Predicting intestinal precipitation-A case example for a basic BCS class II drug

Pharmaceutical Research

Volumn 27, Issue 10, 2010, Pages 2119-2130

  Carlert, Sara ^a   Pålsson, Anna ^b   Hanisch, Gunilla ^b   Von Corswant, Christian ^b   Nilsson, Catarina ^b   Lindfors, Lennart ^b   Lennernäs, Hans ^a   Abrahamsson, Bertil ^b  

^a UPPSALA UNIVERSITY   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

absorption biopharmaceutics classification system; gastrointestinal; in vitro in vivo correlations (IVIVC); precipitation

Indexed keywords

8 (2,6 DIMETHYLBENZYLAMINO) N (2 HYDROXYETHYL) 2,3 DIMETHYLIMIDAZO[1,2 A]PYRIDINE 6 CARBOXAMIDE;

AREA UNDER THE CURVE; ARTICLE; CALCULATION; CLINICAL TRIAL; COMPUTER MODEL; CONCENTRATION RESPONSE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG EXPOSURE; DRUG FORMULATION; DRUG SOLUBILITY; DRUG STRUCTURE; HUMAN; HUMAN EXPERIMENT; IN VITRO STUDY; IN VIVO STUDY; INTESTINE; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PHYSICAL CHEMISTRY; PRECIPITATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIMULATION;

BIOLOGICAL AVAILABILITY; BODY FLUIDS; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMICAL PRECIPITATION; CRYSTALLIZATION; HUMANS; IMIDAZOLES; INTESTINES; MALE; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; PYRIDINES; SOLUBILITY; TISSUE DISTRIBUTION;

EID: 77957371289     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-010-0213-8     Document Type: Article

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