메뉴 건너뛰기




Volumn 54, Issue 1, 2014, Pages 86-112

Recent insights into the molecular pathophysiology of lipid droplet formation in hepatocytes

Author keywords

Cellular cross talks; Hepatocyte; Lipid droplets; Lipotoxicity; Metabolic syndrome; Non alcoholic fatty liver disease (NAFLD)

Indexed keywords

ALPHA TOCOPHEROL; ANGIOTENSIN RECEPTOR ANTAGONIST; ATORVASTATIN; BIOLOGICAL MARKER; CAVEOLIN; CCAAT ENHANCER BINDING PROTEIN; CD36 ANTIGEN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; EXENDIN 4; FAT DROPLET; FATTY ACID BINDING PROTEIN; FATTY ACID TRANSPORTER; HORMONE RECEPTOR BLOCKING AGENT; LIVER FATTY ACID BINDING PROTEIN; LIVER X RECEPTOR ALPHA; LONG CHAIN FATTY ACID; LONG CHAIN FATTY ACID COENZYME A LIGASE; METFORMIN; MONOCYTE CHEMOTACTIC PROTEIN 1 ANTAGONIST; PERILIPIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RAB PROTEIN; RETINOID X RECEPTOR; SNARE PROTEIN; SPIRONOLACTONE; TAUROURSODEOXYCHOLIC ACID; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 84896991817     PISSN: 01637827     EISSN: 18732194     Source Type: Journal    
DOI: 10.1016/j.plipres.2014.02.002     Document Type: Review
Times cited : (97)

References (325)
  • 2
    • 80054120815 scopus 로고    scopus 로고
    • A thematic review series: Lipid droplet storage and metabolism: From yeast to man
    • K. Reue A thematic review series: lipid droplet storage and metabolism: from yeast to man J Lipid Res 52 2011 1865 1868
    • (2011) J Lipid Res , vol.52 , pp. 1865-1868
    • Reue, K.1
  • 3
    • 84862668222 scopus 로고    scopus 로고
    • The dynamic roles of intracellular lipid droplets: From archaea to mammals
    • D.J. Murphy The dynamic roles of intracellular lipid droplets: from archaea to mammals Protoplasma 249 2012 541 585
    • (2012) Protoplasma , vol.249 , pp. 541-585
    • Murphy, D.J.1
  • 4
    • 38849096602 scopus 로고    scopus 로고
    • Imaging of lipid biosynthesis: How a neutral lipid enters lipid droplets
    • DOI 10.1111/j.1600-0854.2007.00689.x
    • L. Kuerschner, C. Moessinger, and C. Thiele Imaging of lipid biosynthesis: how a neutral lipid enters lipid droplets Traffic 9 2008 338 352 (Pubitemid 351188994)
    • (2008) Traffic , vol.9 , Issue.3 , pp. 338-352
    • Kuerschner, L.1    Moessinger, C.2    Thiele, C.3
  • 5
    • 78650825607 scopus 로고    scopus 로고
    • Quantitative analysis of lipid droplet fusion: Inefficient steady state fusion but rapid stimulation by chemical fusogens
    • S. Murphy, S. Martin, and R.G. Parton Quantitative analysis of lipid droplet fusion: inefficient steady state fusion but rapid stimulation by chemical fusogens PLoS One 5 2010 e15030
    • (2010) PLoS One , vol.5 , pp. 15030
    • Murphy, S.1    Martin, S.2    Parton, R.G.3
  • 6
    • 84861913952 scopus 로고    scopus 로고
    • Lipid droplets and cellular lipid metabolism
    • T.C. Walther, and R.V. Farese Jr. Lipid droplets and cellular lipid metabolism Annu Rev Biochem 81 2012 687 714
    • (2012) Annu Rev Biochem , vol.81 , pp. 687-714
    • Walther, T.C.1    Farese, Jr.R.V.2
  • 7
    • 85027952816 scopus 로고    scopus 로고
    • Role of lipid droplet proteins in liver steatosis
    • T. Okumura Role of lipid droplet proteins in liver steatosis J Physiol Biochem 67 2011 629 636
    • (2011) J Physiol Biochem , vol.67 , pp. 629-636
    • Okumura, T.1
  • 8
    • 46249097997 scopus 로고    scopus 로고
    • Differential pattern of lipid droplet-associated proteins and de novo perilipin expression in hepatocyte steatogenesis
    • DOI 10.1002/hep.22268
    • B.K. Straub, P. Stoeffel, H. Heid, R. Zimbelmann, and P. Schirmacher Differential pattern of lipid droplet-associated proteins and de novo perilipin expression in hepatocyte steatogenesis Hepatology 47 2008 1936 1946 (Pubitemid 351945561)
    • (2008) Hepatology , vol.47 , Issue.6 , pp. 1936-1946
    • Straub, B.K.1    Stoeffel, P.2    Heid, H.3    Zimbelmann, R.4    Schirmacher, P.5
  • 11
    • 4043077961 scopus 로고    scopus 로고
    • Molecular mediators of hepatic steatosis and liver injury
    • DOI 10.1172/JCI200422422
    • J.D. Browning, and J.D. Horton Molecular mediators of hepatic steatosis and liver injury J Clin Invest 114 2004 147 152 (Pubitemid 39071617)
    • (2004) Journal of Clinical Investigation , vol.114 , Issue.2 , pp. 147-152
    • Browning, J.D.1    Horton, J.D.2
  • 12
    • 84863012179 scopus 로고    scopus 로고
    • Pharmacological ER stress promotes hepatic lipogenesis and lipid droplet formation
    • J.S. Lee, R. Mendez, H.H. Heng, Z.Q. Yang, and K. Zhang Pharmacological ER stress promotes hepatic lipogenesis and lipid droplet formation Am J Transl Res 4 2012 102 113
    • (2012) Am J Transl Res , vol.4 , pp. 102-113
    • Lee, J.S.1    Mendez, R.2    Heng, H.H.3    Yang, Z.Q.4    Zhang, K.5
  • 13
    • 79957943690 scopus 로고    scopus 로고
    • Molecular mechanisms of steatosis in nonalcoholic fatty liver disease
    • P. Pettinelli, A.M. Obregon, and L.A. Videla Molecular mechanisms of steatosis in nonalcoholic fatty liver disease Nutr Hosp 26 2011 441 450
    • (2011) Nutr Hosp , vol.26 , pp. 441-450
    • Pettinelli, P.1    Obregon, A.M.2    Videla, L.A.3
  • 14
    • 84863356961 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress-associated lipid droplet formation and type II diabetes
    • X. Zhang, and K. Zhang Endoplasmic reticulum stress-associated lipid droplet formation and type II diabetes Biochem Res Int 2012 2012 247275
    • (2012) Biochem Res Int , vol.2012 , pp. 247275
    • Zhang, X.1    Zhang, K.2
  • 15
    • 84877039529 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: Current issues and novel treatment approaches
    • R. Lomonaco, N.E. Sunny, F. Bril, and K. Cusi Nonalcoholic fatty liver disease: current issues and novel treatment approaches Drugs 73 2013 1 14
    • (2013) Drugs , vol.73 , pp. 1-14
    • Lomonaco, R.1    Sunny, N.E.2    Bril, F.3    Cusi, K.4
  • 16
    • 81855213130 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: The therapeutic challenge of a global epidemic
    • J.M. Schattenberg, and D. Schuppan Nonalcoholic steatohepatitis: the therapeutic challenge of a global epidemic Curr Opin Lipidol 22 2011 479 488
    • (2011) Curr Opin Lipidol , vol.22 , pp. 479-488
    • Schattenberg, J.M.1    Schuppan, D.2
  • 17
    • 54049150442 scopus 로고    scopus 로고
    • Molecular mechanisms and therapeutic targets in steatosis and steatohepatitis
    • N. Anderson, and J. Borlak Molecular mechanisms and therapeutic targets in steatosis and steatohepatitis Pharmacol Rev 60 2008 311 357
    • (2008) Pharmacol Rev , vol.60 , pp. 311-357
    • Anderson, N.1    Borlak, J.2
  • 18
    • 34249711303 scopus 로고    scopus 로고
    • Metabolic Syndrome and NASH
    • DOI 10.1016/j.cld.2007.02.013, PII S108932610700013X, Non-Alcoholic Steatohepatitis and Non-Alcoholic Fatty Liver Disease
    • G. Marchesini, and R. Marzocchi Metabolic syndrome and NASH Clin Liver Dis 11 2007 105 117 ix (Pubitemid 46829976)
    • (2007) Clinics in Liver Disease , vol.11 , Issue.1 , pp. 105-117
    • Marchesini, G.1    Marzocchi, R.2
  • 19
    • 80051495481 scopus 로고    scopus 로고
    • Dynamic modification of sphingomyelin in lipid microdomains controls development of obesity, fatty liver, and type 2 diabetes
