메뉴 건너뛰기




Volumn 12, Issue 10, 2013, Pages 791-799

Interplays between ATM/Tel1 and ATR/Mec1 in sensing and signaling DNA double-strand breaks

Author keywords

ATM Tel1; ATR Mec1; Checkpoint; DNA double strand breaks; MRN MRX; Resection

Indexed keywords

ATM PROTEIN; ATR PROTEIN; DOUBLE STRANDED DNA;

EID: 84885369839     PISSN: 15687864     EISSN: 15687856     Source Type: Journal    
DOI: 10.1016/j.dnarep.2013.07.009     Document Type: Review
Times cited : (80)

References (131)
  • 1
    • 77953229115 scopus 로고    scopus 로고
    • The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway
    • Lieber M.R. The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annual Review of Biochemistry 2010, 79:181-211.
    • (2010) Annual Review of Biochemistry , vol.79 , pp. 181-211
    • Lieber, M.R.1
  • 3
    • 78649336706 scopus 로고    scopus 로고
    • The DNA damage response: making it safe to play with knives
    • Ciccia A., Elledge S.J. The DNA damage response: making it safe to play with knives. Molecular Cell 2010, 40:179-204.
    • (2010) Molecular Cell , vol.40 , pp. 179-204
    • Ciccia, A.1    Elledge, S.J.2
  • 4
    • 0028827312 scopus 로고
    • The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species
    • Savitsk K., Sfez S., Tagle D.A., Ziv Y., Sartiel A., Collins F.S., Shiloh Y., Rotman G. The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species. Human Molecular Genetics 1995, 4:2025-2032.
    • (1995) Human Molecular Genetics , vol.4 , pp. 2025-2032
    • Savitsk, K.1    Sfez, S.2    Tagle, D.A.3    Ziv, Y.4    Sartiel, A.5    Collins, F.S.6    Shiloh, Y.7    Rotman, G.8
  • 5
    • 0345073699 scopus 로고    scopus 로고
    • A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome
    • O'Driscoll M., Ruiz-Perez V.L., Woods C.G., Jeggo P.A., Goodship J.A. A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome. Nature Genetics 2003, 33:497-501.
    • (2003) Nature Genetics , vol.33 , pp. 497-501
    • O'Driscoll, M.1    Ruiz-Perez, V.L.2    Woods, C.G.3    Jeggo, P.A.4    Goodship, J.A.5
  • 6
    • 4544281398 scopus 로고    scopus 로고
    • Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins
    • Lisby M., Barlow J.H., Burgess R.C., Rothstein R. Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins. Cell 2004, 118:699-713.
    • (2004) Cell , vol.118 , pp. 699-713
    • Lisby, M.1    Barlow, J.H.2    Burgess, R.C.3    Rothstein, R.4
  • 7
    • 0035930342 scopus 로고    scopus 로고
    • Promotion of Dnl4-catalyzed DNA end-joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 complexes
    • Chen L., Trujillo K., Ramos W., Sung P., Tomkinson A.E. Promotion of Dnl4-catalyzed DNA end-joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 complexes. Molecular Cell 2001, 8:1105-1115.
    • (2001) Molecular Cell , vol.8 , pp. 1105-1115
    • Chen, L.1    Trujillo, K.2    Ramos, W.3    Sung, P.4    Tomkinson, A.E.5
  • 9
    • 61849109768 scopus 로고    scopus 로고
    • Recruitment of Saccharomyces cerevisiae Dnl4-Lif1 complex to a double-strand break requires interactions with Yku80 and the Xrs2 FHA domain
    • Palmbos P.L., Wu D., Daley J.M., Wilson T.E. Recruitment of Saccharomyces cerevisiae Dnl4-Lif1 complex to a double-strand break requires interactions with Yku80 and the Xrs2 FHA domain. Genetics 2008, 180:1809-1819.
    • (2008) Genetics , vol.180 , pp. 1809-1819
    • Palmbos, P.L.1    Wu, D.2    Daley, J.M.3    Wilson, T.E.4
  • 11
    • 0028212415 scopus 로고
    • Mutations in XRS2 and RAD50 delay but do not prevent mating-type switching in Saccharomyces cerevisiae
    • Ivanov E.L., Sugawara N., White C.I., Fabre F., Haber J.E. Mutations in XRS2 and RAD50 delay but do not prevent mating-type switching in Saccharomyces cerevisiae. Molecular and Cellular Biology 1994, 14:3414-3425.
    • (1994) Molecular and Cellular Biology , vol.14 , pp. 3414-3425
    • Ivanov, E.L.1    Sugawara, N.2    White, C.I.3    Fabre, F.4    Haber, J.E.5
  • 12
    • 33644691699 scopus 로고    scopus 로고
    • The Saccharomyces cerevisiae Sae2 protein promotes resection and bridging of double strand break ends
    • Clerici M., Mantiero D., Lucchini G., Longhese M.P. The Saccharomyces cerevisiae Sae2 protein promotes resection and bridging of double strand break ends. Journal of Biological Chemistry 2005, 280:38631-38638.
    • (2005) Journal of Biological Chemistry , vol.280 , pp. 38631-38638
    • Clerici, M.1    Mantiero, D.2    Lucchini, G.3    Longhese, M.P.4
  • 14
    • 0032085295 scopus 로고    scopus 로고
    • The 3' to 5' exonuclease activity of Mre11 facilitates repair of DNA double-strand breaks
    • Paull T.T., Gellert M. The 3' to 5' exonuclease activity of Mre11 facilitates repair of DNA double-strand breaks. Molecular Cell 1998, 1:969-979.
