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Volumn 5, Issue 1, 2014, Pages 147-175

Molecular mechanisms of DNA replication checkpoint activation

Author keywords

ATR; DNA damage; DNA replication fork arrest; DNA replication stress; Single stranded DNA

Indexed keywords

ATR PROTEIN; CYCLIN DEPENDENT KINASE; DNA; SINGLE STRANDED DNA;

EID: 84897513735     PISSN: None     EISSN: 20734425     Source Type: Journal    
DOI: 10.3390/genes5010147     Document Type: Review
Times cited : (22)

References (180)
  • 1
    • 84879750259 scopus 로고    scopus 로고
    • Principles and concepts of DNA replication in bacteria, archaea, and eukarya
    • doi: 10. 1101/cshperspect. a010108
    • O'Donnell, M.; Langston, L.; Stillman, B. Principles and concepts of DNA replication in bacteria, archaea, and eukarya. Cold Spring Harb. Perspect. Biol. 2013, doi: 10. 1101/cshperspect. a010108.
    • (2013) Cold Spring Harb. Perspect. Biol
    • O'Donnell, M.1    Langston, L.2    Stillman, B.3
  • 2
    • 84875581201 scopus 로고    scopus 로고
    • Loading and activation of DNA replicative helicases: The key step of initiation of DNA replication
    • Li, Y.; Araki, H. Loading and activation of DNA replicative helicases: The key step of initiation of DNA replication. Genes Cells 2013, 18, 266-277.
    • (2013) Genes Cells , vol.18 , pp. 266-277
    • Li, Y.1    Araki, H.2
  • 3
    • 84864913906 scopus 로고    scopus 로고
    • Control over DNA replication in time and space
    • Symeonidou, I. E.; Taraviras, S.; Lygerou, Z. Control over DNA replication in time and space. FEBS Lett. 2012, 586, 2803-2812.
    • (2012) FEBS Lett , vol.586 , pp. 2803-2812
    • Symeonidou, I.E.1    Taraviras, S.2    Lygerou, Z.3
  • 4
    • 0035997368 scopus 로고    scopus 로고
    • DNA replication in eukaryotic cells
    • Bell, S. P.; Dutta, A. DNA replication in eukaryotic cells. Annu. Rev. Biochem. 2002, 71, 333-374.
    • (2002) Annu. Rev. Biochem , vol.71 , pp. 333-374
    • Bell, S.P.1    Dutta, A.2
  • 5
    • 70350751416 scopus 로고    scopus 로고
    • Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing
    • Remus, D.; Beuron, F.; Tolun, G.; Griffith, J. D.; Morris, E. P.; Diffley, J. F. Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing. Cell 2009, 139, 719-730.
    • (2009) Cell , vol.139 , pp. 719-730
    • Remus, D.1    Beuron, F.2    Tolun, G.3    Griffith, J.D.4    Morris, E.P.5    Diffley, J.F.6
  • 6
    • 73949091058 scopus 로고    scopus 로고
    • A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication
    • Evrin, C.; Clarke, P.; Zech, J.; Lurz, R.; Sun, J.; Uhle, S.; Li, H.; Stillman, B.; Speck, C. A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication. Proc. Natl. Acad. Sci. USA 2009, 106, 20240-20245.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 20240-20245
    • Evrin, C.1    Clarke, P.2    Zech, J.3    Lurz, R.4    Sun, J.5    Uhle, S.6    Li, H.7    Stillman, B.8    Speck, C.9
  • 8
    • 84875368528 scopus 로고    scopus 로고
    • ATPase-dependent quality control of DNA replication origin licensing
    • Frigola, J.; Remus, D.; Mehanna, A.; Diffley, J. F. ATPase-dependent quality control of DNA replication origin licensing. Nature 2013, 495, 339-343.
    • (2013) Nature , vol.495 , pp. 339-343
    • Frigola, J.1    Remus, D.2    Mehanna, A.3    Diffley, J.F.4
  • 9
    • 0032511148 scopus 로고    scopus 로고
    • Geminin, an inhibitor of DNA replication, is degraded during mitosis
    • McGarry, T. J.; Kirschner, M. W. Geminin, an inhibitor of DNA replication, is degraded during mitosis. Cell 1998, 93, 1043-1053.
    • (1998) Cell , vol.93 , pp. 1043-1053
    • McGarry, T.J.1    Kirschner, M.W.2
  • 10
    • 0035147434 scopus 로고    scopus 로고
    • Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin
    • Tada, S.; Li, A.; Maiorano, D.; Mechali, M.; Blow, J. J. Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin. Nat. Cell Biol. 2001, 3, 107-113.
    • (2001) Nat. Cell Biol , vol.3 , pp. 107-113
    • Tada, S.1    Li, A.2    Maiorano, D.3    Mechali, M.4    Blow, J.J.5
  • 12
    • 28244461615 scopus 로고    scopus 로고
    • Identification of full genes and proteins of MCM9, a novel, vertebrate-specific member of the MCM2-8 protein family
    • Lutzmann, M.; Maiorano, D.; Mechali, M. Identification of full genes and proteins of MCM9, a novel, vertebrate-specific member of the MCM2-8 protein family. Gene 2005, 362, 51-56.
    • (2005) Gene , vol.362 , pp. 51-56
    • Lutzmann, M.1    Maiorano, D.2    Mechali, M.3
  • 13
    • 47349113682 scopus 로고    scopus 로고
    • MCM9 binds Cdt1 and is required for the assembly of prereplication complexes
    • Lutzmann, M.; Mechali, M. MCM9 binds Cdt1 and is required for the assembly of prereplication complexes. Mol. Cell 2008, 31, 190-200.
    • (2008) Mol. Cell , vol.31 , pp. 190-200
    • Lutzmann, M.1    Mechali, M.2
  • 14
    • 84876249764 scopus 로고    scopus 로고
    • Mcm8 and Mcm9 form a dimeric complex in Xenopus laevis egg extract that is not essential for DNA replication initiation
    • Gambus, A.; Blow, J. J. Mcm8 and Mcm9 form a dimeric complex in Xenopus laevis egg extract that is not essential for DNA replication initiation. Cell Cycle 2013, 12, 1225-1232.
    • (2013) Cell Cycle , vol.12 , pp. 1225-1232
    • Gambus, A.1    Blow, J.J.2
  • 17
    • 84865353862 scopus 로고    scopus 로고
    • Mcm8 and Mcm9 form a complex that functions in homologous recombination repair induced by DNA interstrand crosslinks
    • Nishimura, K.; Ishiai, M.; Horikawa, K.; Fukagawa, T.; Takata, M.; Takisawa, H.; Kanemaki, M. T. Mcm8 and Mcm9 form a complex that functions in homologous recombination repair induced by DNA interstrand crosslinks. Mol. Cell 2012, 47, 511-522.
    • (2012) Mol. Cell , vol.47 , pp. 511-522
    • Nishimura, K.1    Ishiai, M.2    Horikawa, K.3    Fukagawa, T.4    Takata, M.5    Takisawa, H.6    Kanemaki, M.T.7
  • 18
    • 0344198460 scopus 로고    scopus 로고
    • Perpetuating the double helix: Molecular machines at eukaryotic DNA replication origins
    • Mendez, J.; Stillman, B. Perpetuating the double helix: Molecular machines at eukaryotic DNA replication origins. Bioessays 2003, 25, 1158-1167.
    • (2003) Bioessays , vol.25 , pp. 1158-1167
    • Mendez, J.1    Stillman, B.2
  • 19
    • 0032190507 scopus 로고    scopus 로고
    • Xenopus Cdc45-dependent loading of DNA polymerase alpha onto chromatin under the control of S-phase Cdk
    • Mimura, S.; Takisawa, H. Xenopus Cdc45-dependent loading of DNA polymerase alpha onto chromatin under the control of S-phase Cdk. EMBO J. 1998, 17, 5699-5707.
    • (1998) EMBO J , vol.17 , pp. 5699-5707
    • Mimura, S.1    Takisawa, H.2
  • 20
    • 0033936230 scopus 로고    scopus 로고
    • Central role for cdc45 in establishing an initiation complex of DNA replication in Xenopus egg extracts
    • Mimura, S.; Masuda, T.; Matsui, T.; Takisawa, H. Central role for cdc45 in establishing an initiation complex of DNA replication in Xenopus egg extracts. Genes Cells 2000, 5, 439-452.
    • (2000) Genes Cells , vol.5 , pp. 439-452
    • Mimura, S.1    Masuda, T.2    Matsui, T.3    Takisawa, H.4
  • 21
    • 0033637837 scopus 로고    scopus 로고
    • Initiation of eukaryotic DNA replication: Origin unwinding and sequential chromatin association of Cdc45, RPA, and DNA polymerase alpha
    • Walter, J.; Newport, J. Initiation of eukaryotic DNA replication: Origin unwinding and sequential chromatin association of Cdc45, RPA, and DNA polymerase alpha. Mol. Cell 2000, 5, 617-627.
    • (2000) Mol. Cell , vol.5 , pp. 617-627
    • Walter, J.1    Newport, J.2
  • 22
    • 74349122718 scopus 로고    scopus 로고
    • Structure and function of the GINS complex, a key component of the eukaryotic replisome
    • MacNeill, S. A. Structure and function of the GINS complex, a key component of the eukaryotic replisome. Biochem. J. 2010, 425, 489-500.