    • S. Mitsutake, K. Zama, H. Yokota, T. Yoshida, M. Tanaka, and M. Mitsui et al. Dynamic modification of sphingomyelin in lipid microdomains controls development of obesity, fatty liver, and type 2 diabetes J Biol Chem 286 2011 28544 28555
    • (2011) J Biol Chem , vol.286 , pp. 28544-28555
    • Mitsutake, S.1    Zama, K.2    Yokota, H.3    Yoshida, T.4    Tanaka, M.5    Mitsui, M.6
  • 20
    • 33244493738 scopus 로고    scopus 로고
    • f 60-400 particle composition reduces uptake of LDL by HepG2 cells
    • DOI 10.1194/jlr.M500382-JLR200
    • K.G. Jackson, V. Maitin, D.S. Leake, P. Yaqoob, and C.M. Williams Saturated fat-induced changes in Sf 60-400 particle composition reduces uptake of LDL by HepG2 cells J Lipid Res 47 2006 393 403 (Pubitemid 43276925)
    • (2006) Journal of Lipid Research , vol.47 , Issue.2 , pp. 393-403
    • Jackson, K.G.1    Maitin, V.2    Leake, D.S.3    Yaqoob, P.4    Williams, C.M.5
  • 22
    • 50849085763 scopus 로고    scopus 로고
    • Fatty acid flip-flop in a model membrane is faster than desorption into the aqueous phase
    • J.R. Simard, B.K. Pillai, and J.A. Hamilton Fatty acid flip-flop in a model membrane is faster than desorption into the aqueous phase Biochemistry 47 2008 9081 9089
    • (2008) Biochemistry , vol.47 , pp. 9081-9089
    • Simard, J.R.1    Pillai, B.K.2    Hamilton, J.A.3
  • 23
    • 0037832573 scopus 로고    scopus 로고
    • Fast flip-flop of cholesterol and fatty acids in membranes: Implications for membrane transport proteins
    • DOI 10.1097/00041433-200306000-00006
    • J.A. Hamilton Fast flip-flop of cholesterol and fatty acids in membranes: implications for membrane transport proteins Curr Opin Lipidol 14 2003 263 271 (Pubitemid 36688205)
    • (2003) Current Opinion in Lipidology , vol.14 , Issue.3 , pp. 263-271
    • Hamilton, J.A.1
  • 24
    • 38449087713 scopus 로고    scopus 로고
    • ChREBP, a transcriptional regulator of glucose and lipid metabolism
    • DOI 10.1146/annurev.nutr.27.061406.093618
    • C. Postic, R. Dentin, P.D. Denechaud, and J. Girard ChREBP, a transcriptional regulator of glucose and lipid metabolism Annu Rev Nutr 27 2007 179 192 (Pubitemid 351373354)
    • (2007) Annual Review of Nutrition , vol.27 , pp. 179-192
    • Postic, C.1    Dentin, R.2    Denechaud, P.-D.3    Girard, J.4
  • 25
    • 80054745073 scopus 로고    scopus 로고
    • Overexpression of CD36 and acyl-CoA synthetases FATP2, FATP4 and ACSL1 increases fatty acid uptake in human hepatoma cells
    • J. Krammer, M. Digel, F. Ehehalt, W. Stremmel, J. Fullekrug, and R. Ehehalt Overexpression of CD36 and acyl-CoA synthetases FATP2, FATP4 and ACSL1 increases fatty acid uptake in human hepatoma cells Int J Med Sci 8 2011 599 614
    • (2011) Int J Med Sci , vol.8 , pp. 599-614
    • Krammer, J.1    Digel, M.2    Ehehalt, F.3    Stremmel, W.4    Fullekrug, J.5    Ehehalt, R.6
  • 26
    • 84860311914 scopus 로고    scopus 로고
    • The N-terminal region of acyl-CoA synthetase 3 is essential for both the localization on lipid droplets and the function in fatty acid uptake
    • M. Poppelreuther, B. Rudolph, C. Du, R. Grossmann, M. Becker, and C. Thiele et al. The N-terminal region of acyl-CoA synthetase 3 is essential for both the localization on lipid droplets and the function in fatty acid uptake J Lipid Res 53 2012 888 900
    • (2012) J Lipid Res , vol.53 , pp. 888-900
    • Poppelreuther, M.1    Rudolph, B.2    Du, C.3    Grossmann, R.4    Becker, M.5    Thiele, C.6
  • 28
    • 65449159320 scopus 로고    scopus 로고
    • Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice
    • Q. Wang, L. Jiang, J. Wang, S. Li, Y. Yu, and J. You et al. Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice Hepatology 49 2009 1166 1175
    • (2009) Hepatology , vol.49 , pp. 1166-1175
    • Wang, Q.1    Jiang, L.2    Wang, J.3    Li, S.4    Yu, Y.5    You, J.6
  • 29
    • 65549136260 scopus 로고    scopus 로고
    • Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: Role of stearoyl-CoA desaturase
    • Z.Z. Li, M. Berk, T.M. McIntyre, and A.E. Feldstein Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase J Biol Chem 284 2009 5637 5644
    • (2009) J Biol Chem , vol.284 , pp. 5637-5644
    • Li, Z.Z.1    Berk, M.2    McIntyre, T.M.3    Feldstein, A.E.4
  • 30
    • 34250827848 scopus 로고    scopus 로고
    • ELOVL2 overexpression enhances triacylglycerol synthesis in 3T3-L1 and F442A cells
    • DOI 10.1016/j.febslet.2007.05.081, PII S0014579307006436
    • T. Kobayashi, D. Zadravec, and A. Jacobsson ELOVL2 overexpression enhances triacylglycerol synthesis in 3T3-L1 and F442A cells FEBS Lett 581 2007 3157 3163 (Pubitemid 46977355)
    • (2007) FEBS Letters , vol.581 , Issue.17 , pp. 3157-3163
    • Kobayashi, T.1    Zadravec, D.2    Jacobsson, A.3
  • 31
    • 78649818490 scopus 로고    scopus 로고
    • Ablation of the very-long-chain fatty acid elongase ELOVL3 in mice leads to constrained lipid storage and resistance to diet-induced obesity
    • D. Zadravec, A. Brolinson, R.M. Fisher, C. Carneheim, R.I. Csikasz, and J. Bertrand-Michel et al. Ablation of the very-long-chain fatty acid elongase ELOVL3 in mice leads to constrained lipid storage and resistance to diet-induced obesity FASEB J 24 2010 4366 4377
    • (2010) FASEB J , vol.24 , pp. 4366-4377
    • Zadravec, D.1    Brolinson, A.2    Fisher, R.M.3    Carneheim, C.4    Csikasz, R.I.5    Bertrand-Michel, J.6
  • 32
    • 77953515738 scopus 로고    scopus 로고
    • Role of fatty acid elongases in determination of de novo synthesized monounsaturated fatty acid species
    • C.D. Green, C.G. Ozguden-Akkoc, Y. Wang, D.B. Jump, and L.K. Olson Role of fatty acid elongases in determination of de novo synthesized monounsaturated fatty acid species J Lipid Res 51 2010 1871 1877
    • (2010) J Lipid Res , vol.51 , pp. 1871-1877
    • Green, C.D.1    Ozguden-Akkoc, C.G.2    Wang, Y.3    Jump, D.B.4    Olson, L.K.5
  • 33
    • 64149083800 scopus 로고    scopus 로고
    • Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice
    • Y.A. Moon, R.E. Hammer, and J.D. Horton Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice J Lipid Res 50 2009 412 423
    • (2009) J Lipid Res , vol.50 , pp. 412-423
    • Moon, Y.A.1    Hammer, R.E.2    Horton, J.D.3
  • 34
    • 77950612089 scopus 로고    scopus 로고
    • A subset of dysregulated metabolic and survival genes is associated with severity of hepatic steatosis in obese Zucker rats
    • X. Buque, M.J. Martinez, A. Cano, M.E. Miquilena-Colina, C. Garcia-Monzon, and P. Aspichueta et al. A subset of dysregulated metabolic and survival genes is associated with severity of hepatic steatosis in obese Zucker rats J Lipid Res 51 2010 500 513
    • (2010) J Lipid Res , vol.51 , pp. 500-513
    • Buque, X.1    Martinez, M.J.2    Cano, A.3    Miquilena-Colina, M.E.4    Garcia-Monzon, C.5    Aspichueta, P.6
  • 35
    • 42949091932 scopus 로고    scopus 로고
    • Genetic susceptibility to chronic hepatitis is inherited codominantly in Helicobacter hepaticus-infected AB6F1 and B6AF1 hybrid male mice, and progression to hepatocellular carcinoma is linked to hepatic expression of lipogenic genes and immune function-associated networks
    • DOI 10.1128/IAI.01044-07
