-
1
-
-
70350504453
-
The DNA-damage response in human biology and disease.
-
10.1038/nature08467, 2906700, 19847258
-
Jackson SP, Bartek J. The DNA-damage response in human biology and disease. Nature 2009, 461:1071-1078. 10.1038/nature08467, 2906700, 19847258.
-
(2009)
Nature
, vol.461
, pp. 1071-1078
-
-
Jackson, S.P.1
Bartek, J.2
-
2
-
-
77958498222
-
The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer.
-
Smith J, Tho LM, Xu N, Gillespie DA. The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer. Adv Cancer Res 2010, 108:73-112.
-
(2010)
Adv Cancer Res
, vol.108
, pp. 73-112
-
-
Smith, J.1
Tho, L.M.2
Xu, N.3
Gillespie, D.A.4
-
3
-
-
33846821915
-
P53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage.
-
10.1016/j.ccr.2006.11.024, 2742175, 17292828
-
Reinhardt HC, Aslanian AS, Lees JA, Yaffe MB. p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage. Cancer Cell 2007, 11:175-189. 10.1016/j.ccr.2006.11.024, 2742175, 17292828.
-
(2007)
Cancer Cell
, vol.11
, pp. 175-189
-
-
Reinhardt, H.C.1
Aslanian, A.S.2
Lees, J.A.3
Yaffe, M.B.4
-
4
-
-
63749131243
-
Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2.
-
10.1016/j.ceb.2009.01.018, 2699687, 19230643
-
Reinhardt HC, Yaffe MB. Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2. Curr Opin Cell Biol 2009, 21:245-255. 10.1016/j.ceb.2009.01.018, 2699687, 19230643.
-
(2009)
Curr Opin Cell Biol
, vol.21
, pp. 245-255
-
-
Reinhardt, H.C.1
Yaffe, M.B.2
-
5
-
-
0037365789
-
ATM and related protein kinases: safeguarding genome integrity.
-
10.1038/nrc1011, 12612651
-
Shiloh Y. ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer 2003, 3:155-168. 10.1038/nrc1011, 12612651.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 155-168
-
-
Shiloh, Y.1
-
6
-
-
36448973875
-
CHK2 kinase: cancer susceptibility and cancer therapy - two sides of the same coin?.
-
10.1038/nrc2251, 18004398
-
Antoni L, Sodha N, Collins I, Garrett MD. CHK2 kinase: cancer susceptibility and cancer therapy - two sides of the same coin?. Nat Rev Cancer 2007, 7:925-936. 10.1038/nrc2251, 18004398.
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 925-936
-
-
Antoni, L.1
Sodha, N.2
Collins, I.3
Garrett, M.D.4
-
7
-
-
0034102337
-
ATR disruption leads to chromosomal fragmentation and early embryonic lethality.
-
316378, 10691732
-
Brown EJ, Baltimore D. ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev 2000, 14:397-402. 316378, 10691732.
-
(2000)
Genes Dev
, vol.14
, pp. 397-402
-
-
Brown, E.J.1
Baltimore, D.2
-
8
-
-
0037335861
-
Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance.
-
10.1101/gad.1067403, 196009, 12629044
-
Brown EJ, Baltimore D. Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance. Genes Dev 2003, 17:615-628. 10.1101/gad.1067403, 196009, 12629044.
-
(2003)
Genes Dev
, vol.17
, pp. 615-628
-
-
Brown, E.J.1
Baltimore, D.2
-
9
-
-
17644432403
-
Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint.
-
316686, 10859164
-
Liu Q, Guntuku S, Cui XS, Matsuoka S, Cortez D, Tamai K, Luo G, Carattini-Rivera S, DeMayo F, Bradley A, Donehower LA, Elledge SJ. Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev 2000, 14:1448-1459. 316686, 10859164.
-
(2000)
Genes Dev
, vol.14
, pp. 1448-1459
-
-
Liu, Q.1
Guntuku, S.2
Cui, X.S.3
Matsuoka, S.4
Cortez, D.5
Tamai, K.6
Luo, G.7
Carattini-Rivera, S.8
DeMayo, F.9
Bradley, A.10
Donehower, L.A.11
Elledge, S.J.12
-
10
-
-
0034659341
-
Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice.
-
316691, 10859163
-
Takai H, Tominaga K, Motoyama N, Minamishima YA, Nagahama H, Tsukiyama T, Ikeda K, Nakayama K, Nakanishi M. Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice. Genes Dev 2000, 14:1439-1447. 316691, 10859163.
-
(2000)
Genes Dev
, vol.14
, pp. 1439-1447
-
-
Takai, H.1
Tominaga, K.2
Motoyama, N.3
Minamishima, Y.A.4
Nagahama, H.5
Tsukiyama, T.6
Ikeda, K.7
Nakayama, K.8
Nakanishi, M.9
-
11
-
-
2942598149
-
PhosphoSite: A bioinformatics resource dedicated to physiological protein phosphorylation.
