The Cdt1 protein is required to license DNA for replication in fission yeast

Nature

Volumn 404, Issue 6778, 2000, Pages 625-628

  Nishitani, Hideo ^a,b   Lygerou, Zoi ^a,c   Nishimoto, Takeharu ^b   Nurse, Paul ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b KYUSHU UNIVERSITY   (Japan)

^c UNIVERSITY OF PATRAS   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; DNA; PROTEIN;

ARTICLE; DNA REPLICATION; DNA SYNTHESIS; NONHUMAN; PRIORITY JOURNAL; YEAST;

CELL CYCLE; CELL CYCLE PROTEINS; CELL NUCLEUS; CHROMATIN; DNA REPLICATION; DNA, FUNGAL; DNA-BINDING PROTEINS; FUNGAL PROTEINS; PROTEIN BINDING; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS;

EUKARYOTA; METAZOA; SCHIZOSACCHAROMYCES POMBE;

EID: 0034611749     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35007110     Document Type: Article

References (25)

1. Blow, J. J. & Laskey, R. A. A role for the nuclear envelope in controlling DNA replication within the cell cycle. Nature 332, 546-548 (1988).
2. Kubota, Y., Mimura, S., Nishimoto, S., Takisawa, H. & Nojima, H. Identification of the yeast MCM3-related protein as a component of Xenopus DNA replication licensing factor. Cell 81, 601-609 (1995).
3. Chong, J., Mahbubani, H., Khoo, C. & Blow, J. Purification of an MCM-containing complex as a component of the DNA replication licensing system. Nature 375, 418-421 (1995).
4. Madine, M., Khoo, C., Mills, A. D. & Laskey, R. A. MCM3 complex required for cell cycle regulation of DNA replication in vertebrate cells. Nature 375, 421-424 (1995).
5. Rowles, A. et al. Interaction between the origin recognition complex and the replication licensing system in Xenopus. Cell 87, 287-296 (1996).
6. Coleman, T. R., Carpenter, P. B. & Dunphy, W. G. The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts. Cell 87, 53-63 (1996).
7. Donovan, S., Harwood, J., Drury, L. S. & Diffley, J. F. Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast. Proc. Natl Acad. Sci. USA 94, 5611-5616 (1997).
8. Liang, C. & Stillman, B. Persistent initiation of DNA replication and chromatin-bound MCM proteins during the cell cycle in cdc6 mutants. Genes Dev. 11, 3375-3386 (1997).
9. Aparicio, O. M., Weinstein, D. M. & Bell, S. P. Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phase. Cell 91, 59-69 (1997).
10. Tanaka, T., Knapp, D. & Nasmyth, K. Loading of an Mcm protein onto DNA replication origins is regulated by Cdc6p and CDKs. Cell 90, 649-660 (1997).
11. Kelly, T. J. et al. The fission yeast cdc18 gene product couples S-phase to start and mitosis. Cell 74, 371-382 (1993).
12. cdc18 plays a major role controlling the initiation of DNA replication in fission yeast. Cell 83, 397-405 (1995).
13. Tada, S., Chong, J. P. J., Mahbubani, H. M. & Blow, J. J. The RLF-B component of the replication licensing system is distinct from Cdc6 and functions after Cdc6 binds to chromatin. Curr. Biol. 9, 211-214 (1999).
14. Hofmann, J. F. X. & Beach, D. cdc1 is an essential target of the Cdc10/Sct1 transcription factor: requirement for DNA replication and inhibition of mitosis. EMBO J. 13, 425-434 (1994).
15. Dutta, A. & Bell, S. P. Initiation of DNA replication in eukaryotic cells. Annu. Rev. Cell. Dev. Biol. 13, 293-332 (1997).
16. Muzi-Falconi, M. & Kelly, T. J. Orp1, a member of the Cdc18/Cdc6 family of S-phase regulators, is homologous to a component of the origin recognition complex. Proc. Natl Acad. Sci. USA 92, 12475-12479 (1995).
17. Grallert, B. & Nurse, P. The ORC1 homologue orp1 in fission yeast plays a key role in regulating onset of S phase. Genes Dev. 10, 2644-2654 (1996).
18. Masai, H., Miyake, T. & Arai, K. hsk1+, a Schizosaccharomyces pombe gene related to Saccharomyces cerevisiae CDC7, is required for chromosomal replication. EMBO J. 14, 3094-3104 (1995).
19. Fernandez-Sarabia, M., McInerny, C., Harris, P., Gordon, C. & Fantes, P. The cell cycle genes cdc22 and suc22 of the fission yeast Schizosaccharomyces pombe encode the large and small subunits of ribonucleotide reductase. Mol. Gen. Genet. 238, 241-251 (1993).
20. Greenwood, E., Nishitani, H. & Nurse, P. Cdc18p can block mitosis by two independent mechanisms. J. Cell Sci. 111, 3101-3108 (1998).
21. + regulates initiation of DNA replication in Schizosaccharomyces pombe. Proc. Natl Acad. Sci. USA 93, 1566-1570 (1996).
22. Maiorano, D., van Assendelft, G. B. & Kearsey, S. E. Fission yeast cdc21, a member of the MCM protein family, is required for onset of S phase and is located in the nucleus throughout the cell cycle. EMBO J. 15, 861-872 (1996).
23. Lygerou, Z. & Nurse, P. The fission yeast origin recognition complex is constitutively associated with chromatin and is differentially modified through the cell cycle. J. Cell Sci. 112, 3703-3712 (1999).
24. Moreno, S., Klar, A. & Nurse, P. Molecular genetic analysis of fission yeast Schizosaccharomyces pombe. Methods Enzymol. 194, 795-823 (1991).
25. Alfa, C., Fantes, P., Hyams, J., McLeod, M. & Warbrick, E. Experiments with Fission Yeast - A Laboratory Course Manual (CSHL Press, New York, 1993).