The Xenopus Chk1 protein kinase mediates caffeine-sensitive pathway of checkpoint control in cell-free extracts

Journal of Cell Biology

Volumn 142, Issue 6, 1998, Pages 1559-1569

  Kumagai, Akiko ^a   Guo, Zijian ^a   Emami, Katayoon H ^a   Wang, Sophie X ^a   Dunphy, William G ^a  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

14 3 3 proteins; Caffeine; Cdc2; Cdc25; Chk1

Indexed keywords

CAFFEINE; CHECKPOINT KINASE 1; PROTEIN KINASE; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DNA DAMAGE; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SEQUENCE ANALYSIS; XENOPUS;

14-3-3 PROTEINS; AMINO ACID SEQUENCE; ANIMALS; CAFFEINE; CDC25 PHOSPHATASE; CELL CYCLE PROTEINS; CELL EXTRACTS; CELL-FREE SYSTEM; CLONING, MOLECULAR; HUMANS; MITOSIS; MOLECULAR SEQUENCE DATA; OVUM; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORYLATION; PROTEIN KINASES; PROTEINS; SERINE; SIGNAL TRANSDUCTION; TYROSINE 3-MONOOXYGENASE; XENOPUS;

EID: 0032555924     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.142.6.1559     Document Type: Article

References (54)

