Towards the bioequivalence of pressurised metered dose inhalers 2. Aerodynamically equivalent particles (with and without glycerol) exhibit different biopharmaceutical profiles in vitro

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 86, Issue 1, 2014, Pages 38-45

  Haghi, M ^a,b   Bebawy, M ^c   Colombo, P ^d   Forbes, B ^e   Lewis, D A ^f   Salama, R ^a,b   Traini, D ^a,b   Young, P M ^a,b  

^a UNIVERSITY OF SYDNEY   (Australia)

^b University of Sydney   (Australia)

^c UNIVERSITY OF TECHNOLOGY SYDNEY   (Australia)

^d UNIVERSITY OF PARMA   (Italy)

^e KING'S COLLEGE LONDON   (United Kingdom)

^f CHIESI FARMACEUTICI S P A   (Italy)

Author keywords

Beclomethasone dipropionate; Bioequivalence; Calu 3; Epithelial cell model; Glycerol; Non volatile excipients; pMDI

Indexed keywords

BECLOMETASONE DIPROPIONATE; FLUTICASONE; GLYCEROL;

AEROSOL; ARTICLE; BIOEQUIVALENCE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG METABOLISM; DRUG RELEASE; DRUG SOLUBILITY; DRUG TRANSPORT; EPITHELIUM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; METERED DOSE INHALER; PARTICLE SIZE; PRESSURISED METERED DOSE INHALER; RESPIRATORY EPITHELIUM;

BECLOMETHASONE DIPROPIONATE; BIOEQUIVALENCE; CALU-3; EPITHELIAL CELL MODEL; GLYCEROL; NON-VOLATILE EXCIPIENTS; PMDI;

ADMINISTRATION, INHALATION; AEROSOLS; BECLOMETHASONE; CELL LINE; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; EPITHELIAL CELLS; EXCIPIENTS; GLYCEROL; HUMANS; METERED DOSE INHALERS; MODELS, BIOLOGICAL; SOLUBILITY; SOLUTIONS; THERAPEUTIC EQUIVALENCY; VOLATILIZATION;

EID: 84896691331     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2013.02.020     Document Type: Article

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