    • (2010) Biochem. J , vol.425 , pp. 489-500
    • McNeill, S.A.1
  • 24
    • 73849129578 scopus 로고    scopus 로고
    • The Dbf4-Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4
    • Sheu, Y. J.; Stillman, B. The Dbf4-Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4. Nature 2010, 463, 113-117.
    • (2010) Nature , vol.463 , pp. 113-117
    • Sheu, Y.J.1    Stillman, B.2
  • 25
    • 78149462002 scopus 로고    scopus 로고
    • Mec1 is one of multiple kinases that prime the Mcm2-7 helicase for phosphorylation by Cdc7
    • Randell, J. C.; Fan, A.; Chan, C.; Francis, L. I.; Heller, R. C.; Galani, K.; Bell, S. P. Mec1 is one of multiple kinases that prime the Mcm2-7 helicase for phosphorylation by Cdc7. Mol. Cell 2010, 40, 353-363.
    • (2010) Mol. Cell , vol.40 , pp. 353-363
    • Randell, J.C.1    Fan, A.2    Chan, C.3    Francis, L.I.4    Heller, R.C.5    Galani, K.6    Bell, S.P.7
  • 26
    • 33846330909 scopus 로고    scopus 로고
    • CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast
    • Tanaka, S.; Umemori, T.; Hirai, K.; Muramatsu, S.; Kamimura, Y.; Araki, H. CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast. Nature 2007, 445, 328-332.
    • (2007) Nature , vol.445 , pp. 328-332
    • Tanaka, S.1    Umemori, T.2    Hirai, K.3    Muramatsu, S.4    Kamimura, Y.5    Araki, H.6
  • 27
    • 33846328709 scopus 로고    scopus 로고
    • Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast
    • Zegerman, P.; Diffley, J. F. Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast. Nature 2007, 445, 281-285.
    • (2007) Nature , vol.445 , pp. 281-285
    • Zegerman, P.1    Diffley, J.F.2
  • 28
    • 79959957543 scopus 로고    scopus 로고
    • Eukaryotic origin-dependent DNA replication in vitro reveals sequential action of DDK and S-CDK kinases
    • Heller, R. C.; Kang, S.; Lam, W. M.; Chen, S.; Chan, C. S.; Bell, S. P. Eukaryotic origin-dependent DNA replication in vitro reveals sequential action of DDK and S-CDK kinases. Cell 2011, 146, 80-91.
    • (2011) Cell , vol.146 , pp. 80-91
    • Heller, R.C.1    Kang, S.2    Lam, W.M.3    Chen, S.4    Chan, C.S.5    Bell, S.P.6
  • 29
    • 77949354732 scopus 로고    scopus 로고
    • CDK-dependent complex formation between replication proteins Dpb11, Sld2, Pol (epsilon}, and GINS in budding yeast
    • Muramatsu, S.; Hirai, K.; Tak, Y. S.; Kamimura, Y.; Araki, H. CDK-dependent complex formation between replication proteins Dpb11, Sld2, Pol (epsilon}, and GINS in budding yeast. Genes Dev. 2010, 24, 602-612.
    • (2010) Genes Dev , vol.24 , pp. 602-612
    • Muramatsu, S.1    Hirai, K.2    Tak, Y.S.3    Kamimura, Y.4    Araki, H.5
  • 30
    • 79956144011 scopus 로고    scopus 로고
    • Sld7, an Sld3-associated protein required for efficient chromosomal DNA replication in budding yeast
    • Tanaka, T.; Umemori, T.; Endo, S.; Muramatsu, S.; Kanemaki, M.; Kamimura, Y.; Obuse, C.; Araki, H. Sld7, an Sld3-associated protein required for efficient chromosomal DNA replication in budding yeast. EMBO J. 2011, 30, 2019-2030.
    • (2011) EMBO J , vol.30 , pp. 2019-2030
    • Tanaka, T.1    Umemori, T.2    Endo, S.3    Muramatsu, S.4    Kanemaki, M.5    Kamimura, Y.6    Obuse, C.7    Araki, H.8
  • 32
    • 0026583949 scopus 로고
    • Interaction of DNA polymerase a-primase with cellular replication protein A and SV40 T antigen
    • Dorneiter, I.; Erdile, L. F.; Gilbert, I. U.; von Winkler, D.; Kelly, T. J.; Fanning, E. Interaction of DNA polymerase a-primase with cellular replication protein A and SV40 T antigen. EMBO 1992, 11, 769-776.
    • (1992) EMBO , vol.11 , pp. 769-776
    • Dorneiter, I.1    Erdile, L.F.2    Gilbert, I.U.3    von Winkler, D.4    Kelly, T.J.5    Fanning, E.6
  • 34
    • 0031663505 scopus 로고    scopus 로고
    • The DNA replication fork in eukaryotic cells
    • Waga, S.; Stillman, B. The DNA replication fork in eukaryotic cells. Annu. Rev. Biochem. 1998, 67, 721-751.
    • (1998) Annu. Rev. Biochem , vol.67 , pp. 721-751
    • Waga, S.1    Stillman, B.2
  • 35
    • 34447336941 scopus 로고    scopus 로고
    • Yeast DNA polymerase epsilon participates in leading-strand DNA replication
    • Pursell, Z. F.; Isoz, I.; Lundstrom, E. B.; Johansson, E.; Kunkel, T. A. Yeast DNA polymerase epsilon participates in leading-strand DNA replication. Science 2007, 317, 127-130.
    • (2007) Science , vol.317 , pp. 127-130
    • Pursell, Z.F.1    Isoz, I.2    Lundstrom, E.B.3    Johansson, E.4    Kunkel, T.A.5
  • 36
    • 33748481354 scopus 로고    scopus 로고
    • The DNA polymerase activity of Pol epsilon holoenzyme is required for rapid and efficient chromosomal DNA replication in Xenopus egg extracts
    • Shikata, K.; Sasa-Masuda, T.; Okuno, Y.; Waga, S.; Sugino, A. The DNA polymerase activity of Pol epsilon holoenzyme is required for rapid and efficient chromosomal DNA replication in Xenopus egg extracts. BMC Biochem. 2006, 7, 21.
    • (2006) BMC Biochem , vol.7 , pp. 21
    • Shikata, K.1    Sasa-Masuda, T.2    Okuno, Y.3    Waga, S.4    Sugino, A.5
  • 37
    • 42949142111 scopus 로고    scopus 로고
    • DNA polymerases at the replication fork in eukaryotes
    • Stillman, B. DNA polymerases at the replication fork in eukaryotes. Mol. Cell 2008, 30, 259-260.
    • (2008) Mol. Cell , vol.30 , pp. 259-260
    • Stillman, B.1
  • 38
    • 13544252547 scopus 로고    scopus 로고
    • MCM8 is an MCM2-7-related protein that functions as a DNA helicase during replication elongation and not initiation
    • Maiorano, D.; Cuvier, O.; Danis, E.; Mechali, M. MCM8 is an MCM2-7-related protein that functions as a DNA helicase during replication elongation and not initiation. Cell 2005, 120, 315-328.
    • (2005) Cell , vol.120 , pp. 315-328
    • Maiorano, D.1    Cuvier, O.2    Danis, E.3    Mechali, M.4
  • 41
    • 0013887376 scopus 로고
    • Autoradiography of chromosomal DNA fibers from Chinese hamster cells
    • Huberman, J. A.; Riggs, A. D. Autoradiography of chromosomal DNA fibers from Chinese hamster cells. Proc. Natl. Acad. Sci. USA 1966, 55, 599-606.
    • (1966) Proc. Natl. Acad. Sci. USA , vol.55 , pp. 599-606
    • Huberman, J.A.1    Riggs, A.D.2
  • 42
    • 84857443720 scopus 로고    scopus 로고
    • Cellular epigenetic stability and cancer
    • Sarkies, P.; Sale, J. E. Cellular epigenetic stability and cancer. Trends Genet. 2012, 28, 118-127.
    • (2012) Trends Genet , vol.28 , pp. 118-127
    • Sarkies, P.1    Sale, J.E.2
  • 43
    • 0035430416 scopus 로고    scopus 로고
    • DNA replication origins: From sequence specificity to epigenetics
    • Mechali, M. DNA replication origins: From sequence specificity to epigenetics. Nat. Rev. Genet. 2001, 2, 640-645.
    • (2001) Nat. Rev. Genet , vol.2 , pp. 640-645
    • Mechali, M.1
  • 44
    • 78651502357 scopus 로고    scopus 로고
    • MCM-BP regulates unloading of the MCM2-7 helicase in late S phase
    • Nishiyama, A.; Frappier, L.; Mechali, M. MCM-BP regulates unloading of the MCM2-7 helicase in late S phase. Genes Dev. 2011, 25, 165-175.
    • (2011) Genes Dev , vol.25 , pp. 165-175
    • Nishiyama, A.1    Frappier, L.2    Mechali, M.3
  • 45
    • 0014938777 scopus 로고
    • Mammalian cell fusion: Studies on the regulation of DNA synthesis and mitosis
    • Rao, P. N.; Johnson, R. T. Mammalian cell fusion: Studies on the regulation of DNA synthesis and mitosis. Nature 1970, 225, 159-164.
