Early pharmaceutical profiling to predict oral drug absorption: Current status and unmet needs

European Journal of Pharmaceutical Sciences

Volumn 57, Issue 1, 2014, Pages 173-199

  Bergström, Christel A S ^a   Holm, René ^b   Jørgensen, Søren Astrup ^c   Andersson, Sara B E ^a   Artursson, Per ^a   Beato, Stefania ^d   Borde, Anders ^e   Box, Karl ^f   Brewster, Marcus ^g   Dressman, Jennifer ^h   Feng, Kung I ⁱ   Halbert, Gavin ^j   Kostewicz, Edmund ^h   McAllister, Mark ^k   Muenster, Uwe ^l   Thinnes, Julian ^h   Taylor, Robert ^f   Mullertz, Anette ^c  

^a UPPSALA UNIVERSITY   (Sweden)

^b H LUNDBECK A S   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d NOVARTIS PHARMA AG   (Switzerland)

^e ASTRAZENECA R AND D   (Sweden)

^f Sirius Analytical Instruments Ltd   (United Kingdom)

^g JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^h GOETHE UNIVERSITY   (Germany)

ⁱ MERCK RESEARCH LABORATORIES   (United States)

^j UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^k PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^l BAYER PHARMA AG   (Germany)

more..

Author keywords

Absorption; Biorelevant media; Intestinal fluid; Pharmaceutical profiling; Physicochemical properties; Preformulation

Indexed keywords

BILE SALT; BUFFER; DRUG; FATTY ACID; MONOACYLGLYCEROL; PHOSPHOLIPID; EXCIPIENT;

ARTICLE; ARTIFICIAL MEMBRANE; COMPUTER MODEL; DRUG ABSORPTION; DRUG DEVELOPMENT; DRUG FORMULATION; DRUG PENETRATION; DRUG SOLUBILITY; DUODENUM; HUMAN; INTESTINE FLUID; JEJUNUM; NONHUMAN; OSMOLARITY; PH; PHYSICAL CHEMISTRY; PREFORMULATION; PRIORITY JOURNAL; STOMACH JUICE; SURFACE TENSION; WETTABILITY; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; COMPUTER SIMULATION; GASTROINTESTINAL TRACT; INTESTINAL SECRETIONS; INTESTINE ABSORPTION; MEDICINAL CHEMISTRY; METABOLISM; ORAL DRUG ADMINISTRATION; PHARMACEUTICS; PHARMACOKINETICS; PHYSIOLOGY; PROCEDURES; SOLUBILITY;

ADMINISTRATION, ORAL; ANIMALS; BIOPHARMACEUTICS; CHEMISTRY, PHARMACEUTICAL; COMPUTER SIMULATION; EXCIPIENTS; GASTRIC JUICE; GASTROINTESTINAL TRACT; HUMANS; HYDROGEN-ION CONCENTRATION; INTESTINAL ABSORPTION; INTESTINAL SECRETIONS; MODELS, BIOLOGICAL; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL;

EID: 84899990647     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2013.10.015     Document Type: Article

References (343)

