The Dbf4-Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4

Nature

Volumn 463, Issue 7277, 2010, Pages 113-117

  Sheu, Yi Jun ^a   Stillman, Bruce ^a  

^a Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO TERMINAL SERINE THREONINE RICH DOMAIN; CYCLIN DEPENDENT KINASE; DBF4 CDC7 KINASE; DBF4 DEPENDENT PROTEIN KINASE; HYDROXYUREA; MINICHROMOSOME MAINTENANCE PROTEIN 4; MUTANT PROTEIN; PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG;

BACTERIUM; DNA; ENVIRONMENTAL CUE; ENZYME ACTIVITY; GENETIC ANALYSIS; MUTATION;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CONTROLLED STUDY; DNA DAMAGE; DNA REPLICATION; DNA SYNTHESIS; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; EUKARYOTE; GENE MUTATION; NONHUMAN; NULL CELL; PRIORITY JOURNAL;

CELL CYCLE PROTEINS; CELL PROLIFERATION; DNA DAMAGE; DNA-BINDING PROTEINS; G1 PHASE; GENES, ESSENTIAL; HYDROXYUREA; MICROBIAL VIABILITY; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; S PHASE; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE DELETION; SUBSTRATE SPECIFICITY;

EUKARYOTA; SACCHAROMYCES CEREVISIAE;

EID: 73849129578     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature08647     Document Type: Article

References (28)

1. Bell, S. P. & Dutta, A. DNA replication in eukaryotic cells. Annu. Rev. Biochem. 71, 333-374 (2002).
2. Diffley, J. F. Regulation of early events in chromosome replication. Curr. Biol. 14, R778-R786 (2004).
3. Masai, H. & Arai, K. Cdc7 kinase complex: a key regulator in the initiation of DNA replication. J. Cell. Physiol. 190, 287-296 (2002).
4. Sclafani, R. A. Cdc7p-Dbf4p becomes famous in the cell cycle. J. Cell Sci. 113, 2111-2117 (2000).
5. Stillman, B. Cell cycle control of DNA replication. Science 274, 1659-1663 (1996).
6. Tanaka, S. et al. CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast. Nature 445, 328-332 (2007).
7. Zegerman, P. & Diffley, J. F. Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast. Nature 445, 281-285 (2007).
8. Rao, P. N. & Johnson, R. T. Mammalian cell fusion: studies on the regulation of DNA synthesis and mitosis. Nature 225, 159-164 (1970).
9. Forsburg, S. L. Eukaryotic MCM proteins: beyond replication initiation. Microbiol. Mol. Biol. Rev. 68, 109-131 (2004).
10. Laskey, R. A., Fairman, M. P. & Blow, J. J. S phase of the cell cycle. Science 246, 609-614 (1989).
11. Gambus, A. et al. GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks. Nature Cell Biol. 8, 358-366 (2006).
12. Moyer, S. E., Lewis, P. W. & Botchan, M. R. Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase. Proc. Natl Acad. Sci. USA 103, 10236-10241 (2006).
13. Pacek, M., Tutter, A. V., Kubota, Y., Takisawa, H. & Walter, J. C. Localization of MCM2-7, Cdc45, and GINS to the site of DNA unwinding during eukaryotic DNA replication. Mol. Cell 21, 581-587 (2006).
14. Masumoto, H., Muramatsu, S., Kamimura, Y. & Araki, H. S-Cdk-dependent phosphorylation of Sld2 essential for chromosomal DNA replication in budding yeast. Nature 415, 651-655 (2002).
15. Francis, L. I., Randell, J. C., Takara, T. J., Uchima, L. & Bell, S. P. Incorporation into the prereplicative complex activates the Mcm2-7 helicase for Cdc7-Dbf4 phosphorylation. Genes Dev. 23, 643-654 (2009).
16. Hardy, C. F., Dryga, O., Seematter, S., Pahl, P. M. & Sclafani, R. A. mcm5/cdc46-bob1 bypasses the requirement for the S phase activator Cdc7p. Proc. Natl Acad. Sci. USA 94, 3151-3155 (1997).
17. Lei, M. et al. Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis. Genes Dev. 11, 3365-3374 (1997).
18. Sheu, Y. J. & Stillman, B. Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression. Mol. Cell 24, 101-113 (2006).
19. Weinreich, M. & Stillman, B. Cdc7p-Dbf4p kinase binds to chromatin during S phase and is regulated by both the APC and the RAD53 checkpoint pathway. EMBO J. 18, 5334-5346 (1999).
20. Devault, A., Gueydon, E. & Schwob, E. Interplay between S-cyclin-dependent kinase and Dbf4-dependent kinase in controlling DNA replication through phosphorylation of yeast Mcm4 N-terminal domain. Mol. Biol. Cell 19, 2267-2277 (2008).
21. Cho, W. H., Lee, Y. J., Kong, S. I., Hurwitz, J. & Lee, J. K. CDC7 kinase phosphorylates serine residues adjacent to acidic amino acids in the minichromosome maintenance 2 protein. Proc. Natl Acad. Sci. USA 103, 11521-11526 (2006).
22. Montagnoli, A. et al. Identification of Mcm2 phosphorylation sites by S-phaseregulating kinases. J. Biol. Chem. 281, 10281-10290 (2006).
23. Aparicio, O. M., Weinstein, D. M. & Bell, S. P. Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution ofMCMproteins and Cdc45p during S phase. Cell 91, 59-69 (1997).
24. Masai, H. et al. Phosphorylation of MCM4 by Cdc7 kinase facilitates its interaction with Cdc45 on the chromatin. J. Biol. Chem. 281, 39249-39261 (2006).
25. Zou, L. & Stillman, B. Formation of a preinitiation complex by S-phase cyclin CDKdependent loading of Cdc45p onto chromatin. Science 280, 593-596 (1998).
26. Jiang, W., McDonald, D., Hope, T. J. & Hunter, T. Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication. EMBO J. 18, 5703-5713 (1999).
27. Ogi, H., Wang, C. Z., Nakai, W., Kawasaki, Y. & Masumoto, H. The role of the Saccharomyces cerevisiae Cdc7-Dbf4 complex in the replication checkpoint. Gene 414, 32-40 (2008).
28. Shimada, K., Pasero, P. & Gasser, S. M. ORC and the intra-S-phase checkpoint: a threshold regulates Rad53p activation in S phase. Genes Dev. 16, 3236-3252 (2002).