    • (1998) Molecular Cell , vol.1 , pp. 969-979
    • Paull, T.T.1    Gellert, M.2
  • 15
    • 0032555480 scopus 로고    scopus 로고
    • Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95
    • Trujillo K.M., Yuan S.S., Lee E.Y., Sung P. Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95. Journal of Biological Chemistry 1998, 273:21447-21450.
    • (1998) Journal of Biological Chemistry , vol.273 , pp. 21447-21450
    • Trujillo, K.M.1    Yuan, S.S.2    Lee, E.Y.3    Sung, P.4
  • 16
    • 53649104599 scopus 로고    scopus 로고
    • Sae2, Exo1, Sgs1 collaborate in DNA double-strand break processing
    • Mimitou E.P., Symington L.S. Sae2, Exo1, Sgs1 collaborate in DNA double-strand break processing. Nature 2008, 455:770-774.
    • (2008) Nature , vol.455 , pp. 770-774
    • Mimitou, E.P.1    Symington, L.S.2
  • 17
    • 51549095956 scopus 로고    scopus 로고
    • Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends
    • Zhu Z., Chung W.H., Shim E.Y., Lee S.E., Ira G. Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends. Cell 2008, 134:981-994.
    • (2008) Cell , vol.134 , pp. 981-994
    • Zhu, Z.1    Chung, W.H.2    Shim, E.Y.3    Lee, S.E.4    Ira, G.5
  • 18
    • 36248942617 scopus 로고    scopus 로고
    • Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex
    • Lengsfeld B.M., Rattray A.J., Bhaskara V., Ghirlando R., Paull T.T. Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex. Molecular Cell 2007, 28:638-651.
    • (2007) Molecular Cell , vol.28 , pp. 638-651
    • Lengsfeld, B.M.1    Rattray, A.J.2    Bhaskara, V.3    Ghirlando, R.4    Paull, T.T.5
  • 19
    • 34948872046 scopus 로고    scopus 로고
    • Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination
    • Limbo O., Chahwan C., Yamada Y., de Bruin R.A., Wittenberg C., Russell P. Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination. Molecular Cell 2007, 28:134-146.
    • (2007) Molecular Cell , vol.28 , pp. 134-146
    • Limbo, O.1    Chahwan, C.2    Yamada, Y.3    de Bruin, R.A.4    Wittenberg, C.5    Russell, P.6
  • 21
    • 53349162987 scopus 로고    scopus 로고
    • CDK targets Sae2 to control DNA-end resection and homologous recombination
    • Huertas P., Cortes-Ledesma F., Sartori A.A., Aguilera A., Jackson S.P. CDK targets Sae2 to control DNA-end resection and homologous recombination. Nature 2008, 455:689-692.
    • (2008) Nature , vol.455 , pp. 689-692
    • Huertas, P.1    Cortes-Ledesma, F.2    Sartori, A.A.3    Aguilera, A.4    Jackson, S.P.5
  • 22
    • 43149118369 scopus 로고    scopus 로고
    • Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair
    • Chen L., Nievera C.J., Lee A.Y., Wu X. Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair. Journal of Biological Chemistry 2008, 283:7713-7720.
    • (2008) Journal of Biological Chemistry , vol.283 , pp. 7713-7720
    • Chen, L.1    Nievera, C.J.2    Lee, A.Y.3    Wu, X.4
  • 23
    • 66149114020 scopus 로고    scopus 로고
    • Human CtIP mediates cell cycle control of DNA end resection and double strand break repair
    • Huertas P., Jackson S.P. Human CtIP mediates cell cycle control of DNA end resection and double strand break repair. Journal of Biological Chemistry 2009, 284:9558-9565.
    • (2009) Journal of Biological Chemistry , vol.284 , pp. 9558-9565
    • Huertas, P.1    Jackson, S.P.2
  • 24
    • 67349246802 scopus 로고    scopus 로고
    • CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle
    • Yun M.H., Hiom K. CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle. Nature 2009, 459:460-463.
    • (2009) Nature , vol.459 , pp. 460-463
    • Yun, M.H.1    Hiom, K.2
  • 25
    • 11244269445 scopus 로고    scopus 로고
    • The CDK regulates repair of double-strand breaks by homologous recombination during the cell cycle
    • Aylon Y., Liefshitz B., Kupiec M. The CDK regulates repair of double-strand breaks by homologous recombination during the cell cycle. EMBO Journal 2004, 23:4868-4875.
    • (2004) EMBO Journal , vol.23 , pp. 4868-4875
    • Aylon, Y.1    Liefshitz, B.2    Kupiec, M.3
  • 28
    • 0032476658 scopus 로고    scopus 로고
    • Distinct roles of two separable in vitro activities of yeast Mre11 in mitotic and meiotic recombination
    • Furuse M., Nagase Y., Tsubouchi H., Murakami-Murofushi K., Shibata T., Ohta K. Distinct roles of two separable in vitro activities of yeast Mre11 in mitotic and meiotic recombination. EMBO Journal 1998, 17:6412-6425.
