L. Campbell, C. von Ruhland, B. Jasani, and M. Gumbleton Caveolin and its cellular and subcellular immunolocalisation in lung alveolar epithelium: implications for alveolar type I cell function Cell Tissue Res. 295 1999 111 120
    • (1999) Cell Tissue Res. , vol.295 , pp. 111-120
    • Newman, G.R.1    Campbell, L.2    Von Ruhland, C.3    Jasani, B.4    Gumbleton, M.5
  • 67
    • 0032198791 scopus 로고    scopus 로고
    • Receptor for advanced glycation endproducts (RAGE) exhibits highly differential cellular and subcellular localisation in rat and human lung
    • H. Fehrenbach, M. Kasper, T. Tschernig, M.S. Shearman, D. Schuh, and M. Muller Receptor for advanced glycation endproducts (RAGE) exhibits highly differential cellular and subcellular localisation in rat and human lung Cell. Mol. Biol. 44 1998 1147 1157
    • (1998) Cell. Mol. Biol. , vol.44 , pp. 1147-1157
    • Fehrenbach, H.1    Kasper, M.2    Tschernig, T.3    Shearman, M.S.4    Schuh, D.5    Muller, M.6
  • 68
    • 0036765170 scopus 로고    scopus 로고
    • Heterocellular cultures of pulmonary alveolar epithelial cells grown on laminin-5 supplemented matrix
    • B.E. Isakson, G.J. Seedorf, R.L. Lubman, and S. Boitano Heterocellular cultures of pulmonary alveolar epithelial cells grown on laminin-5 supplemented matrix In Vitro Cell Dev. Biol. Anim. 38 2002 443 449
    • (2002) In Vitro Cell Dev. Biol. Anim. , vol.38 , pp. 443-449
    • Isakson, B.E.1    Seedorf, G.J.2    Lubman, R.L.3    Boitano, S.4
  • 69
    • 0001952404 scopus 로고    scopus 로고
    • Differences in drug transport across bronchial and gastrointestinal drug absorption models
    • B. Forbes, and A.B. Lansley Differences in drug transport across bronchial and gastrointestinal drug absorption models J. Pharm. Pharmacol. 50 1998 96
    • (1998) J. Pharm. Pharmacol. , vol.50 , pp. 96
    • Forbes, B.1    Lansley, A.B.2
  • 70
    • 0002673070 scopus 로고    scopus 로고
    • Transport characteristics of formoterol and salbutamol across a bronchial epithelial drug absorption model
    • B. Forbes, and A.B. Lansley Transport characteristics of formoterol and salbutamol across a bronchial epithelial drug absorption model Eur. J. Pharm. Sci. 6 1998 S24
    • (1998) Eur. J. Pharm. Sci. , vol.6 , pp. 24
    • Forbes, B.1    Lansley, A.B.2
  • 71
    • 4243952188 scopus 로고    scopus 로고
    • Calu-3 in the horizontal diffusion chamber system, a model of pulmonary drug transport
    • C.S. O'Shaughnessy, and E.S. Prosser Calu-3 in the horizontal diffusion chamber system, a model of pulmonary drug transport Pharm. Res. 13 1996 S169
    • (1996) Pharm. Res. , vol.13 , pp. 169
    • O'Shaughnessy, C.S.1    Prosser, E.S.2
  • 72
    • 0025311288 scopus 로고
    • Epithelial transport of drugs in cell culture I. A model for studying the passive diffusion of drugs over intestinal absorptive (Caco-2) cells
    • P. Artursson Epithelial transport of drugs in cell culture I. A model for studying the passive diffusion of drugs over intestinal absorptive (Caco-2) cells J. Pharm. Sci. 79 1990 476 482
    • (1990) J. Pharm. Sci. , vol.79 , pp. 476-482
    • Artursson, P.1
  • 73
    • 0028126785 scopus 로고
    • Influence of lipophilicity on beta-blocker permeation across rat alveolar epithelial monolayers
