ATM protein physically and functionally interacts with proliferating cell nuclear antigen to regulate DNA synthesis

Journal of Biological Chemistry

Volumn 287, Issue 15, 2012, Pages 12445-12454

  Gamper, Armin M ^a   Choi, Serah ^a   Matsumoto, Yoshihiro ^c   Banerjee, Dibyendu ^c   Tomkinson, Alan E ^c   Bakkenist, Christopher J ^a,b  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF NEW MEXICO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACID REGION; ATAXIA TELANGIECTASIA; BIALLELIC MUTATIONS; C TERMINUS; CELLULAR EXTRACTS; CELLULAR RESPONSE; CO-PRECIPITATES; DNA DAMAGES; DNA DOUBLE STRANDS; DNA POLYMERASE; DNA REPAIR PROCESS; DNA REPLICATIONS; DNA SYNTHESISS; IN-VITRO; KINASE DOMAINS; KINASE INHIBITION; PHYSICAL INTERACTIONS; PROLIFERATING CELL NUCLEAR ANTIGENS; PROTEIN KINASE; SISTER CHROMATID EXCHANGE; STRONG BINDING; TRUNCATION MUTANTS;

AMINO ACIDS; ANTIGENS; BIOSYNTHESIS; CELL PROLIFERATION; DNA; ENZYMES; GENE ENCODING; IONIZING RADIATION; MACHINERY; PROTEINS; RADIATION SHIELDING;

INTERNET PROTOCOLS;

AMINO ACID; ATM PROTEIN; ATR PROTEIN; CYCLINE; DNA; DNA DIRECTED DNA POLYMERASE DELTA; MUTANT PROTEIN; PHOSPHOTRANSFERASE;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DNA REPLICATION; DNA SYNTHESIS INHIBITION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN DEFECT; PROTEIN DNA BINDING; PROTEIN DNA INTERACTION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION;

3' UNTRANSLATED REGIONS; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; BASE SEQUENCE; CELL CYCLE PROTEINS; CELL LINE; DNA; DNA POLYMERASE III; DNA REPAIR; DNA REPLICATION; DNA-BINDING PROTEINS; GENE KNOCKDOWN TECHNIQUES; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MORPHOLINES; PEPTIDE FRAGMENTS; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN-SERINE-THREONINE KINASES; RNA INTERFERENCE; THIOXANTHENES; TUMOR SUPPRESSOR PROTEINS;

ATAXIA TELANGIECTASIA;

EID: 84859483030     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.352310     Document Type: Article

References (35)

