-
1
-
-
0033128171
-
LC/MS applications in drug development
-
Li M.S., and Kerns E.K. LC/MS applications in drug development. Mass Spectrum Rev. 18 (2000) 187-279
-
(2000)
Mass Spectrum Rev.
, vol.18
, pp. 187-279
-
-
Li, M.S.1
Kerns, E.K.2
-
2
-
-
0042058435
-
Introduction
-
Stahl P.H., and Wermuth C.G. (Eds), Wiley-VCH
-
Wermuth C.G., and Stahl P.H. Introduction. In: Stahl P.H., and Wermuth C.G. (Eds). Handbook of Pharmaceutical Salts: Properties, Selection and Use (2002), Wiley-VCH 1-7
-
(2002)
Handbook of Pharmaceutical Salts: Properties, Selection and Use
, pp. 1-7
-
-
Wermuth, C.G.1
Stahl, P.H.2
-
4
-
-
0347765876
-
Crystal structures of drugs: advances in determination, prediction and engineering
-
Datta S., and Grant D.J.W. Crystal structures of drugs: advances in determination, prediction and engineering. Nat. Rev. Drug Discov. 3 (2004) 42-57
-
(2004)
Nat. Rev. Drug Discov.
, vol.3
, pp. 42-57
-
-
Datta, S.1
Grant, D.J.W.2
-
5
-
-
0021876419
-
Predictive relationships in the water solubility of salts of a nonsteroidal anti-inflammatory drug
-
Anderson B.D., and Conradi R.A. Predictive relationships in the water solubility of salts of a nonsteroidal anti-inflammatory drug. J. Pharm. Sci. 74 (1985) 815-820
-
(1985)
J. Pharm. Sci.
, vol.74
, pp. 815-820
-
-
Anderson, B.D.1
Conradi, R.A.2
-
6
-
-
0034345216
-
Salt selection and optimization procedures for pharmaceutical new chemical entities
-
Bastin R.J., et al. Salt selection and optimization procedures for pharmaceutical new chemical entities. Org. Process Res. Dev. 4 (2000) 427-435
-
(2000)
Org. Process Res. Dev.
, vol.4
, pp. 427-435
-
-
Bastin, R.J.1
-
7
-
-
0017623487
-
Pharmaceutical salts
-
Berge S.M., et al. Pharmaceutical salts. J. Pharm. Sci. 66 (1977) 1-19
-
(1977)
J. Pharm. Sci.
, vol.66
, pp. 1-19
-
-
Berge, S.M.1
-
8
-
-
33749994108
-
Solubility: it's not just for physical chemists
-
Bhattachar S.N., et al. Solubility: it's not just for physical chemists. Drug Discov. Today 11 (2006) 1012-1018
-
(2006)
Drug Discov. Today
, vol.11
, pp. 1012-1018
-
-
Bhattachar, S.N.1
-
9
-
-
0035845754
-
Preparation and characterisation of a range of diclofenac salts
-
Connor K.M.O., and Corrigan O.I. Preparation and characterisation of a range of diclofenac salts. Int. J. Pharm. 226 (2001) 163-169
-
(2001)
Int. J. Pharm.
, vol.226
, pp. 163-169
-
-
Connor, K.M.O.1
Corrigan, O.I.2
-
10
-
-
33645115596
-
Polymorphism, salts, and crystallization: the relevance of solid-state development
-
Raumer V.M., et al. Polymorphism, salts, and crystallization: the relevance of solid-state development. Chem. Today 24 (2006) 41-44
-
(2006)
Chem. Today
, vol.24
, pp. 41-44
-
-
Raumer, V.M.1
-
11
-
-
0029890220
-
Factors governing the dissolution of diclofenac salts
-
Fini A., et al. Factors governing the dissolution of diclofenac salts. Int. J. Pharm. 4 (1996) 231-238
-
(1996)
Int. J. Pharm.