1. J. Aaltonen, M. Alleso, S. Mirza, V. Koradia, K.C. Gordon, and J. Rantanen Solid form screening - a review European Journal of Pharmaceutics and Biopharmaceutics e. 71 2009 23 37
2. Y.A. Abramov Current computational approaches to support pharmaceutical solid form selection Organic Process Research & Development 17 2012 472 485
3. A. Adson, T.J. Raub, P.S. Burton, C.L. Barsuhn, A.R. Hilgers, K.L. Audus, and N.F. Ho Quantitative approaches to delineate paracellular diffusion in cultured epithelial cell monolayers Journal of Pharmaceutical Sciences 83 1994 1529 1536 (Pubitemid 24348320)
4. A. Adson, P.S. Burton, T.J. Raub, C.L. Barsuhn, K.L. Audus, and N.F. Ho Passive diffusion of weak organic electrolytes across Caco-2 cell monolayers: uncoupling the contributions of hydrodynamic, transcellular, and paracellular barriers Journal of Pharmaceutical Sciences 84 1995 1197 1204
5. A. Albert, and E.P. Sergeant The Determination of Ionization Constants - A Laboratory Manual 1984 Chapman and Hall New York 70
6. A.M. Al-Ghananeem, M. Abbassi, S. Shrestha, G. Raman, H. Wulff, L. Pereira, and A. Ansari Formulation-based approach to support early drug discovery and development efforts: a case study with enteric microencapsulation dosage form development for a triarylmethane derivative TRAM-34; a novel potential immunosuppressant Drug Development and Industrial Pharmacy 36 2010 563 569
7. J. Alsenz, and M. Kansy High throughput solubility measurement in drug discovery and development Advanced Drug Delivery Reviews 59 2007 546 567 (Pubitemid 47285404)
8. D. Alvaro, A. Cantafora, A.F. Attili, S. Ginanni Corradini, C. De Luca, G. Minervini, A. Di Blase, and M. Angelico Relationships between bile salts hydrophilicity and phospholipid composition in bile of various animal species Comparative Biochemistry and Physiology Part B: Comparative Biochemistry 83 1986 551 554
9. G.L. Amidon, H. Lennernas, V.P. Shah, and J.R. Crison A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability Pharmaceutical Research 12 1995 413 420
10. P.R. Andrews, D.J. Craik, and J.L. Martin Functional group contributions to drug-receptor interactions Journal of Medicinal Chemistry 27 1984 1648 1657 (Pubitemid 15177908)
11. M. Armand, P. Borel, C. Dubois, M. Senft, J. Peyrot, J. Salducci, H. Lafont, and D. Lairon Characterization of emulsions and lipolysis of dietary lipids in the human stomach The American Journal of Physiology 266 1994 G372 G381
12. M. Armand, P. Borel, B. Pasquier, C. Dubois, M. Senft, M. Andre, J. Peyrot, J. Salducci, and D. Lairon Physicochemical characteristics of emulsions during fat digestion in human stomach and duodenum The American Journal of Physiology 271 1996 G172 G183
13. P. Artursson Epithelial transport of drugs in cell culture. I: A model for studying the passive diffusion of drugs over intestinal absorptive (Caco-2) cells Journal of Pharmaceutical Sciences 79 1990 476 482 (Pubitemid 20221389)
14. P. Artursson, and J. Karlsson Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells Biochemical and Biophysical Research Communications 175 1991 880 885
15. R. Asthana, and N. Sobczak Wettability, spreading, and interfacial phenomena in high-temperature coatings JOM-e 52 2000 1 19
16. AstraZeneca, data on file. Personal Communication with Bertil Abrahamsson och Anders Borde.
17. P. Augustijns, and M.E. Brewster Supersaturating drug delivery systems: fast is not necessarily good enough Journal of Pharmaceutical Sciences 101 2012 7 9
18. A. Avdeef pH-metric solubility. 1. Solubility-pH profiles from Bjerrum Plots. Gibbs buffer and pKa in the solid state Pharmacy and Pharmacology Communications 4 1998 165 178 (Pubitemid 28142433)
19. A. Avdeef Physicochemical profiling (solubility, permeability and charge state) Current Topics in Medicinal Chemistry 1 2001 277 351
20. A. Avdeef Absorption and Drug Development 2003 Wiley-Interscience New York 116-246
21. A. Avdeef Solubility of sparingly-soluble ionizable drugs Advanced Drug Delivery Reviews 59 2007 568 590 (Pubitemid 47285405)
22. A. Avdeef, and O. Tsinman PAMPA-a drug absorption in vitro model 13. Chemical selectivity due to membrane hydrogen bonding: in combo comparisons of HDM-, DOPC-, and DS-PAMPA models European Journal of Pharmaceutical Sciences 28 2006 43 50
23. A. Avdeef, and O. Tsinman Miniaturized rotating disk intrinsic dissolution rate measurement: effects of buffer capacity in comparisons to traditional wood's apparatus Pharmaceutical Research 25 2008 2613 2627
24. A. Avdeef, P. Artursson, S. Neuhoff, L. Lazorova, J. Grasjo, and S. Tavelin Caco-2 permeability of weakly basic drugs predicted with the double-sink PAMPA pKa(flux) method European Journal of Pharmaceutical Sciences 24 2005 333 349 (Pubitemid 40283516)
25. A. Avdeef, S. Bendels, L. Di, B. Faller, M. Kansy, K. Sugano, and Y. Yamauchi PAMPA-critical factors for better predictions of absorption Journal of Pharmaceutical Sciences 96 2007 2893 2909 (Pubitemid 350221191)
26. G. Baki, J. Bajdik, D. Djuric, K. Knop, P. Kleinebudde, and K. Pintye-Hodi Role of surface free energy and spreading coefficient in the formulation of active agent-layered pellets European Journal of Pharmaceutics and Biopharmaceutics 74 2010 324 331
27. S.K. Balani, G.T. Miwa, L.S. Gan, J.T. Wu, and F.W. Lee Strategy of utilizing in vitro and in vivo ADME tools for lead optimization and drug candidate selection Current Topics in Medicinal Chemistry 5 2005 1033 1038 (Pubitemid 41582117)
28. S. Balbach, and C. Korn Pharmaceutical evaluation of early development candidates "the 100 mg-approach" International Journal of Pharmaceutics 275 2004 1 12 (Pubitemid 38481515)
29. B. Bard, S. Martel, and P.A. Carrupt High throughput UV method for the estimation of thermodynamic solubility and the determination of the solubility in biorelevant media European Journal of Pharmaceutical Sciences 33 2008 230 240
30. D. Bassolino-Klimas, H.E. Alper, and T.R. Stouch Solute diffusion in lipid bilayer membranes: an atomic level study by molecular dynamics simulation Biochemistry (Mosc) 32 1993 12624 12637 (Pubitemid 24005858)
31. J. Bauer, S. Spanton, R. Henry, J. Quick, W. Dziki, W. Porter, and J. Morris Ritonavir: an extraordinary example of conformational polymorphism Pharmaceutical Research 18 2001 859 866 (Pubitemid 32783524)
32. I. Behrens, P. Stenberg, P. Artursson, and T. Kissel Transport of lipophilic drug molecules in a new mucus-secreting cell culture model based on HT29-MTX cells Pharmaceutical Research 18 2001 1138 1145 (Pubitemid 32900399)
33. C.A.S. Bergstrom, U. Norinder, K. Luthman, and P. Artursson Experimental and computational screening models for prediction of aqueous drug solubility Pharmaceutical Research 19 2002 182 188 (Pubitemid 34165404)
34. C.A.S. Bergstrom, C.M. Wassvik, U. Norinder, K. Luthman, and P. Artursson Global and local computational models for aqueous solubility prediction of drug-like molecules Journal of Chemical Information and Computer Sciences 44 2004 1477 1488
35. C.A.S. Bergstrom, C.M. Wassvik, K. Johansson, and I. Hubatsch Poorly soluble marketed drugs display solvation limited solubility Journal of Medicinal Chemistry 50 2007 5858 5862 (Pubitemid 350106040)
36. C.D. Bevan, and R.S. Lloyd A high-throughput screening method for the determination of aqueous drug solubility using laser nephelometry in microtiter plates Analytical Chemistry 72 2000 1781 1787 (Pubitemid 30220169)
37. J. Bevernage, J. Brouwers, S. Clarysse, M. Vertzoni, J. Tack, P. Annaert, and P. Augustijns Drug supersaturation in simulated and human intestinal fluids representing different nutritional states Journal of Pharmaceutical Sciences 99 2010 4525 4534
38. J. Bevernage, T. Forier, J. Brouwers, J. Tack, P. Annaert, and P. Augustijns Excipient-mediated supersaturation stabilization in human intestinal fluids Molecular Pharmaceutics 8 2011 564 570
39. J. Bevernage, J. Brouwers, M.E. Brewster, and P. Augustijns Evaluation of gastrointestinal drug supersaturation and precipitation: strategies and issues International Journal of Pharmaceutics 453 2013 25 35
40. J. Bevernage, B. Hens, J. Brouwers, J. Tack, P. Annaert, and P. Augustijns Supersaturation in human gastric fluids European Journal of Pharmaceutics and Biopharmaceutics e. 81 2012 184 189
41. B. Bittner, and R.J. Mountfield Intravenous administration of poorly soluble new drug entities in early drug discovery: the potential impact of formulation on pharmacokinetic parameters Current Opinion in Drug Discovery & Development 5 2002 59 71 (Pubitemid 34453243)
42. J.F. Blake Examination of the computed molecular properties of compounds selected for clinical development BioTechniques Suppl. 2003 16 20
43. O. Bortolini, T. Bernardi, G. Fantin, V. Ferretti, and M. Fogagnolo Relative acidity scale of glycine- and taurine-conjugated bile acids through ESI-MS measurements Steroids 76 2011 596 602
44. K.J. Box, and J.E. Comer Using measured pKa, LogP and solubility to investigate supersaturation and predict BCS class Current Drug Metabolism 9 2008 869 878
45. K.J. Box, G. Volgyi, E. Baka, M. Stuart, K. Takacs-Novak, and J.E. Comer Equilibrium versus kinetic measurements of aqueous solubility, and the ability of compounds to supersaturate in solution - a validation study Journal of Pharmaceutical Sciences 95 2006 1298 1307 (Pubitemid 43874443)
46. K.J. Box, R.E. Donkor, P.A. Jupp, I.P. Leader, D.F. Trew, and C.H. Turner The chemistry of multi-protic drugs. Part 1: a potentiometric, multi-wavelength UV and NMR pH titrimetric study of the micro-speciation of SKI-606 Journal of Pharmaceutical and Biomedical Analysis 47 2008 303 311
47. C.B.C. Boyce, and B.V. Milborrow A simple assessment of partition data for correlating structure and biological activity using thin-layer chromatography Nature 208 1965 537 539
48. S. Branchu, P.G. Rogueda, A.P. Plumb, and W.G. Cook A decision-support tool for the formulation of orally active, poorly soluble compounds European Journal of Pharmaceutical Sciences 32 2007 128 139 (Pubitemid 47299301)
49. T. Braumann, G. Weber, and L.H. Grimme Quantitative structure-activity- relationships for herbicides - reversed-phase liquid-chromatographic retention parameter, log Kw, versus liquid-liquid partition-coefficient as a model of the hydrophobicity of phenylureas, s-triazines and phenoxycarbonic acid-derivatives Journal of Chromatography 261 1983 329 343 (Pubitemid 13054545)