    • P. Saha, K.J. Kim, H. Yamahara, E.D. Crandall, and V.H.L. Lee Influence of lipophilicity on beta-blocker permeation across rat alveolar epithelial monolayers J. Control Rel. 32 1994 191 200
    • (1994) J. Control Rel. , vol.32 , pp. 191-200
    • Saha, P.1    Kim, K.J.2    Yamahara, H.3    Crandall, E.D.4    Lee, V.H.L.5
  • 75
    • 0038408540 scopus 로고    scopus 로고
    • Drug absorption from the isolated perfused rat lung - correlations with drug physicochemical properties and epithelial permeability
    • A. Tronde, B. Norden, A.B. Jeppsson, P. Brunmark, E. Nilsson, H. Lennernas, and U.H. Bengtsson Drug absorption from the isolated perfused rat lung - correlations with drug physicochemical properties and epithelial permeability J. Drug Target. 11 2003 61 74
    • (2003) J. Drug Target. , vol.11 , pp. 61-74
    • Tronde, A.1    Norden, B.2    Jeppsson, A.B.3    Brunmark, P.4    Nilsson, E.5    Lennernas, H.6    Bengtsson, U.H.7
  • 77
    • 0017253226 scopus 로고
    • Active transport of phenol red by rat lung slices
    • T.H. Gardiner, and L.S. Schanker Active transport of phenol red by rat lung slices J. Pharmacol. Exp. Ther. 196 1976 455 462
    • (1976) J. Pharmacol. Exp. Ther. , vol.196 , pp. 455-462
    • Gardiner, T.H.1    Schanker, L.S.2
  • 78
    • 0035132126 scopus 로고    scopus 로고
    • Localization of the peptide transporter PEPT2 in the lung: implications for pulmonary oligopeptide uptake
    • D.A. Groneberg, M. Nickolaus, J. Springer, F. Doring, H. Daniel, and A. Fischer Localization of the peptide transporter PEPT2 in the lung: implications for pulmonary oligopeptide uptake Am. J. Pathol. 158 2001 707 714
    • (2001) Am. J. Pathol. , vol.158 , pp. 707-714
    • Groneberg, D.A.1    Nickolaus, M.2    Springer, J.3    Doring, F.4    Daniel, H.5    Fischer, A.6
  • 79
  • 80
    • 12444302842 scopus 로고    scopus 로고
    • 16HBE14o- human bronchial epithelial cell layers express P-glycoprotein, lung resistance-related protein, and caveolin-1
    • C. Ehrhardt, C. Kneuer, M. Laue, U.F. Schaefer, K.J. Kim, and C.M. Lehr 16HBE14o- human bronchial epithelial cell layers express P-glycoprotein, lung resistance-related protein, and caveolin-1 Pharm. Res. 20 2003 545 551
    • (2003) Pharm. Res. , vol.20 , pp. 545-551
    • Ehrhardt, C.1    Kneuer, C.2    Laue, M.3    Schaefer, U.F.4    Kim, K.J.5    Lehr, C.M.6
  • 81
    • 0036844744 scopus 로고    scopus 로고
    • Transport of HIV-gprotease inhibitors across 1 alpha,25di-hydroxy vitamin D3-treated Calu-3 cell monolayers: modulation of P-glycoprotein activity
    • J. Patel, D. Pal, V. Vangal, M. Gandhi, and A.L. Mitra Transport of HIV-gprotease inhibitors across 1 alpha,25di-hydroxy vitamin D3-treated Calu-3 cell monolayers: modulation of P-glycoprotein activity Pharm. Res. 19 2002 1696 1703
    • (2002) Pharm. Res. , vol.19 , pp. 1696-1703
    • Patel, J.1    Pal, D.2    Vangal, V.3    Gandhi, M.4    Mitra, A.L.5
  • 82
    • 0030784505 scopus 로고    scopus 로고
    • Transepithelial transport of the fluoroquinolone ciprofloxacin by human airway epithelial Calu-3 cells
    • M.E. Cavet, M. West, and N.L. Simmons Transepithelial transport of the fluoroquinolone ciprofloxacin by human airway epithelial Calu-3 cells Antimicrob. Agents Chemother. 41 1997 2693 2698
