Estimation of Caco-2 cell permeability using calculated molecular descriptors

Quantitative Structure-Activity Relationships

Volumn 15, Issue 6, 1996, Pages 480-490

  Van Waterbeemd, Han De ^a   Camenisch, Gian ^a   Folkers, Gerd ^b   Raevsky, Oleg A ^c  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b ETH ZURICH   (Switzerland)

^c INSTITUTE OF PHYSIOLOGICALLY ACTIVE COMPOUNDS   (Russian Federation)

Author keywords

Caco 2; Drug absorption; Hydrogen bonding; Lipophilicity; Molecular size; Molecular weight; Permeability

Indexed keywords

BIOLOGICAL MEMBRANES; CELLS; CYTOLOGY; HYDROGEN;

CACO-2; CACO-2 CELLS; CELL PERMEABILITY; DESCRIPTORS; DRUG ABSORPTION; LIPOPHILICITY; MOLECULAR DESCRIPTORS; MOLECULAR SIZE; PASSIVE DIFFUSIONS; PERMEABILITY;

HYDROGEN BONDS;

ARTICLE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DIFFUSION; DRUG ABSORPTION; HUMAN; HUMAN CELL; HYDROGEN BOND; LIPOPHILICITY; MEMBRANE TRANSPORT; MOLECULAR SIZE; MOLECULAR WEIGHT; MONOLAYER CULTURE; PRIORITY JOURNAL;

EID: 0030481554     PISSN: 09318771     EISSN: None     Source Type: Journal    
DOI: 10.1002/qsar.19960150604     Document Type: Article

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