In vitro and in vivo performance of biocompatible negatively-charged salbutamol-loaded nanoparticles

Journal of Controlled Release

Volumn 141, Issue 1, 2010, Pages 101-107

  Rytting, Erik ^a   Bur, Michael ^b   Cartier, Regis ^c   Bouyssou, Thierry ^c   Wang, Xiaoying ^a   Krüger, Michael ^c   Lehr, Claus Michael ^b   Kissel, Thomas ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

^c BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

Biocompatibility; In vitro in vivo correlation; Nanoparticle; Pulmonary drug delivery; Salbutamol

Indexed keywords

AVERAGE PARTICLE SIZE; CHARGED POLYMERS; DRUG RELEASE; DRUG TRANSPORT; FREE BASE; GUINEA PIGS; IN VITRO-IN VIVO CORRELATION; IN-CELL; IN-VITRO; IN-VITRO TESTS; IN-VIVO; INFLAMMATORY ACTIVITY; NANOMEDICINES; POLY(D , L-LACTIC-CO-GLYCOLIC ACID); PREPARATION PROCESS; PULMONARY DELIVERY; PULMONARY DRUG DELIVERY; SALBUTAMOL; SUSTAINED RELEASE; VINYLALCOHOL;

BIOCOMPATIBILITY; CELL CULTURE; MEDICAL NANOTECHNOLOGY; NANOPARTICLES; ZETA POTENTIAL;

CONTROLLED DRUG DELIVERY;

NANOPARTICLE; POLY(VINYL SULFONATE CO VINYL ALCOHOL) G POLY(DEXTRO LEVO LACTIC CO GLYCOLIC ACID); POLYMER; SALBUTAMOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BIOCOMPATIBILITY; BRONCHOSPASM; CONTROLLED STUDY; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG DESIGN; FEASIBILITY STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; NANOMEDICINE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; SUSTAINED RELEASE FORMULATION; ZETA POTENTIAL;

ALBUTEROL; ANIMALS; BIOCOMPATIBLE MATERIALS; BRONCHIAL SPASM; BRONCHODILATOR AGENTS; DISEASE MODELS, ANIMAL; DRUG CARRIERS; DRUG COMPOUNDING; DRUG STABILITY; EPITHELIAL CELLS; GUINEA PIGS; HUMANS; NANOPARTICLES; PARTICLE SIZE; POLYESTERS; POLYVINYL ALCOHOL; STATIC ELECTRICITY;

EID: 70849084242     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2009.08.021     Document Type: Article

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