    • (1998) EMBO Journal , vol.17 , pp. 6412-6425
    • Furuse, M.1    Nagase, Y.2    Tsubouchi, H.3    Murakami-Murofushi, K.4    Shibata, T.5    Ohta, K.6
  • 29
    • 0031983191 scopus 로고    scopus 로고
    • A novel mre11 mutation impairs processing of double-strand breaks of DNA during both mitosis and meiosis
    • Tsubouchi H., Ogawa H. A novel mre11 mutation impairs processing of double-strand breaks of DNA during both mitosis and meiosis. Molecular and Cellular Biology 1998, 18:260-268.
    • (1998) Molecular and Cellular Biology , vol.18 , pp. 260-268
    • Tsubouchi, H.1    Ogawa, H.2
  • 30
    • 0032567108 scopus 로고    scopus 로고
    • Complex formation and functional versatility of Mre11 of budding yeast in recombination
    • Usui T., Ohta T., Oshiumi H., Tomizawa J., Ogawa H., Ogawa T. Complex formation and functional versatility of Mre11 of budding yeast in recombination. Cell 1998, 95:705-716.
    • (1998) Cell , vol.95 , pp. 705-716
    • Usui, T.1    Ohta, T.2    Oshiumi, H.3    Tomizawa, J.4    Ogawa, H.5    Ogawa, T.6
  • 31
    • 0032931844 scopus 로고    scopus 로고
    • The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance
    • Moreau S., Ferguson J.R., Symington L.S. The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance. Molecular and Cellular Biology 1999, 19:556-566.
    • (1999) Molecular and Cellular Biology , vol.19 , pp. 556-566
    • Moreau, S.1    Ferguson, J.R.2    Symington, L.S.3
  • 32
    • 0037169325 scopus 로고    scopus 로고
    • The Mre11 complex is required for repair of hairpin-capped double-strand breaks and prevention of chromosome rearrangements
    • Lobachev K.S., Gordenin D.A., Resnick M.A. The Mre11 complex is required for repair of hairpin-capped double-strand breaks and prevention of chromosome rearrangements. Cell 2002, 108:183-193.
    • (2002) Cell , vol.108 , pp. 183-193
    • Lobachev, K.S.1    Gordenin, D.A.2    Resnick, M.A.3
  • 36
    • 77957786786 scopus 로고    scopus 로고
    • Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks
    • Shim E.Y., Chung W.H., Nicolette M.L., Zhang Y., Davis M., Zhu Z., Paull T.T., Ira G., Lee S.E. Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks. EMBO Journal 2010, 29:3370-3380.
    • (2010) EMBO Journal , vol.29 , pp. 3370-3380
    • Shim, E.Y.1    Chung, W.H.2    Nicolette, M.L.3    Zhang, Y.4    Davis, M.5    Zhu, Z.6    Paull, T.T.7    Ira, G.8    Lee, S.E.9
  • 39
    • 78951472460 scopus 로고    scopus 로고
    • Replication protein A promotes 5'-3' end processing during homology-dependent DNA double-strand break repair
    • Yan H., Toczylowski T., McCane J., Chen C., Liao S. Replication protein A promotes 5'-3' end processing during homology-dependent DNA double-strand break repair. Journal of Cell Biology 2011, 192:251-261.
    • (2011) Journal of Cell Biology , vol.192 , pp. 251-261
    • Yan, H.1    Toczylowski, T.2    McCane, J.3    Chen, C.4    Liao, S.5
  • 40
    • 84878183628 scopus 로고    scopus 로고
    • RPA coordinates DNA end resection and prevents formation of DNA hairpins
    • Chen H., Lisby M., Symington L.S. RPA coordinates DNA end resection and prevents formation of DNA hairpins. Molecular Cell 2013, 50:589-600.
    • (2013) Molecular Cell , vol.50 , pp. 589-600
    • Chen, H.1    Lisby, M.2    Symington, L.S.3
  • 43
    • 84872858478 scopus 로고    scopus 로고
    • Tbf1, Vid22 promote resection and non-homologous end joining of DNA double-strand break ends
    • Bonetti D., Anbalagan S., Lucchini G., Clerici M., Longhese M.P. Tbf1, Vid22 promote resection and non-homologous end joining of DNA double-strand break ends. EMBO Journal 2013, 32:275-289.
    • (2013) EMBO Journal , vol.32 , pp. 275-289
    • Bonetti, D.1    Anbalagan, S.2    Lucchini, G.3    Clerici, M.4    Longhese, M.P.5
  • 47
    • 0033522443 scopus 로고    scopus 로고
    • Cohabitation of insulators and silencing elements in yeast subtelomeric regions
    • Fourel G., Revardel E., Koering C.E., Gilson E. Cohabitation of insulators and silencing elements in yeast subtelomeric regions. EMBO Journal 1999, 18:2522-2537.
    • (1999) EMBO Journal , vol.18 , pp. 2522-2537
    • Fourel, G.1    Revardel, E.2    Koering, C.E.3    Gilson, E.4
  • 48
    • 48649086824 scopus 로고    scopus 로고
    • The Yku70-Yku80 complex contributes to regulate double-strand break processing and checkpoint activation during the cell cycle
    • Clerici M., Mantiero D., Guerini I., Lucchini G., Longhese M.P. The Yku70-Yku80 complex contributes to regulate double-strand break processing and checkpoint activation during the cell cycle. EMBO Reports 2008, 9:810-818.