-
10.1002/pmic.200300772, 15174125
-
Hornbeck PV, Chabra I, Kornhauser JM, Skrzypek E, Zhang B. PhosphoSite: A bioinformatics resource dedicated to physiological protein phosphorylation. Proteomics 2004, 4:1551-1561. 10.1002/pmic.200300772, 15174125.
-
(2004)
Proteomics
, vol.4
, pp. 1551-1561
-
-
Hornbeck, P.V.1
Chabra, I.2
Kornhauser, J.M.3
Skrzypek, E.4
Zhang, B.5
-
12
-
-
78651277460
-
PHOSIDA 2011: the posttranslational modification database.
-
10.1093/nar/gkq1159, 3013726, 21081558
-
Gnad F, Gunawardena J, Mann M. PHOSIDA 2011: the posttranslational modification database. Nucleic Acids Res 2011, 39:D253-260. 10.1093/nar/gkq1159, 3013726, 21081558.
-
(2011)
Nucleic Acids Res
, vol.39
-
-
Gnad, F.1
Gunawardena, J.2
Mann, M.3
-
13
-
-
34249947699
-
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
-
10.1126/science.1140321, 17525332
-
Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 2007, 316:1160-1166. 10.1126/science.1140321, 17525332.
-
(2007)
Science
, vol.316
, pp. 1160-1166
-
-
Matsuoka, S.1
Ballif, B.A.2
Smogorzewska, A.3
McDonald, E.R.4
Hurov, K.E.5
Luo, J.6
Bakalarski, C.E.7
Zhao, Z.8
Solimini, N.9
Lerenthal, Y.10
Shiloh, Y.11
Gygi, S.P.12
Elledge, S.J.13
-
14
-
-
38049184488
-
Profiling of UV-induced ATM/ATR signaling pathways.
-
10.1073/pnas.0707579104, 2148387, 18077418
-
Stokes MP, Rush J, Macneill J, Ren JM, Sprott K, Nardone J, Yang V, Beausoleil SA, Gygi SP, Livingstone M, Zhang H, Polakiewicz RD, Comb MJ. Profiling of UV-induced ATM/ATR signaling pathways. Proc Natl Acad Sci USA 2007, 104:19855-19860. 10.1073/pnas.0707579104, 2148387, 18077418.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 19855-19860
-
-
Stokes, M.P.1
Rush, J.2
Macneill, J.3
Ren, J.M.4
Sprott, K.5
Nardone, J.6
Yang, V.7
Beausoleil, S.A.8
Gygi, S.P.9
Livingstone, M.10
Zhang, H.11
Polakiewicz, R.D.12
Comb, M.J.13
-
15
-
-
0034699382
-
A chemical switch for inhibitor-sensitive alleles of any protein kinase.
-
10.1038/35030148, 11014197
-
Bishop AC, Ubersax JA, Petsch DT, Matheos DP, Gray NS, Blethrow J, Shimizu E, Tsien JZ, Schultz PG, Rose MD, Wood JL, Morgan DO, Shokat KM. A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature 2000, 407:395-401. 10.1038/35030148, 11014197.
-
(2000)
Nature
, vol.407
, pp. 395-401
-
-
Bishop, A.C.1
Ubersax, J.A.2
Petsch, D.T.3
Matheos, D.P.4
Gray, N.S.5
Blethrow, J.6
Shimizu, E.7
Tsien, J.Z.8
Schultz, P.G.9
Rose, M.D.10
Wood, J.L.11
Morgan, D.O.12
Shokat, K.M.13
-
16
-
-
40349092941
-
Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates.
-
10.1073/pnas.0708966105, 2234163, 18234856
-
Blethrow JD, Glavy JS, Morgan DO, Shokat KM. Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates. Proc Natl Acad Sci USA 2008, 105:1442-1447. 10.1073/pnas.0708966105, 2234163, 18234856.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 1442-1447
-
-
Blethrow, J.D.1
Glavy, J.S.2
Morgan, D.O.3
Shokat, K.M.4
-
17
-
-
55049115827
-
Identification of CDK2 substrates in human cell lysates.
-
10.1186/gb-2008-9-10-r149, 2760876, 18847512
-
Chi Y, Welcker M, Hizli AA, Posakony JJ, Aebersold R, Clurman BE. Identification of CDK2 substrates in human cell lysates. Genome Biol 2008, 9:R149. 10.1186/gb-2008-9-10-r149, 2760876, 18847512.
-
(2008)
Genome Biol
, vol.9
-
-
Chi, Y.1
Welcker, M.2
Hizli, A.A.3
Posakony, J.J.4
Aebersold, R.5
Clurman, B.E.6
-
18
-
-
30044438459
-
Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics.