50. W. Brener, T.R. Hendrix, and P.R. McHugh Regulation of the gastric emptying of glucose Gastroenterology 85 1983 76 82 (Pubitemid 13106327)
51. M. Brewster, K. Swinney, S. Stokbroekx, and G. Verreck Solid dispersions as supersaturating drug delivery systems P. Augustijns, Supersaturating Drug Delivery Systems, 104th Bulletin Technique Gattefosse 2011 Gattefosse Saint-Priest, France 33 48
52. J. Brouwers, J. Tack, F. Lammert, and P. Augustijns Intraluminal drug and formulation behavior and integration in in vitro permeability estimation: a case study with amprenavir Journal of Pharmaceutical Sciences 95 2006 372 383 (Pubitemid 43241979)
53. S. Brown, G. Rowley, and J. Pearson Surface treatment of the hydrophobic drug danazol to improve drug dissolution International Journal of Pharmaceutics 165 1998 227 237 (Pubitemid 28239709)
54. P. Buch, C. Meyer, and P. Langguth Improvement of the wettability and dissolution of fenofibrate compacts by plasma treatment International Journal of Pharmaceutics 416 2011 49 54
55. G. Buckton, and P. Darcy The use of gravimetric studies to assess the degree of crystallinity of predominantly crystalline powders International Journal of Pharmaceutics 123 1995 265 271
56. G. Buckton, and J. Newton Assessment of the wettability of powders by use of compressed powder discs Powder Technology 46 1986 201 208 (Pubitemid 16594890)
57. J.M. Butler, and J.B. Dressman The developability classification system: application of biopharmaceutics concepts to formulation development Journal of Pharmaceutical Sciences 99 2010 4940 4954
58. G. Camenisch, J. Alsenz, H. van de Waterbeemd, and G. Folkers Estimation of permeability by passive diffusion through Caco-2 cell monolayers using the drugs' lipophilicity and molecular weight European Journal of Pharmaceutical Sciences 6 1998 313 319 (Pubitemid 28468539)
59. M.C. Carey, and D.M. Small The characteristics of mixed micellar solutions with particular reference to bile The American Journal of Medicine 49 1970 590 608
60. S. Carlert, A. Palsson, G. Hanisch, C. von Corswant, C. Nilsson, L. Lindfors, H. Lennernas, and B. Abrahamsson Predicting intestinal precipitation - a case example for a basic BCS class II drug Pharmaceutical Research 27 2010 2119 2130
61. F. Carriere, J.A. Barrowman, R. Verger, and R. Laugier Secretion and contribution to lipolysis of gastric and pancreatic lipases during a test meal in humans Gastroenterology 105 1993 876 888 (Pubitemid 23249500)
62. F. Carrière, C. Renou, V. Lopez, J. De Caro, F. Ferrato, H. Lengsfeld, A. De Caro, R. Laugier, and R. Verger The specific activities of human digestive lipases measured from the in vivo and in vitro lipolysis of test meals Gastroenterology 119 2000 949 960
63. A. Chawla, G. Buckton, K. Taylor, J. Newton, and M. Johnson Wilhelmy plate contact angle data on powder compacts: considerations of plate perimeter European Journal of Pharmaceutical Sciences 2 1994 253 258 (Pubitemid 24317193)
64. M.A. Cheema, M. Siddiq, S. Barbosa, P. Taboada, and V. Mosquera Surface and bulk properties of two amphiphilic phenothiazine drugs in different aqueous media Journal of Chemical and Engineering Data 53 2007 368 373 (Pubitemid 351488352)
65. S.R. Chemburkar, J. Bauer, K. Deming, H. Spiwek, K. Patel, J. Morris, R. Henry, S. Spanton, W. Dziki, and W. Porter Dealing with the impact of ritonavir polymorphs on the late stages of bulk drug process development Organic Process Research & Development 4 2000 413 417
66. X.Q. Chen, and S. Venkatesh Miniature device for aqueous and non-aqueous solubility measurements during drug discovery Pharmaceutical Research 21 2004 1758 1761 (Pubitemid 39390085)
67. T.M. Chen, H. Shen, and C. Zhu Evaluation of a method for high throughput solubility determination using a multi-wavelength UV plate reader Combinatorial Chemistry & High Throughput Screening 5 2002 575 581 (Pubitemid 35246757)
68. J.O. Christensen, K. Schultz, B. Mollgaard, H.G. Kristensen, and A. Mullertz Solubilisation of poorly water-soluble drugs during in vitro lipolysis of medium- and long-chain triacylglycerols European Journal of Pharmaceutical Sciences 23 2004 287 296 (Pubitemid 39369884)
69. D.E. Clark Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 1. Prediction of intestinal absorption Journal of Pharmaceutical Sciences 88 1999 807 814 (Pubitemid 29398550)
70. S. Clarysse, J. Tack, F. Lammert, G. Duchateau, C. Reppas, and P. Augustijns Postprandial evolution in composition and characteristics of human duodenal fluids in different nutritional states Journal of Pharmaceutical Sciences 98 2009 1177 1192
71. S. Clarysse, J. Brouwers, J. Tack, P. Annaert, and P. Augustijns Intestinal drug solubility estimation based on simulated intestinal fluids: comparison with solubility in human intestinal fluids European Journal of Pharmaceutical Sciences 43 2011 260 269
72. J. Comer Ionization Constants and Ionization profiles D.J. Triggle, J.B. Taylor, Comprehensive Medicinal Chemistry II 2006 Elsevier Oxford 357 397
73. Comer, J., Tam, K., 2001. Lipophilicity profiles: theory and measurement. Testa, B.; van de Waterbeemd, H.; Folkers, G, 275-304.
74. W. Curatolo Physical chemical properties of oral drug candidates in the discovery and exploratory development settings Pharmaceutical Science & Technology Today 1 1998 387 393 (Pubitemid 28559133)
75. J. Dai, L. Jin, S. Yao, and L. Wang Prediction of partition coefficient and toxicity for benzaldehyde compounds by their capacity factors and various molecular descriptors Chemosphere 42 2001 899 907 (Pubitemid 32144640)
76. P. Dewar, R. King, and D. Johnston Bile acid and lysolecithin concentrations in the stomach in patients with duodenal ulcer before operation and after treatment by highly selective vagotomy, partial gastrectomy, or truncal vagotomy and drainage Gut 23 1982 569 577 (Pubitemid 12081108)
77. L. Di, P.V. Fish, and T. Mano Bridging solubility between drug discovery and development Drug Discovery Today 17 2012 486 495
78. K.H. Diehl, R. Hull, D. Morton, R. Pfister, Y. Rabemampianina, D. Smith, J.M. Vidal, C. van de Vorstenbosch, A. European Federation of Pharmaceutical Industries, and M. European Centre for the Validation of Alternative A good practice guide to the administration of substances and removal of blood, including routes and volumes Journal of Applied Toxicology 21 2001 15 23
79. J.G. Dorsey, and M.G. Khaledi Hydrophobicity estimations by reversed-phase liquid chromatography: implications for biological partitioning processes Journal of Chromatography 656 1993 485 499 (Pubitemid 24076423)
80. J. Dove, G. Buckton, and C. Doherty A comparison of two contact angle measurement methods and inverse gas chromatography to assess the surface energies of theophylline and caffeine International Journal of Pharmaceutics 138 1996 199 206 (Pubitemid 26281177)
81. J.B. Dressman Comparison of canine and human gastrointestinal physiology Pharmaceutical Research 3 1986 123 131 (Pubitemid 17195382)
82. J.B. Dressman, and C. Reppas In vitro-in vivo correlations for lipophilic, poorly water-soluble drugs European Journal of Pharmaceutical Sciences 11 2000 S73 S80
83. J.B. Dressman, R.R. Berardi, L.C. Dermentzoglou, T.L. Russell, S.P. Schmaltz, J.L. Barnett, and K.M. Jarvenpaa Upper gastrointestinal (GI) pH in young, healthy men and women Pharmaceutical Research 7 1990 756 761 (Pubitemid 20278376)
84. J. Dressman, G. Amidon, C. Reppas, and V. Shah Dissolution testing as a prognostic tool for oral drug absorption: immediate release dosage forms Pharmaceutical Research 15 1998 11 22 (Pubitemid 28080861)
85. J. Eastoe, and J.S. Dalton Dynamic surface tension and adsorption mechanisms of surfactants at the air-water interface Advances in Colloid and Interface Science 85 2000 103 144 (Pubitemid 30566101)
86. M. Efentakis, and J. Dressman Gastric juice as a dissolution medium: surface tension and pH European Journal of Drug Metabolism and Pharmacokinetics 23 1998 97 102 (Pubitemid 28401090)
87. D. Elder, and R. Holm Aqueous solubility: simple predictive methods (in silico, in vitro and bio-relevant approaches) International Journal of Pharmaceutics 453 2013 3 11
88. D.P. Elder, R. Holm, and H.L. Diego Use of pharmaceutical salts and cocrystals to address the issue of poor solubility International Journal of Pharmaceutics 453 2013 88 100
89. EMA, 2010. Committe for Medicinal Products for Human Use. Guideline on the Investigation of Bioequivalence. < http://www.emea.europa.eu/docs/en-GB/ document-library/Scientific-guideline/2010/01/WC500070039.pdf > (accessed 03.05.13).
90. G. Englund, P. Hallberg, P. Artursson, K. Michaelsson, and H. Melhus Association between the number of coadministered P-glycoprotein inhibitors and serum digoxin levels in patients on therapeutic drug monitoring BMC Medicine 2 2004 8
91. M. Erceg, M. Vertzoni, H. Ceric, M. Dumic, B. Cetina-Cizmek, and C. Reppas In vitro vs. canine data for assessing early exposure of doxazosin base and its mesylate salt European Journal of Pharmaceutics and Biopharmaceutics e. 80 2012 402 409
92. D. Eros, I. Kovesdi, L. Orfi, K. Takacs-Novak, G. Acsady, and G. Keri Reliability of logP predictions based on calculated molecular descriptors: a critical review Current Medicinal Chemistry 9 2002 1819 1829
93. European Medicines Agency, 2013. Guideline on the Investigation of Drug Interactions. In: Committee for Human Medicinal Products (CHMP) (Ed.).
94. C.W. Extrand Contact angles and their hysteresis as a measure of liquid-solid adhesion Langmuir 20 2004 4017 4021
95. G.D. Eytan, R. Regev, G. Oren, and Y.G. Assaraf The role of passive transbilayer drug movement in multidrug resistance and its modulation Journal of Biological Chemistry 271 1996 12897 12902 (Pubitemid 26175862)
96. J.H. Fagerberg, O. Tsinman, N. Sun, K. Tsinman, A. Avdeef, and C.A.S. Bergstrom Dissolution rate and apparent solubility of poorly soluble drugs in biorelevant dissolution media Molecular Pharmaceutics 7 2010 1419 1430
97. J.H. Fagerberg, Y. Al-Tikriti, G. Ragnarsson, and C.A.S. Bergström Ethanol effects on apparent solubility of poorly soluble drugs in simulated intestinal fluid Molecular Pharmaceutics 9 2012 1942 1952
98. V.B. Fainerman, and R. Miller Maximum bubble pressure tensiometry - an analysis of experimental constraints Advances in Colloid and Interface Science 108-109 2004 287 301
99. FDA, 2000. US Food and Drug Administration. Guidance for industry: Waiver of In Vivo Bioavailability and Bioequivalence Studies for Immediate-Release Solid Oral Dosage Forms Based on a Biopharmaceutics Classification System. < http://www.fda.gov/downloads/Drugs/./Guidances/ucm070246.pdf > (accessed 03.05.13).
