Molecular properties that influence the oral bioavailability of drug candidates

Journal of Medicinal Chemistry

Volumn 45, Issue 12, 2002, Pages 2615-2623

  Veber, Daniel F ^a   Johnson, Stephen R ^a,b   Cheng, Hung Yuan ^a   Smith, Brian R ^a   Ward, Keith W ^a   Kopple, Kenneth D ^a,c  

^a GLAXOSMITHKLINE   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEW DRUG;

ANIMAL EXPERIMENT; ARTICLE; ARTIFICIAL MEMBRANE; DRUG BIOAVAILABILITY; DRUG PENETRATION; HYDROGEN BOND; LIPOPHILICITY; MALE; MOLECULAR WEIGHT; NONHUMAN; RAT;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CROSS-OVER STUDIES; DATABASES, FACTUAL; HUMANS; HYDROGEN BONDING; LIPID BILAYERS; MALE; MICROSOMES, LIVER; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; PERMEABILITY; PHARMACOKINETICS; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037030653     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020017n     Document Type: Article

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