    • (1997) Antimicrob. Agents Chemother. , vol.41 , pp. 2693-2698
    • Cavet, M.E.1    West, M.2    Simmons, N.L.3
  • 83
    • 0036282759 scopus 로고    scopus 로고
    • Transport and local metabolism of budesonide and fluticasone propionate in a human bronchial epithelial cell line (Calu-3)
    • G. Borchard, M.L. Cassara, P.E. Roemele, B.I. Florea, and H.E. Junginger Transport and local metabolism of budesonide and fluticasone propionate in a human bronchial epithelial cell line (Calu-3) J. Pharm. Sci. 91 2002 1561 1567
    • (2002) J. Pharm. Sci. , vol.91 , pp. 1561-1567
    • Borchard, G.1    Cassara, M.L.2    Roemele, P.E.3    Florea, B.I.4    Junginger, H.E.5
  • 84
    • 0036220019 scopus 로고    scopus 로고
    • Contribution of efflux pump activity to the delivery of pulmonary therapeutics
    • K.O. Hamilton, M.A. Yazdanian, and K.L. Audus Contribution of efflux pump activity to the delivery of pulmonary therapeutics Curr. Drug Metab. 3 2002 1 12
    • (2002) Curr. Drug Metab. , vol.3 , pp. 1-12
    • Hamilton, K.O.1    Yazdanian, M.A.2    Audus, K.L.3
  • 86
    • 0041331765 scopus 로고    scopus 로고
    • Effects of the permeability enhancers, tetradecylmaltoside and dimethyl-beta-cyclodextrin, on insulin movement across human bronchial epithelial cells (16HBE14o-)
    • F. Ahsan, J.J. Arnold, T. Yang, E. Meezan, E.M. Schwiebert, and D.J. Pillion Effects of the permeability enhancers, tetradecylmaltoside and dimethyl-beta-cyclodextrin, on insulin movement across human bronchial epithelial cells (16HBE14o-) Eur. J. Pharm. Sci. 20 2003 27 34
    • (2003) Eur. J. Pharm. Sci. , vol.20 , pp. 27-34
    • Ahsan, F.1    Arnold, J.J.2    Yang, T.3    Meezan, E.4    Schwiebert, E.M.5    Pillion, D.J.6
  • 89
    • 0037308144 scopus 로고    scopus 로고
    • Protein transport across the lung epithelial barrier
    • K.J. Kim, and A.B. Malik Protein transport across the lung epithelial barrier Am. J. Physiol. 284 2003 L247 L259
    • (2003) Am. J. Physiol. , vol.284
    • Kim, K.J.1    Malik, A.B.2
  • 90
    • 0027172392 scopus 로고
    • Regulation of tight junction permeability by calcium chelators and cell cytoskeleton in rabbit tracheal epithelium
    • M. Bhat, D. Toledo-Velasquez, L. Wang, C.J. Malanga, J.K.H. Ma, and Y. Rojanasakul Regulation of tight junction permeability by calcium chelators and cell cytoskeleton in rabbit tracheal epithelium Pharm. Res. 10 1993 991 997
    • (1993) Pharm. Res. , vol.10 , pp. 991-997
    • Bhat, M.1    Toledo-Velasquez, D.2    Wang, L.3    Malanga, C.J.4    Ma, J.K.H.5    Rojanasakul, Y.6
  • 91
    • 0026666843 scopus 로고
    • The transport barrier of epithelia: comparative study on membrane permeability and charge selectivity in rabbit
    • Y. Rojanasakul, L. Wang, M. Bhat, D.D. Glover, C.J. Malanga, and J.K.H. Ma The transport barrier of epithelia: comparative study on membrane permeability and charge selectivity in rabbit Pharm. Res. 9 1992 1029 1034
    • (1992) Pharm. Res. , vol.9 , pp. 1029-1034
    • Rojanasakul, Y.1    Wang, L.2    Bhat, M.3    Glover, D.D.4    Malanga, C.J.5    Ma, J.K.H.6
  • 92
    • 0020961251 scopus 로고
    • Measurements of pulmonary epithelial permeability in vivo
    • R.M. Effros, G.R. Mason, Measurements of pulmonary epithelial permeability in vivo, Am. Rev. Respir. Dis. 127(1983) S59-S65.
