Caveolae: An alternative membrane transport compartment

Pharmaceutical Research

Volumn 17, Issue 9, 2000, Pages 1035-1048

  Gumbleton, Mark ^a   Abulrob, Abedel nasser G ^a   Campbell, Lee ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Caveolae; Caveolin; Drug delivery; Drug targeting; Endocytosis; Plasmalemmal vesicles; Potocytosis; Transcytosis; Transport

Indexed keywords

ADIPOCYTE; CAPILLARY ENDOTHELIUM; DRUG DELIVERY SYSTEM; DRUG TARGETING; ENDOCYTOSIS; FIBROBLAST; HUMAN; LUNG ALVEOLUS CELL TYPE 1; MEMBRANE TRANSPORT; MEMBRANE VESICLE; MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ANIMALS; BIOLOGICAL TRANSPORT; CAVEOLAE; CAVEOLIN 1; CAVEOLINS; CHOLESTEROL; DRUG RESISTANCE, MULTIPLE; ENDOTHELIUM, VASCULAR; FOLIC ACID; GENE THERAPY; HUMANS; MEMBRANE PROTEINS; PULMONARY ALVEOLI; SIGNAL TRANSDUCTION; SNARE PROTEINS; VESICULAR TRANSPORT PROTEINS;

EID: 0033755733     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1026464526074     Document Type: Review

References (108)

