High-throughput screening of pKa values of pharmaceuticals by pressure-assisted capillary electrophoresis and mass spectrometry

Rapid Communications in Mass Spectrometry

Volumn 17, Issue 23, 2003, Pages 2639-2648

  Wan, Hong ^a   Holmén, Anders G ^a   Wang, Yudong ^a   Lindberg, Walter ^a   Englund, Marie ^a   Någård, Mats B ^a   Thompson, Richard A ^a  

^a ASTRAZENECA R AND D   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

DIMETHYL SULFOXIDE; DRUG PRODUCTS; IONIC STRENGTH; MASS SPECTROMETRY; ORGANIC SOLVENTS; THROUGHPUT;

BACKGROUND ELECTROLYTES; CAPILLARY ELECTROPHORESIS-MASS SPECTROMETRIES; EFFECTIVE MOBILITIES; HIGH THROUGHPUT SCREENING; HIGH-THROUGHPUT; MOBILITY MEASUREMENTS; NONVOLATILE; PH RANGE; PHOSPHATE BUFFERS; SCREENING METHODS;

CAPILLARY ELECTROPHORESIS;

DIMETHYL SULFOXIDE; ELECTROLYTE;

CAPILLARY ELECTROPHORESIS; CONFERENCE PAPER; IONIC STRENGTH; MASS SPECTROMETRY; MEASUREMENT; PH; PKA; PRESSURE; SCREENING;

EID: 0345526990     PISSN: 09514198     EISSN: None     Source Type: Journal    
DOI: 10.1002/rcm.1229     Document Type: Conference Paper

References (43)

1. Lombardo F, Obach RS, Shalaeva MY, Gao F. J. Med. Chem. 2002; 45: 2867.
2. Avdeef A. Curr. Top. Med. Chem. 2001; 1: 277.
3. Clistunoff JB, Johnson KP. J. Phys. Chem. B 1998; 102: 3993.
4. Kerns EH. J. Pharm. Sci. 2001; 90: 1838.
5. Meloun M, Havel J. Computation of Solution Equilibria: A Guide to Methods in Potentiometry, Extraction and Spectrophotometry. Ellis Horwood: Chichester, 1988.
6. Tam KY, Takács-Novák K. Anal. Chim. Acta 2001; 434:157.
7. Box K, Bevan C, Comer J, Hill A, Allen R, Reynolds D. Anal. Chem. 2003; 75: 883.
8. Lipinski CA. J. Pharmacol. Toxicol. Methods 2000; 22: 235.
9. Cleveland JA Jr, Martin CL, Gluck SJ. J. Chromatogr. A 1994; 679: 167.
10. Beckers JL, Everaerts FM, Ackermans MT. J. Chromatogr. 1991; 537: 407.
11. Cai J, Smith JT, Rassi ZE. J. High Resolut. Chromatogr. 1992; 15: 30.
12. Cleveland JA Jr, Benko MH, Gluck SJ, Walbroehl YM. J. Chromatogr. A 1993; 652: 301.
13. Gluck SJ, Cleveland JA Jr. J. Chromatogr. A 1994; 680: 49.
14. Gluck SJ, Cleveland JA Jr. J. Chromatogr. A 1994; 680: 43.
15. Gluck SJ, Steele KP, Benko MH. J. Chromatogr. A 1996; 745: 117.
16. Schmitt P, Poiger T, Simon R, Freitag D, Kettrup A, Garrison AW. Anal. Chem. 1997; 69: 2559.
17. Xu X, Hurtubise RJ. J. Liq. Chromatogr. Relat. Technol. 1999; 22: 669.
18. Mrestani Y, Neubert R, Munk A, Wiese M. J. Chromatogr. A 1998; 803: 273.
19. Mendosa SD, Hurtubise RJ. J. Chromatogr. A 1999; 841: 239.
20. Matoga M, Laborde-Kummer E, Langlois MH, Dallet P, Bosc JJ, Jarry C, Dubost JP. J. Chromatogr. A 2003; 984: 253.
21. Jankowsky R, Friebe M, Noll B, Johannsen B. J. Chromatogr. A 1999; 833: 83.
22. Jiménez-Lozano E, Marques I, Barrón D, Beltrán JL, Barbosa J. Anal. Chim. Acta 2002; 464: 37.
23. Glukhovskiy PV, Vigh G. Electrophoresis 1998; 19: 3166.
24. Barbosa J, Barrón D, Jiménez-Lozano E, Sanz-Nebot V. Anal. Chim. Acta 2001; 437: 309.
25. Uhrová M, Mikåk I, Deyl Z, Bellini S. Process Control Qual. 1997; 10: 151.
26. Ishihama Y, Oda Y, Asakawa N. J. Pharm. Sci. 1994; 83: 1500.
27. Jia Z, Ramstad T, Zhong M. Electrophoresis 2001; 22: 1112.
28. Kibbey CE, Poole SK, Robison B, Jackson JD, Durham D. J. Pharm. Sci. 2001; 90: 1164.
29. Wan H, Holmén A, Någård M, Lindberg W. J. Chromatogr. A 2002; 979: 369.
30. Ishihama Y, Nakamura M, Miwa T, Kajima T, Asakawa N. J. Pharm. Sci. 2002; 91: 933.
31. Available: www.combisep.com.
32. Kane RS, Glink PT, Chapman RG, McDonald JC, Jensen PK, Gao HY, Paša-Tolic L, Smith RD, Whitesides GM. Anal. Chem. 2001; 73: 4028.
33. ACD/Labs 6.00 C; ACD pKa DB Advanced Chemistry Development Inc., 90 Adelaide Street, West Toronto, Ontario, M5H3V9, Canada.
34. Nelder JA, Mead R. Computer J. 1965; 7: 308.
35. a Prediction for Organic Acids and Bases. Chapman and Hall: London, 1981.
36. Fabre H, Altria KD. LC-GC 1994; 19: 498.
37. Dollery C. Therapeutic Drugs (2nd edn). Churchill Livingston: Edinburgh, 1999.
38. Sanz-Nebot V, Toro I, Benavente F, Barbosa J. J. Chromatogr. A 2001; 942: 145.
39. Muzikar J, van de Goor T, Gas B, Kenndler E. Anal. Chem. 2002; 74: 428.
40. Porras SP, Riekkola M-L, Kenndler E. J. Chromatogr. A 2001; 905: 259.
41. Psurek A, Scriba GKE. Electrophoresis 2003; 24: 765.
42. Bellini S, Uhrová M, Deyl Z. J. Chromatogr. A 1997; 772: 91.
43. ID Business Solutions Ltd., O. C., Surrey Research Park, Guildford, Surrey GU2 7QB, UK. Available: http://www.idbs.co.uk/.