    • (1983) Am. Rev. Respir. Dis. , vol.127
    • Effros, R.M.1    Mason, G.R.2
  • 94
    • 0032459952 scopus 로고    scopus 로고
    • Cell lines of pulmonary and non-pulmonary origin as tools to study the effects of house dust mite proteinases on the regulation of epithelial permeability
    • H. Winton, H. Wan, M.B. Cannell, D.C. Gruenert, P.J. Thompson, D.R. Garrod, G.A. Stewart, and C. Robinson Cell lines of pulmonary and non-pulmonary origin as tools to study the effects of house dust mite proteinases on the regulation of epithelial permeability Clin. Exp. Allergy 28 1998 1273 1285
    • (1998) Clin. Exp. Allergy , vol.28 , pp. 1273-1285
    • Winton, H.1    Wan, H.2    Cannell, M.B.3    Gruenert, D.C.4    Thompson, P.J.5    Garrod, D.R.6    Stewart, G.A.7    Robinson, C.8
  • 95
    • 0032531145 scopus 로고    scopus 로고
    • Characterization of the A549 cell line as a type II pulmonary epithelial cell model for drug metabolism
    • K.A. Foster, C.G. Oster, M.M. Mayer, M.L. Avery, and K.L. Audus Characterization of the A549 cell line as a type II pulmonary epithelial cell model for drug metabolism Exp. Cell Res. 243 1998 359 366
    • (1998) Exp. Cell Res. , vol.243 , pp. 359-366
    • Foster, K.A.1    Oster, C.G.2    Mayer, M.M.3    Avery, M.L.4    Audus, K.L.5
  • 96
    • 0035460504 scopus 로고    scopus 로고
    • Expression of xenobiotic-metabolizing enzymes in human pulmonary tissue: possible role in susceptibility for ILD
    • J. Hukkanen, O. Pelkonen, and H. Raunio Expression of xenobiotic-metabolizing enzymes in human pulmonary tissue: possible role in susceptibility for ILD Eur. Respir. J. 32 2001 122s 126s
    • (2001) Eur. Respir. J. , vol.32
    • Hukkanen, J.1    Pelkonen, O.2    Raunio, H.3
  • 97
    • 2342663701 scopus 로고    scopus 로고
    • Benzene metabolism in human lung cell lines BEAS-2B and A549 and cells overexpressing CYP2F1
    • P.L. Sheets, G.S. Yost, and G.P. Carlson Benzene metabolism in human lung cell lines BEAS-2B and A549 and cells overexpressing CYP2F1 J. Biochem. Mol. Toxicol. 18 2004 92 99
    • (2004) J. Biochem. Mol. Toxicol. , vol.18 , pp. 92-99
    • Sheets, P.L.1    Yost, G.S.2    Carlson, G.P.3
  • 98
    • 0032077398 scopus 로고    scopus 로고
    • Characterisation of xenobiotic-metabolising enzyme expression in human bronchial mucosa and peripheral lung tissues
    • K. Mace, E.D. Bowman, P. Vautravers, P.G. Shields, C.C. Harris, and A.M. Pfeifer Characterisation of xenobiotic-metabolising enzyme expression in human bronchial mucosa and peripheral lung tissues Eur. J. Cancer 34 1998 914 920
    • (1998) Eur. J. Cancer , vol.34 , pp. 914-920
    • Mace, K.1    Bowman, E.D.2    Vautravers, P.3    Shields, P.G.4    Harris, C.C.5    Pfeifer, A.M.6
  • 99
    • 7044231565 scopus 로고    scopus 로고
    • Induction of drug-metabolizing enzymes and transporters in human bronchial epithelial cells by beclomethasone dipropionate
    • Y. Kuzuya, T. Adachi, H. Hara, A. Anan, K. Izuhara, and H. Nagai Induction of drug-metabolizing enzymes and transporters in human bronchial epithelial cells by beclomethasone dipropionate IUBMB Life 56 2004 355 359
    • (2004) IUBMB Life , vol.56 , pp. 355-359
    • Kuzuya, Y.1    Adachi, T.2    Hara, H.3    Anan, A.4    Izuhara, K.5    Nagai, H.6
