메뉴 건너뛰기




Volumn 8, Issue 1, 2006, Pages 84-90

PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replication

Author keywords

[No Author keywords available]

Indexed keywords

CDC10 DEPENDENT TRANSCRIPT 1 PROTEIN; CELL PROTEIN; CYCLIN DEPENDENT KINASE; CYCLINE; DNA; DNA POLYMERASE; PROTEIN CUL4 DDB1; PROTEIN DDB1; PROTEIN SUBUNIT; SCAFFOLD PROTEIN; UBIQUITIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

EID: 30344455639     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1346     Document Type: Article
Times cited : (265)

References (32)
  • 1
    • 11844273174 scopus 로고    scopus 로고
    • Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts
    • Arias, E.E. & Walter, J.C. Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts. Genes Dev. 19, 114-126 (2005).
    • (2005) Genes Dev. , vol.19 , pp. 114-126
    • Arias, E.E.1    Walter, J.C.2
  • 2
    • 13444249558 scopus 로고    scopus 로고
    • Cdt1 downregulation by proteolysis and geminin inhibition prevents DNA re-replication in Xenopus
    • Li, A. & Blow, J.J. Cdt1 downregulation by proteolysis and geminin inhibition prevents DNA re-replication in Xenopus. EMBO J. 24, 395-404 (2005).
    • (2005) EMBO J. , vol.24 , pp. 395-404
    • Li, A.1    Blow, J.J.2
  • 3
    • 12544258483 scopus 로고    scopus 로고
    • Recombinant Cdt1 induces rereplication of G2 nuclei in Xenopus egg extracts
    • Maiorano, D., Krasinska, L., Lutzmann, M. & Mechali, M. Recombinant Cdt1 induces rereplication of G2 nuclei in Xenopus egg extracts. Curr. Biol. 15, 146-153 (2005).
    • (2005) Curr. Biol. , vol.15 , pp. 146-153
    • Maiorano, D.1    Krasinska, L.2    Lutzmann, M.3    Mechali, M.4
  • 4
    • 7244239295 scopus 로고    scopus 로고
    • Drosophila double-parked is sufficient to induce re-replication during development and is regulated by cyclin E/CDK2
    • Thomer, M., May, N.R., Aggarwal, B.D., Kwok, G. & Calvi, B.R. Drosophila double-parked is sufficient to induce re-replication during development and is regulated by cyclin E/CDK2. Development 131, 4807-4818 (2004).
    • (2004) Development , vol.131 , pp. 4807-4818
    • Thomer, M.1    May, N.R.2    Aggarwal, B.D.3    Kwok, G.4    Calvi, B.R.5
  • 5
    • 14844357222 scopus 로고    scopus 로고
    • Intrinsic nuclear import activity of geminin is essential to prevent re-initiation of DNA replication in Xenopus eggs
    • Yoshida, K., Takisawa, H. & Kubota, Y. Intrinsic nuclear import activity of geminin is essential to prevent re-initiation of DNA replication in Xenopus eggs. Genes Cells 10, 63-73 (2005).
    • (2005) Genes Cells , vol.10 , pp. 63-73
    • Yoshida, K.1    Takisawa, H.2    Kubota, Y.3
  • 6
    • 0037967230 scopus 로고    scopus 로고
    • CUL-4 ubiquitin ligase maintains genome stability by restraining DNA-replication licensing
    • Zhong, W., Feng, H., Santiago, F.E. & Kipreos, E.T. CUL-4 ubiquitin ligase maintains genome stability by restraining DNA-replication licensing. Nature 423, 885-889 (2003).
    • (2003) Nature , vol.423 , pp. 885-889
    • Zhong, W.1    Feng, H.2    Santiago, F.E.3    Kipreos, E.T.4
  • 7
    • 0041885325 scopus 로고    scopus 로고
    • Proliferating cell nuclear antigen (PCNA): A dancer with many partners