-
10.1038/nsmb1028, 16327805
-
Larochelle S, Batliner J, Gamble MJ, Barboza NM, Kraybill BC, Blethrow JD, Shokat KM, Fisher RP. Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics. Nat Struct Mol Biol 2006, 13:55-62. 10.1038/nsmb1028, 16327805.
-
(2006)
Nat Struct Mol Biol
, vol.13
, pp. 55-62
-
-
Larochelle, S.1
Batliner, J.2
Gamble, M.J.3
Barboza, N.M.4
Kraybill, B.C.5
Blethrow, J.D.6
Shokat, K.M.7
Fisher, R.P.8
-
19
-
-
0142084976
-
Regulation of human Cdc25A stability by Serine 75 phosphorylation is not sufficient to activate a S phase checkpoint.
-
Goloudina A, Yamaguchi H, Chervyakova DB, Appella E, Fornace AJ, Bulavin DV. Regulation of human Cdc25A stability by Serine 75 phosphorylation is not sufficient to activate a S phase checkpoint. Cell Cycle 2003, 2:473-478.
-
(2003)
Cell Cycle
, vol.2
, pp. 473-478
-
-
Goloudina, A.1
Yamaguchi, H.2
Chervyakova, D.B.3
Appella, E.4
Fornace, A.J.5
Bulavin, D.V.6
-
20
-
-
0034967556
-
ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1.
-
10.1128/MCB.21.13.4129-4139.2001, 87074, 11390642
-
Zhao H, Piwnica-Worms H. ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol Cell Biol 2001, 21:4129-4139. 10.1128/MCB.21.13.4129-4139.2001, 87074, 11390642.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 4129-4139
-
-
Zhao, H.1
Piwnica-Worms, H.2
-
21
-
-
77953148666
-
Site-specific phosphorylation dynamics of the nuclear proteome during the DNA damage response.
-
10.1074/mcp.M900616-MCP200, 2877989, 20164059
-
Bennetzen MV, Larsen DH, Bunkenborg J, Lukas J, Andersen JS. Site-specific phosphorylation dynamics of the nuclear proteome during the DNA damage response. Mol Cell Proteomics 2010, 9:1314-1323. 10.1074/mcp.M900616-MCP200, 2877989, 20164059.
-
(2010)
Mol Cell Proteomics
, vol.9
, pp. 1314-1323
-
-
Bennetzen, M.V.1
Larsen, D.H.2
Bunkenborg, J.3
Lukas, J.4
Andersen, J.S.5
-
22
-
-
78649938817
-
ATM-dependent and -independent dynamics of the nuclear phosphoproteome after DNA damage.
-
10.1126/scisignal.2001034, 21139141
-
Bensimon A, Schmidt A, Ziv Y, Elkon R, Wang SY, Chen DJ, Aebersold R, Shiloh Y. ATM-dependent and -independent dynamics of the nuclear phosphoproteome after DNA damage. Sci Signal 2010, 3:rs3. 10.1126/scisignal.2001034, 21139141.
-
(2010)
Sci Signal
, vol.3
-
-
Bensimon, A.1
Schmidt, A.2
Ziv, Y.3
Elkon, R.4
Wang, S.Y.5
Chen, D.J.6
Aebersold, R.7
Shiloh, Y.8
-
23
-
-
67651119997
-
A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability.
-
10.1016/j.molcel.2009.06.021, 2772893, 19647519
-
Paulsen RD, Soni DV, Wollman R, Hahn AT, Yee MC, Guan A, Hesley JA, Miller SC, Cromwell EF, Solow-Cordero DE, Meyer T, Cimprich KA. A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability. Mol Cell 2009, 35:228-239. 10.1016/j.molcel.2009.06.021, 2772893, 19647519.
-
(2009)
Mol Cell
, vol.35
, pp. 228-239
-
-
Paulsen, R.D.1
Soni, D.V.2
Wollman, R.3
Hahn, A.T.4
Yee, M.C.5
Guan, A.6
Hesley, J.A.7
Miller, S.C.8
Cromwell, E.F.9
Solow-Cordero, D.E.10
Meyer, T.11
Cimprich, K.A.12
-
24
-
-
77949410508
-
Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase.
-
10.1083/jcb.200905059, 2835936, 20194642
-
Beck H, Nahse V, Larsen MS, Groth P, Clancy T, Lees M, Jorgensen M, Helleday T, Syljuasen RG, Sorensen CS. Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase. J Cell Biol 2010, 188:629-638. 10.1083/jcb.200905059, 2835936, 20194642.