  • 100
    • 0034605705 scopus 로고    scopus 로고
    • Characterization of the Calu-3 cell line as a tool to screen pulmonary drug delivery
    • K.A. Foster, M.L. Avery, M. Yazdanian, and K.L. Audus Characterization of the Calu-3 cell line as a tool to screen pulmonary drug delivery Int. J. Pharm. 208 2000 1 11
    • (2000) Int. J. Pharm. , vol.208 , pp. 1-11
    • Foster, K.A.1    Avery, M.L.2    Yazdanian, M.3    Audus, K.L.4
  • 101
    • 0033810470 scopus 로고    scopus 로고
    • A highly sensitive fluorescent microplate method for the determination of UDP-glucuronosyl transferase activity in tissues and placental cell lines
    • A.C. Collier, M.D. Tingle, J.A. Keelan, J.W. Paxton, and M.D. Mitchell A highly sensitive fluorescent microplate method for the determination of UDP-glucuronosyl transferase activity in tissues and placental cell lines Drug Metab. Dispos. 28 2000 1184 1186
    • (2000) Drug Metab. Dispos. , vol.28 , pp. 1184-1186
    • Collier, A.C.1    Tingle, M.D.2    Keelan, J.A.3    Paxton, J.W.4    Mitchell, M.D.5
  • 102
    • 0032964522 scopus 로고    scopus 로고
    • Temporal dependence of ectopeptidase expression in alveolar epithelial cell culture: implications for study of peptide absorption
    • B. Forbes, C.G. Wilson, and M. Gumbleton Temporal dependence of ectopeptidase expression in alveolar epithelial cell culture: implications for study of peptide absorption Int. J. Pharm. 180 1999 225 234
    • (1999) Int. J. Pharm. , vol.180 , pp. 225-234
    • Forbes, B.1    Wilson, C.G.2    Gumbleton, M.3
  • 103
    • 0028471137 scopus 로고
    • Glucocorticoids do not alter peptidase expression in on a human bronchial epithelial cell line
    • D. Proud, M.C. Subauste, and P.E. Ward Glucocorticoids do not alter peptidase expression in on a human bronchial epithelial cell line Am. J. Respir. Cell Mol. Biol. 11 1994 57 65
    • (1994) Am. J. Respir. Cell Mol. Biol. , vol.11 , pp. 57-65
    • Proud, D.1    Subauste, M.C.2    Ward, P.E.3
  • 104
    • 4744368322 scopus 로고    scopus 로고
    • Metabolic cleavage of cell-penetrating peptides in ncontact with epithelial models: human calcitonin (hCT)-derived peptides Tat (47-57) and penetratin (43-58)
    • R. Trehin, H.M. Nielsen, H.G. Jahnke, A.G. Beck-Sickinger, and H. Merkle Metabolic cleavage of cell-penetrating peptides in ncontact with epithelial models: human calcitonin (hCT)-derived peptides Tat (47-57) and penetratin (43-58) Biochem. J. 382 2004 924 956
    • (2004) Biochem. J. , vol.382 , pp. 924-956
    • Trehin, R.1    Nielsen, H.M.2    Jahnke, H.G.3    Beck-Sickinger, A.G.4    Merkle, H.5
  • 106
    • 4644249080 scopus 로고    scopus 로고
    • Cigarette smoke inhibits lipopolysaccharide-induced production of inflammatory cytokines by suppressing the activation of activator protein-1 in bronchial epithelial cells
    • M. Laan, S. Bozinovski, and G. Anderson Cigarette smoke inhibits lipopolysaccharide-induced production of inflammatory cytokines by suppressing the activation of activator protein-1 in bronchial epithelial cells J. Immunol. 173 2004 4164 4170
    • (2004) J. Immunol. , vol.173 , pp. 4164-4170
    • Laan, M.1    Bozinovski, S.2    Anderson, G.3
  • 108
    • 0032819018 scopus 로고    scopus 로고
