Role of surface free energy and spreading coefficient in the formulation of active agent-layered pellets

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 74, Issue 2, 2010, Pages 324-331

  Baki, Gabriella ^a   Bajdik, János ^a   Djuric, Dejan ^b   Knop, Klaus ^b   Kleinebudde, Peter ^b   Pintye Hódi, Klára ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

^b HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Friability; HPMC; Layering; Peeling; Spreading coefficient; Wetting

Indexed keywords

HYDROXYPROPYLMETHYLCELLULOSE; MAGNESIUM STEARATE; MICROCRYSTALLINE CELLULOSE; PIRENZEPINE;

AQUEOUS SOLUTION; ARTICLE; CONCENTRATION (PARAMETERS); CONTACT ANGLE; CONTROLLED STUDY; DRUG FORMULATION; DRUG PELLET; DRUG SOLUBILITY; ENERGY; HYDROPHILICITY; HYDROPHOBICITY; MECHANICAL STRESS; SURFACE FREE ENERGY; SURFACE PROPERTY; SURFACE TENSION; WETTABILITY;

CELLULOSE; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; DRUG IMPLANTS; HARDNESS; HYDROPHOBICITY; METHYLCELLULOSE; PARTICLE SIZE; PHYSICAL PROCESSES; PIRENZEPINE; SOLUBILITY; STEARIC ACIDS; SURFACE PROPERTIES; THERMODYNAMICS; WETTABILITY;

EID: 75449105200     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2009.11.007     Document Type: Article

References (26)

1. Stanislaus F., and Huber H.J. Different drug delivery systems in bioavailability studies. In: Müller B.W. (Ed). Controlled Drug Release (1987), Wissenschaftliche Verlagsgesellschaft, Stuttgart 56-68
2. Bodmeier R., and Paeratakul O. Suspensions and dispersible dosage forms of multiparticulates. In: Ghebre-Selassie I. (Ed). Multiparticulate Oral Drug Delivery (1994), Marcel Dekker, New York 143-157
3. Borgquist P., Nevsten P., Nilsson B., Wallenberg L.R., and Axelsson A. Simulation of the release from a multiparticulate system validated by single pellet and dose release experiments. J. Control. Release 97 (2004) 453-465
4. Sharma S., and Pawar A. Low density multiparticulate system for pulsatile release of meloxicam. Int. J. Pharm. 313 (2006) 150-158
5. Li S.P., Felt R.G., Di Paolo L.C., Huang M.-Y., and Williams R.O. Development and in vitro-in vivo evaluation of a multiparticulate sustained release formulation of diltiazem. Pharm. Res. 12 (1995) 1338-1342
6. Nastruzzi C., Cortesi R., Esposito E., Genovesi A., Spadoni A., Vecchio C., and Menegatti E. Influence of formulation and process parameters on pellet production by powder layering technique. AAPS Pharm. Sci. Tech. 1 2 (2000) (article 9)
7. Martinez L., Tchoreloff P., Leclerc B., Besnard M., and Couarraze G. Active layering and direct compression of sugar spheres: content homogeneity in low-dosage tablets. Pharm. Technol. Eur. 13 10 (2001) 1-5
8. Ghebre-Sellassie I., and Knoch A. Pelletization techniques. In: Swarbrick J., and Boylan J.C. (Eds). Encyclopedia of Pharmaceutical Technology. second ed. vol. 3 (2002), Marcel Dekker, New York 2067-2080
9. Möschwitzer J., and Müller R.H. Spray coated pellets as carrier system for mucoadhesive drug nanocrystals. Eur. J. Pharm. Biopharm. 62 (2006) 282-287
10. Eudragit Brochure, Röhm GmbH & Co. KG, Darmstadt, Germany.
11. Nitz M., and Taranto O.P. Film coating of theophylline pellets in a pulsed fluid bed coater. Chem. Eng. Process. 47 (2008) 1412-1419
12. Fowkes F.M. Dispersion force contributions to surface and interfacial tensions, contact angles and heats of immersion. Adv. Chem. Ser. 43 (1964) 99-111
13. Buckton G., and Darcy P. The influence of additives on the recrystallisation of amorphous spray dried lactose. Int. J. Pharm. 121 (1995) 81-87
14. Podczeck F. Particle-Particle Adhesion in Pharmaceutical Powder Handling (1998), Imperial College Press, London pp. 29-34
15. Buckton G. Characterisation of small changes in the physical properties of powders of significance for dry powder inhaler formulations. Adv. Drug. Deliv. Rev. 26 (1997) 17-27
16. Planinšek O., Trojak A., and Srčič S. The dispersive component of the surface free energy of powders assessed using inverse gas chromatography and contact angle measurements. Int. J. Pharm. 221 (2001) 211-217
17. Bajdik J., Fehér M., and Pintye-Hódi K. Effect of plasticizer on surface of free films prepared from aqueous solutions of salts of cationic polymers with different plasticizers. Appl. Surf. Sci. 253 (2007) 7303-7308
18. Wu S., and Brzozowski K.J. Surface free energy and polarity of organic pigments. J. Colloid Interf. Sci. 37 (1971) 686-690
19. Rowe R.C. Binder-substrate interactions in granulation: a theoretical approach based on surface free energy and polarity. Int. J. Pharm. 52 (1989) 149-154
20. Podczeck F., Knight P.E., and Newton J.M. The evaluation of modified microcrystalline cellulose for the preparation of pellets with high drug loading by extrusion/spheronization. Int. J. Pharm. 350 (2008) 145-154
21. Buckton G. Interfacial phenomena in drug delivery and targeting. In: Florence A.T., and Gregoriadis G. (Eds). Drug Delivery and Targeting vol. 5 (1995), Harwood Academic Publishers, Chur, Switzerland 32-81
22. Dashevsky A., Kolter K., and Bodmeier R. pH-independent release of a basic drug from pellets coated with the extended release polymer dispersion Kollicoat SR 30 D and the enteric polymer dispersion Kollicoat MAE 30 DP. Eur. J. Pharm. Biopharm. 58 (2004) 45-49
23. Rowe R.C. Film/tablet adhesion, film thickness, internal stresses and bridging of the intagliations - a unified model with practical implications. Eur. J. Pharm. Sci. 30 (2007) 236-239
24. In: Nürnberg E., and Surmann P. (Eds). Hagers Handbuch der pharmazeutischen Praxis. 5 ed., Bd. 2 Methoden (1991), Springer Verlag, Berlin, New York 60
25. G. Ström, Krüss Users Manual, Contact Angle and Adsorption Measuring System, Krüss GmbH, Hamburg, 1996, pp. 50-77.
26. Tüske Zs., Regdon Jr. G., Ero{combining double acute accent}s I., Srcic S., and Pintye-Hódi K. The role of the surface free energy in the selection of a suitable excipient in the course of a wet-granulation method. Powder Technol. 155 (2005) 139-144