-
(2010)
J Cell Biol
, vol.188
, pp. 629-638
-
-
Beck, H.1
Nahse, V.2
Larsen, M.S.3
Groth, P.4
Clancy, T.5
Lees, M.6
Jorgensen, M.7
Helleday, T.8
Syljuasen, R.G.9
Sorensen, C.S.10
-
25
-
-
73349088472
-
Functional genomic screens identify CINP as a genome maintenance protein.
-
10.1073/pnas.0909345106, 2780779, 19889979
-
Lovejoy CA, Xu X, Bansbach CE, Glick GG, Zhao R, Ye F, Sirbu BM, Titus LC, Shyr Y, Cortez D. Functional genomic screens identify CINP as a genome maintenance protein. Proc Natl Acad Sci USA 2009, 106:19304-19309. 10.1073/pnas.0909345106, 2780779, 19889979.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 19304-19309
-
-
Lovejoy, C.A.1
Xu, X.2
Bansbach, C.E.3
Glick, G.G.4
Zhao, R.5
Ye, F.6
Sirbu, B.M.7
Titus, L.C.8
Shyr, Y.9
Cortez, D.10
-
26
-
-
34247640762
-
Identification of novel substrates for human checkpoint kinase Chk1 and Chk2 through genome-wide screening using a consensus Chk phosphorylation motif.
-
Kim MA, Kim HJ, Brown AL, Lee MY, Bae YS, Park JI, Kwak JY, Chung JH, Yun J. Identification of novel substrates for human checkpoint kinase Chk1 and Chk2 through genome-wide screening using a consensus Chk phosphorylation motif. Exp Mol Med 2007, 39:205-212.
-
(2007)
Exp Mol Med
, vol.39
, pp. 205-212
-
-
Kim, M.A.1
Kim, H.J.2
Brown, A.L.3
Lee, M.Y.4
Bae, Y.S.5
Park, J.I.6
Kwak, J.Y.7
Chung, J.H.8
Yun, J.9
-
27
-
-
0037013243
-
Determination of substrate motifs for human Chk1 and hCds1/Chk2 by the oriented peptide library approach.
-
10.1074/jbc.M111705200, 11821419
-
O'Neill T, Giarratani L, Chen P, Iyer L, Lee CH, Bobiak M, Kanai F, Zhou BB, Chung JH, Rathbun GA. Determination of substrate motifs for human Chk1 and hCds1/Chk2 by the oriented peptide library approach. J Biol Chem 2002, 277:16102-16115. 10.1074/jbc.M111705200, 11821419.
-
(2002)
J Biol Chem
, vol.277
, pp. 16102-16115
-
-
O'Neill, T.1
Giarratani, L.2
Chen, P.3
Iyer, L.4
Lee, C.H.5
Bobiak, M.6
Kanai, F.7
Zhou, B.B.8
Chung, J.H.9
Rathbun, G.A.10
-
28
-
-
34247636044
-
The MDM2 ubiquitination signal in the DNA-binding domain of p53 forms a docking site for calcium calmodulin kinase superfamily members.
-
10.1128/MCB.01595-06, 1899961, 17339337
-
Craig AL, Chrystal JA, Fraser JA, Sphyris N, Lin Y, Harrison BJ, Scott MT, Dornreiter I, Hupp TR. The MDM2 ubiquitination signal in the DNA-binding domain of p53 forms a docking site for calcium calmodulin kinase superfamily members. Mol Cell Biol 2007, 27:3542-3555. 10.1128/MCB.01595-06, 1899961, 17339337.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 3542-3555
-
-
Craig, A.L.1
Chrystal, J.A.2
Fraser, J.A.3
Sphyris, N.4
Lin, Y.5
Harrison, B.J.6
Scott, M.T.7
Dornreiter, I.8
Hupp, T.R.9
-
29
-
-
0034142034
-
The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites.
-
316358, 10673501
-
Shieh SY, Ahn J, Tamai K, Taya Y, Prives C. The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev 2000, 14:289-300. 316358, 10673501.
-
(2000)
Genes Dev
, vol.14
, pp. 289-300
-
-
Shieh, S.Y.1
Ahn, J.2
Tamai, K.3
Taya, Y.4
Prives, C.5
-
30
-
-
33845625801
-
Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin function.
-
10.1074/jbc.M604373200, 16963448
-
Chini CC, Chen J. Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin function. J Biol Chem 2006, 281:33276-33282. 10.1074/jbc.M604373200, 16963448.
-
(2006)
J Biol Chem
, vol.281
, pp. 33276-33282
-
-
Chini, C.C.1
Chen, J.2
-
31
-
-
33746601439
-
Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway.
-
10.1038/ncb1446, 16862143
-
Ziv Y, Bielopolski D, Galanty Y, Lukas C, Taya Y, Schultz DC, Lukas J, Bekker-Jensen S, Bartek J, Shiloh Y. Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway. Nat Cell Biol 2006, 8:870-876. 10.1038/ncb1446, 16862143.
