The effects of food on the dissolution of poorly soluble drugs in human and in model small intestinal fluids

Pharmaceutical Research

Volumn 22, Issue 12, 2005, Pages 2141-2151

  Persson, Eva M ^a   Gustafsson, Ann Sofie ^b   Carlsson, Anders S ^b   Nilsson, Ralf G ^b   Knutson, Lars ^c   Forsell, Patrick ^c   Hanisch, Gunilla ^b   Lennernäs, Hans ^a   Abrahamsson, Bertil ^b  

^a UPPSALA UNIVERSITY   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

^c UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Bile acids; Dissolution rate; Food effects; Poorly soluble drugs; Solubility

Indexed keywords

BILE ACID; CYCLOSPORIN; DANAZOL; FELODIPINE; GRISEOFULVIN; PROBUCOL; UBIQUINONE;

ADULT; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DIET RESTRICTION; DRUG SOLUBILITY; FAT INTAKE; FEEDING; FEMALE; FOOD; HUMAN; INTESTINE FLUID; MALE; NONHUMAN; NORMAL HUMAN; PHYSICAL CHEMISTRY; PREDICTION; PRIORITY JOURNAL; SIMULATION; SMALL INTESTINE;

ADULT; ANIMALS; BODY FLUIDS; CHEMISTRY, PHYSICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; FEMALE; FOOD-DRUG INTERACTIONS; HUMANS; INTESTINES; KINETICS; LIPIDS; MALE; MOLECULAR WEIGHT; PHARMACEUTICAL PREPARATIONS; SOLUBILITY; THERMODYNAMICS;

EID: 29244445764     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-005-8192-x     Document Type: Article

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