Precipitation in and supersaturation of contents of the upper small intestine after administration of two weak bases to fasted adults

Pharmaceutical Research

Volumn 28, Issue 12, 2011, Pages 3145-3158

  Psachoulias, Dimitrios ^a   Vertzoni, Maria ^a   Goumas, Konstantinos ^b   Kalioras, Vasilios ^b   Beato, Stefania ^c   Butler, James ^d   Reppas, Christos ^a  

^a UNIVERSITY OF ATHENS   (Greece)

^b RED CROSS HOSPITAL   (Greece)

^c NOVARTIS PHARMA AG   (Switzerland)

^d GLAXOSMITHKLINE   (United Kingdom)

Author keywords

dipyridamole; intestinal contents; ketoconazole; precipitation; supersaturation

Indexed keywords

DIPYRIDAMOLE; KETOCONAZOLE;

ADULT; AQUEOUS SOLUTION; ARTICLE; ASPIRATION; CONTROLLED STUDY; CROSSOVER PROCEDURE; CRYSTAL STRUCTURE; DIET RESTRICTION; DRUG DOSE COMPARISON; DRUG MEGADOSE; DRUG METABOLISM; DRUG PENETRATION; DRUG SOLUBILITY; FEMALE; HUMAN; HUMAN EXPERIMENT; INCUBATION TIME; INTESTINE FLUID; LIPOPHILICITY; LOW DRUG DOSE; MALE; MICELLE; NORMAL HUMAN; PHYSICAL CHEMISTRY; PHYSICAL PARAMETERS; PRECIPITATION; PRIORITY JOURNAL; SINGLE DRUG DOSE; SMALL INTESTINE; STOMACH PH; SUPERSATURATION; X RAY POWDER DIFFRACTION;

ADULT; ANTIFUNGAL AGENTS; CHEMICAL PRECIPITATION; DIPYRIDAMOLE; FASTING; FEMALE; GASTROINTESTINAL CONTENTS; HUMANS; INTESTINE, SMALL; KETOCONAZOLE; MALE; PHOSPHODIESTERASE INHIBITORS; SOLUBILITY; YOUNG ADULT;

EID: 83555174460     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-011-0506-6     Document Type: Article

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