CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast

Nature

Volumn 445, Issue 7125, 2007, Pages 328-332

  Tanaka, Seiji ^a,b,c   Umemori, Toshiko ^a,c   Hirai, Kazuyuki ^a,c   Muramatsu, Sachiko ^a   Kamimura, Yoichiro ^a,b,c,d   Araki, Hiroyuki ^a,b,c  

^a NATIONAL INSTITUTE OF GENETICS   (Japan)

^b GRADUATE UNIVERSITY FOR ADVANCED STUDIES   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; DNA;

ALLELE; DNA; EUKARYOTE; PROTEIN; SUBSTRATE; YEAST;

ALLELE; ARTICLE; BINDING SITE; BUDDING; CARBOXY TERMINAL SEQUENCE; CHROMOSOME REPLICATION; CONTROLLED STUDY; DNA REPLICATION; EUKARYOTE; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; YEAST;

EUKARYOTA; SACCHAROMYCES CEREVISIAE; SACCHAROMYCETALES;

EID: 33846330909     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature05465     Document Type: Article

References (29)

1. Schwob, E. & Labib, K. Regulating initiation events in yeasts. In DNA Replication and Human Disease 295-311 (Cold Spring Harbor Press, New York, 2006).
2. Kamimura, Y., Masumoto, H., Sugino, A. & Araki, H. Sld2, which interacts with Dpb11 in Saccharomyces cerevisiae, is required for chromosomal DNA replication. Mol. Cell. Biol. 18, 6102-6109 (1998).
3. Masumoto, H., Muramatsu, S., Kamimura, Y. & Araki, H. S-Cdk-dependent phosphorylation of Sld2 essential for chromosomal DNA replication in budding yeast. Nature 415, 651-655 (2002).
4. Tak, Y. S., Tanaka, Y., Endo, S., Kamimura, Y. & Araki, H. A CDK-catalysed regulatory phosphorylation for formation of the DNA replication complex Sld2-Dpb11. EMBO J. 25, 1987-1996 (2006).
5. Kamimura, Y., Tak, Y. S., Sugino, A. & Araki, H. Sld3, which interacts with Cdc45 (Sld4), functions for chromosomal DNA replication in Saccharomyces cerevisiae. EMBO J. 20, 2097-2107 (2001).
6. Diffley, J. F. X. Regulation of early events in chromosome replication. Curr. Biol. 14, R778-R786 (2004).
7. Blow, J. J. & Dutta, A. Preventing re-replication of chromosomal DNA. Nature Rev. Mol. Cell Biol. 6, 476-486 (2005).
8. Sivaprasad, U., Dutta, A. & Bell, S. P. Assembly of pre-replication complexes. In DNA Replication and Human Disease 63-88 (Cold Spring Harbor Press, New York, 2006).
9. Bell, S. P. & Dutta, A. DNA replication in eukaryotic cells. Annu. Rev. Biochem. 71, 333-374 (2002).
10. Kearsey, S. E. & Cotterill, S. Enigmatic variations: divergent modes of regulating eukaryotic DNA replication. Mol. Cell 12, 1067-1075 (2003).
11. Mendez, J. & Stillman, B. Perpetuating the double helix: molecular machines at eukaryotic DNA replication origins. Bioessays 25, 1158-1167 (2003).
12. Walter, J. C. & Araki, H. Activation of pre-replication complexes. In DNA Replication and Human Disease 89-104 (Cold Spring Harbor Press, New York, 2006).
13. Kanemaki, M. & Labib, K. Distinct roles for Sld3 and GINS during establishment and progression of eukaryotic DNA replication forks. EMBO J. 25, 1753-1763 (2006).
14. Nguyen, V. Q., Co, C. & Li, J. J. Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms. Nature 411, 1068-1073 (2001).
15. Mendenhall, M. D. & Hodge, A. E. Regulation of Cdc28 cyclin-dependent protein kinase activity during the cell cycle of the yeast Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev. 62, 1191-1243 (1998).
16. Araki, H., Leem, S. H., Phongdara, A. & Sugino, A. Dpb11, which interacts with DNA polymerase II (ε) in Saccharomyces cerevisiae, has a dual role in S-phase progression and at a cell cycle checkpoint. Proc. Natl Acad. Sci. USA 92, 11791-11795 (1995).
17. Glover, J. N., Williams, R. S. & Lee, M. S. Interactions between BRCT repeats and phosphoproteins: tangled up in two. Trends Biochem. Sci. 29, 579-585 (2004).
18. Zegerman, P. & Diffley, J. F. X. Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast. Nature advance online publication doi:10.1038/nature05432 (13 December 2006).
19. Labib, K., Diffley, J. F. & Kearsey, S. E. G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus. Nature Cell Biol. 1, 415-422 (1999).
20. Bishop, A. C. et al. A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature 407, 395-401 (2000).
21. Masai, H. & Arai, K. Cdc7 kinase complex: a key regulator in the initiation of DNA replication. J. Cell. Physiol. 190, 287-296 (2002).
22. Pacek, M., Tutter, A. V., Kubota, Y., Takisawa, H. & Walter, J. C. Localization of MCM2-7, Cdc45, and GINS to the site of DNA unwinding during eukaryotic DNA replication. Mol. Cell 21, 581-587 (2006).
23. Gambus, A. et al. GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks. Nature Cell Biol. 8, 358-366 (2006).
24. Moyer, S. E., Lewis, P. W. & Botchan, M. R. Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase. Proc. Natl Acad. Sci. USA 103, 10236-10241 (2006).
25. Brewer, B. J. & Fangman, W. L. The localization of replication origins on ARS plasmids in S. cerevisiae. Cell 51, 463-471 (1987).
26. Takayama, Y. et al. GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast. Genes Dev. 17, 1153-1165 (2003).
27. Masumoto, H., Sugino, A. & Araki, H. Dpb11 controls the association between DNA polymerases α and ε and the autonomously replicating sequence region of budding yeast. Mol. Cell. Biol. 20, 2809-2817 (2000).
28. Edwards, S. et al. Saccharomyces cerevisiae DNA polymerase ε and polymerase σ interact physically and functionally, suggesting a role for polymerase ε in sister chromatid cohesion. Mol. Cell. Biol. 23, 2733-2748 (2003).
29. Garcia, V., Furuya, K. & Carr, A. M. Identification and functional analysis of TopBP1 and its homologs. DNA Repair (Amst.) 4, 1227-1239 (2005).