    • A. Garcia, M.M. Ihrig, R.C. Fry, Y. Feng, S. Xu, and S.R. Boutin et al. Genetic susceptibility to chronic hepatitis is inherited codominantly in Helicobacter hepaticus-infected AB6F1 and B6AF1 hybrid male mice, and progression to hepatocellular carcinoma is linked to hepatic expression of lipogenic genes and immune function-associated networks Infect Immun 76 2008 1866 1876 (Pubitemid 351656120)
    • (2008) Infection and Immunity , vol.76 , Issue.5 , pp. 1866-1876
    • Garcia, A.1    Ihrig, M.M.2    Fry, R.C.3    Feng, Y.4    Xu, S.5    Boutin, S.R.6    Rogers, A.B.7    Muthupalani, S.8    Samson, L.D.9    Fox, J.G.10
  • 36
    • 84875671236 scopus 로고    scopus 로고
    • Inhibitors of fatty acid synthesis induce PPAR alpha-regulated fatty acid beta-oxidative genes: Synergistic roles of L-FABP and glucose
    • H. Huang, A.L. McIntosh, G.G. Martin, A.D. Petrescu, K.K. Landrock, and D. Landrock et al. Inhibitors of fatty acid synthesis induce PPAR alpha-regulated fatty acid beta-oxidative genes: synergistic roles of L-FABP and glucose PPAR Res 2013 2013 865604
    • (2013) PPAR Res , vol.2013 , pp. 865604
    • Huang, H.1    McIntosh, A.L.2    Martin, G.G.3    Petrescu, A.D.4    Landrock, K.K.5    Landrock, D.6
  • 37
    • 84871023781 scopus 로고    scopus 로고
    • Liver X receptors and fat cell metabolism
    • J. Laurencikiene, and M. Ryden Liver X receptors and fat cell metabolism Int J Obes Lond 36 2012 1494 1502
    • (2012) Int J Obes Lond , vol.36 , pp. 1494-1502
    • Laurencikiene, J.1    Ryden, M.2
  • 38
    • 84866149370 scopus 로고    scopus 로고
    • Update on ppargamma and nonalcoholic fatty liver disease
    • G.P. Ables Update on ppargamma and nonalcoholic fatty liver disease PPAR Res 2012 2012 912351
    • (2012) PPAR Res , vol.2012 , pp. 912351
    • Ables, G.P.1
  • 40
    • 84869215008 scopus 로고    scopus 로고
    • FGFR3 stimulates stearoyl CoA desaturase 1 activity to promote bladder tumor growth
    • X. Du, Q.R. Wang, E. Chan, M. Merchant, J. Liu, and D. French et al. FGFR3 stimulates stearoyl CoA desaturase 1 activity to promote bladder tumor growth Cancer Res 72 2012 5843 5855
    • (2012) Cancer Res , vol.72 , pp. 5843-5855
    • Du, X.1    Wang, Q.R.2    Chan, E.3    Merchant, M.4    Liu, J.5    French, D.6
  • 41
    • 84861425644 scopus 로고    scopus 로고
    • The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2
    • J. Qi, W. Lang, J.G. Geisler, P. Wang, I. Petrounia, and S. Mai et al. The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2 J Lipid Res 53 2012 1106 1116
    • (2012) J Lipid Res , vol.53 , pp. 1106-1116
    • Qi, J.1    Lang, W.2    Geisler, J.G.3    Wang, P.4    Petrounia, I.5    Mai, S.6
  • 42
    • 84875164496 scopus 로고    scopus 로고
    • Hepatic triacylglycerol synthesis and secretion: DGAT2 as the link between glycaemia and triglyceridaemia
    • V.A. Zammit Hepatic triacylglycerol synthesis and secretion: DGAT2 as the link between glycaemia and triglyceridaemia Biochem J 451 2013 1 12
    • (2013) Biochem J , vol.451 , pp. 1-12
    • Zammit, V.A.1
  • 44
    • 84865227832 scopus 로고    scopus 로고
    • Diacylglycerol acyltransferase 2 acts upstream of diacylglycerol acyltransferase 1 and utilizes nascent diglycerides and de novo synthesized fatty acids in HepG2 cells
    • H.R. Wurie, L. Buckett, and V.A. Zammit Diacylglycerol acyltransferase 2 acts upstream of diacylglycerol acyltransferase 1 and utilizes nascent diglycerides and de novo synthesized fatty acids in HepG2 cells FEBS J 279 2012 3033 3047
    • (2012) FEBS J , vol.279 , pp. 3033-3047
    • Wurie, H.R.1    Buckett, L.2    Zammit, V.A.3
  • 45
    • 84856072854 scopus 로고    scopus 로고
    • Packaging of fat: An evolving model of lipid droplet assembly and expansion
    • D.L. Brasaemle, and N.E. Wolins Packaging of fat: an evolving model of lipid droplet assembly and expansion J Biol Chem 287 2012 2273 2279
    • (2012) J Biol Chem , vol.287 , pp. 2273-2279
    • Brasaemle, D.L.1    Wolins, N.E.2
  • 46
    • 7244242391 scopus 로고    scopus 로고
    • Overexpression of human diacylglycerol acyltransferase 1, acyl-CoA:Cholesterol acyltransferase 1, or acyl-CoA:Cholesterol acyltransferase 2 stimulates secretion of apolipoprotein B-containing lipoproteins in McA-RH7777 cells
    • DOI 10.1074/jbc.M408507200
    • J.J. Liang, P. Oelkers, C. Guo, P.C. Chu, J.L. Dixon, and H.N. Ginsberg et al. Overexpression of human diacylglycerol acyltransferase 1, acyl-coa:cholesterol acyltransferase 1, or acyl-CoA:cholesterol acyltransferase 2 stimulates secretion of apolipoprotein B-containing lipoproteins in McA-RH7777 cells J Biol Chem 279 2004 44938 44944 (Pubitemid 39430907)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.43 , pp. 44938-44944
    • Liang, J.J.1    Oelkers, P.2    Guo, C.3    Chu, P.-C.4    Dixon, J.L.5    Ginsberg, H.N.6    Sturley, S.L.7
  • 47
    • 0034623070 scopus 로고    scopus 로고
    • Immunological quantitation and localization of ACAT-1 and ACAT-2 in human liver and small intestine
    • C.C. Chang, N. Sakashita, K. Ornvold, O. Lee, E.T. Chang, and R. Dong et al. Immunological quantitation and localization of ACAT-1 and ACAT-2 in human liver and small intestine J Biol Chem 275 2000 28083 28092
    • (2000) J Biol Chem , vol.275 , pp. 28083-28092
    • Chang, C.C.1    Sakashita, N.2    Ornvold, K.3    Lee, O.4    Chang, E.T.5    Dong, R.6
  • 48
    • 0031847230 scopus 로고    scopus 로고
    • Immunodepletion experiments suggest that acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1) protein plays a major catalytic role in adult human liver, adrenal gland, macrophages, and kidney, but not in intestines
    • O. Lee, C.C. Chang, W. Lee, and T.Y. Chang Immunodepletion experiments suggest that acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1) protein plays a major catalytic role in adult human liver, adrenal gland, macrophages, and kidney, but not in intestines J Lipid Res 39 1998 1722 1727 (Pubitemid 28377938)
    • (1998) Journal of Lipid Research , vol.39 , Issue.8 , pp. 1722-1727
    • Lee, O.1    Chang, C.C.Y.2    Lee, W.3    Chang, T.-Y.4
  • 49
    • 0034520194 scopus 로고    scopus 로고
    • Differential expression of ACAT1 and ACAT2 among cells within liver, intestine, kidney, and adrenal of nonhuman primates
    • R.G. Lee, M.C. Willingham, M.A. Davis, K.A. Skinner, and L.L. Rudel Differential expression of ACAT1 and ACAT2 among cells within liver, intestine, kidney, and adrenal of nonhuman primates J Lipid Res 41 2000 1991 2001 (Pubitemid 32038994)
    • (2000) Journal of Lipid Research , vol.41 , Issue.12 , pp. 1991-2001
    • Lee, R.G.1    Willingham, M.C.2    Davis, M.A.3    Skinner, K.A.4    Rudel, L.L.5
  • 51
    • 0035081589 scopus 로고    scopus 로고
    • Acyl coenzyme A: Cholesterol acyltransferase types 1 and 2: Structure and function in atherosclerosis
    • DOI 10.1097/00041433-200104000-00005
    • L.L. Rudel, R.G. Lee, and T.L. Cockman Acyl coenzyme A:cholesterol acyltransferase types 1 and 2: structure and function in atherosclerosis Curr Opin Lipidol 12 2001 121 127 (Pubitemid 32242919)
    • (2001) Current Opinion in Lipidology , vol.12 , Issue.2 , pp. 121-127
    • Rudel, L.L.1    Lee, R.G.2    Cockman, T.L.3
  • 52
    • 84897017252 scopus 로고    scopus 로고
    • The AOCS Lipid Library [Internet]; July [cited 19.11.2013]
    • Fillimore N, Alrob OA, Lopaschuk GD. Fatty acid β oxidation. The AOCS Lipid Library [Internet]; July 2011. < http://lipidlibrary.aocs.org/ animbio/faoxid/index.htm > [cited 19.11.2013].