100. K.S. Fenner, M.D. Troutman, S. Kempshall, J.A. Cook, J.A. Ware, D.A. Smith, and C.A. Lee Drug-drug interactions mediated through P-glycoprotein: clinical relevance and in vitro-in vivo correlation using digoxin as a probe drug Clinical Pharmacology and Therapeutics 85 2009 173 181
101. P. Finholt, and S. Solvang Dissolution kinetics of drugs in human gastric juice - the role of surface tension Journal of Pharmaceutical Sciences 57 1968 1322 1326
102. A. Fini, and A. Roda Chemical properties of bile acids. IV. Acidity constants of glycine-conjugated bile acids Journal of Lipid Research 28 1987 755 759
103. Food and Drug Administration, 2012. Drug Interaction Studies - Study Design, Data Analysis, Implications for Dosing, and Labeling Recommendations. In: Center for Drug Evaluation and Research (CDER).
104. N. Fotaki, M. Symillides, and C. Reppas Canine versus in vitro data for predicting input profiles of l-sulpiride after oral administration European Journal of Pharmaceutical Sciences 26 2005 324 333 (Pubitemid 41278638)
105. S.C. Gad, C.D. Cassidy, N. Aubert, B. Spainhour, and H. Robbe Nonclinical vehicle use in studies by multiple routes in multiple species International Journal of Toxicology 25 2006 499 521 (Pubitemid 44888807)
106. L. Galet, S. Patry, and J. Dodds Determination of the wettability of powders by the Washburn capillary rise method with bed preparation by a centrifugal packing technique Journal of Colloid and Interface Science 346 2010 470 475
107. E. Galia, E. Nicolaides, D. Horter, R. Lobenberg, C. Reppas, and J.B. Dressman Evaluation of various dissolution media for predicting in vivo performance of class I and II drugs Pharmaceutical Research 15 1998 698 705 (Pubitemid 28275645)
108. E.D. Gamsiz, M. Ashtikar, J. Crison, W. Woltosz, M.B. Bolger, and R.L. Carrier Predicting the effect of fed-state intestinal contents on drug dissolution Pharmaceutical Research 27 2010 2646 2656
109. G. Gerebtzoff, X. Li-Blatter, H. Fischer, A. Frentzel, and A. Seelig Halogenation of drugs enhances membrane binding and permeation ChemBioChem 5 2004 676 684 (Pubitemid 39257090)
110. K.M. Giacomini, S.-M. Huang, D.J. Tweedie, L.Z. Benet, K.L. Brouwer, X. Chu, A. Dahlin, R. Evers, V. Fischer, and K.M. Hillgren Membrane transporters in drug development Nature Reviews Drug Discovery 9 2010 215 236
111. M.P. Gleeson Generation of a set of simple, interpretable ADMET rules of thumb Journal of Medicinal Chemistry 51 2008 817 834 (Pubitemid 351304691)
112. M.P. Gleeson, A. Hersey, D. Montanari, and J. Overington Probing the links between in vitro potency, ADMET and physicochemical parameters Nature Reviews Drug Discovery 10 2011 197 208
113. A. Glomme, J. Marz, and J.B. Dressman Comparison of a miniaturized shake-flask solubility method with automated potentiometric acid/base titrations and calculated solubilities Journal of Pharmaceutical Sciences 94 2005 1 16 (Pubitemid 40116365)
114. S. Gocan, G. Cimpan, and J. Comer Lipophilicity measurements by liquid chromatography Advance in Chromatography New York 44 2006 79 176
115. S. Gopinathan, A. Nouraldeen, and A.G. Wilson Development and application of a high-throughput formulation screening strategy for oral administration in drug discovery Future Medicinal Chemistry 2 2010 1391 1398
116. W.B. Gough, R.H. Zeiler, P. Barreca, and N. El-Sherif Hypotensive action of commercial intravenous amiodarone and polysorbate 80 in dogs Journal of Cardiovascular Pharmacology 4 1982 375 380 (Pubitemid 12115822)
117. S. Gould, and R.C. Scott 2-Hydroxypropyl-beta-cyclodextrin (HP-beta-CD): a toxicology review Food and Chemical Toxicology 43 2005 1451 1459
118. T. Gravestock, K. Box, J. Comer, E. Frake, S. Judge, and R. Ruiz The "GI dissolution" method: a low volume, in vitro apparatus for assessing the dissolution/precipitation behaviour of an active pharmaceutical ingredient under biorelevant conditions Analytical Methods 3 2011 560 567
119. M. Grove, G.P. Pedersen, J.L. Nielsen, and A. Mullertz Bioavailability of seocalcitol I: Relating solubility in biorelevant media with oral bioavailability in rats-effect of medium and long chain triglycerides Journal of Pharmaceutical Sciences 94 2005 1830 1838 (Pubitemid 41360876)
120. A. Grunenberg Polymorphie und thermische Analyse pharmazeutischer Wirkstoffe Pharmazie in Unserer Zeit 26 1997 224 231 (Pubitemid 27514542)
121. N. Gulyaeva, A. Zaslavsky, P. Lechner, M. Chlenov, O. McConnell, A. Chait, V. Kipnis, and B. Zaslavsky Relative hydrophobicity and lipophilicity of drugs measured by aqueous two-phase partitioning, octanol-buffer partitioning and HPLC: a simple model for predicting blood-brain distribution European Journal of Medicinal Chemistry 38 2003 391 396 (Pubitemid 36577189)
122. M.J. Hageman Preformulation designed to enable discovery and assess developability Combinatorial Chemistry & High Throughput Screening 13 2010 90 100
123. A. Hanafy, H. Spahn-Langguth, G. Vergnault, P. Grenier, M. Tubic Grozdanis, T. Lenhardt, and P. Langguth Pharmacokinetic evaluation of oral fenofibrate nanosuspensions and SLN in comparison to conventional suspensions of micronized drug Advanced Drug Delivery Reviews 59 2007 419 426 (Pubitemid 47260709)
124. B.C. Hancock, and M. Parks What is the true solubility advantage for amorphous pharmaceuticals? Pharmaceutical Research 17 2000 397 404 (Pubitemid 30395293)
125. M.M. Hann, and G.M. Keseru Finding the sweet spot: the role of nature and nurture in medicinal chemistry Nature Reviews Drug Discovery 11 2012 355 365
126. S.W. Harder, D.A. Zuck, and J.A. Wood Characterization of tablet surfaces by their critical surface-tension values Journal of Pharmaceutical Sciences 59 1970 1787 1792
127. H. Hedeman, H. Brondsted, A. Mullertz, and S. Frokjaer Fat emulsions based on structured lipids (1,3-specific triglycerides): an investigation of the in vivo fate Pharmaceutical Research 13 1996 725 728 (Pubitemid 26156221)
128. O. Hernell, J.E. Staggers, and M.C. Carey Physical-chemical behavior of dietary and biliary lipids during intestinal digestion and absorption. 2. Phase analysis and aggregation states of luminal lipids during duodenal fat digestion in healthy adult human beings Biochemistry 29 1990 2041 2056 (Pubitemid 20085429)
129. I.J. Hidalgo, T.J. Raub, and R.T. Borchardt Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability Gastroenterology 96 1989 736 749 (Pubitemid 19057595)
130. J. Higgins, M.E. Cartwright, and A.C. Templeton Progressing preclinical drug candidates: strategies on preclinical safety studies and the quest for adequate exposure Drug Discovery Today 17 2012 828 836
131. C. Hilgendorf, G. Ahlin, A. Seithel, P. Artursson, A.L. Ungell, and J. Karlsson Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines Drug Metabolism and Disposition 35 2007 1333 1340 (Pubitemid 47121774)
132. A.R. Hilgers, R.A. Conradi, and P.S. Burton Caco-2 cell monolayers as a model for drug transport across the intestinal mucosa Pharmaceutical Research 7 1990 902 910 (Pubitemid 20349761)
133. J. Hirtz The gastrointestinal absorption of drugs in man: a review of current concepts and methods of investigation British Journal of Clinical Pharmacology 19 1985 77S 83S (Pubitemid 16193625)
134. A.M. Hoare, M.R. Keighley, B. Starkey, and J. Alexander-Williams Measurement of bile acids in fasting gastric aspirates: an objective test for bile reflux after gastric surgery Gut 19 1978 166 169 (Pubitemid 8318425)
135. R. Holm, A. Mullertz, E. Christensen, C.E. Hoy, and H.G. Kristensen Comparison of total oral bioavailability and the lymphatic transport of halofantrine from three different unsaturated triglycerides in lymph-cannulated conscious rats European Journal of Pharmaceutical Sciences 14 2001 331 337 (Pubitemid 33001626)
136. R. Holm, A. Mullertz, G.P. Pedersen, and H.G. Kristensen Comparison of the lymphatic transport of halofantrine administered in disperse systems containing three different unsaturated fatty acids Pharmaceutical Research 18 2001 1299 1304 (Pubitemid 32846323)
137. R. Holm, C.J. Porter, A. Mullertz, H.G. Kristensen, and W.N. Charman Structured triglyceride vehicles for oral delivery of halofantrine: examination of intestinal lymphatic transport and bioavailability in conscious rats Pharmaceutical Research 19 2002 1354 1361
138. R. Holm, C.J. Porter, G.A. Edwards, A. Mullertz, H.G. Kristensen, and W.N. Charman Examination of oral absorption and lymphatic transport of halofantrine in a triple-cannulated canine model after administration in self-microemulsifying drug delivery systems (SMEDDS) containing structured triglycerides European Journal of Pharmaceutical Sciences 20 2003 91 97 (Pubitemid 37103236)
139. R. Holm, A. Mullertz, and H. Mu Bile salts and their importance for drug absorption International Journal of Pharmaceutics 453 2013 44 55
140. Y.L. Hsieh, G.A. Ilevbare, B. Van Eerdenbrugh, K.J. Box, M.V. Sanchez-Felix, and L.S. Taylor pH-Induced precipitation behavior of weakly basic compounds: determination of extent and duration of supersaturation using potentiometric titration and correlation to solid state properties Pharmaceutical Research 29 2012 2738 2753
141. L.F. Huang, and W.Q. Tong Impact of solid state properties on developability assessment of drug candidates Advanced Drug Delivery Reviews 56 2004 321 334
142. I. Hubatsch, E.G. Ragnarsson, and P. Artursson Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers Nature Protocols 2 2007 2111 2119 (Pubitemid 351565848)
143. E. Huehn, and P. Langguth In Vitro-In Vivo Correlations General principles and methodologies, regulatory aspects and applications (Part 2) Pharmazeutische Industrie 75 2013 312 318
144. J.D. Hughes, J. Blagg, D.A. Price, S. Bailey, G.A. DeCrescenzo, R.V. Devraj, E. Ellsworth, Y.M. Fobian, M.E. Gibbs, and R.W. Gilles Physiochemical drug properties associated with in vivo toxicological outcomes Bioorganic & Medicinal Chemistry Letters 18 2008 4872 4875
145. Y. Ishihama, Y. Oda, and N. Asakawa Microscale determination of dissociation constants of multivalent pharmaceuticals by capillary electrophoresis Journal of Pharmaceutical Sciences 83 1994 1500 1507 (Pubitemid 24315290)
146. N. Jain, and S.H. Yalkowsky Estimation of the aqueous solubility I: application to organic nonelectrolytes Journal of Pharmaceutical Sciences 90 2001 234 252 (Pubitemid 32158051)