    • (1970) Nature , vol.225 , pp. 159-164
    • Rao, P.N.1    Johnson, R.T.2
  • 46
    • 0023904730 scopus 로고
    • A role for the nuclear envelope in controlling DNA replication within the cell cycle
    • Blow, J. J.; Laskey, R. A role for the nuclear envelope in controlling DNA replication within the cell cycle. Nature 1988, 332, 546-548.
    • (1988) Nature , vol.332 , pp. 546-548
    • Blow, J.J.1    Laskey, R.2
  • 47
    • 0028989339 scopus 로고
    • Purification of an MCM-containing complex as a component of the DNA replication licensing system
    • Chong, J. P.; Mahbubani, H. M.; Khoo, C.-Y.; Blow, J. J. Purification of an MCM-containing complex as a component of the DNA replication licensing system. Nature 1995, 375, 418-421.
    • (1995) Nature , vol.375 , pp. 418-421
    • Chong, J.P.1    Mahbubani, H.M.2    Khoo, C.-Y.3    Blow, J.J.4
  • 48
    • 0030030623 scopus 로고    scopus 로고
    • An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast
    • Cocker, J. H.; Piatti, S.; Santocanale, C.; Nasmyth, K.; Diffley, J. F. X. An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast. Nature 1996, 379, 180-182.
    • (1996) Nature , vol.379 , pp. 180-182
    • Cocker, J.H.1    Piatti, S.2    Santocanale, C.3    Nasmyth, K.4    Diffley, J.F.X.5
  • 49
    • 34249821619 scopus 로고    scopus 로고
    • Cdt1 and geminin: Role during cell cycle progression and DNA damage in higher eukaryotes
    • Tada, S. Cdt1 and geminin: Role during cell cycle progression and DNA damage in higher eukaryotes. Front. Biosci. 2007, 12, 1629-1641.
    • (2007) Front. Biosci , vol.12 , pp. 1629-1641
    • Tada, S.1
  • 50
    • 84880681103 scopus 로고    scopus 로고
    • Geminin deploys multiple mechanisms to regulate Cdt1 before cell division thus ensuring the proper execution of DNA replication
    • Ballabeni, A.; Zamponi, R.; Moore, J. K.; Helin, K.; Kirschner, M. W. Geminin deploys multiple mechanisms to regulate Cdt1 before cell division thus ensuring the proper execution of DNA replication. Proc. Natl. Acad. Sci. USA 2013, 110, E2848-E2853.
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110
    • Ballabeni, A.1    Zamponi, R.2    Moore, J.K.3    Helin, K.4    Kirschner, M.W.5
  • 51
    • 0034611807 scopus 로고    scopus 로고
    • XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis
    • Maiorano, D.; Moreau, J.; Mechali, M. XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis. Nature 2000, 404, 622-625.
    • (2000) Nature , vol.404 , pp. 622-625
    • Maiorano, D.1    Moreau, J.2    Mechali, M.3
  • 52
    • 0036537510 scopus 로고    scopus 로고
    • Essential role of human CDT1 in DNA replication and chromatin licensing
    • Rialland, M.; Sola, F.; Santocanale, C. Essential role of human CDT1 in DNA replication and chromatin licensing. J. Cell Sci. 2002, 115, 1435-1440.
    • (2002) J. Cell Sci , vol.115 , pp. 1435-1440
    • Rialland, M.1    Sola, F.2    Santocanale, C.3
  • 53
    • 0035976980 scopus 로고    scopus 로고
    • The human licensing factor for DNA replication Cdt1 accumulates in G1 and is destabilized after initiation of S-phase
    • Nishitani, H.; Taraviras, S.; Lygerou, Z.; Nishimoto, T. The human licensing factor for DNA replication Cdt1 accumulates in G1 and is destabilized after initiation of S-phase. J. Biol. Chem. 2001, 276, 44905-44911.
    • (2001) J. Biol. Chem , vol.276 , pp. 44905-44911
    • Nishitani, H.1    Taraviras, S.2    Lygerou, Z.3    Nishimoto, T.4
  • 54
    • 30344455639 scopus 로고    scopus 로고
    • PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replication
    • Arias, E. E.; Walter, J. C. PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replication. Nat. Cell Biol. 2006, 8, 84-90.
    • (2006) Nat. Cell Biol , vol.8 , pp. 84-90
    • Arias, E.E.1    Walter, J.C.2
  • 55
    • 12544258483 scopus 로고    scopus 로고
    • Recombinant Cdt1 induces rereplication of G2 nuclei in Xenopus egg extracts
    • Maiorano, D.; Krasinska, L.; Lutzmann, M.; Mechali, M. Recombinant Cdt1 induces rereplication of G2 nuclei in Xenopus egg extracts. Curr. Biol. 2005, 15, 146-153.
    • (2005) Curr. Biol , vol.15 , pp. 146-153
    • Maiorano, D.1    Krasinska, L.2    Lutzmann, M.3    Mechali, M.4
  • 56
    • 13444249558 scopus 로고    scopus 로고
    • Cdt1 downregulation by proteolysis and geminin inhibition prevents DNA re-replication in Xenopus
    • Li, A.; Blow, J. J. Cdt1 downregulation by proteolysis and geminin inhibition prevents DNA re-replication in Xenopus. EMBO J. 2005, 24, 395-404.
    • (2005) EMBO J , vol.24 , pp. 395-404
    • Li, A.1    Blow, J.J.2
  • 57
    • 11844273174 scopus 로고    scopus 로고
    • Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts
    • Arias, E. E.; Walter, J. C. Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts. Genes Dev. 2005, 19, 114-126.
    • (2005) Genes Dev , vol.19 , pp. 114-126
    • Arias, E.E.1    Walter, J.C.2
  • 58
    • 14844357222 scopus 로고    scopus 로고
    • Intrinsic nuclear import activity of geminin is essential to prevent re-initiation of DNA replication in Xenopus eggs
    • Yoshida, K.; Takisawa, H.; Kubota, Y. Intrinsic nuclear import activity of geminin is essential to prevent re-initiation of DNA replication in Xenopus eggs. Genes Cells 2005, 10, 63-73.
    • (2005) Genes Cells , vol.10 , pp. 63-73
    • Yoshida, K.1    Takisawa, H.2    Kubota, Y.3
  • 59
    • 33845690902 scopus 로고    scopus 로고
    • A Cdt1-geminin complex licenses chromatin for DNA replication and prevents rereplication during S phase in Xenopus
    • Lutzmann, M.; Maiorano, D.; Mechali, M. A Cdt1-geminin complex licenses chromatin for DNA replication and prevents rereplication during S phase in Xenopus. EMBO J. 2006, 25, 5764-5774.
    • (2006) EMBO J , vol.25 , pp. 5764-5774
    • Lutzmann, M.1    Maiorano, D.2    Mechali, M.3
  • 61
    • 0033224310 scopus 로고    scopus 로고
    • G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus
    • Labib, K.; Diffley, J. F.; Kearsey, S. E. G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus. Nat. Cell Biol. 1999, 1, 415-422.
    • (1999) Nat. Cell Biol , vol.1 , pp. 415-422
    • Labib, K.1    Diffley, J.F.2    Kearsey, S.E.3
  • 62
    • 0034611749 scopus 로고    scopus 로고
    • The Cdt1 protein is required to license DNA for replication in fission yeast
    • Nishitani, H.; Lygerou, Z.; Nishimoto, T.; Nurse, P. The Cdt1 protein is required to license DNA for replication in fission yeast. Nature 2000, 404, 625-628.
    • (2000) Nature , vol.404 , pp. 625-628
    • Nishitani, H.1    Lygerou, Z.2    Nishimoto, T.3    Nurse, P.4
  • 63
    • 81055137194 scopus 로고    scopus 로고
    • A quantitative model for cyclin-dependent kinase control of the cell cycle: Revisited
    • Uhlmann, F.; Bouchoux, C.; Lopez-Aviles, S. A quantitative model for cyclin-dependent kinase control of the cell cycle: Revisited. Philos. Trans. R. Soc. Lond. B Biol. Sci. 2011, 366, 3572-3583.
    • (2011) Philos. Trans. R. Soc. Lond. B Biol. Sci , vol.366 , pp. 3572-3583
    • Uhlmann, F.1    Bouchoux, C.2    Lopez-Aviles, S.3
  • 64
    • 84855321395 scopus 로고    scopus 로고
    • Multiple degradation pathways regulate versatile CIP/KIP CDK inhibitors
    • Starostina, N. G.; Kipreos, E. T. Multiple degradation pathways regulate versatile CIP/KIP CDK inhibitors. Trends Cell Biol. 2011, 22, 33-41.
    • (2011) Trends Cell Biol , vol.22 , pp. 33-41
    • Starostina, N.G.1    Kipreos, E.T.2
  • 66
    • 0029670828 scopus 로고    scopus 로고
    • A single fission yeast mitotic cyclin B-p34cdc2 kinase promotes both S-phase and mitosis in the absence of G1-cyclins
    • Fisher, D.; Nurse, P. A single fission yeast mitotic cyclin B-p34cdc2 kinase promotes both S-phase and mitosis in the absence of G1-cyclins. EMBO J. 1996, 15, 850-860.