    • (2008) EMBO Reports , vol.9 , pp. 810-818
    • Clerici, M.1    Mantiero, D.2    Guerini, I.3    Lucchini, G.4    Longhese, M.P.5
  • 49
    • 46949098616 scopus 로고    scopus 로고
    • Break dosage, cell cycle stage and DNA replication influence DNA double strand break response
    • Zierhut C., Diffley J.F. Break dosage, cell cycle stage and DNA replication influence DNA double strand break response. EMBO Journal 2008, 27:1875-1885.
    • (2008) EMBO Journal , vol.27 , pp. 1875-1885
    • Zierhut, C.1    Diffley, J.F.2
  • 50
    • 77957805302 scopus 로고    scopus 로고
    • Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2
    • Mimitou E.P., Symington L.S. Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2. EMBO Journal 2010, 29:3358-3369.
    • (2010) EMBO Journal , vol.29 , pp. 3358-3369
    • Mimitou, E.P.1    Symington, L.S.2
  • 51
    • 45149104841 scopus 로고    scopus 로고
    • Recruitment and dissociation of nonhomologous end joining proteins at a DNA double-strand break in Saccharomyces cerevisiae
    • Wu D., Topper L.M., Wilson T.E. Recruitment and dissociation of nonhomologous end joining proteins at a DNA double-strand break in Saccharomyces cerevisiae. Genetics 2008, 178:1237-1249.
    • (2008) Genetics , vol.178 , pp. 1237-1249
    • Wu, D.1    Topper, L.M.2    Wilson, T.E.3
  • 52
    • 0028882869 scopus 로고
    • Yeast checkpoint genes in DNA damage processing: implications for repair and arrest
    • Lydall D., Weinert T. Yeast checkpoint genes in DNA damage processing: implications for repair and arrest. Science 1995, 270:1488-1491.
    • (1995) Science , vol.270 , pp. 1488-1491
    • Lydall, D.1    Weinert, T.2
  • 54
    • 84866954195 scopus 로고    scopus 로고
    • The Fun30 nucleosome remodeller promotes resection of DNA double-strand break ends
    • Chen X., Cui D., Papusha A., Zhang X., Chu C.D., Tang J., Chen K., Pan X., Ira G. The Fun30 nucleosome remodeller promotes resection of DNA double-strand break ends. Nature 2012, 489:576-580.
    • (2012) Nature , vol.489 , pp. 576-580
    • Chen, X.1    Cui, D.2    Papusha, A.3    Zhang, X.4    Chu, C.D.5    Tang, J.6    Chen, K.7    Pan, X.8    Ira, G.9
  • 56
    • 84868694661 scopus 로고    scopus 로고
    • The Saccharomyces cerevisiae chromatin remodeler Fun30 regulates DNA end resection and checkpoint deactivation
    • Eapen V.V., Sugawara N., Tsabar M., Wu W.H., Haber J.E. The Saccharomyces cerevisiae chromatin remodeler Fun30 regulates DNA end resection and checkpoint deactivation. Molecular and Cellular Biology 2012, 32:4727-4740.
    • (2012) Molecular and Cellular Biology , vol.32 , pp. 4727-4740
    • Eapen, V.V.1    Sugawara, N.2    Tsabar, M.3    Wu, W.H.4    Haber, J.E.5
  • 65
    • 0026623241 scopus 로고
    • A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation
    • Hardy C.F., Sussel L., Shore D. A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation. Genes and Development 1992, 6:801-814.
    • (1992) Genes and Development , vol.6 , pp. 801-814
    • Hardy, C.F.1    Sussel, L.2    Shore, D.3
  • 66
    • 77953245442 scopus 로고    scopus 로고
    • Shelterin-like proteins and Yku inhibit nucleolytic processing of Saccharomyces cerevisiae telomeres
    • Bonetti D., Clerici M., Anbalagan S., Martina M., Lucchini G., Longhese M.P. Shelterin-like proteins and Yku inhibit nucleolytic processing of Saccharomyces cerevisiae telomeres. PLoS Genetics 2010, 6:e1000966.
    • (2010) PLoS Genetics , vol.6
    • Bonetti, D.1    Clerici, M.2    Anbalagan, S.3    Martina, M.4    Lucchini, G.5    Longhese, M.P.6
  • 67
    • 79953732578 scopus 로고    scopus 로고
    • Rif1 supports the function of the CST complex in yeast telomere capping
    • Anbalagan S., Bonetti D., Lucchini G., Longhese M.P. Rif1 supports the function of the CST complex in yeast telomere capping. PLoS Genetics 2011, 7:e1002024.
    • (2011) PLoS Genetics , vol.7
    • Anbalagan, S.1    Bonetti, D.2    Lucchini, G.3    Longhese, M.P.4
  • 68
    • 84855279235 scopus 로고    scopus 로고
    • A novel checkpoint and RPA inhibitory pathway regulated by Rif1
    • Xue Y., Rushton M.D., Maringele L. A novel checkpoint and RPA inhibitory pathway regulated by Rif1. PLoS Genetics 2011, 7:e1002417.
    • (2011) PLoS Genetics , vol.7
    • Xue, Y.1    Rushton, M.D.2    Maringele, L.3
  • 70
    • 70350324640 scopus 로고    scopus 로고
    • Emerging common themes in regulation of PIKKs and PI3Ks
    • Lempiäinen H., Halazonetis T.D. Emerging common themes in regulation of PIKKs and PI3Ks. EMBO Journal 2009, 28:3067-3073.
