Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): Influence of protein expression on drug-drug interactions

Journal of Medicinal Chemistry

Volumn 55, Issue 10, 2012, Pages 4740-4763

  Karlgren, Maria ^a,b   Vildhede, Anna ^a   Norinder, Ulf ^a,c   Wisniewski, Jacek R ^d   Kimoto, Emi ^e   Lai, Yurong ^e   Haglund, Ulf ^b   Artursson, Per ^a,b  

^a UPPSALA UNIVERSITY   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c ASTRAZENECA R AND D   (Sweden)

^d MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^e PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASTEMIZOLE; ATORVASTATIN; BAICALIN; BENZBROMARONE; CHOLECYSTOKININ OCTAPEPTIDE; COUMESTROL; DIETHYLSTILBESTROL; DIPYRIDAMOLE; ERLOTINIB; FLUTAMIDE; GENISTEIN; GLYCOCHENODEOXYCHOLIC ACID; GLYCODEOXYCHOLIC ACID; ITRACONAZOLE; IVERMECTIN; LEVOTHYROXINE; MORIN; NEFAZODONE; NELFINAVIR; NIFEDIPINE; NOVOBIOCIN; NYSTATIN; ORGANIC ANION TRANSPORTING POLYPEPTIDE 1B1 INHIBITOR; ORGANIC ANION TRANSPORTING POLYPEPTIDE 1B3 INHIBITOR; ORGANIC ANION TRANSPORTING POLYPEPTIDE 2B1 INHIBITOR; PIROXICAM; PROTEIN INHIBITOR; RESERPINE; SILYMARIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; BINDING AFFINITY; COMPUTER MODEL; CONTROLLED STUDY; DRUG DETERMINATION; DRUG DRUG INTERACTION; DRUG INTERACTION; DRUG SCREENING; DRUG TRANSPORT; HUMAN; HUMAN CELL; HUMAN TISSUE; IC 50; IN VITRO STUDY; IN VIVO STUDY; LIPOPHILICITY; LIVER; MAXIMAL TRANSPORT ACTIVITY; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; SURFACE PROPERTY; TRANSPORT KINETICS;

BIOLOGICAL TRANSPORT; DRUG INTERACTIONS; ESTRADIOL; ESTRONE; HEK293 CELLS; HEPTANOIC ACIDS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LEAST-SQUARES ANALYSIS; LIVER; MODELS, MOLECULAR; MULTIVARIATE ANALYSIS; ORGANIC ANION TRANSPORTERS; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; PROTEIN ISOFORMS; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 84861494749     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300212s     Document Type: Article

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