-
(2006)
Nat Cell Biol
, vol.8
, pp. 870-876
-
-
Ziv, Y.1
Bielopolski, D.2
Galanty, Y.3
Lukas, C.4
Taya, Y.5
Schultz, D.C.6
Lukas, J.7
Bekker-Jensen, S.8
Bartek, J.9
Shiloh, Y.10
-
32
-
-
0033915781
-
Mice lacking the transcriptional corepressor TIF1beta are defective in early postimplantation development.
-
Cammas F, Mark M, Dolle P, Dierich A, Chambon P, Losson R. Mice lacking the transcriptional corepressor TIF1beta are defective in early postimplantation development. Development 2000, 127:2955-2963.
-
(2000)
Development
, vol.127
, pp. 2955-2963
-
-
Cammas, F.1
Mark, M.2
Dolle, P.3
Dierich, A.4
Chambon, P.5
Losson, R.6
-
33
-
-
47349107760
-
ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin.
-
10.1016/j.molcel.2008.05.017, 18657500
-
Goodarzi AA, Noon AT, Deckbar D, Ziv Y, Shiloh Y, Lobrich M, Jeggo PA. ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin. Mol Cell 2008, 31:167-177. 10.1016/j.molcel.2008.05.017, 18657500.
-
(2008)
Mol Cell
, vol.31
, pp. 167-177
-
-
Goodarzi, A.A.1
Noon, A.T.2
Deckbar, D.3
Ziv, Y.4
Shiloh, Y.5
Lobrich, M.6
Jeggo, P.A.7
-
34
-
-
75949122330
-
53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair.
-
10.1038/ncb2017, 20081839
-
Noon AT, Shibata A, Rief N, Lobrich M, Stewart GS, Jeggo PA, Goodarzi AA. 53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair. Nat Cell Biol 2010, 12:177-184. 10.1038/ncb2017, 20081839.
-
(2010)
Nat Cell Biol
, vol.12
, pp. 177-184
-
-
Noon, A.T.1
Shibata, A.2
Rief, N.3
Lobrich, M.4
Stewart, G.S.5
Jeggo, P.A.6
Goodarzi, A.A.7
-
35
-
-
52949139387
-
AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies.
-
10.1158/1535-7163.MCT-08-0492, 18790776
-
Zabludoff SD, Deng C, Grondine MR, Sheehy AM, Ashwell S, Caleb BL, Green S, Haye HR, Horn CL, Janetka JW, Liu D, Mouchet E, Ready S, Rosenthal JL, Queva C, Schwartz GK, Taylor KJ, Tse AN, Walker GE, White AM. AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies. Mol Cancer Ther 2008, 7:2955-2966. 10.1158/1535-7163.MCT-08-0492, 18790776.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 2955-2966
-
-
Zabludoff, S.D.1
Deng, C.2
Grondine, M.R.3
Sheehy, A.M.4
Ashwell, S.5
Caleb, B.L.6
Green, S.7
Haye, H.R.8
Horn, C.L.9
Janetka, J.W.10
Liu, D.11
Mouchet, E.12
Ready, S.13
Rosenthal, J.L.14
Queva, C.15
Schwartz, G.K.16
Taylor, K.J.17
Tse, A.N.18
Walker, G.E.19
White, A.M.20
more..
-
36
-
-
9744271049
-
Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM.
-
10.1158/0008-5472.CAN-04-2727, 15604286
-
Hickson I, Zhao Y, Richardson CJ, Green SJ, Martin NM, Orr AI, Reaper PM, Jackson SP, Curtin NJ, Smith GC. Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Res 2004, 64:9152-9159. 10.1158/0008-5472.CAN-04-2727, 15604286.
-
(2004)
Cancer Res
, vol.64
, pp. 9152-9159
-
-
Hickson, I.1
Zhao, Y.2
Richardson, C.J.3
Green, S.J.4
Martin, N.M.5
Orr, A.I.6
Reaper, P.M.7
Jackson, S.P.8
Curtin, N.J.9
Smith, G.C.10
-
37
-
-
0033199892
-
Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine.
-
Sarkaria JN, Busby EC, Tibbetts RS, Roos P, Taya Y, Karnitz LM, Abraham RT. Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. Cancer Res 1999, 59:4375-4382.
-
(1999)
Cancer Res
, vol.59
, pp. 4375-4382
-
-
Sarkaria, J.N.1
Busby, E.C.2
Tibbetts, R.S.3
Roos, P.4
Taya, Y.5
Karnitz, L.M.6
Abraham, R.T.7
-
38
-
-
30344463835
-
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks.
-
10.1038/ncb1337, 16327781
-
Jazayeri A, Falck J, Lukas C, Bartek J, Smith GC, Lukas J, Jackson SP. ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat Cell Biol 2006, 8:37-45. 10.1038/ncb1337, 16327781.