1. Crowded little caves: Structure and function of caveolae
2. Molecular and cellular biology of caveolae: Paradoxes and plasticities
3. Role of plasmalemmal vesicles in signal transduction
4. The caveolae membrane system
5. Regulated internalisation of caveolae
6. Exploitation of major histocompatibility complex class I molecules and caveolae by simian virus 40
7. Caveolin, a protein component of caveolae membrane coats
8. Functional rafts in cell membranes
9. Caveolin isoforms differ in their N-terminal protein sequence and subcellular distribution
10. Identification, sequence, and expression of caveolin-2 defines a caveolin gene family
11. Molecular cloning of caveolin-3, a novel member of the caveolin gene family expressed predominantly in muscle
12. VIP21-caveolin, a membrane protein constituent of caveolae coat, oligomerizes in-vivo and in-vitro
13. Caveolin and its cellular and subcellular immunolocalisation in lung alveolar epithelium: Implications for alveolar type I cell function
14. Expression of caveolin-3 in skeletal, cardiac and smooth muscle cells
15. Caveolin-1 and - 2 in the exocytic pathway of MDCK cells
16. Affinity-purification and characterisation of cavoelins from the brain: Differential expression of caveolin-1, -2, and -3 in brain endothelial and astroglial cell types
17. Identification of caveolin and caveolin-related proteins in the brain
18. Expression of caveolin-1 and -2 in differentiating PC12 cells and dorsal root ganglion neurons: Caveolin-2 is upregulated in response to injury
19. Human neutrophils are devoid of the integral membrane protein caveolin
20. Expression of caveolin-1 in human T-cell leukemia cell lines
21. Caveolae can be alternative endocytic structures in elicited macrophages
22. Cell-type and tissue-specific expression of caveolin-2. Caveolins 1 and 2 co-localize and form a stable heterooligomeric complex in-vivo
23. Caveolin-2 localises to the Golgi complex but redistributes to plasma membrane, caveolae and rafts when co-expressed with caveolin-1
24. Oligomeric structure of caveolin: Implications for caveolae membrane organisation
25. Mutational analysis of the properties of caveolin-1
26. VIP21/caveolin is a cholesterol-binding protein
27. Oligomerisation of VIP21-caveolin in-vitro is stabilized by long chain fatty acylation or cholesterol
28. Mutational analysis of caveolin-induced vesicle formation
29. Induction of caveolin during adipogenesis and association of GLUT4 with caveolin-rich vesicles
30. Caveolin-1 expresion and caveolae biogenesis during cell transdifferentiation in lung alveolar epithelial primary cultures
31. Reduction of caveolin and caveolae in oncogenically transformed cells
32. De novo formation of caveolae in lymphocytes by expression of VIP21-caveolin
33. Baculovirus-based expression of mammalian caveolin in Sf21 insect cells
34. Expression of caveolin-1 and polarised formation of invaginated caveolae in Caco-2 and MDCK II cells
35. Caveolin moves from caveolae to Golgi apparatus in response to cholesterol oxidation
36. Identification of caveolin-1 in lipoprotein particles secreted by exocrine cells
37. Caveolin is present in intestinal cells: Role in cholesterol trafficking
38. Fillipin-sensitive caveolae-mediated transport in endothelium: Reduced transcytosis, scavenger endocytosis and capillary permeability of select macromolecules
39. Inhibitors that block both the internalization of caveolae and the return of plasmalemmal vesicles
40. A role for caveolin in transport of cholesterol from endoplasmic reticulum to plasma membrane
41. Transcytosis in the continuous endothelium of the myocardial microvasculature is inhibited by N-ethylmaleimide
42. NEM inhibits transcytosis, endocytosis, and capillary permeability: Implication of caveolae fusion in endothelia
43. Multiple domains in caveolin-1 control its intracellular traffic
44. Molecular characterisation of caveolin association with the Golgi Complex: Identification of a Cis-Golgi targeting domain in the caveolin molecule
45. Potocytosis: Sequestration and transport of small molecules by caveolae
46. Caveolae: Where incoming and outgoing messengers meet
47. Cholesterol controls the clustering of the glycophospholipid-anchored membrane receptor for 5-methyltetrahydrofolate
48. Lowering the cholesterol content of MA104 cells inhibits receptor-mediated transport of folate
49. Clustered folate receptors deliver 5-methyltetrahydrofolate to cytoplasm of MA104 cells
50. The folate receptor works in tandem with a probenecid-sensitive anion carrier
51. A vacuolar proton ATPase mediates acidification of plasmalemmal vesicles during potocytosis
52. Hormonal regulation of caveolae internalisation
53. Folate-mediated targeting of antineoplastic drugs, imaging agents, and nucleic acids to cancer cells
54. Intracellular transport of low density lipoprotein derived cholesterol begins at clathrin coated pits and terminates at cell surface caveolae
55. Intracellular cholesterol transport
56. Plasma membrane caveolae mediate the efflux of cellular free cholesterol
57. Role of caveolae in cholesterol transport in arterial smooth muscle cells exposed to lipoproteins in-vitro and in-vivo
58. Characterization of a cytosolic heat-shock protein-caveolin chaperone complex
59. Caveolin mRNA levels are up-regulated by free cholesterol and down-regulated by oxysterols in fibroblast monolayers
60. Regulation of caveolin and caveolae by cholesterol in MDCK cells
61. Two sterol regulatory element-like sequences mediate up-regulation of caveolin gene transcription in response to low density lipoprotein free cholesterol
62. Intracellular cholsterol transport in synchronised human skin fibroblasts
63. Coexpression of scavenger receptor-BI and caveolin-1 is associated with enhanced selective cholesteryl ester uptake in THP-1 macrophages
64. The class B, type I scavenger receptor promotes the selective uptake of high density lipoprotein cholesterol ethers into caveolae
65. Detergent-resistant microdomains from Caco-2 cells do not contain caveolin
66. Accumulation of glucosylceramides in multidrug-resistant cancer cells
67. Up-regulation of caveolar constituents in multidrug-resistant cancer cells
68. Upregulation of caveolin-1 and caveolae organelles in Taxol-resistant A 549 cells
69. Number and distribution of plasmalemma vesicles in the lung
70. Endothelial transport of macromolecules: Transcytosis and endocytosis
71. Protein kinase C activators inhibit receptor-mediated potocytosis by preventing internalisation of caveolae
72. Plasmalemmal vesicles represent the large pore system of continuous microvascular endothelium
73. Plasmalemmal vesicles function as transcytotic carriers for small proteins in the continuous endothelium
74. Transport of macromolecules through microvascular walls
75. Gp60 activation mediates the albumin transcytosis in endothelial cell by tyrosine kinase-dependent pathway
76. Receptor-mediated endocytosis of insulin by cultured endothelial cells
77. SNARE Proteins - Why so many, Why so few?
78. Endothelial caveolae have the molecular transport machinery for vesicle budding, docking, and fusion including VAMP, NSF, SNAP, annexins, and GTPases
79. Caveolae require intact VAMP for targeted transport in vascular endothelium
80. Dynamin at the neck of caveolae mediates their budding to form transport vesicles by GTP-driven fission from the plasma membrane of endothelium
81. Association of the fusion protein NSF with clathrin-coated vesicle membranes
82. An ultrastructural quantitative method for the evaluation of the permeability to horseradish peroxidase of cerebral cortex endothelial cells of the rat
83. A new function for the LDL-receptor: Transcytosis of LDL across the blood brain barrier
84. P-glycoprotein is localised in caveolae in resistant cells and in brain capillaries
85. Breathing life into protein drugs
86. The pharmacokinetics of pulmonary delivered insulin: A comparison of intra-tracheal and aersol administration to the rabbit
87. The influence of regional deposition on the pharmacokinetics of pulmonary-delivered human growth hormone in rabbits
88. Cell number and cell characteristics of normal human lung
89. Numerical densities of cellular vesicles in pulmonary alveolar septa of edematous dog lungs
90. Distribution of vesicles in cells of the air-blood barrier in the rabbit
91. Mechanisms of macromolecule absorption by the lungs
92. An uptake of cationized ferritin by alveolar type I cells in airway-instilled goat lung: Distribution of anionic sites on the epithelial surface
93. 2-macroglobulin-methylamine undergo endocytosis by different mechanisms in rat adipocytes: Comparison of cell surface events
94. Caveolar internalisation of growth hormone
95. Pulmonary absorption of recombinant methionyl human granulocyte colony stimulating factor after intratracheal instillation to hamster
96. Transcytosis and surface presentation of IL-8 by venular endothelial cells
97. Detection of dully antigen in the plasma membranes and caveolae of vascular endothelial and epithelial cells of nonerythroid organs
98. Respiratory epithelial cell culture models for evaluation of ion and drug transport
99. Effect of glucocorticoid upon cell differentiation within an alveolar epithelial cell culture used to model pulmonary absorption in vitro
100. Dexamethasone and thyroid hormone pretreatment upregulate alveolar fluid clearance in adult rats
101. Cationic liposomes target angiogenic endothelial cells on tumors and chronic inflammation in mice
102. Expression of naked plasmids by cultured myotubes and entry of plasmids into T tubules and caveolae of mammalian skeletal muscle
103. Evidence for the role of caveolae in gene delivery
104. Endocytosis of folate-protein conjugates: Ultrastructural localisation in KB cells
105. 1 is concentrated in caveolae
106. Cholera toxin B-mediated targeting of lipid vesicles containing ganglioside GM1 to mucosal epithelial cells
107. Major histocompatibility complex class I molecules mediate association of SV40 with caveolae
108. Bound simian virus 40 translocates to caveolin-enriched domains, and its entry is inhibited by drugs that selectively disrupt caveolae