1. al-Khodairy, F., E. Fotou, K.S. Sheldrick, D.J. Griffiths, A.R. Lehmann, and A.M. Carr. 1994. Identification and characterization of new elements involved in checkpoint and feedback controls in fission yeast. Mol. Biol. Cell. 5:147-160.
2. Bentley, N.J., D.A. Holtzman, G. Flaggs, K.S. Keegan, A. DeMaggio, J.C. Ford, M. Hoekstra, and A.M. Carr. 1996. The Schizosaccharomyces pombe rad3 checkpoint gene. EMBO (Eur. Mol. Biol. Organ.) J. 15:6641-6651.
3. Boddy, M.N., B. Furnari, O. Mondesert, and P. Russell. 1998. Replication checkpoint enforced by kinases Cds1 and Chk1. Science. 280:909-912.
4. Carr, A.M. 1996. Checkpoints take the next step. Science. 271:314-315.
5. Carr, A.M. 1997. Control of cell cycle arrest by the Mec1sc/Rad3sp DNA structure checkpoint pathway. Curr. Opin. Genet. Dev. 7:93-98.
6. Carr, A.M., M. Moudjou, N.J. Bentley, and I.M. Hagan. 1995. The chk1 pathway is required to prevent mitosis following cell-cycle arrest at 'start'. Curr. Biol. 5:1179-1190.
7. Cliby, W.A., C.J. Roberts, K.A. Cimprich, CM. Stringer, J.R. Lamb, S.L. Schreiber, and S.H. Friend. 1998. Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints. EMBO (Eur. Mol. Biol. Organ.) J. 17:159-169.
8. Dasso, M., and J.W. Newport. 1990. Completion of DNA replication is monitored by a feedback system that controls the initiation of mitosis in vitro: studies in Xenopus. Cell. 61:811-823.
9. Dunphy, W.G., and A. Kumagai. 1991. The cdc25 protein contains an intrinsic phosphatase activity. Cell. 67:189-196.
10. Elledge, S.J. 1996. Cell cycle checkpoints: preventing an identity crisis. Science. 274:1664-1672.
11. Featherstone, C., and P. Russell. 1991. Fission yeast p107wee1 mitotic inhibitor is a tyrosine/serine kinase. Nature. 349:808-811.
12. Flaggs, G., A.W. Plug, K.M. Dunks, K.E. Mundt, J.C. Ford, M.R.E. Quiggle, E.M. Taylor, C.H. Westphal, T. Ashley, M.F. Hoekstra, and A.M. Carr. 1997. Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes. Curr. Biol. 7:977-986.
13. Fogarty, P., S.D. Campbell, R. Abu-Shumays, B.S. Phalle, K.R. Yu, G.L. Uy, M.L. Goldberg, and W. Sullivan. 1997. The Drosophila grapes gene is related to checkpoint gene chk1/rad27 and is required for late syncytial division fidelity. Curr. Biol. 7:418-426.
14. Francesconi, S., M. Grenon, D. Bouvier, and G. Baldacci. 1997. p56(chk1) protein kinase is required for the DNA replication checkpoint at 37°C in fission yeast. EMBO (Eur. Mol. Biol. Organ.) J. 16:1332-1341.
15. Furnari, B., N. Rhind, and P. Russell. 1997. Cdc25 mitotic inducer targeted by Chk1 DNA damage checkpoint kinase. Science. 277:1495-1497.
16. Gautier, J., M.J. Solomon, R.N. Booher, J.F. Bazan, and M.W. Kirschner. 1991. cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2. Cell. 67:197-211.
17. Hartwell, L.H., and T.A. Weinert. 1989. Checkpoints: controls that ensure the order of cell cycle events. Science. 246:629-634.
18. Hoffmann, I., P.R. Clarke, M.J. Marcote, E. Karsenti, and G. Draetta. 1993. Phosphorylation and activation of human cdc25-C by cdc2-cyclin B and its involvement in the self-amplification of MPF at mitosis. EMBO (Eur. Mol. Biol. Organ.) J. 12:53-63.
19. Igarashi, M., A. Nagata, S. Jinno, K. Suto, and H. Okayama. 1991. Wee1(+)-like gene in human cells. Nature. 353:80-83.
20. Izumi, T., and J.L. Maller. 1995. Phosphorylation and activation of the Xenopus Cdc25 phosphatase in the absence of Cdc2 and Cdk2 kinase activity. Mol. Biol. Cell. 6:215-226.
21. Izumi, T., D.H. Walker, and J.L. Maller. 1992. Periodic changes in phosphorylation of the Xenopus cdc25 phosphatase regulate its activity. Mol. Biol. Cell. 3:927-939.
22. Keegan, K.S., D.A. Holtzman, A.W. Plug, E.R. Christenson, E.E. Brainerd, G. Flaggs, N.J. Bentley, E.M. Taylor, M.S. Meyn, S.B. Moss, A.M. Carr, T. Ashley, and M.F. Hoekstra. 1996. The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes. Genes Dev. 10: 2423-2437.
23. King, R.W., P.K. Jackson, and M.W. Kirschner. 1994. Mitosis in transition. Cell. 79:563-571.
24. Kumagai, A., and W.G. Dunphy. 1992. Regulation of the cdc25 protein during the cell cycle in Xenopus extracts. Cell. 70:139-151.
25. Kumagai, A., and W.G. Dunphy. 1995. Control of the Cdc2/cyelin B complex in Xenopus egg extracts arrested at a G2/M checkpoint with DNA synthesis inhibitors. Mol. Biol. Cell. 6:199-213.
26. Kumagai, A., and W.G. Dunphy. 1996. Purification and molecular cloning of Plx1, a Cdc25-regulatory kinase from Xenopus egg extracts. Science. 273: 1377-1380.