    • (2011) Fatty Acid β Oxidation
    • Fillimore, N.1    Alrob, O.A.2    Lopaschuk, G.D.3
  • 53
    • 79958841953 scopus 로고    scopus 로고
    • FAT/CD36 is located on the outer mitochondrial membrane, upstream of long-chain acyl-CoA synthetase, and regulates palmitate oxidation
    • B.K. Smith, S.S. Jain, S. Rimbaud, A. Dam, J. Quadrilatero, and R. Ventura-Clapier et al. FAT/CD36 is located on the outer mitochondrial membrane, upstream of long-chain acyl-CoA synthetase, and regulates palmitate oxidation Biochem J 437 2011 125 134
    • (2011) Biochem J , vol.437 , pp. 125-134
    • Smith, B.K.1    Jain, S.S.2    Rimbaud, S.3    Dam, A.4    Quadrilatero, J.5    Ventura-Clapier, R.6
  • 56
    • 77954363354 scopus 로고    scopus 로고
    • Apoptosis is associated with CD36/fatty acid translocase upregulation in non-alcoholic steatohepatitis
    • L.P. Bechmann, R.K. Gieseler, J.P. Sowa, A. Kahraman, J. Erhard, and I. Wedemeyer et al. Apoptosis is associated with CD36/fatty acid translocase upregulation in non-alcoholic steatohepatitis Liver Int 30 2010 850 859
    • (2010) Liver Int , vol.30 , pp. 850-859
    • Bechmann, L.P.1    Gieseler, R.K.2    Sowa, J.P.3    Kahraman, A.4    Erhard, J.5    Wedemeyer, I.6
  • 57
    • 84885993664 scopus 로고    scopus 로고
    • CD36 deletion reduces VLDL secretion, modulates liver prostaglandin levels and exacerbates hepatic steatosis in ob/ob mice
    • F. Nassir, O.L. Adewole, E.M. Brunt, and N.A. Abumrad CD36 deletion reduces VLDL secretion, modulates liver prostaglandin levels and exacerbates hepatic steatosis in ob/ob mice J Lipid Res 2013
    • (2013) J Lipid Res
    • Nassir, F.1    Adewole, O.L.2    Brunt, E.M.3    Abumrad, N.A.4
  • 58
    • 80052596785 scopus 로고    scopus 로고
    • Hepatic fatty acid translocase CD36 upregulation is associated with insulin resistance, hyperinsulinaemia and increased steatosis in non-alcoholic steatohepatitis and chronic hepatitis C
    • M.E. Miquilena-Colina, E. Lima-Cabello, S. Sanchez-Campos, M.V. Garcia-Mediavilla, M. Fernandez-Bermejo, and T. Lozano-Rodriguez et al. Hepatic fatty acid translocase CD36 upregulation is associated with insulin resistance, hyperinsulinaemia and increased steatosis in non-alcoholic steatohepatitis and chronic hepatitis C Gut 60 2011 1394 1402
    • (2011) Gut , vol.60 , pp. 1394-1402
    • Miquilena-Colina, M.E.1    Lima-Cabello, E.2    Sanchez-Campos, S.3    Garcia-Mediavilla, M.V.4    Fernandez-Bermejo, M.5    Lozano-Rodriguez, T.6
  • 60
    • 36849037401 scopus 로고    scopus 로고
    • Increased hepatic CD36 expression contributes to dyslipidemia associated with diet-induced obesity
    • DOI 10.2337/db07-0907
    • D.P. Koonen, R.L. Jacobs, M. Febbraio, M.E. Young, C.L. Soltys, and H. Ong et al. Increased hepatic CD36 expression contributes to dyslipidemia associated with diet-induced obesity Diabetes 56 2007 2863 2871 (Pubitemid 350223619)
    • (2007) Diabetes , vol.56 , Issue.12 , pp. 2863-2871
    • Koonen, D.P.Y.1    Jacobs, R.L.2    Febbraio, M.3    Young, M.E.4    Soltys, C.-L.M.5    Ong, H.6    Vance, D.E.7    Dyck, J.R.B.8
  • 61
    • 0036109168 scopus 로고    scopus 로고
    • Defective fatty acid uptake modulates insulin responsiveness and metabolic responses to diet in CD36-null mice
    • DOI 10.1172/JCI200214596
    • T. Hajri, X.X. Han, A. Bonen, and N.A. Abumrad Defective fatty acid uptake modulates insulin responsiveness and metabolic responses to diet in CD36-null mice J Clin Invest 109 2002 1381 1389 (Pubitemid 34546903)
    • (2002) Journal of Clinical Investigation , vol.109 , Issue.10 , pp. 1381-1389
    • Hajri, T.1    Han, X.X.2    Bonen, A.3    Abumrad, N.A.4
  • 62
    • 74949084316 scopus 로고    scopus 로고
    • Membrane fatty acid transporters as regulators of lipid metabolism: Implications for metabolic disease
    • J.F. Glatz, J.J. Luiken, and A. Bonen Membrane fatty acid transporters as regulators of lipid metabolism: implications for metabolic disease Physiol Rev 90 2010 367 417
    • (2010) Physiol Rev , vol.90 , pp. 367-417
    • Glatz, J.F.1    Luiken, J.J.2    Bonen, A.3
  • 63
    • 12744274513 scopus 로고    scopus 로고
    • Fatty acid translocase (FAT/CD36) is localized on insulin-containing granules in human pancreatic beta-cells and mediates fatty acid effects on insulin secretion
    • H. Noushmehr, E. D'Amico, L. Farilla, H. Hui, K.A. Wawrowsky, and W. Mlynarski et al. Fatty acid translocase (FAT/CD36) is localized on insulin-containing granules in human pancreatic beta-cells and mediates fatty acid effects on insulin secretion Diabetes 54 2005 472 481
    • (2005) Diabetes , vol.54 , pp. 472-481
    • Noushmehr, H.1    D'Amico, E.2    Farilla, L.3    Hui, H.4    Wawrowsky, K.A.5    Mlynarski, W.6
  • 64
  • 65
    • 38649096259 scopus 로고    scopus 로고
    • Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis
    • J. Zhou, M. Febbraio, T. Wada, Y. Zhai, R. Kuruba, and J. He et al. Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis Gastroenterology 134 2008 556 567
    • (2008) Gastroenterology , vol.134 , pp. 556-567
    • Zhou, J.1    Febbraio, M.2    Wada, T.3    Zhai, Y.4    Kuruba, R.5    He, J.6
  • 66
    • 77958196146 scopus 로고    scopus 로고
    • Activation of the aryl hydrocarbon receptor induces hepatic steatosis via the upregulation of fatty acid transport
    • Y. Kawano, S. Nishiumi, S. Tanaka, K. Nobutani, A. Miki, and Y. Yano et al. Activation of the aryl hydrocarbon receptor induces hepatic steatosis via the upregulation of fatty acid transport Arch Biochem Biophys 504 2010 221 227
    • (2010) Arch Biochem Biophys , vol.504 , pp. 221-227
    • Kawano, Y.1    Nishiumi, S.2    Tanaka, S.3    Nobutani, K.4    Miki, A.5    Yano, Y.6
  • 67
    • 77955488532 scopus 로고    scopus 로고
    • A novel role for the dioxin receptor in fatty acid metabolism and hepatic steatosis
    • J.H. Lee, T. Wada, M. Febbraio, J. He, T. Matsubara, and M.J. Lee et al. A novel role for the dioxin receptor in fatty acid metabolism and hepatic steatosis Gastroenterology 139 2010 653 663
    • (2010) Gastroenterology , vol.139 , pp. 653-663
    • Lee, J.H.1    Wada, T.2    Febbraio, M.3    He, J.4    Matsubara, T.5    Lee, M.J.6
  • 68
    • 75149115740 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor functions as a tumor suppressor of liver carcinogenesis
    • Y. Fan, G.P. Boivin, E.S. Knudsen, D.W. Nebert, Y. Xia, and A. Puga The aryl hydrocarbon receptor functions as a tumor suppressor of liver carcinogenesis Cancer Res 70 2010 212 220
    • (2010) Cancer Res , vol.70 , pp. 212-220
    • Fan, Y.1    Boivin, G.P.2    Knudsen, E.S.3    Nebert, D.W.4    Xia, Y.5    Puga, A.6
  • 69
    • 84880570433 scopus 로고    scopus 로고
    • Liver fatty acid binding protein gene-ablation exacerbates weight gain in high-fat fed female mice
    • A.L. McIntosh, B.P. Atshaves, D. Landrock, K.K. Landrock, G.G. Martin, and S.M. Storey et al. Liver fatty acid binding protein gene-ablation exacerbates weight gain in high-fat fed female mice Lipids 48 2013 435 448
    • (2013) Lipids , vol.48 , pp. 435-448
    • McIntosh, A.L.1    Atshaves, B.P.2    Landrock, D.3    Landrock, K.K.4    Martin, G.G.5    Storey, S.M.6
  • 70
    • 84882606619 scopus 로고    scopus 로고
    • Interactions between human liver fatty acid binding protein and peroxisome proliferator activated receptor selective drugs
    • T. Velkov Interactions between human liver fatty acid binding protein and peroxisome proliferator activated receptor selective drugs PPAR Res 2013 2013 938401
    • (2013) PPAR Res , vol.2013 , pp. 938401
    • Velkov, T.1
  • 71
    • 66349121402 scopus 로고    scopus 로고
    • Structural and functional analysis of fatty acid-binding proteins
    • J. Storch, and L. McDermott Structural and functional analysis of fatty acid-binding proteins J Lipid Res 50 Suppl 2009 S126 S131
    • (2009) J Lipid Res , vol.50 , Issue.SUPPL.
