Dissolution rate and apparent solubility of poorly soluble drugs in biorelevant dissolution media

Molecular Pharmaceutics

Volumn 7, Issue 5, 2010, Pages 1419-1430

  Fagerberg, Jonas H ^a   Tsinman, Oksana ^b   Sun, Na ^b   Tsinman, Konstantin ^b   Avdeef, Alex ^b   Bergström, Christel A S ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b PION INC   (United States)

Author keywords

apparent BCS; biorelevant dissolution media; dissolution rate; FaSSIF; FeSSIF; molecular features; physicochemical properties; Poor solubility; solvation limited

Indexed keywords

ALBENDAZOLE; ASTEMIZOLE; CARVEDILOL; CINNARIZINE; DANAZOL; FELODIPINE; GLIBENCLAMIDE; INDOMETACIN; TAMOXIFEN; TOLFENAMIC ACID;

ARTICLE; DRUG SOLUBILITY; LIPOPHILICITY; MATHEMATICAL MODEL; PREDICTOR VARIABLE; PRIORITY JOURNAL;

ADMINISTRATION, ORAL; BIOLOGICAL AVAILABILITY; BODY FLUIDS; CHEMISTRY, PHARMACEUTICAL; FASTING; HUMANS; HYDROGEN-ION CONCENTRATION; INTESTINAL ABSORPTION; MINIATURIZATION; MODELS, BIOLOGICAL; POWDERS; SOLUBILITY; SOLUTIONS;

EID: 77957736510     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp100049m     Document Type: Article

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