Potentiometric pK(a) determination of water-insoluble compounds: Validation study in methanol/water mixtures

International Journal of Pharmaceutics

Volumn 151, Issue 2, 1997, Pages 235-248

  Takács Novák, Krisztina ^a   Box, Karl J ^b   Avdeef, Alex ^c  

^a SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

^b Sirius Analytical Instruments Ltd   (United Kingdom)

^c pION   (United States)

Author keywords

Methanol water mixture; Solvent mixture procedure; Validation

Indexed keywords

ALBENDAZOLE SULFOXIDE; CEFALEXIN; CHLORPROMAZINE; DERAMCICLANE FUMARATE; EPHEDRINE; FLUMEQUINE; HALOPERIDOL; HEXACHLOROPHENE; HYDROCHLOROTHIAZIDE; IBUPROFEN; METHANOL; MEXILETINE; MORPHINE; NIFLUMIC ACID; NITRAZEPAM; ORGANIC SOLVENT; PAPAVERINE; PARACETAMOL; PHENOBARBITAL; PROSTAGLANDIN E1; PROSTAGLANDIN E2; QUININE; SALICYLIC ACID; SOLVENT; VANCOMYCIN;

AQUEOUS SOLUTION; ARTICLE; ASSAY; DISSOCIATION CONSTANT; IONIZATION; MEASUREMENT; POTENTIOMETRIC TITRATION; PRIORITY JOURNAL; REPRODUCIBILITY; TECHNIQUE;

EID: 0142028495     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(97)04907-7     Document Type: Article

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