    • (1996) EMBO J , vol.15 , pp. 850-860
    • Fisher, D.1    Nurse, P.2
  • 68
    • 75749103708 scopus 로고    scopus 로고
    • Treslin collaborates with TopBP1 in triggering the initiation of DNA replication
    • Kumagai, A.; Shevchenko, A.; Dunphy, W. G. Treslin collaborates with TopBP1 in triggering the initiation of DNA replication. Cell 2010, 140, 349-359.
    • (2010) Cell , vol.140 , pp. 349-359
    • Kumagai, A.1    Shevchenko, A.2    Dunphy, W.G.3
  • 69
    • 77951976827 scopus 로고    scopus 로고
    • GEMC1 is a TopBP1-interacting protein required for chromosomal DNA replication
    • Balestrini, A.; Cosentino, C.; Errico, A.; Garner, E.; Costanzo, V. GEMC1 is a TopBP1-interacting protein required for chromosomal DNA replication. Nat. Cell Biol. 2010, 12, 484-491.
    • (2010) Nat. Cell Biol , vol.12 , pp. 484-491
    • Balestrini, A.1    Cosentino, C.2    Errico, A.3    Garner, E.4    Costanzo, V.5
  • 70
    • 84862800693 scopus 로고    scopus 로고
    • Treslin, DUE-B, and GEMC1 cannot complement Sld3 mutants in fission yeast
    • Wang, Z.; Kim, E.; Leffak, M.; Xu, Y. J. Treslin, DUE-B, and GEMC1 cannot complement Sld3 mutants in fission yeast. FEMS Yeast Res. 2012, 12, 486-490.
    • (2012) FEMS Yeast Res , vol.12 , pp. 486-490
    • Wang, Z.1    Kim, E.2    Leffak, M.3    Xu, Y.J.4
  • 71
    • 0030249292 scopus 로고    scopus 로고
    • A quantitative model for the cdc2 control of S phase and mitosis in fission yeast
    • Stern, B.; Nurse, P. A quantitative model for the cdc2 control of S phase and mitosis in fission yeast. Trends Genet. 1996, 12, 345-350.
    • (1996) Trends Genet , vol.12 , pp. 345-350
    • Stern, B.1    Nurse, P.2
  • 72
    • 0034725635 scopus 로고    scopus 로고
    • A direct interaction between proliferating cell nuclear antigen (PCNA) and Cdk2 targets PCNA-interacting proteins for phosphorylation
    • Koundrioukoff, S.; Jonsson, Z. O.; Hasan, S.; de Jong, R. N.; van der Vliet, P. C.; Hottiger, M. O.; Hubscher, U. A direct interaction between proliferating cell nuclear antigen (PCNA) and Cdk2 targets PCNA-interacting proteins for phosphorylation. J. Biol. Chem. 2000, 275, 22882-22887.
    • (2000) J. Biol. Chem , vol.275 , pp. 22882-22887
    • Koundrioukoff, S.1    Jonsson, Z.O.2    Hasan, S.3    de Jong, R.N.4    van der Vliet, P.C.5    Hottiger, M.O.6    Hubscher, U.7
  • 73
    • 0024425887 scopus 로고
    • Checkpoints: Controls that ensure the order of cell cycle events
    • Hartwell, L. H.; Weinert, T. A. Checkpoints: Controls that ensure the order of cell cycle events. Science 1989, 246, 629-634.
    • (1989) Science , vol.246 , pp. 629-634
    • Hartwell, L.H.1    Weinert, T.A.2
  • 74
    • 80755187806 scopus 로고    scopus 로고
    • Double-strand break end resection and repair pathway choice
    • Symington, L. S.; Gautier, J. Double-strand break end resection and repair pathway choice. Annu. Rev. Genet. 2011, 45, 247-271.
    • (2011) Annu. Rev. Genet , vol.45 , pp. 247-271
    • Symington, L.S.1    Gautier, J.2
  • 75
    • 21244448288 scopus 로고    scopus 로고
    • Checkpoint responses to replication fork barriers
    • Lambert, S.; Carr, A. M. Checkpoint responses to replication fork barriers. Biochimie 2005, 87, 591-602.
    • (2005) Biochimie , vol.87 , pp. 591-602
    • Lambert, S.1    Carr, A.M.2
  • 76
    • 0014432520 scopus 로고
    • Discontinuities in the DNA synthesized in an excision-defective strain of Escherichia coli following ultraviolet irradiation
    • Rupp, W. D.; Howard-Flanders, P. Discontinuities in the DNA synthesized in an excision-defective strain of Escherichia coli following ultraviolet irradiation. J. Mol. Biol. 1968, 31, 291-304.
    • (1968) J. Mol. Biol , vol.31 , pp. 291-304
    • Rupp, W.D.1    Howard-Flanders, P.2
  • 77
    • 0037799191 scopus 로고    scopus 로고
    • Uncoupling of leading-and lagging-strand DNA replication during lesion bypass in vivo
    • Pages, V.; Fuchs, R. P. Uncoupling of leading-and lagging-strand DNA replication during lesion bypass in vivo. Science 2003, 300, 1300-1303.
    • (2003) Science , vol.300 , pp. 1300-1303
    • Pages, V.1    Fuchs, R.P.2
  • 78
    • 78649336706 scopus 로고    scopus 로고
    • The DNA damage response: Making it safe to play with knives
    • Ciccia, A.; Elledge, S. J. The DNA damage response: Making it safe to play with knives. Mol. Cell 2010, 40, 179-204.
    • (2010) Mol. Cell , vol.40 , pp. 179-204
    • Ciccia, A.1    Elledge, S.J.2
  • 80
    • 0034102337 scopus 로고    scopus 로고
    • ATR disruption leads to chromosomal fragmentation and early embryonic lethality
    • Brown, E. J.; Baltimore, D. ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev. 2000, 14, 397-402.
    • (2000) Genes Dev , vol.14 , pp. 397-402
    • Brown, E.J.1    Baltimore, D.2
  • 84
    • 77957149919 scopus 로고    scopus 로고
    • Checkpoint-dependent inhibition of DNA replication initiation by Sld3 and Dbf4 phosphorylation
    • Zegerman, P.; Diffley, J. F. Checkpoint-dependent inhibition of DNA replication initiation by Sld3 and Dbf4 phosphorylation. Nature 2010, 467, 474-478.
    • (2010) Nature , vol.467 , pp. 474-478
    • Zegerman, P.1    Diffley, J.F.2
  • 86
    • 0033636737 scopus 로고    scopus 로고
    • Reconstitution of an ATM-dependent checkpoint that inhibits chromosomal DNA replication following DNA damage
    • Costanzo, V.; Robertson, K.; Ying, C. Y.; Kim, E.; Avvedimento, E.; Gottesman, M.; Grieco, D.; Gautier, J. Reconstitution of an ATM-dependent checkpoint that inhibits chromosomal DNA replication following DNA damage. Mol. Cell 2000, 6, 649-659.
    • (2000) Mol. Cell , vol.6 , pp. 649-659
    • Costanzo, V.1    Robertson, K.2    Ying, C.Y.3    Kim, E.4    Avvedimento, E.5    Gottesman, M.6    Grieco, D.7    Gautier, J.8
  • 87
    • 57749116059 scopus 로고    scopus 로고
    • The role of Dbf4/Drf1-dependent kinase Cdc7 in DNA-damage checkpoint control
    • Tsuji, T.; Lau, E.; Chiang, G. G.; Jiang, W. The role of Dbf4/Drf1-dependent kinase Cdc7 in DNA-damage checkpoint control. Mol. Cell 2008, 32, 862-869.
    • (2008) Mol. Cell , vol.32 , pp. 862-869
    • Tsuji, T.1    Lau, E.2    Chiang, G.G.3    Jiang, W.4
  • 88
    • 84862972549 scopus 로고    scopus 로고
    • Dbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint
    • Lee, A. Y.; Chiba, T.; Truong, L. N.; Cheng, A. N.; Do, J.; Cho, M. J.; Chen, L.; Wu, X. Dbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint. J. Biol. Chem. 2012, 287, 2531-2543.
    • (2012) J. Biol. Chem , vol.287 , pp. 2531-2543
    • Lee, A.Y.1    Chiba, T.2    Truong, L.N.3    Cheng, A.N.4    Do, J.5    Cho, M.J.6    Chen, L.7    Wu, X.8
  • 89
    • 18244371925 scopus 로고    scopus 로고
    • Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint
    • Byun, T. S.; Pacek, M.; Yee, M. C.; Walter, J. C.; Cimprich, K. A. Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint. Genes Dev. 2005, 19, 1040-1052.
    • (2005) Genes Dev , vol.19 , pp. 1040-1052
    • Byun, T.S.1    Pacek, M.2    Yee, M.C.3    Walter, J.C.4    Cimprich, K.A.5
  • 90
    • 0037178740 scopus 로고    scopus 로고
    • Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects
    • Sogo, J. M.; Lopes, M.; Foiani, M. Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects. Science 2002, 297, 599-602.
    • (2002) Science , vol.297 , pp. 599-602
    • Sogo, J.M.1    Lopes, M.2    Foiani, M.3
  • 91
    • 0023845204 scopus 로고
    • Extensive regions of single-stranded DNA in aphidicolin-treated melanoma cells
    • Lonn, U.; Lonn, S. Extensive regions of single-stranded DNA in aphidicolin-treated melanoma cells. Biochemistry 1988, 27, 566-570.