-
(2006)
Nat Cell Biol
, vol.8
, pp. 37-45
-
-
Jazayeri, A.1
Falck, J.2
Lukas, C.3
Bartek, J.4
Smith, G.C.5
Lukas, J.6
Jackson, S.P.7
-
39
-
-
68249126215
-
Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response.
-
Stracker TH, Usui T, Petrini JH. Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response. DNA Repair (Amst) 2009, 8:1047-1054.
-
(2009)
DNA Repair (Amst)
, vol.8
, pp. 1047-1054
-
-
Stracker, T.H.1
Usui, T.2
Petrini, J.H.3
-
40
-
-
0018649179
-
Effect of aphidicolin on viral and human DNA polymerases.
-
10.1016/0006-291X(79)91106-9, 224865
-
Pedrali-Noy G, Spadari S. Effect of aphidicolin on viral and human DNA polymerases. Biochem Biophys Res Commun 1979, 88:1194-1202. 10.1016/0006-291X(79)91106-9, 224865.
-
(1979)
Biochem Biophys Res Commun
, vol.88
, pp. 1194-1202
-
-
Pedrali-Noy, G.1
Spadari, S.2
-
41
-
-
79952235291
-
Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications.
-
10.1101/gad.2021311, 3049283, 21363960
-
Polo SE, Jackson SP. Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications. Genes Dev 2011, 25:409-433. 10.1101/gad.2021311, 3049283, 21363960.
-
(2011)
Genes Dev
, vol.25
, pp. 409-433
-
-
Polo, S.E.1
Jackson, S.P.2
-
42
-
-
30944435598
-
Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response.
-
10.1016/j.cub.2005.11.066, 16360315
-
Smits VA, Reaper PM, Jackson SP. Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response. Curr Biol 2006, 16:150-159. 10.1016/j.cub.2005.11.066, 16360315.
-
(2006)
Curr Biol
, vol.16
, pp. 150-159
-
-
Smits, V.A.1
Reaper, P.M.2
Jackson, S.P.3
-
43
-
-
0037341599
-
Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage.
-
10.1038/ncb945, 12598907
-
Lukas C, Falck J, Bartkova J, Bartek J, Lukas J. Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage. Nat Cell Biol 2003, 5:255-260. 10.1038/ncb945, 12598907.
-
(2003)
Nat Cell Biol
, vol.5
, pp. 255-260
-
-
Lukas, C.1
Falck, J.2
Bartkova, J.3
Bartek, J.4
Lukas, J.5
-
44
-
-
36749009119
-
PHD domain-mediated E3 ligase activity directs intramolecular sumoylation of an adjacent bromodomain required for gene silencing.
-
10.1016/j.molcel.2007.11.012, 18082607
-
Ivanov AV, Peng H, Yurchenko V, Yap KL, Negorev DG, Schultz DC, Psulkowski E, Fredericks WJ, White DE, Maul GG, Sadofsky MJ, Zhou MM, Rauscher FJ. PHD domain-mediated E3 ligase activity directs intramolecular sumoylation of an adjacent bromodomain required for gene silencing. Mol Cell 2007, 28:823-837. 10.1016/j.molcel.2007.11.012, 18082607.
-
(2007)
Mol Cell
, vol.28
, pp. 823-837
-
-
Ivanov, A.V.1
Peng, H.2
Yurchenko, V.3
Yap, K.L.4
Negorev, D.G.5
Schultz, D.C.6
Psulkowski, E.7
Fredericks, W.J.8
White, D.E.9
Maul, G.G.10
Sadofsky, M.J.11
Zhou, M.M.12
Rauscher, F.J.13
-
45
-
-
47749150659
-
Phosphorylation at Ser473 regulates heterochromatin protein 1 binding and corepressor function of TIF1beta/KAP1.
-
10.1186/1471-2199-9-61, 2474647, 18590578
-
Chang CW, Chou HY, Lin YS, Huang KH, Chang CJ, Hsu TC, Lee SC. Phosphorylation at Ser473 regulates heterochromatin protein 1 binding and corepressor function of TIF1beta/KAP1. BMC Mol Biol 2008, 9:61. 10.1186/1471-2199-9-61, 2474647, 18590578.
-
(2008)
BMC Mol Biol
, vol.9
, pp. 61
-
-
Chang, C.W.1
Chou, H.Y.2
Lin, Y.S.3
Huang, K.H.4
Chang, C.J.5
Hsu, T.C.6
Lee, S.C.7
-
46
-
-
78650817044
-
Is post-transcriptional stabilization, splicing and translation of selective mRNAs a key to the DNA damage response?.
-
Reinhardt HC, Cannell IG, Morandell S, Yaffe MB. Is post-transcriptional stabilization, splicing and translation of selective mRNAs a key to the DNA damage response?. Cell Cycle 2011, 10:23-27.
