A vertebrate gene, ticrr, is an essential checkpoint and replication regulator

Genes and Development

Volumn 24, Issue 2, 2010, Pages 183-194

  Sansam, Christopher L ^a   Cruz, Nelly M ^a   Danielian, Paul S ^a   Amsterdam, Adam ^a   Lau, Melissa L ^a   Hopkins, Nancy ^a   Lees, Jacqueline A ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

DNA replication; G2 M checkpoint; Pre IC; Pre RC; S M checkpoint; SLD3; TopBP1

Indexed keywords

ANIMAL CELL; ARTICLE; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CHROMATIN; CHROMATIN CONDENSATION; CONTROLLED STUDY; DNA DAMAGE; DNA REPLICATION; GENE; GENE INSERTION; GENE MUTATION; METAZOON; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; TICRR GENE; ZEBRA FISH;

ANIMALS; CARRIER PROTEINS; CHROMATIN; DNA REPLICATION; DNA-BINDING PROTEINS; EMBRYO, NONMAMMALIAN; GENES, CDC; HUMANS; MITOSIS; MUTATION; PHENOTYPE; ZEBRAFISH; ZEBRAFISH PROTEINS;

DANIO RERIO; EUKARYOTA; METAZOA; VERTEBRATA;

EID: 75149162077     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.1860310     Document Type: Article

References (41)