    • (1988) Biochemistry , vol.27 , pp. 566-570
    • Lonn, U.1    Lonn, S.2
  • 92
    • 84885369839 scopus 로고    scopus 로고
    • Interplays between ATM/Tel1 and ATR/Mec1 in sensing and signaling DNA double-strand breaks
    • Gobbini, E.; Cesena, D.; Galbiati, A.; Lockhart, A.; Longhese, M. P. Interplays between ATM/Tel1 and ATR/Mec1 in sensing and signaling DNA double-strand breaks. DNA Repair 2013, 12, 791-799.
    • (2013) DNA Repair , vol.12 , pp. 791-799
    • Gobbini, E.1    Cesena, D.2    Galbiati, A.3    Lockhart, A.4    Longhese, M.P.5
  • 93
    • 0036276388 scopus 로고    scopus 로고
    • The Mre11 complex: At the crossroads of dna repair and checkpoint signalling
    • D'Amours, D.; Jackson, S. P. The Mre11 complex: At the crossroads of dna repair and checkpoint signalling. Nat. Rev. Mol. Cell Biol. 2002, 3, 317-327.
    • (2002) Nat. Rev. Mol. Cell Biol , vol.3 , pp. 317-327
    • D'Amours, D.1    Jackson, S.P.2
  • 94
    • 84879527609 scopus 로고    scopus 로고
    • APE2 is required for ATR-Chk1 checkpoint activation in response to oxidative stress
    • Willis, J.; Patel, Y.; Lentz, B. L.; Yan, S. APE2 is required for ATR-Chk1 checkpoint activation in response to oxidative stress. Proc. Natl. Acad. Sci. USA 2013, 110, 10592-10597.
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 10592-10597
    • Willis, J.1    Patel, Y.2    Lentz, B.L.3    Yan, S.4
  • 95
    • 84859483030 scopus 로고    scopus 로고
    • ATM protein physically and functionally interacts with proliferating cell nuclear antigen to regulate DNA synthesis
    • Gamper, A. M.; Choi, S.; Matsumoto, Y.; Banerjee, D.; Tomkinson, A. E.; Bakkenist, C. J. ATM protein physically and functionally interacts with proliferating cell nuclear antigen to regulate DNA synthesis. J. Biol. Chem. 2012, 287, 12445-12454.
    • (2012) J. Biol. Chem , vol.287 , pp. 12445-12454
    • Gamper, A.M.1    Choi, S.2    Matsumoto, Y.3    Banerjee, D.4    Tomkinson, A.E.5    Bakkenist, C.J.6
  • 96
    • 0037245862 scopus 로고    scopus 로고
    • An ATR-and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication
    • Costanzo, V.; Shechter, D.; Lupardus, P. J.; Cimprich, K. A.; Gottesman, M.; Gautier, J. An ATR-and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication. Mol. Cell 2003, 11, 203-213.
    • (2003) Mol. Cell , vol.11 , pp. 203-213
    • Costanzo, V.1    Shechter, D.2    Lupardus, P.J.3    Cimprich, K.A.4    Gottesman, M.5    Gautier, J.6
  • 97
    • 0345564858 scopus 로고    scopus 로고
    • Replication protein A-mediated recruitment and activation of Rad17 complexes
    • Zou, L.; Liu, D.; Elledge, S. J. Replication protein A-mediated recruitment and activation of Rad17 complexes. Proc. Natl. Acad. Sci. USA 2003, 100, 13827-13832.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 13827-13832
    • Zou, L.1    Liu, D.2    Elledge, S.J.3
  • 98
    • 18244385718 scopus 로고    scopus 로고
    • ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation
    • Ball, H. L.; Myers, J. S.; Cortez, D. ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation. Mol. Biol. Cell 2005, 16, 2372-2381.
    • (2005) Mol. Biol. Cell , vol.16 , pp. 2372-2381
    • Ball, H.L.1    Myers, J.S.2    Cortez, D.3
  • 99
    • 0035941021 scopus 로고    scopus 로고
    • ATR and ATRIP: Partners in checkpoint signaling
    • Cortez, D.; Guntuku, S.; Qin, J.; Elledge, S. J. ATR and ATRIP: Partners in checkpoint signaling. Science 2001, 294, 1713-1716.
    • (2001) Science , vol.294 , pp. 1713-1716
    • Cortez, D.1    Guntuku, S.2    Qin, J.3    Elledge, S.J.4
  • 100
    • 1942437440 scopus 로고    scopus 로고
    • Recruitment of the cell cycle checkpoint kinase ATR to chromatin during S-phase
    • Dart, D. A.; Adams, K. E.; Akerman, I.; Lakin, N. D. Recruitment of the cell cycle checkpoint kinase ATR to chromatin during S-phase. J. Biol. Chem. 2004, 279, 16433-16440.
    • (2004) J. Biol. Chem , vol.279 , pp. 16433-16440
    • Dart, D.A.1    Adams, K.E.2    Akerman, I.3    Lakin, N.D.4
  • 101
    • 84860356328 scopus 로고    scopus 로고
    • Role of replication protein A as sensor in activation of the S-phase checkpoint in Xenopus egg extracts
    • Recolin, B.; van der Laan, S.; Maiorano, D. Role of replication protein A as sensor in activation of the S-phase checkpoint in Xenopus egg extracts. Nucleic Acids Res. 2012, 40, 3431-3442.
    • (2012) Nucleic Acids Res , vol.40 , pp. 3431-3442
    • Recolin, B.1    van der Laan, S.2    Maiorano, D.3
  • 102
    • 4043088472 scopus 로고    scopus 로고
    • DNA replication defects, spontaneous DNA damage, and ATM-dependent checkpoint activation in replication protein A-deficient cells
    • Dodson, G. E.; Shi, Y.; Tibbetts, R. S. DNA replication defects, spontaneous DNA damage, and ATM-dependent checkpoint activation in replication protein A-deficient cells. J. Biol. Chem. 2004, 279, 34010-34014.
    • (2004) J. Biol. Chem , vol.279 , pp. 34010-34014
    • Dodson, G.E.1    Shi, Y.2    Tibbetts, R.S.3
  • 103
    • 1442351990 scopus 로고    scopus 로고
    • Checkpoint-mediated control of replisome-fork association and signalling in response to replication pausing
    • Lucca, C.; Vanoli, F.; Cotta-Ramusino, C.; Pellicioli, A.; Liberi, G.; Haber, J.; Foiani, M. Checkpoint-mediated control of replisome-fork association and signalling in response to replication pausing. Oncogene 2004, 23, 1206-1213.
    • (2004) Oncogene , vol.23 , pp. 1206-1213
    • Lucca, C.1    Vanoli, F.2    Cotta-Ramusino, C.3    Pellicioli, A.4    Liberi, G.5    Haber, J.6    Foiani, M.7
  • 104
    • 0037567268 scopus 로고    scopus 로고
    • Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
    • Zou, L.; Elledge, S. J. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 2003, 300, 1542-1548.
    • (2003) Science , vol.300 , pp. 1542-1548
    • Zou, L.1    Elledge, S.J.2
  • 105
    • 84875528224 scopus 로고    scopus 로고
    • Human single-stranded DNA binding proteins are essential for maintaining genomic stability
    • Ashton, N. W.; Bolderson, E.; Cubeddu, L.; O'Byrne, K. J.; Richard, D. J. Human single-stranded DNA binding proteins are essential for maintaining genomic stability. BMC Mol. Biol. 2013, 14, 9.
    • (2013) BMC Mol. Biol , vol.14 , pp. 9
    • Ashton, N.W.1    Bolderson, E.2    Cubeddu, L.3    O'Byrne, K.J.4    Richard, D.J.5
  • 108
    • 47749141560 scopus 로고    scopus 로고
    • ATR: An essential regulator of genome integrity
    • Cimprich, K. A.; Cortez, D. ATR: An essential regulator of genome integrity. Nat. Rev. Mol. Cell Biol. 2008, 9, 616-627.
    • (2008) Nat. Rev. Mol. Cell Biol , vol.9 , pp. 616-627
    • Cimprich, K.A.1    Cortez, D.2
  • 109
    • 0037452605 scopus 로고    scopus 로고
    • Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro
    • Bermudez, V. P.; Lindsey-Boltz, L. A.; Cesare, A. J.; Maniwa, Y.; Griffith, J. D.; Hurwitz, J.; Sancar, A. Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro. Proc. Natl. Acad. Sci. USA 2003, 100, 1633-1638.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 1633-1638
    • Bermudez, V.P.1    Lindsey-Boltz, L.A.2    Cesare, A.J.3    Maniwa, Y.4    Griffith, J.D.5    Hurwitz, J.6    Sancar, A.7
  • 110
    • 4243156107 scopus 로고    scopus 로고
    • Biochemical characterization of DNA damage checkpoint complexes: Clamp loader and clamp complexes with specificity for 5' recessed DNA
    • Ellison, V.; Stillman, B. Biochemical characterization of DNA damage checkpoint complexes: Clamp loader and clamp complexes with specificity for 5' recessed DNA. PLoS Biol. 2003, 1, E33.
