Intestinal drug solubility estimation based on simulated intestinal fluids: Comparison with solubility in human intestinal fluids

European Journal of Pharmaceutical Sciences

Volumn 43, Issue 4, 2011, Pages 260-269

  Clarysse, Sarah ^a   Brouwers, Joachim ^a   Tack, Jan ^b   Annaert, Pieter ^a   Augustijns, Patrick ^a  

^a DEPARTMENT OF PHARMACEUTICAL AND PHARMACOLOGICAL SCIENCES   (Belgium)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

Drug discovery; Human intestinal fluids; Simulated intestinal fluids; Solubility estimation; Solubilizing capacity; TPGS

Indexed keywords

CARBAMAZEPINE; CINNARIZINE; DANAZOL; DIAZEPAM; FENOFIBRATE; FUROSEMIDE; GLIBENCLAMIDE; GLIPIZIDE; HYDROCHLOROTHIAZIDE; INDOMETACIN; KETOCONAZOLE; LOVIRIDE; NIFEDIPINE; PHOSPHATE BUFFERED SALINE; PREDNISOLONE; QUINIDINE; RITONAVIR; SALAZOSULFAPYRIDINE; TAUROCHOLIC ACID; TOCOFERSOLAN;

ADULT; ARTICLE; DRUG SOLUBILITY; FASTED STATE SIMULATED INTESTINAL FLUID; FED STATE SIMULATED INTESTINAL FLUID; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INTESTINE FLUID; MALE; NORMAL HUMAN; POSTPRANDIAL STATE; PRIORITY JOURNAL; SIMULATION; VALIDATION PROCESS;

ADULT; AGED; AGED, 80 AND OVER; BODY FLUIDS; DRUG DISCOVERY; EATING; FASTING; FEMALE; HUMANS; INTESTINES; MALE; MIDDLE AGED; PHARMACEUTICAL PREPARATIONS; POSTPRANDIAL PERIOD; SOLUBILITY; YOUNG ADULT;

EID: 79959606451     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2011.04.016     Document Type: Article

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