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Volumn 46, Issue 7, 2003, Pages 1250-1256

A comparison of physiochemical property profiles of development and marketed oral drugs

Author keywords

[No Author keywords available]

Indexed keywords

DRUG; PRAMIPEXOLE;

EID: 0037468884     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm021053p     Document Type: Article
Times cited : (521)

References (27)
  • 1
    • 0023947965 scopus 로고
    • Pharmaceutical innovation by the seven UK-owned pharmaceutical companies (1964-1985)
    • Prentis, R. A.; Lis, Y.; Walker, S. R. Pharmaceutical innovation by the seven UK-owned pharmaceutical companies (1964-1985). Br. J. Clin. Pharm. 1988, 25, 387-396.
    • (1988) Br. J. Clin. Pharm. , vol.25 , pp. 387-396
    • Prentis, R.A.1    Lis, Y.2    Walker, S.R.3
  • 2
    • 0034002261 scopus 로고    scopus 로고
    • Role of the development scientist in compound lead selection and optimization
    • Venkatesh, S.; Lipper, R. A. Role of the development scientist in compound lead selection and optimization. J. Pharm. Sci. 2000, 89, 145-154.
    • (2000) J. Pharm. Sci. , vol.89 , pp. 145-154
    • Venkatesh, S.1    Lipper, R.A.2
  • 3
    • 0031741846 scopus 로고    scopus 로고
    • Physical chemical properties of oral drug candidates in the discovery and exploratory development settings
    • Curatolo, W. Physical chemical properties of oral drug candidates in the discovery and exploratory development settings. Pharm. Sci. Technol. Today 1998, 1, 387-393.
    • (1998) Pharm. Sci. Technol. Today , vol.1 , pp. 387-393
    • Curatolo, W.1
  • 4
    • 0035953319 scopus 로고    scopus 로고
    • Property-based design: Optimization of drug absorption and pharmacokinetics
    • van de Waterbeemd, H.; Smith, D. A.; Beaumont, K.; Walker, D. K. Property-based design: Optimization of drug absorption and pharmacokinetics. J. Med. Chem. 2001, 44, 1313-1333.
    • (2001) J. Med. Chem. , vol.44 , pp. 1313-1333
    • Van De Waterbeemd, H.1    Smith, D.A.2    Beaumont, K.3    Walker, D.K.4
  • 5
    • 0034950245 scopus 로고    scopus 로고
    • Development of a generalized, quantitative physicochemical model of CYP3A4 inhibition for use in early drug discovery
    • Riley, R. J.; Parker, A. J.; Trigg, S.; Manners, C. N. Development of a generalized, quantitative physicochemical model of CYP3A4 inhibition for use in early drug discovery. Pharm. Res. 2001, 18, 652-655.
    • (2001) Pharm. Res. , vol.18 , pp. 652-655
    • Riley, R.J.1    Parker, A.J.2    Trigg, S.3    Manners, C.N.4
  • 6
    • 0034256965 scopus 로고    scopus 로고
    • On the recognition of mammalian microsomal cytochrome P450 substrates and their characteristics. Towards the prediction of human P450 substrate specificity and metabolism
    • Lewis, D. F. V. On the recognition of mammalian microsomal cytochrome P450 substrates and their characteristics. Towards the prediction of human P450 substrate specificity and metabolism. Biochem. Pharmacol. 2000, 60, 293-306.
    • (2000) Biochem. Pharmacol. , vol.60 , pp. 293-306
    • Lewis, D.F.V.1
  • 7
    • 0030763355 scopus 로고    scopus 로고
    • Properties of cytochrome P450 isoenzymes and their substrates part 2: Properties of cytochrome P450 substrates
    • Smith, D. A.; Ackland, M. J.; Jones, B. C. Properties of cytochrome P450 isoenzymes and their substrates part 2: Properties of cytochrome P450 substrates. Drug Discovery Today 1997, 2, 479-486.
    • (1997) Drug Discovery Today , vol.2 , pp. 479-486
    • Smith, D.A.1    Ackland, M.J.2    Jones, B.C.3
  • 9
    • 0030803801 scopus 로고    scopus 로고
    • Drug-phospholipid interactions. 2. Predicting the sites of drug distribution using n-octanol/water and membrane/water distribution coefficients
    • Barton, P.; Davis, A. M.; McCarthy, D. J.; Webborn, P. J. H. Drug-phospholipid interactions. 2. Predicting the sites of drug distribution using n-octanol/water and membrane/water distribution coefficients. J. Pharm. Sci. 1997, 86, 1034-1039.
    • (1997) J. Pharm. Sci. , vol.86 , pp. 1034-1039
    • Barton, P.1    Davis, A.M.2    McCarthy, D.J.3    Webborn, P.J.H.4
  • 10
    • 0000312699 scopus 로고    scopus 로고
    • Physiochemical and drug-delivery considerations for oral drug bioavailability