    • Storch, J.1    McDermott, L.2
  • 73
    • 48749109440 scopus 로고    scopus 로고
    • Activation of PPARgamma reverses a defect of surfactant synthesis in mice lacking two types of fatty acid binding protein
    • C. Schachtrup, S. Malcharek, J.J. Haitsma, B. Lachmann, Y. Owada, and B. Binas et al. Activation of PPARgamma reverses a defect of surfactant synthesis in mice lacking two types of fatty acid binding protein Biochim Biophys Acta 1781 2008 314 320
    • (2008) Biochim Biophys Acta , vol.1781 , pp. 314-320
    • Schachtrup, C.1    Malcharek, S.2    Haitsma, J.J.3    Lachmann, B.4    Owada, Y.5    Binas, B.6
  • 74
    • 84873700660 scopus 로고    scopus 로고
    • The human liver fatty acid binding protein (FABP1) gene is activated by FOXA1 and PPARalpha; And repressed by C/EBPalpha: Implications in FABP1 down-regulation in nonalcoholic fatty liver disease
    • C. Guzman, M. Benet, S. Pisonero-Vaquero, M. Moya, M.V. Garcia-Mediavilla, and M.L. Martinez-Chantar et al. The human liver fatty acid binding protein (FABP1) gene is activated by FOXA1 and PPARalpha; and repressed by C/EBPalpha: implications in FABP1 down-regulation in nonalcoholic fatty liver disease Biochim Biophys Acta 1831 2013 803 818
    • (2013) Biochim Biophys Acta , vol.1831 , pp. 803-818
    • Guzman, C.1    Benet, M.2    Pisonero-Vaquero, S.3    Moya, M.4    Garcia-Mediavilla, M.V.5    Martinez-Chantar, M.L.6
  • 76
    • 34248337907 scopus 로고    scopus 로고
    • Fatty acid transport proteins
    • DOI 10.1097/MOL.0b013e3281338558, PII 0004143320070600000008
    • R.E. Gimeno Fatty acid transport proteins Curr Opin Lipidol 18 2007 271 276 (Pubitemid 46743050)
    • (2007) Current Opinion in Lipidology , vol.18 , Issue.3 , pp. 271-276
    • Gimeno, R.E.1
  • 77
    • 77956803815 scopus 로고    scopus 로고
    • FATP2 is a hepatic fatty acid transporter and peroxisomal very long-chain acyl-CoA synthetase
    • A. Falcon, H. Doege, A. Fluitt, B. Tsang, N. Watson, and M.A. Kay et al. FATP2 is a hepatic fatty acid transporter and peroxisomal very long-chain acyl-CoA synthetase Am J Physiol Endocrinol Metab 299 2010 E384 E393
    • (2010) Am J Physiol Endocrinol Metab , vol.299
    • Falcon, A.1    Doege, H.2    Fluitt, A.3    Tsang, B.4    Watson, N.5    Kay, M.A.6
  • 79
    • 84864365408 scopus 로고    scopus 로고
    • Specific bile acids inhibit hepatic fatty acid uptake in mice
    • B. Nie, H.M. Park, M. Kazantzis, M. Lin, A. Henkin, and S. Ng et al. Specific bile acids inhibit hepatic fatty acid uptake in mice Hepatology 56 2012 1300 1310
    • (2012) Hepatology , vol.56 , pp. 1300-1310
    • Nie, B.1    Park, H.M.2    Kazantzis, M.3    Lin, M.4    Henkin, A.5    Ng, S.6
  • 81
    • 77956820329 scopus 로고    scopus 로고
    • SR-BI, CD36, and caveolin-1 contribute positively to cholesterol efflux in hepatic cells
    • T.Q. Truong, D. Aubin, L. Falstrault, M.R. Brodeur, and L. Brissette SR-BI, CD36, and caveolin-1 contribute positively to cholesterol efflux in hepatic cells Cell Biochem Funct 28 2010 480 489
    • (2010) Cell Biochem Funct , vol.28 , pp. 480-489
    • Truong, T.Q.1    Aubin, D.2    Falstrault, L.3    Brodeur, M.R.4    Brissette, L.5
  • 82
    • 84859786953 scopus 로고    scopus 로고
    • Caveolins and caveolae, roles in insulin signalling and diabetes
    • P. Stralfors Caveolins and caveolae, roles in insulin signalling and diabetes Adv Exp Med Biol 729 2012 111 126
    • (2012) Adv Exp Med Biol , vol.729 , pp. 111-126
    • Stralfors, P.1
  • 84
    • 0036737860 scopus 로고    scopus 로고
    • Uptake of long-chain fatty acids in HepG2 cells involves caveolae: Analysis of a novel pathway
    • J. Pohl, A. Ring, and W. Stremmel Uptake of long-chain fatty acids in HepG2 cells involves caveolae: analysis of a novel pathway J Lipid Res 43 2002 1390 1399
    • (2002) J Lipid Res , vol.43 , pp. 1390-1399
    • Pohl, J.1    Ring, A.2    Stremmel, W.3
  • 85
    • 84858072223 scopus 로고    scopus 로고
    • Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression
    • K.D. Corbin, and S.H. Zeisel Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression Curr Opin Gastroenterol 28 2012 159 165
    • (2012) Curr Opin Gastroenterol , vol.28 , pp. 159-165
    • Corbin, K.D.1    Zeisel, S.H.2
  • 86
    • 33747079056 scopus 로고    scopus 로고
    • A choline-deficient diet exacerbates fatty liver but attenuates insulin resistance and glucose intolerance in mice fed a high-fat diet
    • DOI 10.2337/db06-0097
    • P.J. Raubenheimer, M.J. Nyirenda, and B.R. Walker A choline-deficient diet exacerbates fatty liver but attenuates insulin resistance and glucose intolerance in mice fed a high-fat diet Diabetes 55 2006 2015 2020 (Pubitemid 44509974)
    • (2006) Diabetes , vol.55 , Issue.7 , pp. 2015-2020
    • Raubenheimer, P.J.1    Nyirenda, M.J.2    Walker, B.R.3
  • 88
    • 84858796689 scopus 로고    scopus 로고
    • Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR
    • A.C. Calkin, and P. Tontonoz Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR Nat Rev Mol Cell Biol 13 2012 213 224
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 213-224
    • Calkin, A.C.1    Tontonoz, P.2
  • 89
    • 84896924220 scopus 로고    scopus 로고
    • The role of liver X receptor in hepatic de novo lipogenesis and cross-talk with insulin and glucose signaling
    • Rodrigo Valenzuela Baez, InTech
    • Line M. Grønning-Wang, Christian Bindesbøll, and Hilde I. Nebb The role of liver X receptor in hepatic de novo lipogenesis and cross-talk with insulin and glucose signaling Rodrigo Valenzuela Baez, Lipid metabolism 2013 InTech 60
    • (2013) Lipid Metabolism , pp. 60
    • Grønning-Wang, L.M.1    Bindesbøll, C.2    Nebb, H.I.3
  • 91
    • 55849105651 scopus 로고    scopus 로고
    • Liver X receptors (LXR) as therapeutic targets in dyslipidemia
    • J. Beltowski Liver X receptors (LXR) as therapeutic targets in dyslipidemia Cardiovasc Ther 26 2008 297 316
    • (2008) Cardiovasc Ther , vol.26 , pp. 297-316
    • Beltowski, J.1
  • 92
    • 84866609881 scopus 로고    scopus 로고
    • Metabolism: LRH-1 is a transcriptional regulator of glucokinase in the liver
    • C. Wilson Metabolism: LRH-1 is a transcriptional regulator of glucokinase in the liver Nat Rev Endocrinol 8 2012 566
    • (2012) Nat Rev Endocrinol , vol.8 , pp. 566
    • Wilson, C.1
  • 94
    • 34547111086 scopus 로고    scopus 로고
    • A key role for orphan nuclear receptor liver receptor homologue-1 in activation of fatty acid synthase promoter by liver X receptor
    • DOI 10.1074/jbc.M702895200
    • K.E. Matsukuma, L. Wang, M.K. Bennett, and T.F. Osborne A key role for orphan nuclear receptor liver receptor homologue-1 in activation of fatty acid synthase promoter by liver X receptor J Biol Chem 282 2007 20164 20171 (Pubitemid 47099984)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.28 , pp. 20164-20171