1. Amsterdam A, Nissen RM, Sun Z, Swindell EC, Farrington S, Hopkins N. 2004. Identification of 315 genes essential for early zebrafish development. Proc Natl Acad Sci 101: 12792-12797.
2. Aparicio T, Guillou E, Coloma J, Montoya G, Mendez J. 2009. The human GINS complex associates with Cdc45 and MCM and is essential for DNA replication. Nucleic Acids Res 37: 2087-2095.
3. Austin RJ, Orr-Weaver TL, Bell SP. 1999. Drosophila ORC specifically binds to ACE3, an origin of DNA replication control element. Genes & Dev 13: 2639-2649.
4. Bartek J, Lukas C, Lukas J. 2004. Checking on DNA damage in S phase. Nat Rev Mol Cell Biol 5: 792-804.
5. Bell SP, Dutta A. 2002. DNA replication in eukaryotic cells. Annu Rev Biochem 71: 333-374.
6. Brown EJ, Baltimore D. 2003. Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance. Genes & Dev 17: 615-628.
7. Canman CE. 2001. Replication checkpoint: Preventing mitotic catastrophe. Curr Biol 11: R121-R124. doi: 10.1016/S0960-9822(01)00057-4.
8. DeGregori J, Leone G, Ohtani K, Miron A, Nevins JR. 1995. E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity. Genes & Dev 9: 2873-2887.
9. Delacroix S, Wagner JM, Kobayashi M, Yamamoto K, Karnitz LM. 2007. The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1. Genes & Dev 21: 1472-1477.
10. Furuya K, Poitelea M, Guo L, Caspari T, Carr AM. 2004. Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4TOPBP1. Genes & Dev 18: 1154-1164.
11. Garcia V, Furuya K, Carr AM. 2005. Identification and functional analysis of TopBP1 and its homologs. DNA Repair (Amst) 4: 1227-1239.
12. Harper JW, Elledge SJ. 2007. The DNA damage response: Ten years after. Mol Cell 28: 739-745.
13. Harrison JC, Haber JE. 2006. Surviving the breakup: The DNA damage checkpoint. Annu Rev Genet 40: 209-235.
14. Hashimoto Y, Takisawa H. 2003. Xenopus Cut5 is essential for a CDK-dependent process in the initiation of DNA replication. EMBO J 22: 2526-2535.
15. Hashimoto Y, Tsujimura T, Sugino A, Takisawa H. 2006. The phosphorylated C-terminal domain of Xenopus Cut5 directly mediates ATR-dependent activation of Chk1. Genes Cells 11: 993-1007.
16. Hendzel MJ, Wei Y, Mancini MA, Van Hooser A, Ranalli T, Brinkley BR, Bazett-Jones DP, Allis CD. 1997. Mitosisspecific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation. Chromosoma 106: 348-360.
17. Kamimura Y, Tak YS, Sugino A, Araki H. 2001. Sld3, which interacts with Cdc45 (Sld4), functions for chromosomal DNA replication in Saccharomyces cerevisiae. EMBO J 20: 2097-2107.
18. Katsu Y, Yamashita M, Kajiura H, Nagahama Y. 1993. Behavior of the components of maturation-promoting factor, cdc2 kinase and cyclin B, during oocyte maturation of goldfish. Dev Biol 160: 99-107.
19. Kubota Y, Takase Y, Komori Y, Hashimoto Y, Arata T, Kamimura Y, Araki H, Takisawa H. 2003. A novel ring-like complex of Xenopus proteins essential for the initiation of DNA replication. Genes & Dev 17: 1141-1152.
20. Kumagai A, Lee J, Yoo HY, Dunphy WG. 2006. TopBP1 activates the ATR-ATRIP complex. Cell 124: 943-955.
21. Labib K, Kearsey SE, Diffley JF. 2001. MCM2-7 proteins are essential components of prereplicative complexes that accumulate cooperatively in the nucleus during G1-phase and are required to establish, but not maintain, the S-phase checkpoint. Mol Biol Cell 12: 3658-3667.
22. Lee J, Kumagai A, Dunphy WG. 2007. The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR. J Biol Chem 282: 28036-28044.
23. Matsuno K, Kumano M, Kubota Y, Hashimoto Y, Takisawa H. 2006. The N-terminal noncatalytic region of Xenopus RecQ4 is required for chromatin binding of DNA polymerase a in the initiation of DNA replication. Mol Cell Biol 26: 4843-4852.
24. McFarlane RJ, Carr AM, Price C. 1997. Characterisation of the Schizosaccharomyces pombe rad4/cut5 mutant phenotypes: Dissection of DNA replication and G2 checkpoint control function. Mol Gen Genet 255: 332-340.
25. Mendez J, Stillman B. 2000. Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: Assembly of prereplication complexes in late mitosis. Mol Cell Biol 20: 8602-8612.
26. Michael WM, Ott R, Fanning E, Newport J. 2000. Activation of the DNA replication checkpoint through RNA synthesis by primase. Science 289: 2133-2137.
27. Nghiem P, Park PK, Kim Y, Vaziri C, Schreiber SL. 2001. ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation. Proc Natl Acad Sci 98: 9092-9097.
28. Pozarowski P, Darzynkiewicz Z. 2004. Analysis of cell cycle by flow cytometry. Methods Mol Biol 281: 301-311.
29. Saka Y, Esashi F, Matsusaka T, Mochida S, Yanagida M. 1997. Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1. Genes & Dev 11: 3387-3400.
30. Sansam CL, Shepard JL, Lai K, Ianari A, Danielian PS, Amsterdam A, Hopkins N, Lees JA. 2006. DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint. Genes & Dev 20: 3117-3129.
31. Schmidt U, Wollmann Y, Franke C, Grosse F, Saluz HP, Hanel F. 2008. Characterization of the interaction between the human DNA topoisomerase IIb-binding protein 1 (TopBP1) and the cell division cycle 45 (Cdc45) protein. Biochem J 409: 169-177.
32. Sclafani RA, Holzen TM. 2007. Cell cycle regulation of DNA replication. Annu Rev Genet 41: 237-280.
33. Takayama Y, Kamimura Y, Okawa M, Muramatsu S, Sugino A, Araki H. 2003. GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast. Genes & Dev 17: 1153-1165.
34. Tanaka S, Umemori T, Hirai K, Muramatsu S, Kamimura Y, Araki H. 2007. CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast. Nature 445: 328-332.
35. Tercero JA, Labib K, Diffley JF. 2000. DNA synthesis at individual replication forks requires the essential initiation factor Cdc45p. EMBO J 19: 2082-2093.
36. Van Hatten RA, Tutter AV, Holway AH, Khederian AM, Walter JC, Michael WM. 2002. The Xenopus Xmus101 protein is required for the recruitment of Cdc45 to origins of DNA replication. J Cell Biol 159: 541-547.
37. Yamamoto RR, Axton JM, Yamamoto Y, Saunders RD, Glover DM, Henderson DS. 2000. The Drosophila mus101 gene, which links DNA repair, replication and condensation of heterochromatin in mitosis, encodes a protein with seven BRCA1 C-terminus domains. Genetics 156: 711-721.
38. Yamane K, Wu X, Chen J. 2002. A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival. Mol Cell Biol 22: 555-566.
39. Yan S, Michael WM. 2009. TopBP1 and DNA polymerase-a directly recruit the 9-1-1 complex to stalled DNA replication forks. J Cell Biol 184: 793-804.
40. Yan S, Lindsay HD, Michael WM. 2006. Direct requirement for Xmus101 in ATR-mediated phosphorylation of Claspin bound Chk1 during checkpoint signaling. J Cell Biol 173: 181-186.
41. Zegerman P, Diffley JF. 2007. Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast. Nature 445: 281-285.