    • (2009) EMBO Journal , vol.28 , pp. 3067-3073
    • Lempiäinen, H.1    Halazonetis, T.D.2
  • 72
    • 0037462453 scopus 로고    scopus 로고
    • The ATRs, ATMs, and TORs are giant HEAT repeat proteins
    • Perry J., Kleckner N. The ATRs, ATMs, and TORs are giant HEAT repeat proteins. Cell 2003, 112:151-155.
    • (2003) Cell , vol.112 , pp. 151-155
    • Perry, J.1    Kleckner, N.2
  • 74
    • 0033527787 scopus 로고    scopus 로고
    • Control of the DNA damage checkpoint by Chk1 and Rad53 protein kinases through distinct mechanisms
    • Sanchez Y., Bachant J., Wang H., Hu F., Liu D., Tetzlaff M., Elledge S.J. Control of the DNA damage checkpoint by Chk1 and Rad53 protein kinases through distinct mechanisms. Science 1999, 286:1166-1171.
    • (1999) Science , vol.286 , pp. 1166-1171
    • Sanchez, Y.1    Bachant, J.2    Wang, H.3    Hu, F.4    Liu, D.5    Tetzlaff, M.6    Elledge, S.J.7
  • 75
    • 0032504069 scopus 로고    scopus 로고
    • Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint
    • Sun Z., Hsiao J., Fay D.S., Stern S.F. Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint. Science 1998, 281:272-274.
    • (1998) Science , vol.281 , pp. 272-274
    • Sun, Z.1    Hsiao, J.2    Fay, D.S.3    Stern, S.F.4
  • 76
    • 0036281710 scopus 로고    scopus 로고
    • Rad9 phosphorylation sites couple Rad53 to the Saccharomyces cerevisiae DNA damage checkpoint
    • Schwartz M.F., Duong J.K., Sun Z., Morrow J.S., Pradhan D., Stern D.F. Rad9 phosphorylation sites couple Rad53 to the Saccharomyces cerevisiae DNA damage checkpoint. Molecular Cell 2002, 9:1055-1065.
    • (2002) Molecular Cell , vol.9 , pp. 1055-1065
    • Schwartz, M.F.1    Duong, J.K.2    Sun, Z.3    Morrow, J.S.4    Pradhan, D.5    Stern, D.F.6
  • 78
    • 0030593033 scopus 로고    scopus 로고
    • Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways
    • Sanchez Y., Desany B.A., Jones W.J., Liu Q., Wang B., Elledge S.J. Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways. Science 1996, 271:357-360.
    • (1996) Science , vol.271 , pp. 357-360
    • Sanchez, Y.1    Desany, B.A.2    Jones, W.J.3    Liu, Q.4    Wang, B.5    Elledge, S.J.6
  • 79
    • 0029928222 scopus 로고    scopus 로고
    • Spk1/Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways
    • Sun Z., Fay D.S., Marini F., Foiani M., Stern D.F. Spk1/Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways. Genes and Development 1996, 10:395-406.
    • (1996) Genes and Development , vol.10 , pp. 395-406
    • Sun, Z.1    Fay, D.S.2    Marini, F.3    Foiani, M.4    Stern, D.F.5
  • 80
    • 58649097740 scopus 로고    scopus 로고
    • Maintenance of the DNA-damage checkpoint requires DNA-damage-induced mediator protein oligomerization
    • Usui T., Foster S.S., Petrini J.H. Maintenance of the DNA-damage checkpoint requires DNA-damage-induced mediator protein oligomerization. Molecular Cell 2009, 33:147-159.
    • (2009) Molecular Cell , vol.33 , pp. 147-159
    • Usui, T.1    Foster, S.S.2    Petrini, J.H.3
  • 81
    • 0034881760 scopus 로고    scopus 로고
    • Budding yeast Rad9 is an ATP-dependent Rad53 activating machine
    • Gilbert C.S., Green C.M., Lowndes N.F. Budding yeast Rad9 is an ATP-dependent Rad53 activating machine. Molecular Cell 2001, 8:129-136.
    • (2001) Molecular Cell , vol.8 , pp. 129-136
    • Gilbert, C.S.1    Green, C.M.2    Lowndes, N.F.3
  • 84
    • 35548970638 scopus 로고    scopus 로고
    • Rad9 BRCT domain interaction with phosphorylated H2AX regulates the G1 checkpoint in budding yeast
    • Hammet A., Magill C., Heierhorst J., Jackson S.P. Rad9 BRCT domain interaction with phosphorylated H2AX regulates the G1 checkpoint in budding yeast. EMBO Reports 2007, 8:851-857.
    • (2007) EMBO Reports , vol.8 , pp. 851-857
    • Hammet, A.1    Magill, C.2    Heierhorst, J.3    Jackson, S.P.4
  • 86
    • 3042793923 scopus 로고    scopus 로고
    • Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast
    • Nakamura T.M., Du L.L., Redon C., Russell P. Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast. Molecular and Cellular Biology 2004, 24:6215-6230.