    • Preliminary investigations into the use of a human bronchial cell line (16HBE14o-) to screen for respiratory toxins in vitro
    • C. Westmoreland, T. Walker, J. Matthews, and J. Murdock Preliminary investigations into the use of a human bronchial cell line (16HBE14o-) to screen for respiratory toxins in vitro Toxicol. In Vitro 13 1999 761 764
    • (1999) Toxicol. In Vitro , vol.13 , pp. 761-764
    • Westmoreland, C.1    Walker, T.2    Matthews, J.3    Murdock, J.4
  • 109
    • 0033735533 scopus 로고    scopus 로고
    • Formulation of inhaled medicines: effect of delivery vehicle on immortalized epithelial cells
    • B. Forbes, N. Hashmi, G.P. Martin, and A.B. Lansley Formulation of inhaled medicines: effect of delivery vehicle on immortalized epithelial cells J. Aerosol. Med. 13 2000 281 288
    • (2000) J. Aerosol. Med. , vol.13 , pp. 281-288
    • Forbes, B.1    Hashmi, N.2    Martin, G.P.3    Lansley, A.B.4
  • 110
    • 20444403247 scopus 로고    scopus 로고
    • Pulmonary delivery of low molecular weight heparins
    • T.Z. Yang, F. Mustafa, S.H. Bai, and F. Ahsan Pulmonary delivery of low molecular weight heparins Pharm. Res. 21 2004 2009 2016
    • (2004) Pharm. Res. , vol.21 , pp. 2009-2016
    • Yang, T.Z.1    Mustafa, F.2    Bai, S.H.3    Ahsan, F.4
  • 114
    • 0032961328 scopus 로고    scopus 로고
    • In vitro evaluation of microparticles and polymer gels for use as nasal platforms for protein delivery
    • C. Witschi, and R.J. Mrsny In vitro evaluation of microparticles and polymer gels for use as nasal platforms for protein delivery Pharm. Res. 16 1999 382 390
    • (1999) Pharm. Res. , vol.16 , pp. 382-390
    • Witschi, C.1    Mrsny, R.J.2
  • 115
    • 3242669006 scopus 로고    scopus 로고
    • Pulmonary delivery of deslorelin: large-porous PLGA particles and HPbetaCD complexes
    • K. Koushik, D.S. Dhanda, N.P. Cheruvu, and U.B. Kompella Pulmonary delivery of deslorelin: large-porous PLGA particles and HPbetaCD complexes Pharm. Res. 21 2004 1119 1126
    • (2004) Pharm. Res. , vol.21 , pp. 1119-1126
    • Koushik, K.1    Dhanda, D.S.2    Cheruvu, N.P.3    Kompella, U.B.4
  • 116
    • 2142695730 scopus 로고    scopus 로고
    • Incorporation of biodegradable nanoparticles into human airway epithelium cells-in vitro study of the suitability as a vehicle for drug or gene delivery in pulmonary diseases
    • M. Brzoska, K. Langer, C. Coester, S. Loitsch, T.O. Wagner, and C. Mallinckrodt Incorporation of biodegradable nanoparticles into human airway epithelium cells-in vitro study of the suitability as a vehicle for drug or gene delivery in pulmonary diseases Biochem. Biophys. Res. Commun. 318 2004 562 570
    • (2004) Biochem. Biophys. Res. Commun. , vol.318 , pp. 562-570
    • Brzoska, M.1    Langer, K.2    Coester, C.3    Loitsch, S.4    Wagner, T.O.5    Mallinckrodt, C.6
  • 117
    • 0035140581 scopus 로고    scopus 로고
    • Microparticulate uptake mechanisms of in vitro cell culture models of the respiratory epithelium
    • K.A. Foster, M. Yazdanian, and K.L. Audus Microparticulate uptake mechanisms of in vitro cell culture models of the respiratory epithelium J. Pharm. Pharmacol. 53 2001 57 66
    • (2001) J. Pharm. Pharmacol. , vol.53 , pp. 57-66