, vol.4
, pp. 231-238
-
-
Fini, A.1
-
12
-
-
0346104829
-
Salt selection and simultaneous polymorphism assessment via high-throughput crystallization: the case of sertraline
-
Remenar J.F., et al. Salt selection and simultaneous polymorphism assessment via high-throughput crystallization: the case of sertraline. Org. Process Res. Dev. 7 (2003) 990-996
-
(2003)
Org. Process Res. Dev.
, vol.7
, pp. 990-996
-
-
Remenar, J.F.1
-
13
-
-
36549048649
-
Applications of x-ray powder diffraction in the pharmaceutical industry
-
Stephenson G.A. Applications of x-ray powder diffraction in the pharmaceutical industry. Rigaku J. 22 (2005) 2-15
-
(2005)
Rigaku J.
, vol.22
, pp. 2-15
-
-
Stephenson, G.A.1
-
14
-
-
0028219710
-
An integrated approach to the selection of optimal salt form for a new drug candidate
-
Morris K.R., et al. An integrated approach to the selection of optimal salt form for a new drug candidate. Int. J. Pharm. 105 (1994) 209-217
-
(1994)
Int. J. Pharm.
, vol.105
, pp. 209-217
-
-
Morris, K.R.1
-
15
-
-
1042298890
-
High-throughput crystallization: polymorphs, salts, co-crystals and solvates of pharmaceutical solids
-
Morissette S.L., et al. High-throughput crystallization: polymorphs, salts, co-crystals and solvates of pharmaceutical solids. Adv. Drug Deliv. Rev. 56 (2004) 275-300
-
(2004)
Adv. Drug Deliv. Rev.
, vol.56
, pp. 275-300
-
-
Morissette, S.L.1
-
16
-
-
33646450536
-
Crystalline form information from multiwell plate salt screening by use of Raman microscopy
-
Kojima T., et al. Crystalline form information from multiwell plate salt screening by use of Raman microscopy. Pharm. Res. 23 (2006) 806-812
-
(2006)
Pharm. Res.
, vol.23
, pp. 806-812
-
-
Kojima, T.1
-
17
-
-
33645941544
-
Integrating a Raman microscope into the workflow of a high-throughput crystallization laboratory
-
Lowry S., et al. Integrating a Raman microscope into the workflow of a high-throughput crystallization laboratory. J. Assoc. Lab. Automat. 11 (2006) 75-84
-
(2006)
J. Assoc. Lab. Automat.
, vol.11
, pp. 75-84
-
-
Lowry, S.1
-
18
-
-
33750904749
-
Grid-based molecular modeling for pharmaceutical salt screening: case example of 3,4,6,7,8,9-hexahydro-2H-pyrimido (1,2-a) pyrimidinium acetate
-
Hammond R.B., et al. Grid-based molecular modeling for pharmaceutical salt screening: case example of 3,4,6,7,8,9-hexahydro-2H-pyrimido (1,2-a) pyrimidinium acetate. J. Pharm. Sci. 95 (2006) 2361-2372
-
(2006)
J. Pharm. Sci.
, vol.95
, pp. 2361-2372
-
-
Hammond, R.B.1
-
19
-
-
30344455338
-
Automated integrated forced degradation and drug-excipient compatibility studies
-
Carlson E.D., et al. Automated integrated forced degradation and drug-excipient compatibility studies. J. Assoc. Lab. Automat. 10 (2005) 374-380
-
(2005)
J. Assoc. Lab. Automat.
, vol.10
, pp. 374-380
-
-
Carlson, E.D.1
-
20
-
-
4444230810
-
An integrated high throughput workflow for pre-formulations: polymorph and salt selection studies
-
Carlson E.D., et al. An integrated high throughput workflow for pre-formulations: polymorph and salt selection studies. Pharmachem 1 (2003) 10-15
-
(2003)
Pharmachem
, vol.1
, pp. 10-15
-
-
Carlson, E.D.1
-
21
-
-
4043152787
-
PolySNAP: a computer program for analysing high-throughput powder diffraction data
-
Barr G., et al. PolySNAP: a computer program for analysing high-throughput powder diffraction data. J. Appl. Cryst. 37 (2004) 658-664
-
(2004)