147. M. Jamei, D. Turner, J. Yang, S. Neuhoff, S. Polak, A. Rostami-Hodjegan, and G. Tucker Population-based mechanistic prediction of oral drug absorption The AAPS Journal 11 2009 225 237
148. E. Jantratid, N. Janssen, C. Reppas, and J. Dressman Dissolution media simulating conditions in the proximal human gastrointestinal tract: an update Pharmaceutical Research 25 2008 1663 1676
149. L. Jenkins, and A. Donald Contact angle measurements on fibers in the environmental scanning electron microscope Langmuir 15 1999 7829 7835 (Pubitemid 30503913)
150. Z.J. Jia Physicochemical profiling by capillary electrophoresis Current Pharmaceutical Analysis 1 2005 41 56
151. L. Jia, H. Wong, C. Cerna, and S.D. Weitman Effect of nanonization on absorption of 301029: ex vivo and in vivo pharmacokinetic correlations determined by liquid chromatography/mass spectrometry Pharmaceutical Research 19 2002 1091 1096 (Pubitemid 34984991)
152. J. Jinno, N. Kamada, M. Miyake, K. Yamada, T. Mukai, M. Odomi, H. Toguchi, G.G. Liversidge, K. Higaki, and T. Kimura Effect of particle size reduction on dissolution and oral absorption of a poorly water-soluble drug, cilostazol, in beagle dogs Journal of Controlled Release 111 2006 56 64 (Pubitemid 43289995)
153. S.R. Johnson, and W. Zheng Recent progress in the computational prediction of aqueous solubility and absorption The AAPS Journal 8 2006 E27 E40
154. L. Kalantzi, K. Goumas, V. Kalioras, B. Abrahamsson, J.B. Dressman, and C. Reppas Characterization of the human upper gastrointestinal contents under conditions simulating bioavailability/bioequivalence studies Pharmaceutical Research 23 2006 165 176 (Pubitemid 43214673)
155. L. Kalantzi, E. Persson, B. Polentarutti, B. Abrahamsson, K. Goumas, J. Dressman, and C. Reppas Canine intestinal contents vs. simulated media for the assessment of solubility of two weak bases in the human small intestinal contents Pharmaceutical Research 23 2006 1373 1381 (Pubitemid 43946159)
156. R. Kaliszan High-performance liquid-chromatographic methods and procedures of hydrophobicity determination Quantitative Structure-Activity Relationships 9 1990 83 87 (Pubitemid 20313977)
157. R. Kaliszan Quantitative structure-retention relationships Analytical Chemistry 64 1992 A619
158. R. Kaliszan, P. Wiczling, and M.J. Markuszewski PH gradient high-performance liquid chromatography: theory and applications Jourmal of Chromatography A 1060 2004 165 175 (Pubitemid 39573282)
159. M. Kansy, F. Senner, and K. Gubernator Physicochemical high throughput screening: parallel artificial membrane permeation assay in the description of passive absorption processes Journal of Medicinal Chemistry 41 1998 1007 1010 (Pubitemid 28207375)
160. T.T. Kararli Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals Biopharmaceutics & Drug Disposition 16 1995 351 380
161. M. Karlgren, A. Vildhede, U. Norinder, J.R. Wisniewski, E. Kimoto, Y. Lai, U. Haglund, and P. Artursson Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions Journal of Medicinal Chemistry 55 2012 4740 4763
162. D.M. Karpf, R. Holm, H.G. Kristensen, and A. Mullertz Influence of the type of surfactant and the degree of dispersion on the lymphatic transport of halofantrine in conscious rats Pharmaceutical Research 21 2004 1413 1418 (Pubitemid 39149656)
163. K. Kawakami Current status of amorphous formulation and other special dosage forms as formulations for early clinical phases Journal of Pharmaceutical Sciences 98 2009 2875 2885
164. E.H. Kerns High throughput physicochemical profiling for drug discovery Journal of Pharmaceutical Sciences 90 2001 1838 1858 (Pubitemid 33062605)
165. G.M. Keseru, and G.M. Makara The influence of lead discovery strategies on the properties of drug candidates Nature Reviews Drug Discovery 8 2009 203 212
166. F. Kesisoglou, and A. Mitra Crystalline nanosuspensions as potential toxicology and clinical oral formulations for BCS II/IV compounds The AAPS Journal 14 2012 677 687
167. K. Kleberg, F. Jacobsen, D.G. Fatouros, and A. Mullertz Biorelevant media simulating fed state intestinal fluids: colloid phase characterization and impact on solubilization capacity Journal of Pharmaceutical Sciences 99 2010 3522 3532
168. K. Kleberg, J. Jacobsen, and A. Müllertz Characterising the behaviour of poorly water soluble drugs in the intestine: application of biorelevant media for solubility, dissolution and transport studies Journal of Pharmacy and Pharmacology 62 2010 1656 1668
169. G. Kossena, W. Charman, C. Wilson, B. O'Mahony, B. Lindsay, J. Hempenstall, C. Davison, P. Crowley, and C.H. Porter Low dose lipid formulations: effects on gastric emptying and biliary secretion Pharmaceutical Research 24 2007 2084 2096 (Pubitemid 47493578)
170. Kostewicz, E.S., Aarons, L., Bergstrand, M., Bolger, M.B., Galetin, A., Hatley, O., Jamei, M., Lloyd, R., Pepin, X., Rostami, A., Sjogren, E., Tannergren, C., Turner, D.B., Wagner, C., Weitschies, W., Dressman, J., 2013. PBPK models for the prediction of in vivo performance of oral dosage forms. European Journal of Pharmaceutical Sciences e-pub Sept 21.
171. C. Kramer, B. Beck, and T. Clark Insolubility classification with accurate prediction probabilities using a MetaClassifier Journal of Chemical Information and Modeling 50 2010 404 414
172. M.S. Ku Use of the Biopharmaceutical Classification System in early drug development The AAPS Journal 10 2008 208 212
173. H. Kubinyi Lipophilicity and drug activity: progress in drug research. Fortschritte der Arzneimittelforschung Progres des Recherches Pharmaceutiques 23 1979 97 198
174. L. Kumar, A. Amin, and A.K. Bansal An overview of automated systems relevant in pharmaceutical salt screening Drug Discovery Today 12 2007 1046 1053 (Pubitemid 350186130)
175. E. Kwong, J. Higgins, and A.C. Templeton Strategies for bringing drug delivery tools into discovery International Journal of Pharmaceutics 412 2011 1 7
176. W.J. Lambert Modeling oil-water partitioning and membrane permeation using reversed-phase chromatography Journal of Chromatography A 656 1993 469 484 (Pubitemid 24076422)
177. A.W. Larhed, P. Artursson, J. Grasjo, and E. Bjork Diffusion of drugs in native and purified gastrointestinal mucus Journal of Pharmaceutical Sciences 86 1997 660 665 (Pubitemid 27248815)
178. M. Lazghab, K. Saleh, I. Pezron, P. Guigon, and L. Komunjer Wettability assessment of finely divided solids Powder Technology 157 2005 79 91 (Pubitemid 41435519)
179. Y.C. Lee, P.D. Zocharski, and B. Samas An intravenous formulation decision tree for discovery compound formulation development International Journal of Pharmaceutics 253 2003 111 119 (Pubitemid 36197836)
180. P.D. Leeson, and B. Springthorpe The influence of drug-like concepts on decision-making in medicinal chemistry Nature Reviews Drug Discovery 6 2007 881 890 (Pubitemid 350042396)
181. H. Lennernäs Human intestinal permeability Journal of Pharmaceutical Sciences 87 1998 403 410 (Pubitemid 28175799)
182. H. Lennernäs, K. Palm, U. Fagerholm, and P. Artursson Comparison between active and passive drug transport in human intestinal epithelial (Caco-2) cells in vitro and human jejunum in vivo International Journal of Pharmaceutics 127 1996 103 107 (Pubitemid 26069155)
183. A. Leo, C. Hansch, and D. Elkins Partition Coefficients and Their Uses Chemical Reviews 71 1971 525-+
184. P. Li, and L. Zhao Developing early formulations: practice and perspective International Journal of Pharmaceutics 341 2007 1 19 (Pubitemid 47088122)
185. A. Lindahl, A.-L. Ungell, L. Knutson, and H. Lennernäs Characterization of fluids from the stomach and proximal jejunum in men and women Pharmaceutical Research 14 1997 497 502 (Pubitemid 27205011)
186. J. Linnankoski, J. Makela, J. Palmgren, T. Mauriala, C. Vedin, A.L. Ungell, L. Lazorova, P. Artursson, A. Urtti, and M. Yliperttula Paracellular porosity and pore size of the human intestinal epithelium in tissue and cell culture models Journal of Pharmaceutical Sciences 99 2010 2166 2175
187. C.A. Lipinski Drug-like properties and the causes of poor solubility and poor permeability Journal of Pharmacological and Toxicological Methods 44 2000 235 249 (Pubitemid 32239479)
188. C. Lipinski, and A. Hopkins Navigating chemical space for biology and medicine Nature 432 2004 855 861 (Pubitemid 40037141)
189. C.A. Lipinski, F. Lombardo, B.W. Dominy, and P.J. Feeney Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings Advanced Drug Delivery Reviews 23 1997 3 25 (Pubitemid 27046991)
190. C.A. Lipinski, F. Lombardo, B.W. Dominy, and P.J. Feeney Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings Advanced Drug Delivery Reviews 46 2001 3 26 (Pubitemid 33653411)
191. B.C. Lippold, and A. Ohm Correlation between wettability and dissolution rate of pharmaceutical powders International Journal of Pharmaceutics 28 1986 67 74 (Pubitemid 16210129)
192. G.G. Liversidge, and P. Conzentino Drug particle size reduction for decreasing gastric irritancy and enhancing absorption of naproxen in rats International Journal of Pharmaceutics 125 1995 309 313
193. A. Llinas, and J.M. Goodman Polymorph control: past, present and future Drug Discovery Today 13 2008 198 210
194. M. Lobell, M. Hendrix, B. Hinzen, J. Keldenich, H. Meier, C. Schmeck, R. Schohe-Loop, T. Wunberg, and A. Hillisch In silico ADMET traffic lights as a tool for the prioritization of HTS hits ChemMedChem 1 2006 1229 1236 (Pubitemid 44786929)
195. T. Loftsson, S.B. Vogensen, M.E. Brewster, and F. Konradsdottir Effects of cyclodextrins on drug delivery through biological membranes Journal of Pharmaceutical Sciences 96 2007 2532 2546 (Pubitemid 47597809)
196. F. Lombardo, M.Y. Shalaeva, K.A. Tupper, F. Gao, and M.H. Abraham ElogPoct: a tool for lipophilicity determination in drug discovery Journal of Medicinal Chemistry 43 2000 2922 2928 (Pubitemid 30599650)
197. F. Lombardo, M.Y. Shalaeva, K.A. Tupper, and F. Gao ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds Journal of Medicinal Chemistry 44 2001 2490 2497 (Pubitemid 32852170)
198. J. Maas, W. Kamm, and G. Hauck An integrated early formulation strategy - from hit evaluation to preclinical candidate profiling European Journal of Pharmaceutics and Biopharmaceutics e. 66 2007 1 10 (Pubitemid 46412973)
199. P. Macheras, M. Koupparis, and C. Tsaprounis Drug dissolution studies in milk using the automated flow injection serial dynamic dialysis technique International Journal of Pharmaceutics 33 1986 125 136 (Pubitemid 17197796)