    • (2004) Molecular and Cellular Biology , vol.24 , pp. 6215-6230
    • Nakamura, T.M.1    Du, L.L.2    Redon, C.3    Russell, P.4
  • 87
    • 33745137149 scopus 로고    scopus 로고
    • Histone modification-dependent and -independent pathways for recruitment of checkpoint protein Crb2 to double-strand breaks
    • Du L.L., Nakamura T.M., Russell P. Histone modification-dependent and -independent pathways for recruitment of checkpoint protein Crb2 to double-strand breaks. Genes and Development 2006, 20:1583-1596.
    • (2006) Genes and Development , vol.20 , pp. 1583-1596
    • Du, L.L.1    Nakamura, T.M.2    Russell, P.3
  • 88
    • 33646777111 scopus 로고    scopus 로고
    • Histone H2A phosphorylation and H3 methylation are required for a novel Rad9 DSB repair function following checkpoint activation
    • Toh G.W., O'Shaughnessy A.M., Jimeno S., Dobbie I.M., Grenon M., Maffini S., O'Rorke A., Lowndes N.F. Histone H2A phosphorylation and H3 methylation are required for a novel Rad9 DSB repair function following checkpoint activation. DNA Repair 2006, 5:693-703.
    • (2006) DNA Repair , vol.5 , pp. 693-703
    • Toh, G.W.1    O'Shaughnessy, A.M.2    Jimeno, S.3    Dobbie, I.M.4    Grenon, M.5    Maffini, S.6    O'Rorke, A.7    Lowndes, N.F.8
  • 90
    • 0038143321 scopus 로고    scopus 로고
    • Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX
    • Ward I.M., Minn K., Jorda K.G., Chen J. Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX. Journal of Biological Chemistry 2003, 278:19579-19582.
    • (2003) Journal of Biological Chemistry , vol.278 , pp. 19579-19582
    • Ward, I.M.1    Minn, K.2    Jorda, K.G.3    Chen, J.4
  • 91
    • 0037472924 scopus 로고    scopus 로고
    • DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
    • Bakkenist C.J., Kastan M.B. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 2003, 421:499-506.
    • (2003) Nature , vol.421 , pp. 499-506
    • Bakkenist, C.J.1    Kastan, M.B.2
  • 94
    • 34447551681 scopus 로고    scopus 로고
    • Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair
    • Berkovich E., Monnat R.J., Kastan M.B. Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair. Nature Cell Biology 2007, 9:683-690.
    • (2007) Nature Cell Biology , vol.9 , pp. 683-690
    • Berkovich, E.1    Monnat, R.J.2    Kastan, M.B.3
  • 95
    • 76149146422 scopus 로고    scopus 로고
    • Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites
    • So S., Davis A.J., Chen D.J. Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites. Journal of Cell Biology 2009, 187:977-990.
    • (2009) Journal of Cell Biology , vol.187 , pp. 977-990
    • So, S.1    Davis, A.J.2    Chen, D.J.3
  • 96
    • 78649445307 scopus 로고    scopus 로고
    • Mre11-Rad50-Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks
    • Williams G.J., Lees-Miller S.P., Tainer J.A. Mre11-Rad50-Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks. DNA Repair 2010, 9:1299-1306.
    • (2010) DNA Repair , vol.9 , pp. 1299-1306
    • Williams, G.J.1    Lees-Miller, S.P.2    Tainer, J.A.3
  • 97
    • 0041660970 scopus 로고    scopus 로고
    • ATM-related Tel1 associates with double-strand breaks through an Xrs2-dependent mechanism
    • Nakada D., Matsumoto K., Sugimoto K. ATM-related Tel1 associates with double-strand breaks through an Xrs2-dependent mechanism. Genes and Development 2003, 17:1957-1962.
    • (2003) Genes and Development , vol.17 , pp. 1957-1962
    • Nakada, D.1    Matsumoto, K.2    Sugimoto, K.3
  • 98
    • 15844394846 scopus 로고    scopus 로고
    • Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
    • Falck J., Coates J., Jackson S.P. Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature 2005, 434:605-611.
    • (2005) Nature , vol.434 , pp. 605-611
    • Falck, J.1    Coates, J.2    Jackson, S.P.3
  • 99
    • 17644409069 scopus 로고    scopus 로고
    • ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex
    • Lee J.H., Paull T.T. ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science 2005, 308:551-554.
    • (2005) Science , vol.308 , pp. 551-554
    • Lee, J.H.1    Paull, T.T.2
  • 100
    • 20744436198 scopus 로고    scopus 로고
    • ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1
    • You Z., Chahwan C., Bailis J., Hunter T., Russell P. ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1. Molecular and Cellular Biology 2005, 25:5363-5379.
    • (2005) Molecular and Cellular Biology , vol.25 , pp. 5363-5379
    • You, Z.1    Chahwan, C.2    Bailis, J.3    Hunter, T.4    Russell, P.5
  • 101
    • 45849117573 scopus 로고    scopus 로고
    • Activation of the cellular DNA damage response in the absence of DNA lesions
    • Soutoglou E., Misteli T. Activation of the cellular DNA damage response in the absence of DNA lesions. Science 2008, 320:1507-1510.
    • (2008) Science , vol.320 , pp. 1507-1510
    • Soutoglou, E.1    Misteli, T.2
  • 102
    • 47949121598 scopus 로고    scopus 로고
    • Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity
    • Jazayeri A., Balestrini A., Garner E., Haber J.E., Costanzo V. Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity. EMBO Journal 2008, 27:1953-1962.
