Relative hydrophobicity and lipophilicity of drugs measured by aqueous two-phase partitioning, octanol-buffer partitioning and HPLC. A simple model for predicting blood-brain distribution

European Journal of Medicinal Chemistry

Volumn 38, Issue 4, 2003, Pages 391-396

  Gulyaeva, Nellie ^a   Zaslavsky, Alexander ^a   Lechner, Pamela ^a   Chlenov, Michael ^b   McConnell, Oliver ^b   Chait, Arnon ^a   Kipnis, Victor ^c   Zaslavsky, Boris ^a  

^a Analiza Inc   (United States)

^b PFIZER INC   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Aqueous two phase partitioning; Blood brain barrier; HPLC; Hydrophobicity; Lipophilicity; Log P; Octanol buffer partitioning

Indexed keywords

5 HYDROXYTRYPTOPHAN; ACICLOVIR; ALBENDAZOLE; AMITRIPTYLINE; AMPICILLIN; ASTEMIZOLE; ATENOLOL; BUFFER; CHLORPROMAZINE; CIMETIDINE; CLOMIPRAMINE; DEXTRAN DERIVATIVE; DEXTRAN POLY(ETHYLENE GLYCOL); DOMPERIDONE; EBASTINE; FLUOROURACIL; FUROSEMIDE; IPRONIAZID; METOCLOPRAMIDE; METOPROLOL; METRONIDAZOLE; OCTANOL; PARACETAMOL; PHENAZONE; PHENELZINE; PIRENZEPINE; SALBUTAMOL; TEGAFUR; TERFENADINE; TIAPRIDE; UNCLASSIFIED DRUG;

BLOOD BRAIN BARRIER; CONFERENCE PAPER; DRUG DISTRIBUTION; DRUG PENETRATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHOBICITY; LIPOPHILICITY; MATHEMATICAL MODEL;

EID: 0038393305     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(03)00044-8     Document Type: Conference Paper

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