Simulation of fasting gastric conditions and its importance for the in vivo dissolution of lipophilic compounds

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 60, Issue 3, 2005, Pages 413-417

  Vertzoni, Maria ^a   Dressman, Jennifer ^b   Butler, James ^c   Hempenstall, John ^c   Reppas, Christos ^a  

^a UNIVERSITY OF ATHENS   (Greece)

^b GOETHE UNIVERSITY   (Germany)

^c GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Atovaquone; Dissolution; Fasted state; Gastric composition; GR253035X; Weak base

Indexed keywords

ATOVAQUONE; GASTROINTESTINAL AGENT; GR 253035 X; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; CORRELATION ANALYSIS; DIET RESTRICTION; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG SOLUBILITY; SIMULATION; STOMACH; STOMACH JUICE;

ANIMALS; ATOVAQUONE; CHEMISTRY, PHARMACEUTICAL; ENZYME INHIBITORS; FASTING; GASTRIC EMPTYING; GASTRIC JUICE; HUMANS; MODELS, BIOLOGICAL; NAPHTHOQUINONES; PEPSIN A; PHARMACEUTICAL PREPARATIONS; SOLUBILITY; SWINE;

EID: 21544447265     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2005.03.002     Document Type: Article

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