    • (2008) EMBO Journal , vol.27 , pp. 1953-1962
    • Jazayeri, A.1    Balestrini, A.2    Garner, E.3    Haber, J.E.4    Costanzo, V.5
  • 103
    • 79956144674 scopus 로고    scopus 로고
    • Activation of protein kinase Tel1 through recognition of protein-bound DNA ends
    • Fukunaga K., Kwon Y., Sung P., Sugimoto K. Activation of protein kinase Tel1 through recognition of protein-bound DNA ends. Molecular and Cellular Biology 2011, 31:1959-1971.
    • (2011) Molecular and Cellular Biology , vol.31 , pp. 1959-1971
    • Fukunaga, K.1    Kwon, Y.2    Sung, P.3    Sugimoto, K.4
  • 105
    • 0037567268 scopus 로고    scopus 로고
    • Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
    • Zou L., Elledge S.J. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 2003, 300:1542-1548.
    • (2003) Science , vol.300 , pp. 1542-1548
    • Zou, L.1    Elledge, S.J.2
  • 107
    • 0034663809 scopus 로고    scopus 로고
    • The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast
    • Paciotti V., Clerici M., Lucchini G., Longhese M.P. The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast. Genes and Development 2000, 14:2046-2059.
    • (2000) Genes and Development , vol.14 , pp. 2046-2059
    • Paciotti, V.1    Clerici, M.2    Lucchini, G.3    Longhese, M.P.4
  • 108
    • 0035941021 scopus 로고    scopus 로고
    • ATR and ATRIP: partners in checkpoint signaling
    • Cortez D., Guntuku S., Qin J., Elledge S.J. ATR and ATRIP: partners in checkpoint signaling. Science 2001, 294:1713-1716.
    • (2001) Science , vol.294 , pp. 1713-1716
    • Cortez, D.1    Guntuku, S.2    Qin, J.3    Elledge, S.J.4
  • 109
    • 33845607102 scopus 로고    scopus 로고
    • The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint
    • Majka J., Niedziela-Majka A., Burgers P.M. The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint. Molecular Cell 2006, 24:891-901.
    • (2006) Molecular Cell , vol.24 , pp. 891-901
    • Majka, J.1    Niedziela-Majka, A.2    Burgers, P.M.3
  • 110
    • 71149093704 scopus 로고    scopus 로고
    • The unstructured C-terminal tail of the 9-1-1 clamp subunit Ddc1 activates Mec1/ATR via two distinct mechanisms
    • Navadgi-Patil V.M., Burgers P.M. The unstructured C-terminal tail of the 9-1-1 clamp subunit Ddc1 activates Mec1/ATR via two distinct mechanisms. Molecular Cell 2009, 36:743-753.
    • (2009) Molecular Cell , vol.36 , pp. 743-753
    • Navadgi-Patil, V.M.1    Burgers, P.M.2
  • 111
    • 2442646547 scopus 로고    scopus 로고
    • Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4TOPBP1
    • Furuya K., Poitelea M., Guo L., Caspari T., Carr A.M. Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4TOPBP1. Genes and Development 2004, 18:1154-1164.
    • (2004) Genes and Development , vol.18 , pp. 1154-1164
    • Furuya, K.1    Poitelea, M.2    Guo, L.3    Caspari, T.4    Carr, A.M.5
  • 112
    • 33644757806 scopus 로고    scopus 로고
    • TopBP1 activates the ATR-ATRIP complex
    • Kumagai A., Lee J., Yoo H.Y., Dunphy W.G. TopBP1 activates the ATR-ATRIP complex. Cell 2006, 124:943-955.
    • (2006) Cell , vol.124 , pp. 943-955
    • Kumagai, A.1    Lee, J.2    Yoo, H.Y.3    Dunphy, W.G.4
  • 114
    • 44849093460 scopus 로고    scopus 로고
    • TopBP1 activates ATR through ATRIP and a PIKK regulatory domain
    • Mordes D.A., Glick G.G., Zhao R., Cortez D. TopBP1 activates ATR through ATRIP and a PIKK regulatory domain. Genes and Development 2008, 22:1478-1489.
    • (2008) Genes and Development , vol.22 , pp. 1478-1489
    • Mordes, D.A.1    Glick, G.G.2    Zhao, R.3    Cortez, D.4
  • 116
    • 58149102035 scopus 로고    scopus 로고
    • Yeast DNA replication protein Dpb11 activates the Mec1/ATR checkpoint kinase
    • Navadgi-Patil V.M., Burgers P.M. Yeast DNA replication protein Dpb11 activates the Mec1/ATR checkpoint kinase. Journal of Biological Chemistry 2008, 283:35853-35859.
    • (2008) Journal of Biological Chemistry , vol.283 , pp. 35853-35859
    • Navadgi-Patil, V.M.1    Burgers, P.M.2
  • 118
    • 83555168211 scopus 로고    scopus 로고
    • Dpb11 coordinates Mec1 kinase activation with cell cycle-regulated Rad9 recruitment
    • Pfander B., Diffley J.F. Dpb11 coordinates Mec1 kinase activation with cell cycle-regulated Rad9 recruitment. EMBO Journal 2011, 30:4897-4907.
    • (2011) EMBO Journal , vol.30 , pp. 4897-4907
    • Pfander, B.1    Diffley, J.F.2
  • 119
    • 7644232348 scopus 로고    scopus 로고
    • Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway
    • Nakada D., Hirano Y., Sugimoto K. Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway. Molecular and Cellular Biology 2004, 24:10016-10025.
