Aqueous solubility: Simple predictive methods (in silico, in vitro and bio-relevant approaches)

International Journal of Pharmaceutics

Volumn 453, Issue 1, 2013, Pages 3-11

  Elder, David ^a   Holm, René ^b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b H LUNDBECK A S   (Denmark)

Author keywords

Aqueous solubility; Drug formulation; Equilibrium solubility; In silico solubility; Kinetic solubility; Predicting solubility; Solubility challenge

Indexed keywords

ACETYLSALICYLIC ACID; ATOVAQUONE; CYCLOSPORIN; DANAZOL; DIFLUNISAL; FELODIPINE; FLUOROURACIL; GRISEOFULVIN; IMIPRAMINE; INDOMETACIN; LEVOFLOXACIN; LOPERAMIDE; MARBOFLOXACIN; MECLOZINE; MEFENAMIC ACID; ORBIFLOXACIN; PENICILLIN G; PROBENECID; SERTRALINE; TRIMIPRAMINE;

AQUEOUS SOLUTION; CHEMICAL STRUCTURE; COMPUTER MODEL; CORRELATION COEFFICIENT; DRUG INDUSTRY; DRUG PENETRATION; DRUG SOLUBILITY; HIGH THROUGHPUT SCREENING; HYDROGEN BOND; HYDROPHILICITY; HYDROPHOBICITY; IN VITRO STUDY; IONIC STRENGTH; LIPOPHILICITY; MELTING POINT; NORMAL DISTRIBUTION; PARTICLE SIZE; PHYSICAL CHEMISTRY; PREDICTIVE VALUE; PRIORITY JOURNAL; REVIEW; SCREENING; SOLUBILITY; SUPPORT VECTOR MACHINE;

EID: 84884142861     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.10.041     Document Type: Review

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