Low dose lipid formulations: Effects on gastric emptying and biliary secretion

Pharmaceutical Research

Volumn 24, Issue 11, 2007, Pages 2084-2096

  Kossena, Greg A ^a   Charman, William N ^a   Wilson, Clive G ^b,c   O'Mahony, Bridget ^c   Lindsay, Blythe ^c   Hempenstall, John M ^d   Davison, Christopher L ^d   Crowley, Patrick J ^e   Porter, Christopher J H ^a  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^c Bio Images Research Ltd   (United Kingdom)

^d GLAXOSMITHKLINE   (United Kingdom)

^e GLAXOSMITHKLINE   (United States)

Author keywords

Biliary secretion; Drug absorption; Drug formulation; Gamma scintigraphy; Gastric transit; Lipid based formulations; Poorly water soluble drug; Solubilisation

Indexed keywords

BILE SALT; CHOLESTEROL; GLYCEROL OLEATE; LIPID; MIGLYOL; OLEIC ACID; PHOSPHOLIPID; PLACEBO;

ADULT; ARTICLE; BILE SECRETION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DATA ANALYSIS; DRUG EFFECT; DRUG FORMULATION; DUODENUM BIOPSY; ECHOGRAPHY; GALLBLADDER CONTRACTION; GAMMA SCINTIGRAPHY; HUMAN; HUMAN EXPERIMENT; INTESTINE; LOW DRUG DOSE; MALE; NORMAL HUMAN; ORGAN SIZE; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; STATISTICAL SIGNIFICANCE; STOMACH EMPTYING;

BILE; CHEMISTRY, PHARMACEUTICAL; CROSS-OVER STUDIES; DUODENUM; GALLBLADDER; GASTRIC EMPTYING; HUMANS; LIPIDS; MALE; TECHNETIUM TC 99M PENTETATE;

EID: 34848853277     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-007-9363-8     Document Type: Article

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