    • Chan, O. H.; Stewart, B. H. Physiochemical and drug-delivery considerations for oral drug bioavailability. Drug Discovery Today 1996, 1, 461-473.
    • (1996) Drug Discovery Today , vol.1 , pp. 461-473
    • Chan, O.H.1    Stewart, B.H.2
  • 12
    • 0029865450 scopus 로고    scopus 로고
    • Design of drugs involving the concepts and theories of drug metabolism and pharmacokinetics
    • Smith, D. A.; Jones, B. C.; Walker, D. K. Design of drugs involving the concepts and theories of drug metabolism and pharmacokinetics. Med. Res. Rev. 1996, 16, 243-266.
    • (1996) Med. Res. Rev. , vol.16 , pp. 243-266
    • Smith, D.A.1    Jones, B.C.2    Walker, D.K.3
  • 14
    • 0029102708 scopus 로고
    • The effect of lipophilicity on the protein binding and blood cell uptake of some acidic drugs
    • Lázníček, M.; Lázníčková, A. The effect of lipophilicity on the protein binding and blood cell uptake of some acidic drugs. J. Pharm. Biomed. Anal. 1995, 13, 823-828.
    • (1995) J. Pharm. Biomed. Anal. , vol.13 , pp. 823-828
    • Lázníček, M.1    Lázníčková, A.2
  • 15
    • 0029100542 scopus 로고
    • Partitioning of ionizing molecules between aqueous buffers and phospholipid vesicles
    • Austin, R. P.; Davis, A. M.; Manners, C. N. Partitioning of ionizing molecules between aqueous buffers and phospholipid vesicles. J. Pharm. Sci. 1995, 84, 1180-1183.
    • (1995) J. Pharm. Sci. , vol.84 , pp. 1180-1183
    • Austin, R.P.1    Davis, A.M.2    Manners, C.N.3
  • 17
    • 0031024171 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • Lipinski, C. A.; Lombardo, F.; Dominy, B. W.; Feeny, P. J. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Delivery Rev. 1997, 23, 3-25.
    • (1997) Adv. Drug Delivery Rev. , vol.23 , pp. 3-25
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeny, P.J.4
  • 19
    • 0345314301 scopus 로고    scopus 로고
    • Adis International Ltd
    • Adis International Ltd.
  • 20
    • 0003984768 scopus 로고    scopus 로고
    • Medical Economics Company: Montvale, USA
    • Physicians Desk Reference, 53rd ed.; Medical Economics Company: Montvale, USA, 1999.
    • (1999) Physicians Desk Reference, 53rd Ed.
  • 21
    • 0344451402 scopus 로고    scopus 로고
    • Advanced Chemistry Development Inc., Toronto, Canada
    • Advanced Chemistry Development Inc., Toronto, Canada.
  • 22
    • 0344883211 scopus 로고    scopus 로고
    • Accelrys Inc., San Diego, California, USA
    • Accelrys Inc., San Diego, California, USA.
  • 23
    • 0004086493 scopus 로고
    • Payne, M., Ed.; PWS-KENT Publishing Company: Boston, USA
    • Daniel, W. W. Applied Nonparametric Statistics, 2nd ed.; Payne, M., Ed.; PWS-KENT Publishing Company: Boston, USA, 1990; pp 90-95.
    • (1990) Applied Nonparametric Statistics, 2nd Ed. , pp. 90-95
    • Daniel, W.W.1
  • 24
    • 0037030653 scopus 로고    scopus 로고
    • Molecular properties that influence the oral bioavailability of drug candidates
    • Veber, D. F.; Johnson, S. R.; Cheng, H.; Smith, B. R.; Ward, K. W.; Kopple, K. D. Molecular properties that influence the oral bioavailability of drug candidates. J. Med. Chem. 2002, 45, 2615-2623.
    • (2002) J. Med. Chem. , vol.45 , pp. 2615-2623
    • Veber, D.F.1    Johnson, S.R.2    Cheng, H.3    Smith, B.R.4    Ward, K.W.5    Kopple, K.D.6
  • 25
    • 0035324944 scopus 로고    scopus 로고
    • Molecular complexity and its impact on the probability of finding leads for drug discovery
    • Hann, M. M.; Leach, A. R.; Harper, G. Molecular complexity and its impact on the probability of finding leads for drug discovery. J. Chem. Inf. Comput. Sci. 2001, 41, 856-864.
    • (2001) J. Chem. Inf. Comput. Sci. , vol.41 , pp. 856-864
    • Hann, M.M.1    Leach, A.R.2    Harper, G.3
  • 26
    • 0001723417 scopus 로고    scopus 로고
    • The design of leadlike combinatorial libraries
    • Teague, S. J.; Davis, A. M.; Leeson, P. D.; Oprea, T. The design of leadlike combinatorial libraries. Angew. Chem. 1999, 111, 3962-3967; Teague, S. J.; Davis, A. M.; Leeson, P. D.; Oprea, T. Angew. Chem., Int. Ed. Engl. 1999, 38, 3743-3748.
    • (1999) Angew. Chem. , vol.111 , pp. 3962-3967
    • Teague, S.J.1    Davis, A.M.2    Leeson, P.D.3    Oprea, T.4
  • 27


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.