    • (2003) PLoS Biol , vol.1
    • Ellison, V.1    Stillman, B.2
  • 111
    • 0037080675 scopus 로고    scopus 로고
    • Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin
    • Zou, L.; Cortez, D.; Elledge, S. J. Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin. Genes Dev. 2002, 16, 198-208.
    • (2002) Genes Dev , vol.16 , pp. 198-208
    • Zou, L.1    Cortez, D.2    Elledge, S.J.3
  • 113
    • 33748780358 scopus 로고    scopus 로고
    • Replication protein A directs loading of the DNA damage checkpoint clamp to 5'-DNA junctions
    • Majka, J.; Binz, S. K.; Wold, M. S.; Burgers, P. M. Replication protein A directs loading of the DNA damage checkpoint clamp to 5'-DNA junctions. J. Biol. Chem. 2006, 281, 27855-27861.
    • (2006) J. Biol. Chem , vol.281 , pp. 27855-27861
    • Majka, J.1    Binz, S.K.2    Wold, M.S.3    Burgers, P.M.4
  • 114
    • 0037900888 scopus 로고    scopus 로고
    • Xenopus Cut5 is essential for a CDK-dependent process in the initiation of DNA replication
    • Hashimoto, Y.; Takisawa, H. Xenopus Cut5 is essential for a CDK-dependent process in the initiation of DNA replication. EMBO J. 2003, 22, 2526-2535.
    • (2003) EMBO J , vol.22 , pp. 2526-2535
    • Hashimoto, Y.1    Takisawa, H.2
  • 115
    • 0242413125 scopus 로고    scopus 로고
    • Cut5 is required for the binding of Atr and DNA polymerase alpha to genotoxin-damaged chromatin
    • Parrilla-Castellar, E. R.; Karnitz, L. M. Cut5 is required for the binding of Atr and DNA polymerase alpha to genotoxin-damaged chromatin. J. Biol. Chem. 2003, 278, 45507-45511.
    • (2003) J. Biol. Chem , vol.278 , pp. 45507-45511
    • Parrilla-Castellar, E.R.1    Karnitz, L.M.2
  • 116
    • 33747493040 scopus 로고    scopus 로고
    • The phosphorylated C-terminal domain of Xenopus Cut5 directly mediates ATR-dependent activation of Chk1
    • Hashimoto, Y.; Tsujimura, T.; Sugino, A.; Takisawa, H. The phosphorylated C-terminal domain of Xenopus Cut5 directly mediates ATR-dependent activation of Chk1. Genes Cells 2006, 11, 993-1007.
    • (2006) Genes Cells , vol.11 , pp. 993-1007
    • Hashimoto, Y.1    Tsujimura, T.2    Sugino, A.3    Takisawa, H.4
  • 117
    • 33646119403 scopus 로고    scopus 로고
    • Direct requirement for Xmus101 in ATR-mediated phosphorylation of Claspin bound Chk1 during checkpoint signaling
    • Yan, S.; Lindsay, H. D.; Michael, W. M. Direct requirement for Xmus101 in ATR-mediated phosphorylation of Claspin bound Chk1 during checkpoint signaling. J. Cell Biol. 2006, 173, 181-186.
    • (2006) J. Cell Biol , vol.173 , pp. 181-186
    • Yan, S.1    Lindsay, H.D.2    Michael, W.M.3
  • 118
    • 84871181366 scopus 로고    scopus 로고
    • DNA polymerization-independent functions of DNA polymerase epsilon in assembly and progression of the replisome in fission yeast
    • Handa, T.; Kanke, M.; Takahashi, T. S.; Nakagawa, T.; Masukata, H. DNA polymerization-independent functions of DNA polymerase epsilon in assembly and progression of the replisome in fission yeast. Mol. Biol. Cell 2012, 23, 3240-3253.
    • (2012) Mol. Biol. Cell , vol.23 , pp. 3240-3253
    • Handa, T.1    Kanke, M.2    Takahashi, T.S.3    Nakagawa, T.4    Masukata, H.5
  • 119
    • 34250705797 scopus 로고    scopus 로고
    • The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1
    • Delacroix, S.; Wagner, J. M.; Kobayashi, M.; Yamamoto, K.; Karnitz, L. M. The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1. Genes Dev. 2007, 21, 1472-1477.
    • (2007) Genes Dev , vol.21 , pp. 1472-1477
    • Delacroix, S.1    Wagner, J.M.2    Kobayashi, M.3    Yamamoto, K.4    Karnitz, L.M.5
  • 120
    • 34948889415 scopus 로고    scopus 로고
    • The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR
    • Lee, J.; Kumagai, A.; Dunphy, W. G. The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR. J. Biol. Chem. 2007, 282, 28036-28044.
    • (2007) J. Biol. Chem , vol.282 , pp. 28036-28044
    • Lee, J.1    Kumagai, A.2    Dunphy, W.G.3
  • 121
    • 2442646547 scopus 로고    scopus 로고
    • Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4TOPBP1
    • Furuya, K.; Poitelea, M.; Guo, L.; Caspari, T.; Carr, A. M. Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4TOPBP1. Genes Dev. 2004, 18, 1154-1164.
    • (2004) Genes Dev , vol.18 , pp. 1154-1164
    • Furuya, K.1    Poitelea, M.2    Guo, L.3    Caspari, T.4    Carr, A.M.5
  • 122
    • 44849093460 scopus 로고    scopus 로고
    • TopBP1 activates ATR through ATRIP and a PIKK regulatory domain
    • Mordes, D. A.; Glick, G. G.; Zhao, R.; Cortez, D. TopBP1 activates ATR through ATRIP and a PIKK regulatory domain. Genes Dev. 2008, 22, 1478-1489.
    • (2008) Genes Dev , vol.22 , pp. 1478-1489
    • Mordes, D.A.1    Glick, G.G.2    Zhao, R.3    Cortez, D.4
  • 123
    • 33644757806 scopus 로고    scopus 로고
    • TopBP1 activates the ATR-ATRIP complex
    • Kumagai, A.; Lee, J.; Yoo, H. Y.; Dunphy, W. G. TopBP1 activates the ATR-ATRIP complex. Cell 2006, 124, 943-955.
    • (2006) Cell , vol.124 , pp. 943-955
    • Kumagai, A.1    Lee, J.2    Yoo, H.Y.3    Dunphy, W.G.4
  • 124
    • 70349281497 scopus 로고    scopus 로고
    • TopBP1 and DNA polymerase alpha-mediated recruitment of the 9-1-1 complex to stalled replication forks: Implications for a replication restart-based mechanism for ATR checkpoint activation
    • Yan, S.; Michael, W. M. TopBP1 and DNA polymerase alpha-mediated recruitment of the 9-1-1 complex to stalled replication forks: Implications for a replication restart-based mechanism for ATR checkpoint activation. Cell Cycle 2009, 8, 2877-2884.
    • (2009) Cell Cycle , vol.8 , pp. 2877-2884
    • Yan, S.1    Michael, W.M.2
  • 125
    • 75949092280 scopus 로고    scopus 로고
    • BACH1/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control
    • Gong, Z.; Kim, J. E.; Leung, C. C.; Glover, J. N.; Chen, J. BACH1/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control. Mol. Cell 2010, 37, 438-446.
    • (2010) Mol. Cell , vol.37 , pp. 438-446
    • Gong, Z.1    Kim, J.E.2    Leung, C.C.3    Glover, J.N.4    Chen, J.5
  • 126
    • 79955516080 scopus 로고    scopus 로고
    • MDC1 collaborates with TopBP1 in DNA replication checkpoint control
    • Wang, J.; Gong, Z.; Chen, J. MDC1 collaborates with TopBP1 in DNA replication checkpoint control. J. Cell Biol. 2011, 193, 267-273.
    • (2011) J. Cell Biol , vol.193 , pp. 267-273
    • Wang, J.1    Gong, Z.2    Chen, J.3
  • 127
    • 84876097735 scopus 로고    scopus 로고
    • A role for the MRN complex in ATR activation via TOPBP1 recruitment
    • Duursma, A. M.; Driscoll, R.; Elias, J. E.; Cimprich, K. A. A role for the MRN complex in ATR activation via TOPBP1 recruitment. Mol. Cell 2013, 50, 116-122.
    • (2013) Mol. Cell , vol.50 , pp. 116-122
    • Duursma, A.M.1    Driscoll, R.2    Elias, J.E.3    Cimprich, K.A.4
  • 128
    • 84877156564 scopus 로고    scopus 로고
    • The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks
    • Lee, J.; Dunphy, W. G. The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks. Mol. Biol. Cell 2013, 24, 1343-1353.
    • (2013) Mol. Biol. Cell , vol.24 , pp. 1343-1353
    • Lee, J.1    Dunphy, W.G.2
  • 129
    • 0034703330 scopus 로고    scopus 로고
    • Activation of the DNA replication checkpoint through RNA synthesis by primase
    • Michael, W. M.; Ott, R.; Fanning, E.; Newport, J. Activation of the DNA replication checkpoint through RNA synthesis by primase. Science 2000, 289, 2133-2137.