27. Kumagai, A., P.S. Yakowec, and W.G. Dunphy. 1998. 14-3-3 Proteins act as negative regulators of the mitotic inducer Cdc25 in Xenopus egg extracts. Mol. Biol. Cell. 9:345-354.
28. Morgan, D.O. 1997. Cyclin-dependent kinases: engines, clocks, and microprocessors. Annu. Rev. Cell Dev. Biol. 13:261-291.
29. Mueller, P.R., T.R. Coleman, and W.G. Dunphy. 1995a. Cell cycle regulation of a Xenopus Wee1-like kinase. Mol. Biol. Cell. 6:119-134.
30. Mueller, P.R., T.R. Coleman, A. Kumagai, and W.G. Dunphy. 1995b. Myt1: a membrane-associated inhibitory kinase that phosphorylates Cdc2 on both threonine-14 and tyrosine-15. Science. 270:86-90.
31. Murray, A.W. 1991. Cell cycle extracts. Methods Cell Biol. 36:581-605.
32. Murray, A.W. 1995. The genetics of cell cycle checkpoints. Curr. Opin. Genet. Dev. 5:5-11.
33. Nurse, P. 1997. Checkpoint pathways come of age. Cell. 91:865-867.
34. O'Connell, M.J., J.M. Raleigh, H.M. Verkade, and P. Nurse. 1997. Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation. EMBO (Eur. Mol. Biol. Organ.) J. 16:545-554.
35. Parker, L.L., S. Atherton-Fessler, and H. Piwnica-Worms. 1992. p107weel is a dual-specificity kinase that phosphorylates p34cdc2 on tyrosine 15. Proc. Nat. Acad. Sci. USA. 89:2917-2921.
36. Paulovich, A.G., and L.H. Hartwell. 1995. A checkpoint regulates the rate of progression through S phase in S. cerevisiae in response to DNA damage. Cell. 82:841-847.
37. Peng, C.Y., P.R. Graves, S. Ogg, R.S. Thoma, M.J. Byrnes, Z. Wu, M.T. Stephenson, and H. Piwnica-Worms. 1998. C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding. Cell Growth Differ. 9:197-208.
38. Peng, C.Y., P.R. Graves, R.S. Thoma, Z. Wu, A.S. Shaw, and H. Piwnica-Worms. 1997. Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Science. 277:1501-1505.
39. Poon, R.Y., M.S. Chau, K. Yamashita, and T. Hunter. 1997. The role of Cdc2 feedback loop control in the DNA damage checkpoint in mammalian cells. Cancer Res. 57:5168-5178.
40. Rhind, N., B. Furnari, and P. Russell. 1997. Cdc2 tyrosine phosphorylation is required for the DNA damage checkpoint in fission yeast. Genes Dev. 11:504-511.
41. Saka, Y., F. Esashi, T. Matsusaka, S. Mochida, and M. Yunagida. 1997. Damage and replication checkpoint control in fission yeast is ensured by interactions of crb2, a protein with BKCT motif, with cut5 and chk1. Genes Dev. 11: 3387-3400.
42. Sanchez, Y., B.A. Desany, W.J. Jones, Q. Liu, B. Wang, and S.J. Elledge. 1996. Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways. Science. 271:357-360.
43. Sanchez, Y., C. Wong, R.S. Thoma, R. Richman, Z. Wu, H. Piwnica-Worms, and S.J. Elledge. 1997. Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. Science. 277:1497-1501.
44. Schlegel, R., and A.B. Pardee. 1986. Caffeine-induced uncoupling of mitosis from the completion of DNA replication in mammalian cells. Science. 232: 1264-1266.
45. Sihon, O.C., V.A. Stevenson, and W.E. Theurkauf. 1997. DNA-replication checkpoint control at the Drosophila midblastula transition. Nature. 388:93-97.
46. Smith, D.B., and K.S. Johnson. 1988. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene. 67:31-40.
47. Strausfeld, U., J.C. Labbe, D. Fesquet, J.C. Cavadore, A. Picard, K. Sadhu, P. Russell, and M. Doree. 1991. Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein. Nature. 351: 242-245.
48. Sun, Z., D.S. Fay, F. Marini, M. Foiani, and D.F. Stern. 1996. Spk1/Rad53 is regulated hy Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways. Genes Dev. 10:395-406.
49. Walworth, N., S. Davey, and D. Beach. 1993. Fission yeast chk1 protein kinase links the rad checkpoint pathway to cdc2. Nature. 363:368-371.
50. Walworth, N.C., and R. Bernards. 1996. rad-dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint. Science. 271:353-356.
51. Watanabe, N., M. Broome, and T. Hunter. 1995. Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle. EMBO (Eur. Mol. Biol. Organ.) J. 14:1878-1891.
52. Weinert, T. 1997. A DNA damage checkpoint meets the cell cycle engine. Science. 277:1450-1451.
53. Westphal, C.H. 1997. Aim displays its many talents. Curr. Biol. 7:R789-R792.
54. Yaffe, M.B., K. Rittinger, S. Volinia, P.R. Caron, A. Aitken, H. Leffers, S.J. Gamblin, S.J. Smerdon, and L.C. Cantley. 1997. The structural basis for 14-3-3:phosphopeptide binding specificity. Cell. 91:961-971.