    • Matsukuma, K.E.1    Wang, L.2    Bennett, M.K.3    Osborne, T.F.4
  • 95
    • 77950613528 scopus 로고    scopus 로고
    • FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats
    • S. Cipriani, A. Mencarelli, G. Palladino, and S. Fiorucci FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats J Lipid Res 51 2010 771 784
    • (2010) J Lipid Res , vol.51 , pp. 771-784
    • Cipriani, S.1    Mencarelli, A.2    Palladino, G.3    Fiorucci, S.4
  • 96
    • 84876477803 scopus 로고    scopus 로고
    • Synthetic FXR agonist GW4064 prevents diet-induced hepatic steatosis and insulin resistance
    • Y. Ma, Y. Huang, L. Yan, M. Gao, and D. Liu Synthetic FXR agonist GW4064 prevents diet-induced hepatic steatosis and insulin resistance Pharm Res 30 2013 1447 1457
    • (2013) Pharm Res , vol.30 , pp. 1447-1457
    • Ma, Y.1    Huang, Y.2    Yan, L.3    Gao, M.4    Liu, D.5
  • 97
    • 78649576502 scopus 로고    scopus 로고
    • Pregnane X receptor and constitutive androstane receptor at the crossroads of drug metabolism and energy metabolism
    • J. Gao, and W. Xie Pregnane X receptor and constitutive androstane receptor at the crossroads of drug metabolism and energy metabolism Drug Metab Dispos 38 2010 2091 2095
    • (2010) Drug Metab Dispos , vol.38 , pp. 2091-2095
    • Gao, J.1    Xie, W.2
  • 99
    • 84878543117 scopus 로고    scopus 로고
    • Focus on therapeutic strategies of nonalcoholic fatty liver disease
    • M. Durazzo, P. Belci, A. Collo, E. Grisoglio, and S. Bo Focus on therapeutic strategies of nonalcoholic fatty liver disease Int J Hepatol 2012 2012 464706
    • (2012) Int J Hepatol , vol.2012 , pp. 464706
    • Durazzo, M.1    Belci, P.2    Collo, A.3    Grisoglio, E.4    Bo, S.5
  • 100
    • 84859157277 scopus 로고    scopus 로고
    • Roles of PPARs in NAFLD: Potential therapeutic targets
    • A. Tailleux, K. Wouters, and B. Staels Roles of PPARs in NAFLD: potential therapeutic targets Biochim Biophys Acta 1821 2012 809 818
    • (2012) Biochim Biophys Acta , vol.1821 , pp. 809-818
    • Tailleux, A.1    Wouters, K.2    Staels, B.3
  • 102
    • 0034052579 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor α is restricted to hepatic parenchymal cells, not Kupffer cells: Implications for the mechanism of action of peroxisome proliferators in hepatocarcinogenesis
    • J.M. Peters, I. Rusyn, M.L. Rose, F.J. Gonzalez, and R.G. Thurman Peroxisome proliferator-activated receptor alpha is restricted to hepatic parenchymal cells, not Kupffer cells: implications for the mechanism of action of peroxisome proliferators in hepatocarcinogenesis Carcinogenesis 21 2000 823 826 (Pubitemid 30214043)
    • (2000) Carcinogenesis , vol.21 , Issue.4 , pp. 823-826
    • Peters, J.M.1    Rusyn, I.2    Rose, M.L.3    Gonzalez, F.J.4    Thurman, R.G.5
  • 103
    • 0034076888 scopus 로고    scopus 로고
    • The role of hepatic peroxisome proliferator-activated receptors (PPARs) in health and disease
    • DOI 10.1034/j.1600-0676.2000.020003191.x
    • L. Everett, A. Galli, and D. Crabb The role of hepatic peroxisome proliferator-activated receptors (PPARs) in health and disease Liver 20 2000 191 199 (Pubitemid 30342716)
    • (2000) Liver , vol.20 , Issue.3 , pp. 191-199
    • Everett, L.1    Galli, A.2    Crabb, D.3
  • 105
    • 77954987061 scopus 로고    scopus 로고
    • PPARalpha: Energy combustion, hypolipidemia, inflammation and cancer
    • S.R. Pyper, N. Viswakarma, S. Yu, and J.K. Reddy PPARalpha: energy combustion, hypolipidemia, inflammation and cancer Nucl Recept Signal 8 2010 e002
    • (2010) Nucl Recept Signal , vol.8 , pp. 002
    • Pyper, S.R.1    Viswakarma, N.2    Yu, S.3    Reddy, J.K.4
  • 106
    • 84856139907 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-alpha agonist, Wy 14,643, improves metabolic indices, steatosis and ballooning in diabetic mice with non-alcoholic steatohepatitis
    • C.Z. Larter, M.M. Yeh, D.M. Van Rooyen, J. Brooling, K. Ghatora, and G.C. Farrell Peroxisome proliferator-activated receptor-alpha agonist, Wy 14,643, improves metabolic indices, steatosis and ballooning in diabetic mice with non-alcoholic steatohepatitis J Gastroenterol Hepatol 27 2012 341 350
    • (2012) J Gastroenterol Hepatol , vol.27 , pp. 341-350
    • Larter, C.Z.1    Yeh, M.M.2    Van Rooyen, D.M.3    Brooling, J.4    Ghatora, K.5    Farrell, G.C.6
  • 107
    • 75449101395 scopus 로고    scopus 로고
    • Kupffer cells promote hepatic steatosis via interleukin-1beta-dependent suppression of peroxisome proliferator-activated receptor alpha activity
    • R. Stienstra, F. Saudale, C. Duval, S. Keshtkar, J.E. Groener, and N. van Rooijen et al. Kupffer cells promote hepatic steatosis via interleukin-1beta- dependent suppression of peroxisome proliferator-activated receptor alpha activity Hepatology 51 2010 511 522
    • (2010) Hepatology , vol.51 , pp. 511-522
    • Stienstra, R.1    Saudale, F.2    Duval, C.3    Keshtkar, S.4    Groener, J.E.5    Van Rooijen, N.6
  • 108
    • 84859980069 scopus 로고    scopus 로고
    • Caveolin-1 orchestrates the balance between glucose and lipid-dependent energy metabolism: Implications for liver regeneration
    • M.A. Fernandez-Rojo, C. Restall, C. Ferguson, N. Martel, S. Martin, and M. Bosch et al. Caveolin-1 orchestrates the balance between glucose and lipid-dependent energy metabolism: implications for liver regeneration Hepatology 55 2012 1574 1584
    • (2012) Hepatology , vol.55 , pp. 1574-1584
    • Fernandez-Rojo, M.A.1    Restall, C.2    Ferguson, C.3    Martel, N.4    Martin, S.5    Bosch, M.6
  • 109
    • 84872161392 scopus 로고    scopus 로고
    • PPAR could contribute to the pathogenesis of hepatocellular carcinoma
    • O. Kimura, Y. Kondo, and T. Shimosegawa PPAR could contribute to the pathogenesis of hepatocellular carcinoma PPAR Res 2012 2012 574180
    • (2012) PPAR Res , vol.2012 , pp. 574180
    • Kimura, O.1    Kondo, Y.2    Shimosegawa, T.3
  • 110
    • 0030047806 scopus 로고    scopus 로고
    • Differential expression of peroxisome proliferator-activated receptors (PPARs): Tissue distribution of PPAR-α, -β, and -γ in the adult rat
    • DOI 10.1210/en.137.1.354
    • O. Braissant, F. Foufelle, C. Scotto, M. Dauca, and W. Wahli Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat Endocrinology 137 1996 354 366 (Pubitemid 26005011)
    • (1996) Endocrinology , vol.137 , Issue.1 , pp. 354-366
    • Braissant, O.1    Foufelle, F.2    Scotto, C.3    Dauca, M.4    Wahli, W.5
  • 111
    • 84867370115 scopus 로고    scopus 로고
    • PPARs in liver diseases and cancer: Epigenetic regulation by microRNAs