    • Maga, G. & Hubscher, U. Proliferating cell nuclear antigen (PCNA): A dancer with many partners. J. Cell Sci. 116, 3051-3060 (2003).
    • (2003) J. Cell Sci. , vol.116 , pp. 3051-3060
    • Maga, G.1    Hubscher, U.2
  • 8
    • 5444274523 scopus 로고    scopus 로고
    • Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage
    • Hu, J., McCall, C.M., Ohta, T. & Xiong, Y. Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage. Nature Cell Biol. 6, 1003-1009 (2004).
    • (2004) Nature Cell Biol. , vol.6 , pp. 1003-1009
    • Hu, J.1    McCall, C.M.2    Ohta, T.3    Xiong, Y.4
  • 9
    • 0031467141 scopus 로고    scopus 로고
    • Initiation of DNA replication in eukaryotic cells
    • Dutta, A. & Bell, S.P. Initiation of DNA replication in eukaryotic cells. Annu. Rev. Cell. Dev. Biol. 13, 293-332 (1997).
    • (1997) Annu. Rev. Cell. Dev. Biol. , vol.13 , pp. 293-332
    • Dutta, A.1    Bell, S.P.2
  • 10
    • 0029807797 scopus 로고    scopus 로고
    • Once and only once upon a time: Specifying and regulating origins of DNA replication in eukaryotic cells
    • Diffley, J.F. Once and only once upon a time: Specifying and regulating origins of DNA replication in eukaryotic cells. Genes Dev. 10, 2819-2830 (1996).
    • (1996) Genes Dev. , vol.10 , pp. 2819-2830
    • Diffley, J.F.1
  • 11
    • 0035147434 scopus 로고    scopus 로고
    • Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin
    • Tada, S., Li, A., Maiorano, D., Mechali, M. & Blow, J.J. Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin. Nature Cell Biol. 3, 107-113 (2001).
    • (2001) Nature Cell Biol. , vol.3 , pp. 107-113
    • Tada, S.1    Li, A.2    Maiorano, D.3    Mechali, M.4    Blow, J.J.5
  • 12
    • 0034704221 scopus 로고    scopus 로고
    • Inhibition of eukaryotic DNA replication by geminin binding to cdt1
    • Wohlschlegel, J.A. et al. Inhibition of eukaryotic DNA replication by geminin binding to cdt1. Science 290, 2309-2312 (2000).
    • (2000) Science , vol.290 , pp. 2309-2312
    • Wohlschlegel, J.A.1
  • 13
    • 0035976980 scopus 로고    scopus 로고
    • The human licensing factor for DNA replication Cdt1 accumulates in G1 and is destabilized after initiation of S-phase
    • Nishitani, H., Taraviras, S., Lygerou, Z. & Nishimoto, T. The human licensing factor for DNA replication Cdt1 accumulates in G1 and is destabilized after initiation of S-phase. J. Biol. Chem. 276, 44905-44911 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 44905-44911
    • Nishitani, H.1    Taraviras, S.2    Lygerou, Z.3    Nishimoto, T.4
  • 14
    • 0242525214 scopus 로고    scopus 로고
    • Radiation-mediated proteolysis of CDT1 by CUL4-ROC1 and CSN complexes constitutes a new checkpoint
    • Higa, L.A., Mihaylov, I.S., Banks, D.P., Zheng, J. & Zhang, H. Radiation-mediated proteolysis of CDT1 by CUL4-ROC1 and CSN complexes constitutes a new checkpoint. Nature Cell Biol. 5, 1008-1015 (2003).
    • (2003) Nature Cell Biol. , vol.5 , pp. 1008-1015
    • Higa, L.A.1    Mihaylov, I.S.2    Banks, D.P.3    Zheng, J.4    Zhang, H.5
  • 15
    • 3042686494 scopus 로고    scopus 로고
    • Rapid degradation of Cdt1 upon UV-induced DNA damage is mediated by SCFSkp2 complex