    • (2000) Science , vol.289 , pp. 2133-2137
    • Michael, W.M.1    Ott, R.2    Fanning, E.3    Newport, J.4
  • 130
    • 0037106186 scopus 로고    scopus 로고
    • A requirement for replication in activation of the ATR-dependent DNA damage checkpoint
    • Lupardus, P. J.; Byun, T.; Yee, M. C.; Hekmat-Nejad, M.; Cimprich, K. A. A requirement for replication in activation of the ATR-dependent DNA damage checkpoint. Genes Dev. 2002, 16, 2327-2332.
    • (2002) Genes Dev , vol.16 , pp. 2327-2332
    • Lupardus, P.J.1    Byun, T.2    Yee, M.C.3    Hekmat-Nejad, M.4    Cimprich, K.A.5
  • 131
    • 77951193923 scopus 로고    scopus 로고
    • Continued primer synthesis at stalled replication forks contributes to checkpoint activation
    • Van, C.; Yan, S.; Michael, W. M.; Waga, S.; Cimprich, K. A. Continued primer synthesis at stalled replication forks contributes to checkpoint activation. J. Cell Biol. 2010, 189, 233-246.
    • (2010) J. Cell Biol , vol.189 , pp. 233-246
    • Van, C.1    Yan, S.2    Michael, W.M.3    Waga, S.4    Cimprich, K.A.5
  • 133
    • 0037472924 scopus 로고    scopus 로고
    • DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
    • Bakkenist, C. J.; Kastan, M. B. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 2003, 421, 499-506.
    • (2003) Nature , vol.421 , pp. 499-506
    • Bakkenist, C.J.1    Kastan, M.B.2
  • 134
    • 47949121598 scopus 로고    scopus 로고
    • Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity
    • Jazayeri, A.; Balestrini, A.; Garner, E.; Haber, J. E.; Costanzo, V. Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity. EMBO J. 2008, 27, 1953-1962.
    • (2008) EMBO J , vol.27 , pp. 1953-1962
    • Jazayeri, A.1    Balestrini, A.2    Garner, E.3    Haber, J.E.4    Costanzo, V.5
  • 135
    • 84890043448 scopus 로고    scopus 로고
    • PrimPol breaks replication barriers
    • Helleday, T. PrimPol breaks replication barriers. Nat. Struct. Mol. Biol. 2013, 20, 1348-1350.
    • (2013) Nat. Struct. Mol. Biol , vol.20 , pp. 1348-1350
    • Helleday, T.1
  • 138
    • 84889093850 scopus 로고    scopus 로고
    • hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity
    • Wan, L.; Lou, J.; Xia, Y.; Su, B.; Liu, T.; Cui, J.; Sun, Y.; Lou, H.; Huang, J. hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity. EMBO Rep. 2013, 14, 1104-1112.
    • (2013) EMBO Rep , vol.14 , pp. 1104-1112
    • Wan, L.1    Lou, J.2    Xia, Y.3    Su, B.4    Liu, T.5    Cui, J.6    Sun, Y.7    Lou, H.8    Huang, J.9
  • 142
    • 0034649590 scopus 로고    scopus 로고
    • Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint
    • Hekmat-Nejad, M.; You, Z.; Yee, M. C.; Newport, J. W.; Cimprich, K. A. Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint. Curr. Biol. 2000, 10, 1565-1573.
    • (2000) Curr. Biol , vol.10 , pp. 1565-1573
    • Hekmat-Nejad, M.1    You, Z.2    Yee, M.C.3    Newport, J.W.4    Cimprich, K.A.5
  • 143
    • 42949130159 scopus 로고    scopus 로고
    • Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage
    • Bonilla, C. Y.; Melo, J. A.; Toczyski, D. P. Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage. Mol. Cell 2008, 30, 267-276.
    • (2008) Mol. Cell , vol.30 , pp. 267-276
    • Bonilla, C.Y.1    Melo, J.A.2    Toczyski, D.P.3
  • 144
    • 0035498938 scopus 로고    scopus 로고
    • Two checkpoint complexes are independently recruited to sites of DNA damage in vivo
    • Melo, J. A.; Cohen, J.; Toczyski, D. P. Two checkpoint complexes are independently recruited to sites of DNA damage in vivo. Genes Dev. 2001, 15, 2809-2821.
    • (2001) Genes Dev , vol.15 , pp. 2809-2821
    • Melo, J.A.1    Cohen, J.2    Toczyski, D.P.3
  • 145
    • 45849117573 scopus 로고    scopus 로고
    • Activation of the cellular DNA damage response in the absence of DNA lesions
    • Soutoglou, E.; Misteli, T. Activation of the cellular DNA damage response in the absence of DNA lesions. Science 2008, 320, 1507-1510.
    • (2008) Science , vol.320 , pp. 1507-1510
    • Soutoglou, E.1    Misteli, T.2
  • 146
    • 84858383984 scopus 로고    scopus 로고
    • Colocalization of Mec1 and Mrc1 is sufficient for Rad53 phosphorylation in vivo
    • Berens, T. J.; Toczyski, D. P. Colocalization of Mec1 and Mrc1 is sufficient for Rad53 phosphorylation in vivo. Mol. Biol. Cell 2012, 23, 1058-1067.
    • (2012) Mol. Biol. Cell , vol.23 , pp. 1058-1067
    • Berens, T.J.1    Toczyski, D.P.2
  • 148
    • 0035930537 scopus 로고    scopus 로고
    • Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress
    • Ward, I. M.; Chen, J. Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. J. Biol. Chem. 2001, 276, 47759-47762.
    • (2001) J. Biol. Chem , vol.276 , pp. 47759-47762
    • Ward, I.M.1    Chen, J.2
  • 149
    • 0043092109 scopus 로고    scopus 로고
    • Identification of MCM4 as a target of the DNA replication block checkpoint system
    • Ishimi, Y.; Komamura-Kohno, Y.; Kwon, H. J.; Yamada, K.; Nakanishi, M. Identification of MCM4 as a target of the DNA replication block checkpoint system. J. Biol. Chem. 2003, 278, 24644-24650.
    • (2003) J. Biol. Chem , vol.278 , pp. 24644-24650
    • Ishimi, Y.1    Komamura-Kohno, Y.2    Kwon, H.J.3    Yamada, K.4    Nakanishi, M.5
  • 150
    • 3342925792 scopus 로고    scopus 로고
    • MCM proteins and checkpoint kinases get together at the fork
    • Shechter, D.; Gautier, J. MCM proteins and checkpoint kinases get together at the fork. Proc. Natl. Acad. Sci. USA 2004, 101, 10845-10846.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 10845-10846
    • Shechter, D.1    Gautier, J.2
  • 151
    • 4544339736 scopus 로고    scopus 로고
    • Replication protein A and the Mre11. Rad50. Nbs1 complex co-localize and interact at sites of stalled replication forks
    • Robison, J. G.; Elliott, J.; Dixon, K.; Oakley, G. G. Replication protein A and the Mre11. Rad50. Nbs1 complex co-localize and interact at sites of stalled replication forks. J. Biol. Chem. 2004, 279, 34802-34810.
    • (2004) J. Biol. Chem , vol.279 , pp. 34802-34810
    • Robison, J.G.1    Elliott, J.2    Dixon, K.3    Oakley, G.G.4
  • 152
    • 0028355488 scopus 로고
    • UV light-induced DNA synthesis arrest in HeLa cells is associated with changes in phosphorylation of human single-stranded DNA-binding protein
    • Carty, M. P.; Zernik-Kobak, M.; McGrath, S.; Dixon, K. UV light-induced DNA synthesis arrest in HeLa cells is associated with changes in phosphorylation of human single-stranded DNA-binding protein. EMBO J. 1994, 13, 2114-2123.
    • (1994) EMBO J , vol.13 , pp. 2114-2123
    • Carty, M.P.1    Zernik-Kobak, M.2    McGrath, S.3    Dixon, K.4
  • 153
    • 0033104517 scopus 로고    scopus 로고
    • Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA: DNA-PK complexes
    • Shao, R. G.; Cao, C. X.; Zhang, H.; Kohn, K. W.; Wold, M. S.; Pommier, Y. Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA: DNA-PK complexes. EMBO J. 1999, 18, 1397-1406.
    • (1999) EMBO J , vol.18 , pp. 1397-1406
    • Shao, R.G.1    Cao, C.X.2    Zhang, H.3    Kohn, K.W.4    Wold, M.S.5    Pommier, Y.6
  • 154
    • 84868192373 scopus 로고    scopus 로고
    • Implication of RPA32 phosphorylation in S-phase checkpoint signalling at replication forks stalled with aphidicolin in Xenopus egg extracts
    • Recolin, B.; Maiorano, D. Implication of RPA32 phosphorylation in S-phase checkpoint signalling at replication forks stalled with aphidicolin in Xenopus egg extracts. Biochem. Biophys. Res. Commun. 2012, 427, 785-789.
    • (2012) Biochem. Biophys. Res. Commun , vol.427 , pp. 785-789
    • Recolin, B.1    Maiorano, D.2
  • 155
    • 84867794011 scopus 로고    scopus 로고
    • In vitro analysis of the role of RPA and RPA phosphorylation in ATR-mediated checkpoint signaling
    • Lindsey-Boltz, L. A.; Reardon, J. T.; Wold, M. S.; Sancar, A. In vitro analysis of the role of RPA and RPA phosphorylation in ATR-mediated checkpoint signaling. J. Biol. Chem. 2012, 287, 36123-36131.
