Epithelial organic cation transporters ensure pH-dependent drug absorption in the airway

American Journal of Respiratory Cell and Molecular Biology

Volumn 36, Issue 1, 2007, Pages 53-60

  Horvath, Gabor ^a   Schmid, Nathalie ^b   Fragoso, Miryam A ^b   Schmid, Andreas ^b   Conner, Gregory E ^b   Salathe, Matthias ^b   Wanner, Adam ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

Airway epithelia; Airway pH; Bronchodilators; Drug absorption; Organic cation transporters

Indexed keywords

4 [4 (DIMETHYLAMINO)STYRYL] N METHYLPYRIDINIUM; AMPHOLYTE; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BRONCHODILATING AGENT; CARNITINE; CATION; CATION TRANSPORT PROTEIN; FLUORESCENT DYE; FORMOTEROL; MESSENGER RNA; ORGANIC CATION TRANSPORTER; PICOLINE DERIVATIVE; PROTEIN OCTN1; PROTEIN OCTN2; SALBUTAMOL; UNCLASSIFIED DRUG;

ACIDITY; ALKALINITY; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG ABSORPTION; DRUG PROTEIN BINDING; DRUG TRANSPORT; DRUG UPTAKE; EPITHELIUM CELL; FUNCTION TEST; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; IN VITRO STUDY; LIPID SOLUBILITY; NUCLEOTIDE SEQUENCE; PH; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; RESPIRATORY EPITHELIUM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TEMPERATURE SENSITIVITY;

ADRENERGIC BETA-AGONISTS; ALBUTEROL; BIOLOGICAL TRANSPORT, ACTIVE; BRONCHODILATOR AGENTS; CARNITINE; CELLS, CULTURED; EPITHELIAL CELLS; ETHANOLAMINES; HUMANS; HYDROGEN-ION CONCENTRATION; ORGANIC CATION TRANSPORT PROTEINS; PYRIDINIUM COMPOUNDS; RESPIRATORY MUCOSA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 33846100266     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2006-0230OC     Document Type: Article

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