200. Mackie, C., Mortishire-Smith, R., Wuyts, K., Brewster, M., 2008. Assessing Solid Dosage form Feasibility and Solubility/Dissolution Rate Limitations for Drug Candidates - Early Solution-suspension Comparisons in the Rat. American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition, Atlanta, GA.
201. D. Mahlin, and C.A.S. Bergstrom Early drug development predictions of glass-forming ability and physical stability of drugs European Journal of Pharmaceutical Sciences 49 2013 323 332
202. D. Mahlin, S. Ponnambalam, M.H. Hockerfelt, and C.A.S. Bergstrom Toward in silico prediction of glass-forming ability from molecular structure alone: a screening tool in early drug development Molecular Pharmaceutics 8 2011 498 506
203. D.T. Manallack The pK(a) distribution of drugs: application to drug discovery Perspectives in Medicinal Chemistry 1 2008 25 38
204. R. Mannhold, G.I. Poda, C. Ostermann, and I.V. Tetko Calculation of molecular lipophilicity: state-of-the-art and comparison of log P methods on more than 96,000 compounds Journal of Pharmaceutical Sciences 98 2009 861 893
205. C.M. Mansbach, R.S. Cohen, and P.B. Leff Isolation and properties of the mixed lipid micelles present in intestinal content during fat digestion in man The Journal of Clinical Investigation 56 1975 781 791
206. E. Masini, J. Planchenault, F. Pezziardi, P. Gautier, and J.P. Gagnol Histamine-releasing properties of Polysorbate 80 in vitro and in vivo: correlation with its hypotensive action in the dog Agents and Actions 16 1985 470 477 (Pubitemid 16220968)
207. P. Matsson, C.A.S. Bergstrom, N. Nagahara, S. Tavelin, U. Norinder, and P. Artursson Exploring the role of different drug transport routes in permeability screening Journal of Medicinal Chemistry 48 2005 604 613 (Pubitemid 40139802)
208. E.L. McConnell, A.W. Basit, and S. Murdan Measurements of rat and mouse gastrointestinal pH, fluid and lymphoid tissue, and implications for in-vivo experiments Journal of Pharmacy and Pharmacology 60 2008 63 70
209. E.M. Merisko-Liversidge, and G.G. Liversidge Drug nanoparticles: formulating poorly water-soluble compounds Toxicologic Pathology 36 2008 43 48
210. H. Meyer Zur Theorie der Alkoholnarkose Archiv für experimentelle Pathologie und Pharmakologie (Naunyn-Schmiedebergs) 42 1899 109 118
211. F. Milletti, L. Storchi, L. Goracci, S. Bendels, B. Wagner, M. Kansy, and G. Cruciani Extending pKa prediction accuracy: high-throughput pKa measurements to understand pKa modulation of new chemical series European Journal of Medicinal Chemistry 45 2010 4270 4279
212. M.P.d.l.C. Moreno, M. Oth, S. Deferme, F. Lammert, J. Tack, J. Dressman, and P. Augustijns Characterization of fasted-state human intestinal fluids collected from duodenum and jejunum Journal of Pharmacy and Pharmacology 58 2006 1079 1089 (Pubitemid 44213641)
213. K.R. Morris, U.J. Griesser, C.J. Eckhardt, and J.G. Stowell Theoretical approaches to physical transformations of active pharmaceutical ingredients during manufacturing processes Advanced Drug Delivery Reviews 48 2001 91 114 (Pubitemid 32452293)
214. U. Muenster, C. Pelzetter, T. Backensfeld, A. Ohm, T. Kuhlmann, H. Mueller, K. Lustig, J. Keldenich, S. Greschat, A.H. Goller, and M.J. Gnoth Volume to dissolve applied dose (VDAD) and apparent dissolution rate (ADR): tools to predict in vivo bioavailability from orally applied drug suspensions European Journal of Pharmaceutics and Biopharmaceutics e. 78 2011 522 530
215. S.B. Murdande, M.J. Pikal, R.M. Shanker, and R.H. Bogner Aqueous solubility of crystalline and amorphous drugs: challenges in measurement Pharmaceutical Development and Technology 16 2011 187 200
216. A. Nasal, and R. Kaliszan Progress in the use of HPLC for evaluation of lipophilicity Current Computer-Aided Drug Design 2 2006 327 340 (Pubitemid 46029592)
217. S. Neervannan Preclinical formulations for discovery and toxicology: physicochemical challenges Expert Opinion on Drug Metabolism & Toxicology 2 2006 715 731 (Pubitemid 46118317)
218. F.S. Nielsen, and A. Müllertz Development of in vitro methods for the evaluation of formulation performance Bulletin Technique Gattefossé 98 2005 75 87
219. P.B. Nielsen, A. Mullertz, T. Norling, and H.G. Kristensen Comparison of the lymphatic transport of a lipophilic drug from vehicles containing alpha-tocopherol and/or triglycerides in rats The Journal of Pharmacy and Pharmacology 53 2001 1439 1445 (Pubitemid 33064533)
220. P.B. Nielsen, A. Mullertz, T. Norling, and H.G. Kristensen The effect of alpha-tocopherol on the in vitro solubilisation of lipophilic drugs International Journal of Pharmaceutics 222 2001 217 224 (Pubitemid 32568365)
221. D.J. Nolan Rapid duodenal and jejunal intubation Clinical Radiology 30 1979 183 185 (Pubitemid 9138028)
222. U. Norinder, and C.A.S. Bergstrom Prediction of ADMET Properties ChemMedChem 1 2006 920 937 (Pubitemid 44448790)
223. L. Novotny, M. Abdel-Hamid, and H. Hamza Inosine and 2'-deoxyinosine and their synthetic analogues: lipophilicity in the relation to their retention in reversed-phase liquid chromatography and the stability characteristics Journal of Pharmaceutical and Biomedical Analysis 24 2000 125 132
224. R.L. Oberle, T.S. Chen, C. Lloyd, J.L. Barnett, C. Owyang, J. Meyer, and G.L. Amidon The influence of the interdigestive migrating myoelectric complex on the gastric emptying of liquids Gastroenterology 99 1990 1275 1282 (Pubitemid 20381860)
225. D.M. Oh, R.L. Curl, and G.L. Amidon Estimating the fraction dose absorbed from suspensions of poorly soluble compounds in humans: a mathematical model Pharmaceutical Research 10 1993 264 270 (Pubitemid 23041742)
226. M. Ohta, and G. Buckton A study of the differences between two amorphous spray-dried samples of cefditoren pivoxil which exhibited different physical stabilities International Journal of Pharmaceutics 289 2005 31 38 (Pubitemid 40093538)
227. E.R. O'Maille, and T.G. Richards Possible explanations for the differences in secretory characteristics between conjugated and free bile acids The Journal of Physiology 265 1977 855 866 (Pubitemid 8056788)
228. G. Ottaviani, D.J. Gosling, C. Patissier, S. Rodde, L. Zhou, and B. Faller What is modulating solubility in simulated intestinal fluids? European Journal of Pharmaceutical Sciences 41 2010 452 457
229. A. Pagliara, E. Khamis, A. Trinh, P.A. Carrupt, R.S. Tsai, and B. Testa Structural-properties governing retention mechanisms on Rp-Hplc stationary phases used for lipophilicity measurements Journal of Liquid Chromatography 18 1995 1721 1745
230. K. Palm, P. Stenberg, K. Luthman, and P. Artursson Polar molecular surface properties predict the intestinal absorption of drugs in humans Pharmaceutical Research 14 1997 568 571 (Pubitemid 27220272)
231. M. Palucki, J.D. Higgins, E. Kwong, and A.C. Templeton Strategies at the interface of drug discovery and development: early optimization of the solid state phase and preclinical toxicology formulation for potential drug candidates Journal of Medicinal Chemistry 53 2010 5897 5905
232. L. Pan, Q. Ho, K. Tsutsui, and L. Takahashi Comparison of chromatographic and spectroscopic methods used to rank compounds for aqueous solubility Journal of Pharmaceutical Sciences 90 2001 521 529
233. H.M. Pang, J. Kenseth, and S. Coldiron High-throughput multiplexed capillary electrophoresis in drug discovery Drug Discovery Today 9 2004 1072 1080 (Pubitemid 39593657)
234. E.C. Paul, J. Hochman, and A. Quaroni Conditionally immortalized intestinal epithelial cells: novel approach for study of differentiated enterocytes The American Journal of Physiology 265 1993 C266 C278
235. G.M. Pauletti, F.W. Okumu, and R.T. Borchardt Effect of size and charge on the passive diffusion of peptides across Caco-2 cell monolayers via the paracellular pathway Pharmaceutical Research 14 1997 164 168 (Pubitemid 27146358)
236. B.L. Pedersen, A. Müllertz, H. Brøndsted, and H.G. Kristensen A comparison of the solubility of danazol in human and simulated gastrointestinal fluids Pharmaceutical Research 17 2000 891 894 (Pubitemid 30666973)
237. Pedersen, P.B., Vilmann, P., Bar-Shalom, D., Mullertz, A., Baldursdottir, S., 2013. Characterization of human fasted gastric fluid for relevant rheological parameters and gastric lipase activities. European Journal of Pharmaceutics and Biopharmaceutics e-pub May 31.
238. X. Pepin, S. Blanchon, and G. Couarraze A new approach for determination of powder wettability International Journal of Pharmaceutics 152 1997 1 5 (Pubitemid 27254955)
239. E. Persson, A.-S. Gustafsson, A. Carlsson, R. Nilsson, L. Knutson, P. Forsell, G. Hanisch, H. Lennernäs, and B. Abrahamsson The effects of food on the dissolution of poorly soluble drugs in human and in model small intestinal fluids Pharmaceutical Research 22 2005 2141 2151 (Pubitemid 41821594)
240. E. Persson, R. Nilsson, G. Hansson, L. Löfgren, F. Libäck, L. Knutson, B. Abrahamsson, and H. Lennernäs A clinical single-pass perfusion investigation of the dynamic in vivo secretory response to a dietary meal in human proximal small intestine Pharmaceutical Research 23 2006 742 751
241. Petereit, A.C., 2011. Prediction of Biological Membrane Penetration of Poorly Soluble Drugs Using Surface Activity Profiling. Doctoral thesis, Goethe Universität, Frankfurt, Germany.
242. A.C. Petereit, K. Swinney, J. Mensch, C. Mackie, S. Stokbroekx, M. Brewster, and J.B. Dressman Prediction of blood-brain barrier penetration of poorly soluble drug candidates using surface activity profiling European Journal of Pharmaceutics and Biopharmaceutics 75 2010 405 410
243. D.W. Piper, F.L. Broderick, B.H. Fenton, and D. Beeston Effect of histamine on the protein and mucus content of gastric juice The American Journal of Digestive Diseases 10 1965 122 127
244. V. Pliska, B. Testa, and H. van de Waterbeemd Lipophilicity in Drug Action and Toxicology. In: Methods and Principles in Medicinal Chemistry 1996 VCH Weinheim
245. S.K. Poole, S. Patel, K. Dehring, H. Workman, and C.F. Poole Determination of acid dissociation constants by capillary electrophoresis Journal of Chromatography A 1037 2004 445 454 (Pubitemid 38591353)
246. C.J. Porter, N.L. Trevaskis, and W.N. Charman Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs Nature Reviews Drug Discovery 6 2007 231 248 (Pubitemid 46344627)
247. S.L. Price The computational prediction of pharmaceutical crystal structures and polymorphism Advanced Drug Delivery Reviews 56 2004 301 319 (Pubitemid 38201427)
