Chasing equilibrium: Measuring the intrinsic solubility of weak acids and bases

Analytical Chemistry

Volumn 77, Issue 4, 2005, Pages 983-990

  Stuart, Martin ^a   Box, Karl ^a  

^a Sirius Analytical Instruments Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DISSOLUTION; DRUG PRODUCTS; MONITORING; ORGANIC ACIDS; PH EFFECTS; PRECIPITATION (CHEMICAL); SOLUBILITY;

AMPHOLYTES; BASES; EQUILIBRIUM CONDITIONS; TITRANTS;

REACTION KINETICS;

ACID; AMPHOLYTE; BASE; ORGANIC COMPOUND;

ANALYTIC METHOD; ANALYTICAL ERROR; ARTICLE; DISSOLUTION; DRUG DETERMINATION; DRUG ISOLATION; DRUG SOLUBILITY; EQUILIBRIUM CONSTANT; IONIZATION; KINETICS; MEASUREMENT; PH; PRECIPITATION; QUANTITATIVE ANALYSIS; RELIABILITY; REPRODUCIBILITY; TECHNIQUE; THERMODYNAMICS; TITRIMETRY; TURBIDIMETRY;

EID: 13844320734     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac048767n     Document Type: Article

References (18)

1. Dittert, L. W.; Higuchi, T.; Reese, D. S. J. Pharm. Sci. 1964, 53, 1325-1328.
2. Connors, K. A. A Textbook of Pharmaceutical Analysis; John Wiley & Sons: New York, 1982.
3. Avdeef, A. High-Throughput Measurements of Solubility Profiles. In Pharmacokinetic Optimization in Drug Research. Biological, Physicochemical, and Computational Strategies, E; Testa, B., van de Waterbeemd, H., Guy, F. R., Eds.; VCHA: Zürich, 2001; pp 304-325.
4. Hörter, D.; Dressman, J. B. Adv. Drug Delivery Rev. 1997, 25, 3-14.
5. Avdeef, A. Pharm. Pharmacol. Commun. 1998, 4, 165-178.
6. Avdeef, A. In Lipophilicity on Drug Disposition: Practical and Computational Approaches to Molecular Properties Related to Drug Permeation, Absorption, Distribution, Metabolism and Excretion; Testa, B., van de Waterbeemd, H., Folkers, G., Guy, R., Eds.; University of Lausanne, 2000; Chapter 22.
7. Lipinski, C. A.; Lombardo, F.; Dominy, B. W.; Feeney, P. J. Adv. Drug Delivery Rev. 1997, 23 (1-3), 3-25.
8. Bevan, C. D.; Lloyd, R. S. Anal. Chem. 2000, 72 (8), 1781-1787.
9. Goodwin, J.; Sullivan, J.; Crespi, C. Aqueous solubility by flow cytometry II: new prototypes optimised for drug solubility testing. http://www.bdbiosciences.com/discovery_labware/gentest/products/pdf/ SolubilityFlow.pdf
10. Avdeef, A.; Sofen, S. R.; Bregante, T. L.; Raymond, K. N. J. Am. Chem. Soc. 1978, 100, 5362-5370.
11. Avdeef, A.; Bucher, J. J. Anal. Chem. 1978, 50, 2137-2142.
12. Avdeef, A.; Kearney, D. L.; Brown, J. A.; Chemotti, A. R, Jr. Anal. Chem. 1982, 54, 2322-2326.
13. Sirius Technical Application Notes. Vol. 2, Sirius Analytical Instruments Ltd., Forest Row: E. Sussex, U.K., 1996 (ISBN 1 901125 05 X).
14. Avdeef, A.; Berger, C. M.; Brownell, C. Pharm. Res. 2000, 17 (1), 85-89.
15. Sirius Technical Application Notes. Vol. 1, Sirius Analytical Instruments Ltd., Forest Row: E. Sussex, U.K., 1995 (ISBN 901125 00 9).
16. Powell, M. F. In Analytical Profiles of Drug Substances; Florey, K., Ed.; Academic Press: San Diego, 1986; Vol. 15, pp 761-779.
17. Bergström, C. A. S.; Strafford, M.; Lazorova, L.; Avdeef, A.; Luthman, K.; Artursson, P. J. Med. Chem. 2003, 46, 558-570.
18. Butler, J. N. Ionic equilibrium: Solubility and pH calculations; John Wiley & Sons: New York, 1998.