-
(2011)
Cell Cycle
, vol.10
, pp. 23-27
-
-
Reinhardt, H.C.1
Cannell, I.G.2
Morandell, S.3
Yaffe, M.B.4
-
47
-
-
4143152992
-
ZNF143 activates gene expression in response to DNA damage and binds to cisplatin-modified DNA.
-
10.1002/ijc.20358, 15300802
-
Ishiguchi H, Izumi H, Torigoe T, Yoshida Y, Kubota H, Tsuji S, Kohno K. ZNF143 activates gene expression in response to DNA damage and binds to cisplatin-modified DNA. Int J Cancer 2004, 111:900-909. 10.1002/ijc.20358, 15300802.
-
(2004)
Int J Cancer
, vol.111
, pp. 900-909
-
-
Ishiguchi, H.1
Izumi, H.2
Torigoe, T.3
Yoshida, Y.4
Kubota, H.5
Tsuji, S.6
Kohno, K.7
-
48
-
-
78449272175
-
Role of ZNF143 in tumor growth through transcriptional regulation of DNA replication and cell-cycle-associated genes.
-
10.1111/j.1349-7006.2010.01725.x, 20860770
-
Izumi H, Wakasugi T, Shimajiri S, Tanimoto A, Sasaguri Y, Kashiwagi E, Yasuniwa Y, Akiyama M, Han B, Wu Y, Uchiumi T, Arao T, Nishio K, Yamazaki R, Kohno K. Role of ZNF143 in tumor growth through transcriptional regulation of DNA replication and cell-cycle-associated genes. Cancer Sci 2010, 101:2538-2545. 10.1111/j.1349-7006.2010.01725.x, 20860770.
-
(2010)
Cancer Sci
, vol.101
, pp. 2538-2545
-
-
Izumi, H.1
Wakasugi, T.2
Shimajiri, S.3
Tanimoto, A.4
Sasaguri, Y.5
Kashiwagi, E.6
Yasuniwa, Y.7
Akiyama, M.8
Han, B.9
Wu, Y.10
Uchiumi, T.11
Arao, T.12
Nishio, K.13
Yamazaki, R.14
Kohno, K.15
-
49
-
-
77955625496
-
The closely related RNA helicases, UAP56 and URH49, preferentially form distinct mRNA export machineries and coordinately regulate mitotic progression.
-
10.1091/mbc.E09-10-0913, 2921121, 20573985
-
Yamazaki T, Fujiwara N, Yukinaga H, Ebisuya M, Shiki T, Kurihara T, Kioka N, Kambe T, Nagao M, Nishida E, Masuda S. The closely related RNA helicases, UAP56 and URH49, preferentially form distinct mRNA export machineries and coordinately regulate mitotic progression. Mol Biol Cell 2010, 21:2953-2965. 10.1091/mbc.E09-10-0913, 2921121, 20573985.
-
(2010)
Mol Biol Cell
, vol.21
, pp. 2953-2965
-
-
Yamazaki, T.1
Fujiwara, N.2
Yukinaga, H.3
Ebisuya, M.4
Shiki, T.5
Kurihara, T.6
Kioka, N.7
Kambe, T.8
Nagao, M.9
Nishida, E.10
Masuda, S.11
-
50
-
-
4644250615
-
Hcc-1 is a novel component of the nuclear matrix with growth inhibitory function.
-
Leaw CL, Ren EC, Choong ML. Hcc-1 is a novel component of the nuclear matrix with growth inhibitory function. Cell Mol Life Sci 2004, 61:2264-2273.
-
(2004)
Cell Mol Life Sci
, vol.61
, pp. 2264-2273
-
-
Leaw, C.L.1
Ren, E.C.2
Choong, M.L.3
-
51
-
-
79955720082
-
Anticancer therapy with checkpoint inhibitors: what, where and when?.
-
10.1016/j.tips.2011.02.014, 21458083
-
Garrett MD, Collins I. Anticancer therapy with checkpoint inhibitors: what, where and when?. Trends Pharmacol Sci 2011, 32:308-316. 10.1016/j.tips.2011.02.014, 21458083.
-
(2011)
Trends Pharmacol Sci
, vol.32
, pp. 308-316
-
-
Garrett, M.D.1
Collins, I.2
-
52
-
-
79957916529
-
Assessment of Chk1 phosphorylation as a pharmacodynamic biomarker of Chk1 inhibition.