    • Foster, K.A.1    Yazdanian, M.2    Audus, K.L.3
  • 118
    • 0036146377 scopus 로고    scopus 로고
    • An in vitro technique for evaluating inhaled nasal delivery systems
    • B. Forbes, S. Lim, G.P. Martin, and M.B. Brown An in vitro technique for evaluating inhaled nasal delivery systems STP Pharma. Sci. 12 2002 75 79
    • (2002) STP Pharma. Sci. , vol.12 , pp. 75-79
    • Forbes, B.1    Lim, S.2    Martin, G.P.3    Brown, M.B.4
  • 120
    • 0142105943 scopus 로고    scopus 로고
    • Pulmonary absorption of insulin mediated by tetradecyl-beta-maltoside and dimethyl-beta-cyclodextrin
    • A. Hussain, T. Yang, A.A. Zaghloul, and F. Ahsan Pulmonary absorption of insulin mediated by tetradecyl-beta-maltoside and dimethyl-beta-cyclodextrin Pharm. Res. 20 2003 1551 1557
    • (2003) Pharm. Res. , vol.20 , pp. 1551-1557
    • Hussain, A.1    Yang, T.2    Zaghloul, A.A.3    Ahsan, F.4
  • 121
    • 20444378399 scopus 로고    scopus 로고
    • In vivo and in vitro characterization of novel microparticles based on hyaluronan and chitosan hydroglutamate
    • S.T. Lim, B. Forbes, G.P. Martin, and M.B. Brown In vivo and in vitro characterization of novel microparticles based on hyaluronan and chitosan hydroglutamate AAPS Pharma Sci Tech 2 2001 1 14
    • (2001) AAPS Pharma Sci Tech , vol.2 , pp. 1-14
    • Lim, S.T.1    Forbes, B.2    Martin, G.P.3    Brown, M.B.4
  • 122
  • 127
    • 0034605705 scopus 로고    scopus 로고
    • Characterization of the Calu-3 cell line as a tool to screen pulmonary drug delivery
    • K.A. Foster, M.L. Avery, M. Yazdanian, and K.L. Audus Characterization of the Calu-3 cell line as a tool to screen pulmonary drug delivery Int. J. Pharm. 208 2000 1 11
    • (2000) Int. J. Pharm. , vol.208 , pp. 1-11
    • Foster, K.A.1    Avery, M.L.2    Yazdanian, M.3    Audus, K.L.4
  • 128
    • 0030940316 scopus 로고    scopus 로고
    • Vectorial transcytosis of dimeric IgA by the Calu-3 human lung epithelial cell line: upregulation by IFN-gamma
    • S. Loman, J. Radl, H.M. Jansen, T.A. Out, and R. Lutter Vectorial transcytosis of dimeric IgA by the Calu-3 human lung epithelial cell line: upregulation by IFN-gamma Am. J. Physiol. 272 1997 L951 L958
    • (1997) Am. J. Physiol. , vol.272
    • Loman, S.1    Radl, J.2    Jansen, H.M.3    Out, T.A.4    Lutter, R.5
  • 129
    • 0028791564 scopus 로고
    • Development and characterization of rabbit tracheal epithelial cell monolayer models for drug transport studies
    • N.R. Mathias, K.J. Kim, T.W. Robison, and V.H.L. Lee Development and characterization of rabbit tracheal epithelial cell monolayer models for drug transport studies Pharm. Res. 12 1995 1499 1505
    • (1995) Pharm. Res. , vol.12 , pp. 1499-1505
    • Mathias, N.R.1    Kim, K.J.2    Robison, T.W.3    Lee, V.H.L.4
  • 130
    • 0033638754 scopus 로고    scopus 로고
    • Evaluation of the Caco-2 monolayer as a model epithelium for iontophoretic transport
    • M. Leonard, E. Creed, D. Brayden, and A.W. Baird Evaluation of the Caco-2 monolayer as a model epithelium for iontophoretic transport Pharm. Res. 17 2000 1181 1188
    • (2000) Pharm. Res. , vol.17 , pp. 1181-1188
    • Leonard, M.1    Creed, E.2    Brayden, D.3    Baird, A.W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.