Delivery of therapeutic levels of heparin and low-molecular-weight heparin through a pulmonary route

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 26, 2004, Pages 9867-9872

  Qi, Yiwei ^a   Zhao, Ganlin ^a   Liu, Dongfang ^a   Shriver, Zachary ^a   Sundaram, Mallik ^a   Sengupta, Shiladitya ^a   Venkataraman, Ganesh ^a   Langer, Robert ^a   Sasisekharan, Ram ^a  

^a Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; ARDEPARIN; HEPARIN; LOW MOLECULAR WEIGHT HEPARIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL; CONTROLLED STUDY; DRUG ADMINISTRATION ROUTE; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG HALF LIFE; HUMAN; HUMAN CELL; LUNG; LUNG EMPHYSEMA; MALE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RABBIT; RAT; REPRODUCIBILITY; THROMBOSIS;

ABSORPTION; ADMINISTRATION, INHALATION; AEROSOLS; ANIMALS; BIOLOGICAL AVAILABILITY; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EMPHYSEMA; HEPARIN; HEPARIN, LOW-MOLECULAR-WEIGHT; LUNG; MALE; PARTICLE SIZE; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; THROMBOSIS; TIME FACTORS;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 3042791257     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0402891101     Document Type: Article

References (33)

1. Hirsh, J., Dalen, J. E., Deykin, D. & Poller, L. (1992) Chest 10, 337S-351S.
2. Linhardt, R. J. & Gunay, N. S. (1999) Semin. Thromb. Hemostasis 25, Suppl 3, 5-16.
3. Hirsh, J., Warkentin, T. E., Raschke, R., Granger, C., Ohman, E. M. & Dalen, J. E. (1998) Chest 114, 489S-510S.
4. Merli, G. J. (2003) Expert Opin. Pharmacother. 4, 55-65.
5. Wieland, H. A., Laux, V., Kozian, D. & Lorenz, M. (2003) Curr. Opin. Invest. Drugs 4, 264-271.
6. Jiao, Y., Ubrich, N., Hoffart, V., Marchand-Arvier, M., Vigneron, C., Hoffman, M. & Maincent, P. (2002) J. Pharmacol. Sci. 91, 760-768.
7. Leone-Bay, A., Paton, D. R., Variano, B., Leipold, H., Rivera, T., Miura-Fraboni, J., Baughman, R. A. & Santiago, N. (1998) J. Controlled Release 50, 41-49.
8. Lee, Y., Kim, S. H. & Byun, Y. (2000) Pharmacol. Res. 17, 1259-1264.
9. Gonze, M. D., Salartash, K., Sternbergh, W. C., 3rd, Baughman, R. A., Leone-Bay, A. & Money, S. R. (2000) Circulation 101, 2658-2661.
10. Arnold, J., Ahsan, F., Meezan, E. & Pillion, D. J. (2002) J. Pharmacol. Sci. 91, 1707-1714.
11. Edwards, D. A., Hanes, J., Caponetti, G., Hrkach, J. Ben-Jebria, A., Eskew, M. L., Mintzes, J., Deaver, D., Lotan, N. & Langer, R. (1997) Science 276, 1868-1871.
12. Oberdorster, G., Oldiges, H. & Zimmermann, B. (1980) Zentralbl. Bakteriol. B 170, 35-43.
13. Bjornsson, T. D. & Levy, G. (1979) J. Pharmacol. Exp. Ther. 210, 243-246.
14. Bjornsson, T. D. & Levy, G. (1979) J. Pharmacol. Exp. Ther. 210, 237-242.
15. Sundaram, M., Qi, Y., Shriver, Z., Liu, D., Zhao, G., Venkataraman, G., Langer, R. & Sasisekharan, R. (2003) Proc. Natl. Acad. Sci. USA 100, 651-656.
16. Ameer, G. A., Barabino, G., Sasisekharan, R., Harmon, W., Cooney, C. L. & Langer, R. (1999) Proc. Natl. Acad. Sci. USA 96, 2350-2355.
17. Teien, A. N., Lie, M. & Abildgaard, U. (1976) Thromb. Res. 8, 413-416.
18. Wessler, S. (1971) Cardiovasc. Clin. 3, 1-16.
19. Aronson, D. L. & Menache, D. (1987) Dev. Biol. Stand. 67, 149-155.
20. Herbert, J. M., Frehel, D., Rosso, M. P., Seban, E., Castet, C., Pepin, O., Maffrand. J. P. & Le Fur, G. (1992) J. Pharmacol. Exp. Ther. 260, 809-816.
21. Florea, B. I., Cassara, M. L., Junginger, H. E. & Borchard, G. (2003) J. Controlled Release 87, 131-138.
22. Ben-Jebria, A., Chen, D., Eskew, M. L., Vanbever, R., Langer, R. & Edwards, D. A. (1999) Pharmacol. Res. 16, 555-561.
23. Bot, A. I., Tarara, T. E., Smith, D. J., Bot, S. R., Woods, C. M. & Weers, J. G. (2000) Pharmacol. Res. 17, 275-283.
24. Bendstrup, K. E., Gram. J. & Jensen, J. I. (2002) Eur. Respir. J. 19, 606-610.
25. Kanabrocki, E. L., Bremner, W. F., Sothern, R. B., Gruber, S. A., Third, J. L. Bushnell, D. L. & Olwin, J. H. (1992) Q. J. Med. 83, 259-282.
26. Tyrrell, D. J., Horne, A. P., Holme, K. R., Preuss, J. M. & Page, C. P. (1999) Adv. Pharmacol. 46, 151-208.
27. Diamant, Z. & Page, C. P. (2000) Pulm. Pharmacol. Ther. 13, 1-4.
28. Edwards, D. A., Ben-Jebria, A. & Langer, R. (1998) J. Appl. Physiol. 85, 379-385.
29. Matter, K. & Balda, M. S. (2003) Nat. Rev. Mol. Cell. Biol. 4, 225-236.
30. Perez-Moreno, M., Jamora, C. & Fuchs, E. (2003) Cell 112, 535-548.
31. Malkov, D., Wang, H. Z., Dinh, S. & Gomez-Orellana, I. (2002) Pharmacol. Res. 19, 1180-1184.
32. Kohler, D. (1994) J. Aerosol. Med. 7, 307-314.
33. Bendstrup, K. E. & Jensen, J. I. (2000) Respir. Med. 94, 174-175.