-
10.1158/1078-0432.CCR-10-3082, 21482692
-
Parsels LA, Qian Y, Tanska DM, Gross M, Zhao L, Hassan MC, Arumugarajah S, Parsels JD, Hylander-Gans L, Simeone DM, Morosini D, Brown JL, Zabludoff SD, Maybaum J, Lawrence TS, Morgan MA. Assessment of Chk1 phosphorylation as a pharmacodynamic biomarker of Chk1 inhibition. Clin Cancer Res 2011, 17:3706-3715. 10.1158/1078-0432.CCR-10-3082, 21482692.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 3706-3715
-
-
Parsels, L.A.1
Qian, Y.2
Tanska, D.M.3
Gross, M.4
Zhao, L.5
Hassan, M.C.6
Arumugarajah, S.7
Parsels, J.D.8
Hylander-Gans, L.9
Simeone, D.M.10
Morosini, D.11
Brown, J.L.12
Zabludoff, S.D.13
Maybaum, J.14
Lawrence, T.S.15
Morgan, M.A.16
-
53
-
-
0035543198
-
One-step purification of recombinant proteins using a nanomolar-affinity streptavidin-binding peptide, the SBP-Tag.
-
10.1006/prep.2001.1515, 11722181
-
Keefe AD, Wilson DS, Seelig B, Szostak JW. One-step purification of recombinant proteins using a nanomolar-affinity streptavidin-binding peptide, the SBP-Tag. Protein Expr Purif 2001, 23:440-446. 10.1006/prep.2001.1515, 11722181.
-
(2001)
Protein Expr Purif
, vol.23
, pp. 440-446
-
-
Keefe, A.D.1
Wilson, D.S.2
Seelig, B.3
Szostak, J.W.4
-
54
-
-
79955472566
-
Chemical genetic approach for kinase-substrate mapping by covalent capture of thiophosphopeptides and analysis by mass spectrometry.
-
Hertz NT, Wang BT, Allen JJ, Zhang C, Dar AC, Burlingame AL, Shokat KM. Chemical genetic approach for kinase-substrate mapping by covalent capture of thiophosphopeptides and analysis by mass spectrometry. Curr Protoc Chem Biol 2010, 2:15-36.
-
(2010)
Curr Protoc Chem Biol
, vol.2
, pp. 15-36
-
-
Hertz, N.T.1
Wang, B.T.2
Allen, J.J.3
Zhang, C.4
Dar, A.C.5
Burlingame, A.L.6
Shokat, K.M.7
-
55
-
-
34548183872
-
Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips.
-
10.1038/nprot.2007.261, 17703201
-
Rappsilber J, Mann M, Ishihama Y. Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips. Nat Protoc 2007, 2:1896-1906. 10.1038/nprot.2007.261, 17703201.
-
(2007)
Nat Protoc
, vol.2
, pp. 1896-1906
-
-
Rappsilber, J.1
Mann, M.2
Ishihama, Y.3
-
56
-
-
33750456519
-
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
-
10.1016/j.cell.2006.09.026, 17081983
-
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell 2006, 127:635-648. 10.1016/j.cell.2006.09.026, 17081983.
-
(2006)
Cell
, vol.127
, pp. 635-648
-
-
Olsen, J.V.1
Blagoev, B.2
Gnad, F.3
Macek, B.4
Kumar, C.5
Mortensen, P.6
Mann, M.7
-
57
-
-
57449099865
-
MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification.
-
10.1038/nbt.1511, 19029910
-
Cox J, Mann M. MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. Nat Biotechnol 2008, 26:1367-1372. 10.1038/nbt.1511, 19029910.
-
(2008)
Nat Biotechnol
, vol.26
, pp. 1367-1372
-
-
Cox, J.1
Mann, M.2
-
58
-
-
80053224216
-
PeptideAtlas repository.
-
PeptideAtlas repository. , ftp://ftp:a@ftp.peptideatlas.org/pub/PeptideAtlas/Repository/PAe001952/
-
-
-
-
59
-
-
0027190834
-
A new method for introducing double-strand breaks into cellular DNA.
-
10.2307/3578455, 7683818
-
Limoli CL, Ward JF. A new method for introducing double-strand breaks into cellular DNA. Radiat Res 1993, 134:160-169. 10.2307/3578455, 7683818.
-
(1993)
Radiat Res
, vol.134
, pp. 160-169
-
-
Limoli, C.L.1
Ward, J.F.2
-
60
-
-
80053232768
-
Chimera.
-
Chimera. , http://www.cgl.ucsf.edu/chimera
-
-
-
-
61
-
-
70350732744
-
Improved visualization of protein consensus sequences by iceLogo.
-
10.1038/nmeth1109-786, 19876014
-
Colaert N, Helsens K, Martens L, Vandekerckhove J, Gevaert K. Improved visualization of protein consensus sequences by iceLogo. Nat Methods 2009, 6:786-787. 10.1038/nmeth1109-786, 19876014.
-
(2009)
Nat Methods
, vol.6
, pp. 786-787
-
-
Colaert, N.1
Helsens, K.2
Martens, L.3
Vandekerckhove, J.4
Gevaert, K.5
|