    • (2004) Molecular and Cellular Biology , vol.24 , pp. 10016-10025
    • Nakada, D.1    Hirano, Y.2    Sugimoto, K.3
  • 120
    • 33646795891 scopus 로고    scopus 로고
    • Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex
    • Adams K.E., Medhurst A.L., Dart D., Lakin N.D. Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex. Oncogene 2006, 25:3894-3904.
    • (2006) Oncogene , vol.25 , pp. 3894-3904
    • Adams, K.E.1    Medhurst, A.L.2    Dart, D.3    Lakin, N.D.4
  • 121
    • 84876097735 scopus 로고    scopus 로고
    • A role for the MRN complex in ATR activation via TOPBP1 recruitment
    • Duursma A.M., Driscoll R., Elias J.E., Cimprich K.A. A role for the MRN complex in ATR activation via TOPBP1 recruitment. Molecular Cell 2013, 50:116-122.
    • (2013) Molecular Cell , vol.50 , pp. 116-122
    • Duursma, A.M.1    Driscoll, R.2    Elias, J.E.3    Cimprich, K.A.4
  • 123
    • 61649093808 scopus 로고    scopus 로고
    • Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks
    • Shiotani B., Zou L. Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks. Molecular Cell 2009, 33:547-558.
    • (2009) Molecular Cell , vol.33 , pp. 547-558
    • Shiotani, B.1    Zou, L.2
  • 124
    • 34047102946 scopus 로고    scopus 로고
    • Dual role for Saccharomyces cerevisiae Tel1 in the checkpoint response to double-strand breaks
    • Mantiero D., Clerici M., Lucchini G., Longhese M.P. Dual role for Saccharomyces cerevisiae Tel1 in the checkpoint response to double-strand breaks. EMBO Reports 2007, 8:380-387.
    • (2007) EMBO Reports , vol.8 , pp. 380-387
    • Mantiero, D.1    Clerici, M.2    Lucchini, G.3    Longhese, M.P.4
  • 125
    • 33646777679 scopus 로고    scopus 로고
    • Rapid activation of ATR by ionizing radiation requires ATM and Mre11
    • Myers J.S., Cortez D. Rapid activation of ATR by ionizing radiation requires ATM and Mre11. Journal of Biological Chemistry 2006, 281:9346-9350.
    • (2006) Journal of Biological Chemistry , vol.281 , pp. 9346-9350
    • Myers, J.S.1    Cortez, D.2
  • 127
    • 0034964498 scopus 로고    scopus 로고
    • A DNA damage response pathway controlled by Tel1 and the Mre11 complex
    • Usui T., Ogawa H., Petrini J.H. A DNA damage response pathway controlled by Tel1 and the Mre11 complex. Molecular Cell 2001, 7:1255-1266.
    • (2001) Molecular Cell , vol.7 , pp. 1255-1266
    • Usui, T.1    Ogawa, H.2    Petrini, J.H.3
  • 128
    • 33645799075 scopus 로고    scopus 로고
    • The Saccharomyces cerevisiae Sae2 protein negatively regulates DNA damage checkpoint signaling
    • Clerici M., Mantiero D., Lucchini G., Longhese M.P. The Saccharomyces cerevisiae Sae2 protein negatively regulates DNA damage checkpoint signaling. EMBO Reports 2006, 7:212-218.
    • (2006) EMBO Reports , vol.7 , pp. 212-218
    • Clerici, M.1    Mantiero, D.2    Lucchini, G.3    Longhese, M.P.4
  • 129
    • 2942594756 scopus 로고    scopus 로고
    • The functions of budding yeast Sae2 in the DNA damage response require Mec1- and Tel1-dependent phosphorylation
    • Baroni E., Viscardi V., Cartagena-Lirola H., Lucchini G., Longhese M.P. The functions of budding yeast Sae2 in the DNA damage response require Mec1- and Tel1-dependent phosphorylation. Molecular and Cellular Biology 2004, 24:4151-4165.
    • (2004) Molecular and Cellular Biology , vol.24 , pp. 4151-4165
    • Baroni, E.1    Viscardi, V.2    Cartagena-Lirola, H.3    Lucchini, G.4    Longhese, M.P.5
  • 130
    • 33746225419 scopus 로고    scopus 로고
    • Budding yeast Sae2 is an in vivo target of the Mec1 and Tel1 checkpoint kinases during meiosis
    • Cartagena-Lirola H., Guerini I., Viscardi V., Lucchini G., Longhese M.P. Budding yeast Sae2 is an in vivo target of the Mec1 and Tel1 checkpoint kinases during meiosis. Cell Cycle 2006, 5:1549-1559.
    • (2006) Cell Cycle , vol.5 , pp. 1549-1559
    • Cartagena-Lirola, H.1    Guerini, I.2    Viscardi, V.3    Lucchini, G.4    Longhese, M.P.5
  • 131
    • 51949118680 scopus 로고    scopus 로고
    • Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response
    • Morin I., Ngo H.P., Greenall A., Zubko M.K., Morrice N., Lydall D. Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response. EMBO Journal 2008, 27:2400-2410.
    • (2008) EMBO Journal , vol.27 , pp. 2400-2410
    • Morin, I.1    Ngo, H.P.2    Greenall, A.3    Zubko, M.K.4    Morrice, N.5    Lydall, D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.