    • (2012) J. Biol. Chem , vol.287 , pp. 36123-36131
    • Lindsey-Boltz, L.A.1    Reardon, J.T.2    Wold, M.S.3    Sancar, A.4
  • 157
    • 0032555924 scopus 로고    scopus 로고
    • The Xenopus Chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control in cell-free extracts
    • Kumagai, A.; Guo, Z.; Emami, K. H.; Wang, S. X.; Dunphy, W. G. The Xenopus Chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control in cell-free extracts. J. Cell Biol. 1998, 142, 1559-1569.
    • (1998) J. Cell Biol , vol.142 , pp. 1559-1569
    • Kumagai, A.1    Guo, Z.2    Emami, K.H.3    Wang, S.X.4    Dunphy, W.G.5
  • 158
    • 0037291130 scopus 로고    scopus 로고
    • Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17
    • Lee, J.; Kumagai, A.; Dunphy, W. G. Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17. Mol. Cell 2003, 11, 329-340.
    • (2003) Mol. Cell , vol.11 , pp. 329-340
    • Lee, J.1    Kumagai, A.2    Dunphy, W.G.3
  • 159
    • 69149108736 scopus 로고    scopus 로고
    • Mrc1 phosphorylation in response to DNA replication stress is required for Mec1 accumulation at the stalled fork
    • Naylor, M. L.; Li, J. M.; Osborn, A. J.; Elledge, S. J. Mrc1 phosphorylation in response to DNA replication stress is required for Mec1 accumulation at the stalled fork. Proc. Natl. Acad. Sci. USA 2009, 106, 12765-12770.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 12765-12770
    • Naylor, M.L.1    Li, J.M.2    Osborn, A.J.3    Elledge, S.J.4
  • 160
    • 2342628449 scopus 로고    scopus 로고
    • Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation
    • Lin, S. Y.; Li, K.; Stewart, G. S.; Elledge, S. J. Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation. Proc. Natl. Acad. Sci. USA 2004, 101, 6484-6489.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 6484-6489
    • Lin, S.Y.1    Li, K.2    Stewart, G.S.3    Elledge, S.J.4
  • 161
    • 34147201111 scopus 로고    scopus 로고
    • The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement
    • Unsal-Kacmaz, K.; Chastain, P. D.; Qu, P. P.; Minoo, P.; Cordeiro-Stone, M.; Sancar, A.; Kaufmann, W. K. The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement. Mol. Cell. Biol. 2007, 27, 3131-3142.
    • (2007) Mol. Cell. Biol , vol.27 , pp. 3131-3142
    • Unsal-Kacmaz, K.1    Chastain, P.D.2    Qu, P.P.3    Minoo, P.4    Cordeiro-Stone, M.5    Sancar, A.6    Kaufmann, W.K.7
  • 162
    • 77953697332 scopus 로고    scopus 로고
    • Interaction of human MCM2-7 proteins with TIM, TIPIN and Rb
    • Numata, Y.; Ishihara, S.; Hasegawa, N.; Nozaki, N.; Ishimi, Y. Interaction of human MCM2-7 proteins with TIM, TIPIN and Rb. J. Biochem. 2010, 147, 917-927.
    • (2010) J. Biochem , vol.147 , pp. 917-927
    • Numata, Y.1    Ishihara, S.2    Hasegawa, N.3    Nozaki, N.4    Ishimi, Y.5
  • 164
    • 27644514672 scopus 로고    scopus 로고
    • Roles of replication fork-interacting and Chk1-activating domains from claspin in a DNA replication checkpoint response
    • Lee, J.; Gold, D. A.; Shevchenko, A.; Dunphy, W. G. Roles of replication fork-interacting and Chk1-activating domains from claspin in a DNA replication checkpoint response. Mol. Biol. Cell 2005, 16, 5269-5282.
    • (2005) Mol. Biol. Cell , vol.16 , pp. 5269-5282
    • Lee, J.1    Gold, D.A.2    Shevchenko, A.3    Dunphy, W.G.4
  • 166
    • 0035949568 scopus 로고    scopus 로고
    • Serine-345 is required for Rad3-dependent phosphorylation and function of checkpoint kinase Chk1 in fission yeast
    • Lopez-Girona, A.; Tanaka, K.; Chen, X. B.; Baber, B. A.; McGowan, C. H.; Russell, P. Serine-345 is required for Rad3-dependent phosphorylation and function of checkpoint kinase Chk1 in fission yeast. Proc. Natl. Acad. Sci. USA 2001, 98, 11289-11294.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 11289-11294
    • Lopez-Girona, A.1    Tanaka, K.2    Chen, X.B.3    Baber, B.A.4    McGowan, C.H.5    Russell, P.6
  • 167
    • 0032497529 scopus 로고    scopus 로고
    • A Mec1-and Rad53-dependent checkpoint controls late-firing origins of DNA replication
    • Santocanale, C.; Diffley, J. F. A Mec1-and Rad53-dependent checkpoint controls late-firing origins of DNA replication. Nature 1998, 395, 615-618.
    • (1998) Nature , vol.395 , pp. 615-618
    • Santocanale, C.1    Diffley, J.F.2
  • 168
    • 3242670803 scopus 로고    scopus 로고
    • ATR and ATM regulate the timing of DNA replication origin firing
    • Shechter, D.; Costanzo, V.; Gautier, J. ATR and ATM regulate the timing of DNA replication origin firing. Nat. Cell Biol. 2004, 6, 648-655.
    • (2004) Nat. Cell Biol , vol.6 , pp. 648-655
    • Shechter, D.1    Costanzo, V.2    Gautier, J.3
  • 169
    • 33747432986 scopus 로고    scopus 로고
    • Excess Mcm2-7 license dormant origins of replication that can be used under conditions of replicative stress
    • Woodward, A. M.; Gohler, T.; Luciani, M. G.; Oehlmann, M.; Ge, X.; Gartner, A.; Jackson, D. A.; Blow, J. J. Excess Mcm2-7 license dormant origins of replication that can be used under conditions of replicative stress. J. Cell Biol. 2006, 173, 673-683.
    • (2006) J. Cell Biol , vol.173 , pp. 673-683
    • Woodward, A.M.1    Gohler, T.2    Luciani, M.G.3    Oehlmann, M.4    Ge, X.5    Gartner, A.6    Jackson, D.A.7    Blow, J.J.8
  • 170
    • 37249025795 scopus 로고    scopus 로고
    • Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress
    • Ge, X. Q.; Jackson, D. A.; Blow, J. J. Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress. Genes Dev. 2007, 21, 3331-3341.
    • (2007) Genes Dev , vol.21 , pp. 3331-3341
    • Ge, X.Q.1    Jackson, D.A.2    Blow, J.J.3
  • 171
    • 84858053395 scopus 로고    scopus 로고
    • Replisome stability at defective DNA replication forks is independent of S phase checkpoint kinases
    • De Piccoli, G.; Katou, Y.; Itoh, T.; Nakato, R.; Shirahige, K.; Labib, K. Replisome stability at defective DNA replication forks is independent of S phase checkpoint kinases. Mol. Cell 2012, 45, 696-704.
    • (2012) Mol. Cell , vol.45 , pp. 696-704
    • De Piccoli, G.1    Katou, Y.2    Itoh, T.3    Nakato, R.4    Shirahige, K.5    Labib, K.6
  • 174
    • 0034232093 scopus 로고    scopus 로고
    • Human Cdc25 A inactivation in response to S phase inhibition and its role in preventing premature mitosis
    • Molinari, M.; Mercurio, C.; Dominguez, J.; Goubin, F.; Draetta, G. F. Human Cdc25 A inactivation in response to S phase inhibition and its role in preventing premature mitosis. EMBO Rep. 2000, 1, 71-79.
    • (2000) EMBO Rep , vol.1 , pp. 71-79
    • Molinari, M.1    Mercurio, C.2    Dominguez, J.3    Goubin, F.4    Draetta, G.F.5
  • 176
    • 34250865564 scopus 로고    scopus 로고
    • CDC25 phosphatases in cancer cells: Key players? Good targets?
    • Boutros, R.; Lobjois, V.; Ducommun, B. CDC25 phosphatases in cancer cells: Key players? Good targets? Nat. Rev. Cancer 2007, 7, 495-507.
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 495-507
    • Boutros, R.1    Lobjois, V.2    Ducommun, B.3
  • 177
    • 84887195033 scopus 로고    scopus 로고
    • High Dub3 expression in mouse ESCs couples the G1/S checkpoint to pluripotency
    • Van der Laan, S.; Tsanov, N.; Crozet, C.; Maiorano, D. High Dub3 expression in mouse ESCs couples the G1/S checkpoint to pluripotency. Mol. Cell 2013, 52, 366-379.
    • (2013) Mol. Cell , vol.52 , pp. 366-379
    • Van der Laan, S.1    Tsanov, N.2    Crozet, C.3    Maiorano, D.4
  • 180
    • 84876333995 scopus 로고    scopus 로고
    • Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates
    • Neelsen, K. J.; Zanini, I. M.; Herrador, R.; Lopes, M. Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates. J. Cell Biol. 2013, 200, 699-708.
    • (2013) J. Cell Biol , vol.200 , pp. 699-708
    • Neelsen, K.J.1    Zanini, I.M.2    Herrador, R.3    Lopes, M.4


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