J. Appl. Cryst.
, vol.37
, pp. 658-664
-
-
Barr, G.1
-
22
-
-
31144473577
-
Pharma preformulation-a stop along the drug development highway
-
Higgins J.D., and Rocco W.L. Pharma preformulation-a stop along the drug development highway. Today's Chemist at Work 12 (2003) 22-26
-
(2003)
Today's Chemist at Work
, vol.12
, pp. 22-26
-
-
Higgins, J.D.1
Rocco, W.L.2
-
23
-
-
0037418267
-
Elucidation of crystal form diversity of the HIV protease inhibitor ritonavir by high throughput crystallization
-
Morissette S.L., et al. Elucidation of crystal form diversity of the HIV protease inhibitor ritonavir by high throughput crystallization. Proc. Natl. Acad. Sci. 100 (2003) 2180-2184
-
(2003)
Proc. Natl. Acad. Sci.
, vol.100
, pp. 2180-2184
-
-
Morissette, S.L.1
-
24
-
-
23844474036
-
An approach to solvent screening for crystallization of polymorphic pharmaceuticals and fine chemicals
-
Mirmehrabi M., and Rohani S. An approach to solvent screening for crystallization of polymorphic pharmaceuticals and fine chemicals. J. Pharm. Sci. 94 (2005) 1560-1576
-
(2005)
J. Pharm. Sci.
, vol.94
, pp. 1560-1576
-
-
Mirmehrabi, M.1
Rohani, S.2
-
25
-
-
4444316612
-
Grouping solvents by statistical analysis of solvent property parameters: implication to polymorph screening
-
Gu C.H., et al. Grouping solvents by statistical analysis of solvent property parameters: implication to polymorph screening. Int. J. Pharm. 283 (2004) 117-125
-
(2004)
Int. J. Pharm.
, vol.283
, pp. 117-125
-
-
Gu, C.H.1
-
26
-
-
20444461241
-
Towards a PAT-based strategy for crystallization development
-
Birch M., et al. Towards a PAT-based strategy for crystallization development. Org. Process Res. Dev. 9 (2005) 360-364
-
(2005)
Org. Process Res. Dev.
, vol.9
, pp. 360-364
-
-
Birch, M.1
-
27
-
-
36549013413
-
-
Carlson, E.D. et al. [Symyx Technologies] Apparatuses and methods for creating and testing pre-formulations and systems for same. USP6939515
-
-
-
-
28
-
-
11144357547
-
Application of high throughput technologies to drug substance and drug product development
-
Gardner C.R., et al. Application of high throughput technologies to drug substance and drug product development. Comput. Chem. Eng. 28 (2004) 943-953
-
(2004)
Comput. Chem. Eng.
, vol.28
, pp. 943-953
-
-
Gardner, C.R.1
-
29
-
-
1642457350
-
An automated approach to salt selection for new unique trazodone salts
-
Ware E.C., and Lu D.R. An automated approach to salt selection for new unique trazodone salts. Pharm. Res. 21 (2004) 177-184
-
(2004)
Pharm. Res.
, vol.21
, pp. 177-184
-
-
Ware, E.C.1
Lu, D.R.2
-
30
-
-
8844286310
-
The potential of preformulation
-
Desrosiers P.J. The potential of preformulation. Mod. Drug Discov. 7 (2004) 40-43
-
(2004)
Mod. Drug Discov.
, vol.7
, pp. 40-43
-
-
Desrosiers, P.J.1
-
31
-
-
0029070763
-
Pharmaceutical solids: a strategic approach to regulatory considerations
-
Byrn S., et al. Pharmaceutical solids: a strategic approach to regulatory considerations. Pharm. Res. 12 (1995) 945-954
-
(1995)
Pharm. Res.
, vol.12
, pp. 945-954
-
-
Byrn, S.1
-
32
-
-
0035897594
-
Characterization of solid-state: spectroscopic techniques
-
Bugay D.E. Characterization of solid-state: spectroscopic techniques. Adv. Drug Deliv. Rev. 48 (2001) 43-65
-
(2001)
Adv. Drug Deliv. Rev.