    • Kondo, T. et al. Rapid degradation of Cdt1 upon UV-induced DNA damage is mediated by SCFSkp2 complex. J. Biol. Chem. 279, 27315-27319 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 27315-27319
    • Kondo, T.1
  • 16
    • 24344446862 scopus 로고    scopus 로고
    • Initiation of DNA replication in xenopus egg extracts
    • Arias, E.E. & Walter, J.C. Initiation of DNA replication in xenopus egg extracts. Front. Biosci. 9, 3029-3045 (2004).
    • (2004) Front. Biosci. , vol.9 , pp. 3029-3045
    • Arias, E.E.1    Walter, J.C.2
  • 18
    • 3142766071 scopus 로고    scopus 로고
    • Proteolysis of DNA replication licensing factor Cdt1 in S-phase is performed independently of geminin through its N-terminal region
    • Nishitani, H., Lygerou, Z. & Nishimoto, T. Proteolysis of DNA replication licensing factor Cdt1 in S-phase is performed independently of geminin through its N-terminal region. J. Biol. Chem. 279, 30807-30816 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 30807-30816
    • Nishitani, H.1    Lygerou, Z.2    Nishimoto, T.3
  • 19
    • 0043234476 scopus 로고    scopus 로고
    • The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation
    • Li, X., Zhao, Q., Liao, R., Sun, P. & Wu, X. The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation. J. Biol. Chem. 278, 30854-30858 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 30854-30858
    • Li, X.1    Zhao, Q.2    Liao, R.3    Sun, P.4    Wu, X.5
  • 20
    • 20744458539 scopus 로고    scopus 로고
    • Degradation of Cdt1 during S phase is Skp2-independent and is required for efficient progression of mammalian cells through S phase
    • Takeda, D.Y., Parvin, J.D. & Dutta, A. Degradation of Cdt1 during S phase is Skp2-independent and is required for efficient progression of mammalian cells through S phase. J. Biol. Chem. 280, 23416-23423 (2005).
    • (2005) J. Biol. Chem. , vol.280 , pp. 23416-23423
    • Takeda, D.Y.1    Parvin, J.D.2    Dutta, A.3
  • 21
    • 0035325263 scopus 로고    scopus 로고
    • Use of peptides from p21 (Waf1/Cip1) to investigate PCNA function in Xenopus egg extracts
    • Mattock, H. et al. Use of peptides from p21 (Waf1/Cip1) to investigate PCNA function in Xenopus egg extracts. Exp. Cell Res. 265, 242-251 (2001).
    • (2001) Exp. Cell Res. , vol.265 , pp. 242-251
    • Mattock, H.1
  • 22
    • 0033582544 scopus 로고    scopus 로고
    • Replication-dependent marking of DNA by PCNA facilitates CAF-1-coupled inheritance of chromatin
    • Shibahara, K. & Stillman, B. Replication-dependent marking of DNA by PCNA facilitates CAF-1-coupled inheritance of chromatin. Cell 96, 575-585 (1999).
    • (1999) Cell , vol.96 , pp. 575-585
    • Shibahara, K.1    Stillman, B.2
  • 23
    • 0037031834 scopus 로고    scopus 로고
    • MCM2-7 complexes bind chromatin in a distributed pattern surrounding ORC in Xenopus egg extracts
    • Edwards, M.C. et al. MCM2-7 complexes bind chromatin in a distributed pattern surrounding ORC in Xenopus egg extracts. J. Biol. Chem. 277, 33049-33057 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 33049-33057
    • Edwards, M.C.1
  • 24
    • 11244351579 scopus 로고    scopus 로고
    • Function and regulation of cullin-RING ubiquitin ligases