248. S.L. Price From crystal structure prediction to polymorph prediction: interpreting the crystal energy landscape Physical Chemistry Chemical Physics 10 2008 1996 2009
249. D. Psachoulias, M. Vertzoni, K. Goumas, V. Kalioras, S. Beato, J. Butler, and C. Reppas Precipitation in and supersaturation of contents of the upper small intestine after administration of two weak bases to fasted adults Pharmaceutical Research 28 2011 3145 3158
250. M. Pudipeddi, and A.T. Serajuddin Trends in solubility of polymorphs Journal of Pharmaceutical Sciences 94 2005 929 939 (Pubitemid 40780760)
251. V. Puri, A.K. Dantuluri, M. Kumar, N. Karar, and A.K. Bansal Wettability and surface chemistry of crystalline and amorphous forms of a poorly water soluble drug European Journal of Pharmaceutical Sciences 40 2010 84 93
252. J. Rantanen Process analytical applications of Raman spectroscopy Journal of Pharmacy and Pharmacology 59 2007 171 177 (Pubitemid 46203056)
253. T.J. Raub P-glycoprotein recognition of substrates and circumvention through rational drug design Molecular Pharmaceutics 3 2006 3 25 (Pubitemid 43331747)
254. C. Reppas, and M. Vertzoni Biorelevant in-vitro performance testing of orally administered dosage forms Journal of Pharmacy and Pharmacology 64 2012 919 930
255. T.J. Ritchie, and S.J. Macdonald The impact of aromatic ring count on compound developability - are too many aromatic rings a liability in drug design? Drug Discovery Today 14 2009 1011 1020
256. T.J. Ritchie, P. Ertl, and R. Lewis The graphical representation of ADME-related molecule properties for medicinal chemists Drug Discovery Today 16 2011 65 72
257. T.J. Ritchie, S.J. Macdonald, R.J. Young, and S.D. Pickett The impact of aromatic ring count on compound developability: further insights by examining carbo- and hetero-aromatic and -aliphatic ring types Drug Discovery Today 16 2011 164 171
258. R.C. Rowe, P.J. Sheskey, and P.J. Weller Handbook of Pharmaceutical Excipients 2006 Pharmaceutical Press London
259. M. Rowland, C. Peck, and G. Tucker Physiologically-based pharmacokinetics in drug development and regulatory science Annual Review of Pharmacology and Toxicology 51 2011 45 73
260. M. Rupp, R. Korner, and I.V. Tetko Predicting the pKa of small molecule Combinatorial Chemistry & High Throughput Screening 14 2011 307 327
261. C. Saal, and A.C. Petereit Optimizing solubility: kinetic versus thermodynamic solubility temptations and risks European Journal of Pharmaceutical Sciences 47 2012 589 595
262. M. Savolainen, K. Kogermann, A. Heinz, J. Aaltonen, L. Peltonen, C. Strachan, and J. Yliruusi Better understanding of dissolution behaviour of amorphous drugs by in situ solid-state analysis using Raman spectroscopy European Journal of Pharmaceutics and Biopharmaceutics 71 2009 71 79
263. V. Saxena, R. Panicucci, Y. Joshi, and S. Garad Developability assessment in pharmaceutical industry: an integrated group approach for selecting developable candidates Journal of Pharmaceutical Sciences 98 2009 1962 1979
264. N.E. Schindlbeck, C. Heinrich, F. Stellaard, G. Paumgartner, and S.A. Muller-Lissner Healthy controls have as much bile reflux as gastric ulcer patients Gut 28 1987 1577 1583 (Pubitemid 18033063)
265. A. Scholz, B. Abrahamsson, S.M. Diebold, E. Kostewicz, B.I. Polentarutti, A.L. Ungell, and J.B. Dressman Influence of hydrodynamics and particle size on the absorption of felodipine in labradors Pharmaceutical Research 19 2002 42 46 (Pubitemid 34075105)
266. A. Seelig, R. Gottschlich, and R.M. Devant A method to determine the ability of drugs to diffuse through the blood-brain barrier Proceeding of the National Academy of Science USA 91 1994 68 72
267. K.B. Sentell, and J.G. Dorsey Retention mechanisms in reversed-phase liquid chromatography: stationary-phase bonding density and partitioning Analytical Chemistry 61 1989 930 934
268. E.G. Shafrin, and W.A. Zisman Constitutive relations in the wetting of low energy surfaces and the theory of the retraction method of preparing monolayers1 The Journal of Physical Chemistry 64 1960 519 524
269. M.H. Shariare, F.J. Leusen, M. de Matas, P. York, and J. Anwar Prediction of the mechanical behaviour of crystalline solids Pharmaceutical Research 29 2012 319 331
270. J.J. Sheng, D.P. McNamara, and G.L. Amidon Toward an in vivo dissolution methodology: a comparison of phosphate and bicarbonate buffers Molecular Pharmaceutics 6 2009 29 39
271. P.L. Sheridan, G. Buckton, and D.E. Storey The extent of errors associated with contact angles II. Factors affecting data obtained using a Wilhelmy plate technique for powders International Journal of Pharmaceutics 109 1994 155 171
272. D. Singhal, and W. Curatolo Drug polymorphism and dosage form design: a practical perspective Advanced Drug Delivery Reviews 56 2004 335 347 (Pubitemid 38201429)
273. Sjögren, E., Abrahamsson, B., Augustijns, P., Becker, D., Bolger, M.B., Brewster, M., Brouwers, J., Flanagan, T., Harwood, M., Heinen, C., Holm, R., Juretschke, H.-P., Kubbinga, M., Lindahl, A., Lukacova, V., Münster, U., Neuhoff, S., Nguyen, M., van Peerf, A., Reppas, C., Rostami, A., Tannergren, C., Weitschies, W., Wilson, C., Zane, P., Lennernäs, H., Langguth, P., 2013. In vivo methods for drug absorption - comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects. European Journal of Pharmaceutical Sciences (submitted for publication).
274. B. Slater, A. McCormack, A. Avdeef, and J.E. Comer PH-metric log P. 4: comparison of partition coefficients determined by HPLC and potentiometric methods to literature values Journal of Pharmaceutical Sciences 83 1994 1280 1283 (Pubitemid 24282334)
275. H.W. Smith Observations on the flora of the alimentary tract of animals and factors affecting its composition The Journal of Pathology and Bacteriology 89 1965 95 122
276. E. Söderlind, E. Karlsson, A. Carlsson, R. Kong, A. Lenz, S. Lindborg, and J.J. Sheng Simulating fasted human intestinal fluids: understanding the roles of lecithin and bile acids Molecular Pharmaceutics 7 2010 1498 1507
277. J.E. Staggers, S.C. Frost, and M.A. Wells Studies on fat digestion, absorption, and transport in the suckling rat. III. Composition of bile and evidence for enterohepatic circulation of bile salts Journal of Lipid Research 23 1982 1143 1151 (Pubitemid 13187610)
278. B. Steffansen, B. Brodin, C. Uhd Nielsen, and P. Anderlé B. Steffansen, B. Brodin, C. Uhd Nielsen, Molecular Biopharmaceutics: Aspects of Drug Characterisation, Drug Delivery and Dosage form Evaluation 2010 Pharmaceutical Press London, UK 113 222
279. V.J. Stella, and Q. He Cyclodextrins Toxicologic Pathology 36 2008 30 42
280. P. Stenberg, U. Norinder, K. Luthman, and P. Artursson Experimental and computational screening models for the prediction of intestinal drug absorption Journal of Medicinal Chemistry 44 2001 1927 1937 (Pubitemid 32884517)
281. C.J. Strachan, T. Rades, K.C. Gordon, and J. Rantanen Raman spectroscopy for quantitative analysis of pharmaceutical solids The Journal of Pharmacy and Pharmacology 59 2007 179 192 (Pubitemid 46203057)
282. M. Stuart, and K. Box Chasing equilibrium: measuring the intrinsic solubility of weak acids and bases Analytical Chemistry 77 2005 983 990 (Pubitemid 40261763)
283. K. Sugano, Y. Nabuchi, M. Machida, and Y. Asoh Permeation characteristics of a hydrophilic basic compound across a bio-mimetic artificial membrane International Journal of Pharmaceutics 275 2004 271 278 (Pubitemid 38481539)
284. K. Sugano, M. Kansy, P. Artursson, A. Avdeef, S. Bendels, L. Di, G.F. Ecker, B. Faller, H. Fischer, G. Gerebtzoff, H. Lennernaes, and F. Senner Coexistence of passive and carrier-mediated processes in drug transport Nature Reviews Drug Discovery 9 2010 597 614
285. V.H. Sunesen, B.L. Pedersen, H.G. Kristensen, and A. Mullertz In vivo in vitro correlations for a poorly soluble drug, danazol, using the flow-through dissolution method with biorelevant dissolution media European Journal of Pharmaceutical Sciences 24 2005 305 313 (Pubitemid 40283513)
286. P. Suomalainen, C. Johans, T. Soderlund, and P.K. Kinnunen Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability Journal of Medicinal Chemistry 47 2004 1783 1788 (Pubitemid 38380922)
287. adetermination of water-insoluble compounds: validation study in methanol/water mixtures International Journal of Pharmaceutics 151 1997 235 248 (Pubitemid 27223371)
288. M. Talekar, J. Kendall, W. Denny, S. Jamieson, and S. Garg Development and evaluation of PIK75 nanosuspension, a phosphatidylinositol-3-kinase inhibitor European Journal of Pharmaceutical Sciences 47 2012 824 833
289. N.A. Tamimi, and P. Ellis Drug development: from concept to marketing! Nephron Clinical Practice 113 2009 c125 c131
290. S. Tavelin, V. Milovic, G. Ocklind, S. Olsson, and P. Artursson A conditionally immortalized epithelial cell line for studies of intestinal drug transport The Journal of Pharmacology and Experimental Therapeutics 290 1999 1212 1221 (Pubitemid 29400263)
291. S. Tavelin, J. Grasjo, J. Taipalensuu, G. Ocklind, and P. Artursson Applications of epithelial cell culture in studies of drug transport Methods in Molecular Biology 188 2002 233 272
292. S. Tavelin, J. Taipalensuu, L. Soderberg, R. Morrison, S. Chong, and P. Artursson Prediction of the oral absorption of low-permeability drugs using small intestine-like 2/4/A1 cell monolayers Pharmaceutical Research 20 2003 397 405 (Pubitemid 36288368)
293. A. Tchapla, H. Colin, and G. Guiochon Linearity of homologous series retention plots in reversed-phase liquid-chromatography Analytical Chemistry 56 1984 621 625 (Pubitemid 14568633)
294. R.W. Tejwani, M.E. Davis, B.D. Anderson, and T.R. Stouch Functional group dependence of solute partitioning to various locations within a DOPC bilayer: a comparison of molecular dynamics simulations with experiment Journal of Pharmaceutical Sciences 100 2011 2136 2146
295. I.V. Tetko, and G.I. Poda Application of ALOGPS 2.1 to predict log D distribution coefficient for Pfizer proprietary compounds Journal of Medicinal Chemistry 47 2004 5601 5604 (Pubitemid 39447254)
296. F. Tian, N. Sandler, J. Aaltonen, C. Lang, D.J. Saville, K.C. Gordon, C.J. Strachan, J. Rantanen, and T. Rades Influence of polymorphic form, morphology, and excipient interactions on the dissolution of carbamazepine compacts Journal of Pharmaceutical Sciences 96 2007 584 594 (Pubitemid 46466080)