    • M. Peyrou, P. Ramadori, L. Bourgoin, and M. Foti PPARs in liver diseases and cancer: epigenetic regulation by microRNAs PPAR Res 2012 2012 757803
    • (2012) PPAR Res , vol.2012 , pp. 757803
    • Peyrou, M.1    Ramadori, P.2    Bourgoin, L.3    Foti, M.4
  • 112
    • 77952392529 scopus 로고    scopus 로고
    • Metabolic and nonmetabolic regulatory functions of peroxisome proliferator-activated receptor beta
    • P.A. Grimaldi Metabolic and nonmetabolic regulatory functions of peroxisome proliferator-activated receptor beta Curr Opin Lipidol 21 2010 186 191
    • (2010) Curr Opin Lipidol , vol.21 , pp. 186-191
    • Grimaldi, P.A.1
  • 113
    • 52949099182 scopus 로고    scopus 로고
    • PPAR-beta/delta agonists for Type 2 diabetes and dyslipidemia: An adopted orphan still looking for a home
    • A.N. Billin PPAR-beta/delta agonists for Type 2 diabetes and dyslipidemia: an adopted orphan still looking for a home Expert Opin Invest Drug 17 2008 1465 1471
    • (2008) Expert Opin Invest Drug , vol.17 , pp. 1465-1471
    • Billin, A.N.1
  • 114
    • 84861437351 scopus 로고    scopus 로고
    • Protection from liver fibrosis by a peroxisome proliferator-activated receptor delta agonist
    • K. Iwaisako, M. Haimerl, Y.H. Paik, K. Taura, Y. Kodama, and C. Sirlin et al. Protection from liver fibrosis by a peroxisome proliferator-activated receptor delta agonist Proc Natl Acad Sci USA 109 2012 E1369 E1376
    • (2012) Proc Natl Acad Sci USA , vol.109
    • Iwaisako, K.1    Haimerl, M.2    Paik, Y.H.3    Taura, K.4    Kodama, Y.5    Sirlin, C.6
  • 115
    • 1642524221 scopus 로고    scopus 로고
    • Peroxisome Proliferator-activated Receptor γ Induces a Phenotypic Switch from Activated to Quiescent Hepatic Stellate Cells
    • DOI 10.1074/jbc.M310284200
    • S. Hazra, S. Xiong, J. Wang, R.A. Rippe, V. Krishna, and K. Chatterjee et al. Peroxisome proliferator-activated receptor gamma induces a phenotypic switch from activated to quiescent hepatic stellate cells J Biol Chem 279 2004 11392 11401 (Pubitemid 38401638)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.12 , pp. 11392-11401
    • Hazra, S.1    Xiong, S.2    Wang, J.3    Rippe, R.A.4    Chatterjee, V.K.K.5    Tsukamoto, H.6
  • 117
    • 80051706346 scopus 로고    scopus 로고
    • Role for PPARgamma in obesity-induced hepatic steatosis as determined by hepatocyte- and macrophage-specific conditional knockouts
    • E. Moran-Salvador, M. Lopez-Parra, V. Garcia-Alonso, E. Titos, M. Martinez-Clemente, and A. Gonzalez-Periz et al. Role for PPARgamma in obesity-induced hepatic steatosis as determined by hepatocyte- and macrophage-specific conditional knockouts FASEB J 25 2011 2538 2550
    • (2011) FASEB J , vol.25 , pp. 2538-2550
    • Moran-Salvador, E.1    Lopez-Parra, M.2    Garcia-Alonso, V.3    Titos, E.4    Martinez-Clemente, M.5    Gonzalez-Periz, A.6
  • 118
    • 84888285959 scopus 로고    scopus 로고
    • Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
    • B. Staels, A. Rubenstrunk, B. Noel, G. Rigou, P. Delataille, and L.J. Millatt et al. Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis Hepatology 2013
    • (2013) Hepatology
    • Staels, B.1    Rubenstrunk, A.2    Noel, B.3    Rigou, G.4    Delataille, P.5    Millatt, L.J.6
  • 119
    • 78349261937 scopus 로고    scopus 로고
    • Gene expression changes induced by PPAR gamma agonists in animal and human liver
    • A. Rogue, C. Spire, M. Brun, N. Claude, and A. Guillouzo Gene expression changes induced by PPAR gamma agonists in animal and human liver PPAR Res 2010 2010 325183
    • (2010) PPAR Res , vol.2010 , pp. 325183
    • Rogue, A.1    Spire, C.2    Brun, M.3    Claude, N.4    Guillouzo, A.5
  • 120
    • 77952731389 scopus 로고    scopus 로고
    • Inhibitory role of peroxisome proliferator-activated receptor gamma in hepatocarcinogenesis in mice and in vitro
    • J. Yu, B. Shen, E.S. Chu, N. Teoh, K.F. Cheung, and C.W. Wu et al. Inhibitory role of peroxisome proliferator-activated receptor gamma in hepatocarcinogenesis in mice and in vitro Hepatology 51 2010 2008 2019
    • (2010) Hepatology , vol.51 , pp. 2008-2019
    • Yu, J.1    Shen, B.2    Chu, E.S.3    Teoh, N.4    Cheung, K.F.5    Wu, C.W.6
  • 121
    • 0035200209 scopus 로고    scopus 로고
    • Activation of retinoic X receptor and peroxisome proliferator-activated receptor-γ inhibits nitric oxide and tumor necrosis factor-α production in rat Kupffer cells
    • DOI 10.1053/jhep.2001.21145
    • K. Uchimura, M. Nakamuta, M. Enjoji, T. Irie, R. Sugimoto, and T. Muta et al. Activation of retinoic X receptor and peroxisome proliferator-activated receptor-gamma inhibits nitric oxide and tumor necrosis factor-alpha production in rat Kupffer cells Hepatology 33 2001 91 99 (Pubitemid 32016891)
    • (2001) Hepatology , vol.33 , Issue.1 , pp. 91-99
    • Uchimura, K.1    Nakamuta, M.2    Enjoji, M.3    Irie, T.4    Sugimoto, R.5    Muta, T.6    Iwamoto, H.7    Nawata, H.8
  • 122
    • 84884871131 scopus 로고    scopus 로고
    • Amplified inhibition of stellate cell activation pathways by PPAR-gamma, RAR and RXR agonists
    • E. Sharvit, S. Abramovitch, S. Reif, and R. Bruck Amplified inhibition of stellate cell activation pathways by PPAR-gamma, RAR and RXR agonists PLoS One 8 2013 e76541
    • (2013) PLoS One , vol.8 , pp. 76541
    • Sharvit, E.1    Abramovitch, S.2    Reif, S.3    Bruck, R.4
  • 123
    • 2642549921 scopus 로고    scopus 로고
    • Liver-enriched transcription factors in liver function and development. Part II: The C/EBPs and D site-binding protein in cell cycle control, carcinogenesis, circadian gene regulation, liver regeneration, apoptosis, and liver-specific gene regulation
    • DOI 10.1124/pr.56.2.5
    • H. Schrem, J. Klempnauer, and J. Borlak Liver-enriched transcription factors in liver function and development. Part II: The C/EBPs and D site-binding protein in cell cycle control, carcinogenesis, circadian gene regulation, liver regeneration, apoptosis, and liver-specific gene regulation Pharmacol Rev 56 2004 291 330 (Pubitemid 38720832)
    • (2004) Pharmacological Reviews , vol.56 , Issue.2 , pp. 291-330
    • Schrem, H.1    Klempnauer, J.2    Borlak, J.3
  • 124
    • 34547824172 scopus 로고    scopus 로고
    • Foxo1 links insulin signaling to C/EBPα and regulates gluconeogenesis during liver development
    • DOI 10.1038/sj.emboj.7601784, PII 7601784
    • K. Sekine, Y.R. Chen, N. Kojima, K. Ogata, A. Fukamizu, and A. Miyajima Foxo1 links insulin signaling to C/EBPalpha and regulates gluconeogenesis during liver development EMBO J 26 2007 3607 3615 (Pubitemid 47236870)
    • (2007) EMBO Journal , vol.26 , Issue.15 , pp. 3607-3615
    • Sekine, K.1    Chen, Y.-R.2    Kojima, N.3    Ogata, K.4    Fukamizu, A.5    Miyajima, A.6
  • 125
    • 7244221588 scopus 로고    scopus 로고