    • Petroski, M.D. & Deshaies, R.J. Function and regulation of cullin-RING ubiquitin ligases. Natuer Rev. Mol. Cell Biol. 6, 9-20 (2005).
    • (2005) Natuer Rev. Mol. Cell Biol. , vol.6 , pp. 9-20
    • Petroski, M.D.1    Deshaies, R.J.2
  • 26
    • 0034679597 scopus 로고    scopus 로고
    • Two modes of FEN1 binding to PCNA regulated by DNA
    • Gomes, X.V. & Burgers, P.M. Two modes of FEN1 binding to PCNA regulated by DNA. EMBO J. 19, 3811-3821 (2000).
    • (2000) EMBO J. , vol.19 , pp. 3811-3821
    • Gomes, X.V.1    Burgers, P.M.2
  • 27
    • 27144493016 scopus 로고    scopus 로고
    • The origin binding protein Double parked, and its inhibitor geminin, increase in response to replication stress
    • May, N.R., Thorner, M., Murnen, K.F. & Calvi, B.R. The origin binding protein Double parked, and its inhibitor geminin, increase in response to replication stress. J. Cell Sci. 108, 4207-4717 (2005).
    • (2005) J. Cell Sci. , vol.108 , pp. 4207-4717
    • May, N.R.1    Thorner, M.2    Murnen, K.F.3    Calvi, B.R.4
  • 28
    • 27444433046 scopus 로고    scopus 로고
    • Proliferating cell nuclear antigen recruits cyclin-dependent kinase inhibitor Xic1 to DNA and couples its proteolysis to DNA polymerase switching
    • Chuang, L.C. & Yew, P.R. Proliferating cell nuclear antigen recruits cyclin-dependent kinase inhibitor Xic1 to DNA and couples its proteolysis to DNA polymerase switching. J. Biol. Chem. 280, 35299-35309 (2005).
    • (2005) J. Biol. Chem. , vol.280 , pp. 35299-35309
    • Chuang, L.C.1    Yew, P.R.2
  • 29
    • 2342442851 scopus 로고    scopus 로고
    • Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation
    • Liu, E., Li, X., Yan, F., Zhao, Q. & Wu, X. Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation. J. Biol. Chem. 279, 17283-17288 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 17283-17288
    • Liu, E.1    Li, X.2    Yan, F.3    Zhao, Q.4    Wu, X.5
  • 30
    • 14844288292 scopus 로고    scopus 로고
    • Protein associations in DnaA-ATP hydrolysis mediated by the Hda-replicase clamp complex
    • Su'etsugu, M., Shimuta, T.R., Ishida, T., Kawakami, H. & Katayama, T. Protein associations in DnaA-ATP hydrolysis mediated by the Hda-replicase clamp complex. J. Biol. Chem. 280, 6528-6536 (2005).
    • (2005) J. Biol. Chem. , vol.280 , pp. 6528-6536
    • Su'etsugu, M.1    Shimuta, T.R.2    Ishida, T.3    Kawakami, H.4    Katayama, T.5
  • 31
    • 0033936230 scopus 로고    scopus 로고
    • Central role for cdc45 in establishing an initiation complex of DNA replication in Xenopus egg extracts
    • Mimura, S., Masuda, T., Matsui, T. & Takisawa, H. Central role for cdc45 in establishing an initiation complex of DNA replication in Xenopus egg extracts. Genes Cells 5, 439-452 (2000).
    • (2000) Genes Cells , vol.5 , pp. 439-452
    • Mimura, S.1    Masuda, T.2    Matsui, T.3    Takisawa, H.4
  • 32
    • 0032015702 scopus 로고    scopus 로고
    • Regulated chromosomal DNA replication in the absence of a nucleus
    • Walter, J., Sun, L. & Newport, J. Regulated chromosomal DNA replication in the absence of a nucleus. Mol. Cell 1, 519-529 (1998).
    • (1998) Mol. Cell , vol.1 , pp. 519-529
    • Walter, J.1    Sun, L.2    Newport, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.