, vol.48
, pp. 43-65
-
-
Bugay, D.E.1
-
33
-
-
0032005895
-
Utilization of Fourier transform-Raman spectroscopy for the study of pharmaceutical crystal forms
-
Findlay W.P., and Bugay D.E. Utilization of Fourier transform-Raman spectroscopy for the study of pharmaceutical crystal forms. J. Pharm. Biomed. Anal. 16 (1998) 921-930
-
(1998)
J. Pharm. Biomed. Anal.
, vol.16
, pp. 921-930
-
-
Findlay, W.P.1
Bugay, D.E.2
-
34
-
-
36549079328
-
-
Carlson, E.D. et al. [Symyx Technologies] Polymorph characterization. EP1467205A1
-
-
-
-
35
-
-
1842689072
-
Pharmaceutical evaluation of early development candidates "the 100 mg-approach"
-
Balbach S., and Korn C. Pharmaceutical evaluation of early development candidates "the 100 mg-approach". Int. J. Pharm. 275 (2004) 1-12
-
(2004)
Int. J. Pharm.
, vol.275
, pp. 1-12
-
-
Balbach, S.1
Korn, C.2
-
36
-
-
0023761049
-
States of water associated with solids
-
Zografi G. States of water associated with solids. Drug Dev. Ind. Pharm. 14 (1988) 1905-1926
-
(1988)
Drug Dev. Ind. Pharm.
, vol.14
, pp. 1905-1926
-
-
Zografi, G.1
-
37
-
-
0025102704
-
The molecular basis of moisture effects on the physical and chemical stability of drugs in the solid state
-
Ahlneck C., and Zogafi G. The molecular basis of moisture effects on the physical and chemical stability of drugs in the solid state. Int. J. Pharm. 62 (1990) 87-95
-
(1990)
Int. J. Pharm.
, vol.62
, pp. 87-95
-
-
Ahlneck, C.1
Zogafi, G.2
-
38
-
-
84907035417
-
Equilibrium moisture content of pharmaceutical excipients
-
Callahan J.C. Equilibrium moisture content of pharmaceutical excipients. Drug Dev. Ind. Pharm. 8 3 (1982) 355-369
-
(1982)
Drug Dev. Ind. Pharm.
, vol.8
, Issue.3
, pp. 355-369
-
-
Callahan, J.C.1
-
39
-
-
33845213878
-
Hyphenation of Raman spectroscopy with gravimetric analysis to interrogate water-solid interactions in pharmaceutical systems
-
Gift A.D., and Taylor L.S. Hyphenation of Raman spectroscopy with gravimetric analysis to interrogate water-solid interactions in pharmaceutical systems. J. Pharm. Biomed. Anal. 43 (2007) 14-23
-
(2007)
J. Pharm. Biomed. Anal.
, vol.43
, pp. 14-23
-
-
Gift, A.D.1
Taylor, L.S.2
-
40
-
-
0031024171
-
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
-
Lipinski C.A., et al. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev. 23 (1997) 3-25
-
(1997)
Adv. Drug Deliv. Rev.
, vol.23
, pp. 3-25
-
-
Lipinski, C.A.1
-
41
-
-
4344652585
-
A System for dispensing sub-milligram doses of active pharmaceutical powders for early stage solubility assays
-
Kane N.R., et al. A System for dispensing sub-milligram doses of active pharmaceutical powders for early stage solubility assays. J. Assoc. Lab. Automat. 9 (2004) 218-227
-
(2004)
J. Assoc. Lab. Automat.
, vol.9
, pp. 218-227
-
-
Kane, N.R.1
-
42
-
-
30344480523
-
Automated solubility determination using a customized robotic system and a turbidity probe
-
Dinter C., et al. Automated solubility determination using a customized robotic system and a turbidity probe. J. Assoc. Lab. Automat. 10 (2005) 408-411
-
(2005)