1. Lavin, M. F. (2008) Ataxia-telangiectasia. From a rare disorder to a paradigm for cell signalling and cancer. Nat. Rev. Mol. Cell Biol. 9, 759-769
2. Painter, R. B., and Young, B. R. (1980) Radiosensitivity in ataxia-telangiectasia. A new explanation. Proc. Natl. Acad. Sci. U.S.A. 77, 7315-7317
3. Murnane, J. P., and Painter, R. B. (1982) Complementation of the defects of DNA synthesis in irradiated and unirradiated ataxia-telangiectasia cells. Proc. Natl. Acad. Sci. U.S.A. 79, 1960-1963 (Pubitemid 12088548)
4. Cohen, M. M., and Simpson, S. J. (1980) Growth kinetics of ataxia telangiectasia lymphoblastoid cells. Evidence for a prolonged S period. Cytogenet. Cell Genet. 28, 24-33 (Pubitemid 10049525)
5. Cornforth, M. N., and Bedford, J. S. (1985)Onthe nature of a defect in cells from individuals with ataxia-telangiectasia. Science 227, 1589-1591 (Pubitemid 15119467)
6. Riballo, E., Kühne, M., Rief, N., Doherty, A., Smith, G. C., Recio, M. J., Reis, C., Dahm, K., Fricke, A., Krempler, A., Parker, A. R., Jackson, S. P., Gennery, A., Jeggo, P. A., and Löbrich, M. (2004) A pathway of doublestrand break rejoining dependent upon ATM, Artemis, and proteins locating to γ-H2AX foci. Mol. Cell 16, 715-724 (Pubitemid 39586530)
7. Berkovich, E., Monnat, R. J., Jr., and Kastan, M. B. (2007) Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair. Nat. Cell Biol. 9, 683-690 (Pubitemid 47214731)
8. Goodarzi, A. A., Noon, A. T., Deckbar, D., Ziv, Y., Shiloh, Y., Löbrich, M., and Jeggo, P. A. (2008) ATM signaling facilitates repair of DNA doublestrand breaks associated with heterochromatin. Mol. Cell 31, 167-177 (Pubitemid 352001394)
9. Savitsky, K., Bar-Shira, A., Gilad, S., Rotman, G., Ziv, Y., Vanagaite, L., Tagle, D. A., Smith, S., Uziel, T., Sfez, S., Ashkenazi, M., Pecker, I., Frydman, M., Harnik, R., Patanjali, S. R., Simmons, A., Clines, G. A., Sartiel, A., Gatti, R. A., Chessa, L., Sanal, O., Lavin, M. F., Jaspers, N. G., Taylor, A. M., Arlett, C. F., Miki, T., Weissman, S. M., Lovett, M., Collins, F. S., and Shiloh, Y. (1995) A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science 268, 1749-1753
10. Bakkenist, C. J., and Kastan, M. B. (2003) DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421, 499-506 (Pubitemid 36168436)
11. Matsuoka, S., Ballif, B. A., Smogorzewska, A., McDonald, E. R., 3rd, Hurov, K. E., Luo, J., Bakalarski, C. E., Zhao, Z., Solimini, N., Lerenthal, Y., Shiloh, Y., Gygi, S. P., and Elledge, S. J. (2007) ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316, 1160-1166 (Pubitemid 46877472)
12. Olsen, J. V., Vermeulen, M., Santamaria, A., Kumar, C., Miller, M. L., Jensen, L. J., Gnad, F., Cox, J., Jensen, T. S., Nigg, E. A., Brunak, S., and Mann, M. (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signal 3, ra3
13. White, J. S., Choi, S., and Bakkenist, C. J. (2010) Transient ATM kinase inhibition disrupts DNA damage-induced sister chromatid exchange. Sci. Signal 3, ra44
14. Moldovan, G. L., Pfander, B., and Jentsch, S. (2007) PCNA, the maestro of the replication fork. Cell 129, 665-679 (Pubitemid 46802385)
15. Maga, G., and Hubscher, U. (2003) Proliferating cell nuclear antigen (PCNA). A dancer with many partners. J. Cell Sci. 116, 3051-3060 (Pubitemid 37038954)
16. Canman, C. E., Lim, D. S., Cimprich, K. A., Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Kastan, M. B., and Siliciano, J. D. (1998) Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 281, 1677-1679 (Pubitemid 28435584)
17. Fazlieva, R., Spittle, C. S., Morrissey, D., Hayashi, H., Yan, H., and Matsumoto, Y. (2009) Proofreading exonuclease activity of human DNA polymerase δ and its effects on lesion-bypass DNA synthesis. Nucleic Acids Res. 37, 2854-2866
18. Takai, H., Wang, R. C., Takai, K. K., Yang, H., and de Lange, T. (2007) Tel2 regulates the stability of PI3K-related protein kinases. Cell 131, 1248-1259 (Pubitemid 350297416)
19. Lee, J. H., and Paull, T. T. (2004) Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex. Science 304, 93-96
20. Lempiäinen, H., and Halazonetis, T. D. (2009) Emerging common themes in regulation of PIKKs and PI3Ks. EMBO J. 28, 3067-3073
21. Krishna, T. S., Kong, X. P., Gary, S., Burgers, P. M., and Kuriyan, J. (1994) Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA. Cell 79, 1233-1243
22. Gulbis, J. M., Kelman, Z., Hurwitz, J., O'Donnell, M., and Kuriyan, J. (1996) Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA. Cell 87, 297-306 (Pubitemid 26359007)
23. Bruning, J. B., and Shamoo, Y. (2004) Structural and thermodynamic analysis of human PCNA with peptides derived from DNA polymerase-δ p66 subunit and flap endonuclease-1. Structure 12, 2209-2219 (Pubitemid 39593198)
24. Kontopidis, G., Wu, S. Y., Zheleva, D. I., Taylor, P., McInnes, C., Lane, D. P., Fischer, P. M., and Walkinshaw, M. D. (2005) Structural and biochemical studies of human proliferating cell nuclear antigen complexes provide a rationale for cyclin association and inhibitor design. Proc. Natl. Acad. Sci. U.S.A. 102, 1871-1876 (Pubitemid 40261979)
25. Bowman, G. D., O'Donnell, M., and Kuriyan, J. (2004) Structural analysis of a eukaryotic sliding DNA clamp-clamp loader complex. Nature 429, 724-730 (Pubitemid 38833117)
26. Hishiki, A., Hashimoto, H., Hanafusa, T., Kamei, K., Ohashi, E., Shimizu, T., Ohmori, H., and Sato, M. (2009) Structural basis for novel interactions between human translesion synthesis polymerases and proliferating cell nuclear antigen. J. Biol. Chem. 284, 10552-10560
27. Kunkel, T. A., and Burgers, P. M. (2008) Dividing the workload at a eukaryotic replication fork. Trends Cell Biol. 18, 521-527
28. Li, X., Stith, C. M., Burgers, P. M., and Heyer, W. D. (2009) PCNA is required for initiation of recombination-associated DNA synthesis by DNA polymerase δ. Mol. Cell 36, 704-713
29. Lange, S. S., Takata, K., and Wood, R. D. (2011) DNA polymerases and cancer. Nat. Rev. Cancer 11, 96-110
30. Stoimenov, I., and Helleday, T. (2009) PCNA on the crossroad of cancer. Biochem. Soc. Trans. 37, 605-613
31. López de Saro, F. J. (2009) Regulation of interactions with sliding clamps during DNA replication and repair. Curr. Genomics 10, 206-215
32. Fox, J. T., Lee, K. Y., and Myung, K. (2011) Dynamic regulation of PCNA ubiquitylation/deubiquitylation. FEBS Lett. 585, 2780-2785
33. Bergink, S., and Jentsch, S. (2009) Principles of ubiquitin andSUMOmodifications in DNA repair. Nature 458, 461-467
34. Lydeard, J. R., Lipkin-Moore, Z., Sheu, Y. J., Stillman, B., Burgers, P. M., and Haber, J. E. (2010) Break-induced replication requires all essential DNA replication factors except those specific for pre-RC assembly. Genes Dev. 24, 1133-1144
35. Choi, S., Gamper, A. M., White, J. S., and Bakkenist, C. J. (2010) Inhibition of ATM kinase activity does not phenocopy ATM protein disruption: implications for the clinical utility of ATM kinase inhibitors. Cell Cycle 9, 4052-4057