Physiochemical drug properties associated with in vivo toxicological outcomes

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 17, 2008, Pages 4872-4875

  Hughes, Jason D ^a   Blagg, Julian ^b   Price, David A ^c   Bailey, Simon ^c   DeCrescenzo, Gary A ^c   Devraj, Rajesh V ^c   Ellsworth, Edmund ^c   Fobian, Yvette M ^c   Gibbs, Michael E ^c   Gilles, Richard W ^c   Greene, Nigel ^c   Huang, Enoch ^a   Krieger Burke, Teresa ^c   Loesel, Jens ^d   Wager, Travis ^c   Whiteley, Larry ^c   Zhang, Yao ^c  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^c PFIZER INC   (United States)

^d PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Adverse events; C log P; Polar surface area; Toxicity

Indexed keywords

ARTICLE; DRUG TOLERANCE; IN VIVO STUDY; IN VIVO TOLERATION; LIPOPHILICITY; NONHUMAN; OUTCOME ASSESSMENT; PHYSICAL CHEMISTRY; TOXICOLOGICAL PARAMETERS;

ANIMALS; DOGS; DRUG EVALUATION, PRECLINICAL; DRUG TOXICITY; FEMALE; HUMANS; MALE; PHARMACEUTICAL PREPARATIONS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 49849094738     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.07.071     Document Type: Article

References (16)

1. Kola I., and Landis J. Nat. Rev. Drug Disc. 3 (2004) 711
2. Kramer J.A., Sagartz J.E., and Morris D.L. Nat. Rev. Drug Disc. 6 (2007) 636
3. Stevens J.L. Chem. Res. Toxicol. 19 (2006) 1393
4. Song M., and Clark M. J. Chem. Inf. Model. 46 (2006) 392
5. Villar H.O., and Hansen M.R. Curr. Top. Med. Chem. 7 (2007) 1509
6. Blagg J. Ann. Rep. Med. Chem. 41 (2006) 353
7. Robichaud A., Savoie C., Stamatiou P.B., Tattersall F.D., and Chan C.C. Neuropharmacology 40 (2001) 262
8. Smith V.B., and Spina D. Curr. Opin. Investig. Drugs 6 (2005) 1136
9. Krejsa C.M., Horvath D., Rogalski S.L., Penzotti J.E., Mao B., Barbosa F., and Migeon J.C. Curr. Opin. Drug Discov. Dev. 6 (2003) 470
10. Kalgutkar A.S., and Soglia J.R. Expert Opin. Drug Metab. Toxicol. 1 (2005) 91
11. Kalgutkar A.S., Gardner I., Obach R.S., Shaffer C.L., Callegari E., Henne K., Mutlib A.E., Dalvie D.K., Lee J.S., Nakai Y., O'Donnell J.P., Boer J., and Harriman S.P. Curr. Drug Metab. 6 (2005) 161
12. Lipinski C.A., Lombardo F., Dominy B.W., and Feeney P.J. Adv. Drug Deliv. Rev. 46 (2001) 3
13. Smith D.A., van de Waterbeemd H., and Walker D.K. In: Mannhold R., Kubinyi H., and Folkers G. (Eds). Pharmacokinetics and Metabolism in Drug Design. 2nd ed. (2006), Wiley-VCH, New York Chapter 2
14. Ertl P., Rohde B., and Selzer P. J. Med. Chem. 43 (2000) 371
15. Gleeson M.P. J. Med. Chem. 50 (2007) 101
16. Azzaoui K., Hamon J., Faller B., Whitebread S., Jacoby E., Bender A., Jenkins J.L., and Urban L. ChemMedChem 2 (2007) 874