A good practice guide to the administration of substances and removal of blood, including routes and volumes

Journal of Applied Toxicology

Volumn 21, Issue 1, 2001, Pages 15-23

  Diehl, Karl Heinz ^a   Hull, Robin ^b   Morton, David ^c   Pfister, Rudolf ^d   Rabemampianina, Yvon ^e   Smith, David ^f   Vidal, Jean Marc ^g   Van De Vorstenbosch, Cor ^h  

^a SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

^b NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS AND CONTROL   (United Kingdom)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^d NOVARTIS PHARMA AG   (Switzerland)

^e PFIZER INC   (United States)

^f ASTRAZENECA   (United Kingdom)

^g SANOFI   (France)

^h NV ORGANON   (Netherlands)

Author keywords

Administration substances; Blood removal; Blood volumes; Laboratory animals; Refinement

Indexed keywords

BLOOD SUBSTITUTE;

ANIMAL CELL; ANIMAL WELFARE; ARTICLE; BLOOD SAMPLING; BLOOD TRANSFUSION; BLOOD VOLUME; DATA ANALYSIS; DOSE RESPONSE; DRUG INDUSTRY; GOOD CLINICAL PRACTICE; NONHUMAN; PRACTICE GUIDELINE; PRIORITY JOURNAL; SAFETY; TISSUE INJURY;

ANIMALS; ANIMALS, LABORATORY; BLOOD SPECIMEN COLLECTION; BLOOD VOLUME; DRUG ADMINISTRATION ROUTES; EUROPE; RESEARCH DESIGN; XENOBIOTICS;

ANIMALIA;

EID: 0035134037     PISSN: 0260437X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jat.727     Document Type: Article

References (56)

1. EU Council Directive 86/609/EEC of 24 November 1986 on the approximation of laws, regulations and administrative provisions of the Member States regarding the protection of animals used for experimental and other scientific purposes
2. Guideline limit volumes for dosing animals in the preclinical stage of safety evaluation
3. Procedural data
4. Assessing welfare of rats undergoing gavaging with varying volumes. Measurements on open field behaviour, temperature, plasma corticosterone and glucose
5. Food deprivation: Common sense or nonsense?
6. Neglected factors in pharmacology and neuroscience research
7. A limit rapid intravenous injection volume in dogs
8. Effects of infusion rates in rats receiving repeated large volumes of saline solution intravenously
9. Histologic lesions associated with intravenous infusions of large volumes of isotonic saline solution in rats for 30 days
10. Validation of infusion techniques in nonpregnant and pregnant rabbits using a novel harness system
11. Continuous intravenous infusion in the unrestrained rat - Procedures and results
12. Continuous deep intravenous infusion in rat embryotoxity studies: The effects of infusion volume and two different infusion fluids on pregnancy
13. Corneal damage following continuous infusion in rats
14. A continuous intravenous infusion technique in the unrestrained mouse
15. Intravenous infusion in dogs and primates
16. Physiologic effects of rapid infusion of Ringer's Lactate solution into dogs
17. Hemostatic defects associated with two infusion rates of dextran 70 in dogs
18. Acute pulmonary edema after overinfusion of crystalloids versus plasma: Histological observations in the rat
19. Characterization of maximal intravenous dose volumes in the dog (Canis familiaris)
20. Assessment of side-effects induced by injection of different adjuvant/antigen combinations in rabbits and mice
21. First report of the BVA/FRAME/RSPCA/UFAW, Joint working group on refinement removal of blood from laboratory mammals and birds
22. Comparison of iodine-125 and chromium-51 for measurement of total blood volume and residual blood content of tissue in the rat; Evidence for accumulation of 51Cr by tissues
23. Determination of blood volume in the mouse with chromium-51-labeled erythrocytes
24. A method for measurement of circulating blood volume with fluorescein isothiocyanate labeled red blood cells
25. A new method for measuring the blood volume of the rat using 113mIndium as a tracer
26. Heterologous serum albumin as tracer for plasma volume measurements evaluated in conscious nondehydrated and 48-hour water-deprived rats
27. Measurement of plasma volume in rats with use of fluorescentlabeled albumin molecules
28. Validation of plasma volume determinations in the rat using an In-111 labeled polymer and 1-125 human serum albumin
29. Determination of plasma volume with indocyanine green
30. Plasma volume determination by use of enzyme dilution in the dog
31. Determination of plasma volume in swine by the enzyme-dilution method
32. Accuracy and reproductivity of the measurement of actively circulating blood volume with an integrated fiberoptic monitoring system
33. A new method for plasma volume measurements with unlabeled dextran-70 instead of 125l-labeled albumin as an indicator
34. Biological effects of blood loss: Implications for sampling volumes and techniques
35. Clinical and clinicopathological assessment of serial phlebotomy in the Sprague Dawley rat
36. Effects of acute blood removal via the sublingual vein on haematological and clinical parameters in Sprague-Dawley rats
37. Saphenous vein puncture for blood sampling of the mouse, rat, hamster, gerbil, guinea pig, ferret and mink
38. Refinement of blood sampling from the sublingual vein of rats
39. Comparison of clinical pathology parameters with two different blood sampling techniques in rats - Retrobulbar plexus versus sublingual vein
40. Surgery, anesthesia, and experimental techniques
41. Method for obtaining blood from the orbital sinus of the rat or mouse
42. Methods of obtaining body fluids
43. Histological changes in the orbital region of rats after orbital puncture
44. Assessment of discomfort induced by orbital puncture in rats
45. Orbital bleeding in rats while under diethylether anesthesia does not influence telemetrically determined heart rate, body temperature, locomotor activity and eating activity when compared with anesthesia alone
46. Does the repeated orbital sinus puncture alter the occurrence of changes with age in the retina, the lens, or the Harderian gland of laboratory rats?
47. Harderian gland dacryoadenitis in rats resulting from orbital bleeding
48. Repeated orbital sinus puncture in rats induces damages to optic nerve and retina
49. Orbital sinus blood sampling in rats as performed by different animal technicians: The influence of technique and expertise
50. Long-term vascular access in the rat: Importance of asepsis