297. K. Valko, C. Bevan, and D. Reynolds Chromatographic hydrophobicity index by fast-gradient RP-HPLC: a high-throughput alternative to log P/log D Analytical Chemistry 69 1997 2022 2029 (Pubitemid 127698689)
298. K. Valko, C. My Du, C. Bevan, D.P. Reynolds, and M.H. Abraham Rapid method for the estimation of octanol/water partition coefficient (log P(oct)) from gradient RP-HPLC retention and a hydrogen bond acidity term (zetaalpha(2)(H)) Current Medicinal Chemistry 8 2001 1137 1146 (Pubitemid 32633663)
299. H. van De Waterbeemd, G. Camenisch, G. Folkers, and O.A. Raevsky Estimation of Caco-2 cell permeability using calculated molecular descriptors Quantitative Structure-Activity Relationships 15 1996 480 490 (Pubitemid 27023202)
300. H. van de Waterbeemd, R.E. Carter, G. Grassy, H. Kubinyi, Y.C. Martin, M.S. Tute, and P. Willett Glossary of terms used in computational drug design
301. R. Vandecruys, J. Peeters, G. Verreck, and M.E. Brewster Use of a screening method to determine excipients which optimize the extent and stability of supersaturated drug solutions and application of this system to solid formulation design International Journal of Pharmaceutics 342 2007 168 175 (Pubitemid 47259339)
302. D.F. Veber, S.R. Johnson, H.Y. Cheng, B.R. Smith, K.W. Ward, and K.D. Kopple Molecular properties that influence the oral bioavailability of drug candidates Journal of Medicinal Chemistry 45 2002 2615 2623 (Pubitemid 34595232)
303. P. Veng-Pedersen Noncompartmentally-based pharmacokinetic modeling Advanced Drug Delivery Reviews 48 2001 265 300 (Pubitemid 32434407)
304. M. Vertzoni, N. Fotaki, E. Kostewicz, E. Stippler, C. Leuner, E. Nicolaides, J. Dressman, and C. Reppas Dissolution media simulating the intralumenal composition of the small intestine: physiological issues and practical aspects The Journal of Pharmacy and Pharmacology 56 2004 453 462 (Pubitemid 38455610)
305. M. Vertzoni, J. Dressman, J. Butler, J. Hempenstall, and C. Reppas Simulation of fasting gastric conditions and its importance for the in vivo dissolution of lipophilic compounds European Journal of Pharmaceutics and Biopharmaceutics e. 60 2005 413 417 (Pubitemid 40922839)
306. M. Vertzoni, E. Pastelli, D. Psachoulias, L. Kalantzi, and C. Reppas Estimation of intragastric solubility of drugs: In what medium? Pharmaceutical Research 24 2007 909 917 (Pubitemid 46675392)
307. M. Vertzoni, H. Archontaki, and C. Reppas Determination of intralumenal individual bile acids by HPLC with charged aerosol detection Journal of Lipid Research 49 2008 2690 2695
308. M. Vertzoni, C. Markopoulos, M. Symillides, C. Goumas, G. Imanidis, and C. Reppas Luminal lipid phases after administration of a triglyceride solution of danazol in the fed state and their contribution to the flux of danazol across Caco-2 cell monolayers Molecular Pharmaceutics 9 2012 1189 1198
309. J.G. Wagner, and E. Nelson Per cent absorbed time plots derived from blood level and/or urinary excretion data Journal of Pharmaceutical Sciences 52 1963 610 611
310. C. Wagner, E. Jantratid, F. Kesisoglou, M. Vertzoni, C. Reppas, and B.D. Jennifer Predicting the oral absorption of a poorly soluble, poorly permeable weak base using biorelevant dissolution and transfer model tests coupled with a physiologically based pharmacokinetic model European Journal of Pharmaceutics and Biopharmaceutics e.V 82 2012 127 138
311. H. Wan, and A.G. Holmen High throughput screening of physicochemical properties and in vitro ADME profiling in drug discovery Combinatorial Chemistry & High Throughput Screening 12 2009 315 329
312. H. Wan, and J. Ulander High-throughput pKa screening and prediction amenable for ADME profiling Expert Opinion on Drug Metabolism & Toxicology 2 2006 139 155 (Pubitemid 46100733)
313. H. Wan, A.G. Holmen, Y. Wang, W. Lindberg, M. Englund, M.B. Nagard, and R.A. Thompson High-throughput screening of pKa values of pharmaceuticals by pressure-assisted capillary electrophoresis and mass spectrometry Rapid Communications in Mass Spectrometry: RCM 17 2003 2639 2648 (Pubitemid 37498777)
314. F.W. Ward, and M.E. Coates Gastrointestinal pH measurement in rats: influence of the microbial flora, diet and fasting Laboratory Animals 21 1987 216 222
315. M.J. Waring Defining optimum lipophilicity and molecular weight ranges for drug candidates-Molecular weight dependent lower logD limits based on permeability Bioorganic & Medicinal Chemistry Letters 19 2009 2844 2851
316. M.J. Waring Lipophilicity in drug discovery Expert Opinion on Drug Discovery 5 2010 235 248
317. D.B. Warren, H. Benameur, C.J. Porter, and C.W. Pouton Using polymeric precipitation inhibitors to improve the absorption of poorly water-soluble drugs: a mechanistic basis for utility Journal of Drug Targeting 18 2010 704 731
318. D.B. Warren, C.A.S. Bergstrom, H. Benameur, C.J. Porter, and C.W. Pouton Evaluation of the structural determinants of polymeric precipitation inhibitors using solvent shift methods and principle component analysis Molecular Pharmaceutics 10 2013 2823 2848
319. E.W. Washburn The dynamics of capillary flow Physical Reviews 17 1921 273
320. C.M. Wassvik, A.G. Holmen, C.A.S. Bergstrom, I. Zamora, and P. Artursson Contribution of solid-state properties to the aqueous solubility of drugs European Journal of Pharmaceutical Sciences 29 2006 294 305 (Pubitemid 44740132)
321. C.M. Wassvik, A.G. Holmén, R. Draheim, P. Artursson, and C.A.S. Bergström Molecular characteristics for solid-state limited solubility Journal of Medicinal Chemistry 51 2008 3035 3039 (Pubitemid 351706031)
322. M.C. Wenlock, R.P. Austin, P. Barton, A.M. Davis, and P.D. Leeson A comparison of physiochemical property profiles of development and marketed oral drugs Journal of Medicinal Chemistry 46 2003 1250 1256 (Pubitemid 36428230)
323. I. Weuts, F. Van Dycke, J. Voorspoels, S. De Cort, S. Stokbroekx, R. Leemans, M.E. Brewster, D. Xu, B. Segmuller, Y.T. Turner, C.J. Roberts, M.C. Davies, S. Qi, D.Q. Craig, and M. Reading Physicochemical properties of the amorphous drug, cast films, and spray dried powders to predict formulation probability of success for solid dispersions: etravirine Journal of Pharmaceutical Sciences 100 2011 260 274
324. P. Wiczling, M.J. Markuszewski, and R. Kaliszan Determination of pKa by pH gradient reversed-phase HPLC Analytical Chemistry 76 2004 3069 3077 (Pubitemid 38715697)
325. A. Wikman, J. Karlsson, I. Carlstedt, and P. Artursson A drug absorption model based on the mucus layer producing human intestinal goblet cell line HT29-H Pharmaceutical Research 10 1993 843 852 (Pubitemid 23167566)
326. A. Wikman-Larhed, and P. Artursson Co-cultures of human intestinal goblet (HT29-H) and absorptive (Caco-2) cells for studies of drug and peptide absorption European Journal of Pharmaceutical Sciences 3 1995 171 183
327. S. Willmann, K. Thelen, and J. Lippert Integration of dissolution into physiologically-based pharmacokinetic models III: PK-Sim(R) The Journal of Pharmacy and Pharmacology 64 2012 997 1007
328. K.S. Wong, J. Kenseth, and R. Strasburg Validation and long-term assessment of an approach for the high throughput determination of lipophilicity (log POW) values using multiplexed, absorbance-based capillary electrophoresis Journal of Pharmaceutical Sciences 93 2004 916 931 (Pubitemid 38420403)
329. N. Wyttenbach, J. Alsenz, and O. Grassmann Miniaturized assay for solubility and residual solid screening (SORESOS) in early drug development Pharmaceutical Research 24 2007 888 898 (Pubitemid 46675389)
330. D. Xia, F. Cui, H. Piao, D. Cun, H. Piao, Y. Jiang, M. Ouyang, and P. Quan Effect of crystal size on the in vitro dissolution and oral absorption of nitrendipine in rats Pharmaceutical Research 27 2010 1965 1976
331. S.H. Yalkowsky Solubility and Solubilization in Aqueous Media 1999 American Chemical Society Washington, DC
332. S.H. Yalkowsky, and S.C. Valvani Solubility and partitioning I: Solubility of nonelectrolytes in water Journal of Pharmaceutical Sciences 69 1980 912 922 (Pubitemid 11234579)
333. C. Yamagami, K. Kawase, and K. Iwaki Hydrophobicity parameters determined by reversed-phase liquid chromatography. XV: optimal conditions for prediction of log P(oct) by using RP-HPLC procedures Chemical & Pharmaceutical Bulletin 50 2002 1578 1583 (Pubitemid 41694843)
334. T. Yamashita, S. Ozaki, and I. Kushida Solvent shift method for anti-precipitant screening of poorly soluble drugs using biorelevant medium and dimethyl sulfoxide International Journal of Pharmaceutics 419 2011 170 174
335. T. Young An essay on the cohesion of fluids Philosophical Transactions of the Royal Society of London 95 1805 65 87
336. N.M. Zaki, P. Artursson, and C.A.S. Bergström A modified physiological BCS for prediction of intestinal absorption in drug discovery Molecular Pharmaceutics 7 2010 1478 1487
337. N.H. Zangenberg, A. Mullertz, H.G. Kristensen, and L. Hovgaard A dynamic in vitro lipolysis model. I. Controlling the rate of lipolysis by continuous addition of calcium European Journal of Pharmaceutical Sciences 14 2001 115 122 (Pubitemid 32737533)
338. N.H. Zangenberg, A. Mullertz, H.G. Kristensen, and L. Hovgaard A dynamic in vitro lipolysis model. II: Evaluation of the model European Journal of Pharmaceutical Sciences 14 2001 237 244 (Pubitemid 32884320)
339. D.E. Zecevic, and K.G. Wagner Rational development of solid dispersions via hot-melt extrusion using screening, material characterization, and numeric simulation tools Journal of Pharmaceutical Sciences 102 2013 2297 2310
340. W. Zheng, A. Jain, D. Papoutsakis, R.M. Dannenfelser, R. Panicucci, and S. Garad Selection of oral bioavailability enhancing formulations during drug discovery Drug Development and Industrial Pharmacy 38 2012 235 247
341. C. Zhou, Y. Jin, J.R. Kenseth, M. Stella, K.R. Wehmeyer, and W.R. Heineman Rapid pKa estimation using vacuum-assisted multiplexed capillary electrophoresis (VAMCE) with ultraviolet detection Journal of Pharmaceutical Sciences 94 2005 576 589 (Pubitemid 40476522)
342. L. Zhou, L. Yang, S. Tilton, and J. Wang Development of a high throughput equilibrium solubility assay using miniaturized shake-flask method in early drug discovery Journal of Pharmaceutical Sciences 96 2007 3052 3071 (Pubitemid 350221202)
343. A.M. Zissimos, M.H. Abraham, A. Klamt, F. Eckert, and J. Wood A comparison between the two general sets of linear free energy descriptors of Abraham and Klamt Journal of Chemical Information and Computer Sciences 42 2002 1320 1331 (Pubitemid 35468319)