J. Assoc. Lab. Automat.
, vol.10
, pp. 408-411
-
-
Dinter, C.1
-
43
-
-
30344483643
-
An automated screening assay for determination of aqueous equilibrium solubility enabling SPR study during drug lead optimization
-
Tan H., et al. An automated screening assay for determination of aqueous equilibrium solubility enabling SPR study during drug lead optimization. J. Assoc. Lab. Automat. 10 (2005) 364-373
-
(2005)
J. Assoc. Lab. Automat.
, vol.10
, pp. 364-373
-
-
Tan, H.1
-
44
-
-
0036828814
-
Evaluation of a method for high throughput solubility determination using a multi-wavelength UV plate reader
-
Chen T.M., et al. Evaluation of a method for high throughput solubility determination using a multi-wavelength UV plate reader. Comb. Chem. High Throughput Screen. 5 (2002) 575-581
-
(2002)
Comb. Chem. High Throughput Screen.
, vol.5
, pp. 575-581
-
-
Chen, T.M.1
-
45
-
-
6344221288
-
Miniature device for aqueous and non-aqueous solubility measurements during drug discovery
-
Chen X.Q., and Venkatesh S. Miniature device for aqueous and non-aqueous solubility measurements during drug discovery. Pharm. Res. 21 (2004) 1758-1761
-
(2004)
Pharm. Res.
, vol.21
, pp. 1758-1761
-
-
Chen, X.Q.1
Venkatesh, S.2
-
46
-
-
0036203961
-
Automation of chemical reaction kinetics and product distribution studies in pharmaceutical development
-
Fermier A.M., et al. Automation of chemical reaction kinetics and product distribution studies in pharmaceutical development. J. Assoc. Lab. Automat. 7 (2002) 83-88
-
(2002)
J. Assoc. Lab. Automat.
, vol.7
, pp. 83-88
-
-
Fermier, A.M.1
-
47
-
-
30344435296
-
The extended core module robot: a flexible, modular platform for high-throughput development workflows
-
Chandler W., et al. The extended core module robot: a flexible, modular platform for high-throughput development workflows. J. Assoc. Lab. Automat. 10 (2005) 418-422
-
(2005)
J. Assoc. Lab. Automat.
, vol.10
, pp. 418-422
-
-
Chandler, W.1
-
48
-
-
36549021853
-
-
Fermier, A.M. et al. [Ortho McNeil Pharm Inc.] Apparatus for the automation of chemical reaction kinetics studies. WO02077614
-
-
-
-
49
-
-
32844464311
-
Development and application of an automated solution stability assay for drug discovery
-
Di L., et al. Development and application of an automated solution stability assay for drug discovery. J. Biomol. Screen. 11 (2006) 40-47
-
(2006)
J. Biomol. Screen.
, vol.11
, pp. 40-47
-
-
Di, L.1
-
50
-
-
0038669070
-
A new approach to accelerated drug-excipient compatibility testing
-
Sims J.L., et al. A new approach to accelerated drug-excipient compatibility testing. Pharm. Dev. Technol. 8 (2003) 119-126
-
(2003)
Pharm. Dev. Technol.
, vol.8
, pp. 119-126
-
-
Sims, J.L.1
-
51
-
-
28844453310
-
Drug-excipient compatibility testing using a high-throughput approach and statistical design
-
Wyttenbach N., et al. Drug-excipient compatibility testing using a high-throughput approach and statistical design. Pharm. Dev. Technol. 10 (2005) 499-505
-
(2005)
Pharm. Dev. Technol.
, vol.10
, pp. 499-505
-
-
Wyttenbach, N.1
-
52
-
-
0041380934
-
Polymorphism - integrated approach from high-throughput screening to crystallization optimization
-
Hilfiker R., et al. Polymorphism - integrated approach from high-throughput screening to crystallization optimization. J. Therm. Anal. Calorim. 73 (2003) 429-440
-
(2003)
J. Therm. Anal. Calorim.
, vol.73
, pp. 429-440
-
-
Hilfiker, R.1
|