Surface treatment of the hydrophobic drug danazol to improve drug dissolution

International Journal of Pharmaceutics

Volumn 165, Issue 2, 1998, Pages 227-237

  Brown, S ^a   Rowley, G ^b   Pearson, J T ^b  

^a Sanofi Winthrop   (United Kingdom)

^b UNIVERSITY OF SUNDERLAND   (United Kingdom)

Author keywords

Drug dissolution; Hydrophobic solid; Particle wetting and dispersion; Solid surface treatment; Surfactant adsorption

Indexed keywords

DANAZOL; DOCUSATE SODIUM; SURFACTANT;

ADSORPTION; AQUEOUS SOLUTION; ARTICLE; CONTACT ANGLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG FORMULATION; DRUG SOLUBILITY; IN VITRO STUDY; MICROELECTROPHORESIS; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; SOLUBILIZATION; SURFACE PROPERTY; SUSPENSION;

EID: 0032516215     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(98)00020-9     Document Type: Article

References (12)

1. Bakatselou V., Oppenheim R.C., Dressman J.B. Solubilization and wetting effects of bile salts on the dissolution of steroids. Pharm. Res. 8:1991;1461-1469.
2. Geneidi A.S., Adel M.S., Shehata E. Enhanced dissolution of glibenclamide from glibenclamide poloxamer and glibenclamide polyvinylpyrrolidone co-precipitates. Can. J. Pharm. Sci. 15:1981;81-84.
3. Hargreaves B.J., Pearson J.T., Connor P. Physical properties of betamethasone alcohol, polyethylene glycol 6000 solid dispersions. J. Pharm. Pharmacol. 31:1979;47P.
4. Heertjes P.M., Kossen N.W.F. Measuring the contact angles of powder-liquid systems. Powder Techol. 1:1967;33-42.
5. Motomizu S., Fujiwara S., Fujiwara A., Toel K. Solvent extraction - spectrophotometric determination of anionic surfactants with ethyl violet. Anal. Chem. 54:1982;392-397.
6. Naylor L.J., Bakatselou V., Rodriquez-Hornedo N., Weiner N.D., Dressman J.B. Dissolution of steroids in bile salt solutions modified by the presence of lecithin. Eur. J. Pharm. Biopharm. 41(6):1995;346-353.
7. Reddy R.K., Khalil S.A., Gonda M.W. Effect of dioctyl sodium sulflosuccinate and polaxamer 188 on dissolution and intestinal absorption of sulfadiazine and sulfisoxazole in rats. J. Pharm. Sci. 65:1976;115-118.
8. Rowley, G., 1979. Some Effects of Ionic Surfactants on Sulphonamide Drug Release. M. Phil. Thesis.
9. Rowley G., Pearson J.T., Hussain M.S.H., Jones B.E. Modification of hydrophobic drug surfaces by adsorption. J. Pharm. Pharmacol. 37(1985a):1985;111P.
10. Rowley G., Pearson J.T., Hussain M.S.H., Hartup D.E., Jones B.E. A method for improving the wetting and dissolution properties of hydrophobic drugs of low aqueous solubility. J. Pharm. Pharmacol. 37(1985b):1985;112P.
11. Schott H., Kwan L.C., Feldman S. The role of surfactants in the release of very slightly soluble drugs from tablets. J. Pharm. Sci. 71:1982;1038-1045.
12. Sekiguchi K., Obi N. Studies on absorption of eutectic mixture: I. A comparison of the behaviour of eutectic mixture of sulfathiazole and that of ordinary sulfathiazole in man. Chem. Pharm. Bull. 9(1961):1961;866-872.