    • Disruption of hepatic C/EBPα results in impaired glucose tolerance and age-dependent hepatosteatosis
    • DOI 10.1074/jbc.M405177200
    • Y. Inoue, J. Inoue, G. Lambert, S.H. Yim, and F.J. Gonzalez Disruption of hepatic C/EBPalpha results in impaired glucose tolerance and age-dependent hepatosteatosis J Biol Chem 279 2004 44740 44748 (Pubitemid 39430884)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.43 , pp. 44740-44748
    • Inoue, Y.1    Inoue, J.2    Lambert, G.3    Yim, S.H.4    Gonzalez, F.J.5
  • 126
    • 84875811610 scopus 로고    scopus 로고
    • Increased expression of enzymes of triglyceride synthesis is essential for the development of hepatic steatosis
    • J. Jin, P. Iakova, M. Breaux, E. Sullivan, N. Jawanmardi, and D. Chen et al. Increased expression of enzymes of triglyceride synthesis is essential for the development of hepatic steatosis Cell Rep 3 2013 831 843
    • (2013) Cell Rep , vol.3 , pp. 831-843
    • Jin, J.1    Iakova, P.2    Breaux, M.3    Sullivan, E.4    Jawanmardi, N.5    Chen, D.6
  • 127
    • 34248681601 scopus 로고    scopus 로고
    • CCAAT/enhancing binding protein β deletion in mice attenuates inflammation, endoplasmic reticulum stress, and lipid accumulation in diet-induced nonalcoholic steatohepatitis
    • DOI 10.1002/hep.21614
    • S.M. Rahman, J.M. Schroeder-Gloeckler, R.C. Janssen, H. Jiang, I. Qadri, and K.N. Maclean et al. CCAAT/enhancing binding protein beta deletion in mice attenuates inflammation, endoplasmic reticulum stress, and lipid accumulation in diet-induced nonalcoholic steatohepatitis Hepatology 45 2007 1108 1117 (Pubitemid 46775772)
    • (2007) Hepatology , vol.45 , Issue.5 , pp. 1108-1117
    • Rahman, S.M.1    Schroeder-Gloeckler, J.M.2    Janssen, R.C.3    Jiang, H.4    Qadri, I.5    Maclean, K.N.6    Friedman, J.E.7
  • 128
    • 0036200587 scopus 로고    scopus 로고
    • Liver-enriched transcription factors in liver function and development. Part I: The hepatocyte nuclear factor network and liver-specific gene expression
    • DOI 10.1124/pr.54.1.129
    • H. Schrem, J. Klempnauer, and J. Borlak Liver-enriched transcription factors in liver function and development. Part I: The hepatocyte nuclear factor network and liver-specific gene expression Pharmacol Rev 54 2002 129 158 (Pubitemid 34208830)
    • (2002) Pharmacological Reviews , vol.54 , Issue.1 , pp. 129-158
    • Schrem, H.1    Klempnauer, J.2    Borlak, J.3
  • 129
    • 64749097992 scopus 로고    scopus 로고
    • Down-regulation of hepatic HNF4alpha gene expression during hyperinsulinemia via SREBPs
    • X. Xie, H. Liao, H. Dang, W. Pang, Y. Guan, and X. Wang et al. Down-regulation of hepatic HNF4alpha gene expression during hyperinsulinemia via SREBPs Mol Endocrinol 23 2009 434 443
    • (2009) Mol Endocrinol , vol.23 , pp. 434-443
    • Xie, X.1    Liao, H.2    Dang, H.3    Pang, W.4    Guan, Y.5    Wang, X.6
  • 131
  • 132
    • 61949147670 scopus 로고    scopus 로고
    • Reduction of hepatic steatosis in rats and mice after treatment with a liver-targeted thyroid hormone receptor agonist
    • E.E. Cable, P.D. Finn, J.W. Stebbins, J. Hou, B.R. Ito, and P.D. van Poelje et al. Reduction of hepatic steatosis in rats and mice after treatment with a liver-targeted thyroid hormone receptor agonist Hepatology 49 2009 407 417
    • (2009) Hepatology , vol.49 , pp. 407-417
    • Cable, E.E.1    Finn, P.D.2    Stebbins, J.W.3    Hou, J.4    Ito, B.R.5    Van Poelje, P.D.6
  • 133
    • 77950863893 scopus 로고    scopus 로고
    • Nontriglyceride hepatic lipotoxicity: The new paradigm for the pathogenesis of NASH
    • B.A. Neuschwander-Tetri Nontriglyceride hepatic lipotoxicity: the new paradigm for the pathogenesis of NASH Curr Gastroenterol Rep 12 2010 49 56
    • (2010) Curr Gastroenterol Rep , vol.12 , pp. 49-56
    • Neuschwander-Tetri, B.A.1
  • 134
    • 37349081571 scopus 로고    scopus 로고
    • Role of ChREBP in hepatic steatosis and insulin resistance
    • DOI 10.1016/j.febslet.2007.07.084, PII S0014579307008757
    • P.D. Denechaud, R. Dentin, J. Girard, and C. Postic Role of ChREBP in hepatic steatosis and insulin resistance FEBS Lett 582 2008 68 73 (Pubitemid 350297238)
    • (2008) FEBS Letters , vol.582 , Issue.1 , pp. 68-73
    • Denechaud, P.-D.1    Dentin, R.2    Girard, J.3    Postic, C.4
  • 135
    • 84861809881 scopus 로고    scopus 로고
    • The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans
    • F. Benhamed, P.D. Denechaud, M. Lemoine, C. Robichon, M. Moldes, and J. Bertrand-Michel et al. The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans J Clin Invest 122 2012 2176 2194
    • (2012) J Clin Invest , vol.122 , pp. 2176-2194
    • Benhamed, F.1    Denechaud, P.D.2    Lemoine, M.3    Robichon, C.4    Moldes, M.5    Bertrand-Michel, J.6
  • 137
    • 84867067610 scopus 로고    scopus 로고
    • Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase
    • J.L. Owen, Y. Zhang, S.H. Bae, M.S. Farooqi, G. Liang, and R.E. Hammer et al. Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase Proc Natl Acad Sci USA 109 2012 16184 16189
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 16184-16189
    • Owen, J.L.1    Zhang, Y.2    Bae, S.H.3    Farooqi, M.S.4    Liang, G.5    Hammer, R.E.6
  • 138
    • 77957302090 scopus 로고    scopus 로고
    • Hepatic steatosis: A role for de novo lipogenesis and the transcription factor SREBP-1c
    • P. Ferre, and F. Foufelle Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c Diabetes Obes Metab 12 Suppl 2 2010 83 92
    • (2010) Diabetes Obes Metab , vol.12 , Issue.SUPPL.2 , pp. 83-92
    • Ferre, P.1    Foufelle, F.2
  • 139
    • 79960960007 scopus 로고    scopus 로고
    • Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways
    • J.L. Yecies, H.H. Zhang, S. Menon, S. Liu, D. Yecies, and A.I. Lipovsky et al. Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways Cell Metab 14 2011 21 32
    • (2011) Cell Metab , vol.14 , pp. 21-32
    • Yecies, J.L.1    Zhang, H.H.2    Menon, S.3    Liu, S.4    Yecies, D.5    Lipovsky, A.I.6
  • 140
    • 84861043736 scopus 로고    scopus 로고
    • Connecting mTORC1 signaling to SREBP-1 activation
    • I. Bakan, and M. Laplante Connecting mTORC1 signaling to SREBP-1 activation Curr Opin Lipidol 23 2012 226 234
    • (2012) Curr Opin Lipidol , vol.23 , pp. 226-234
    • Bakan, I.1    Laplante, M.2
  • 141
    • 84863086400 scopus 로고    scopus 로고
    • Palmitoleate induces hepatic steatosis but suppresses liver inflammatory response in mice
    • X. Guo, H. Li, H. Xu, V. Halim, W. Zhang, and H. Wang et al. Palmitoleate induces hepatic steatosis but suppresses liver inflammatory response in mice PLoS One 7 2012 e39286
    • (2012) PLoS One , vol.7 , pp. 39286
    • Guo, X.1    Li, H.2    Xu, H.3    Halim, V.4    Zhang, W.5    Wang, H.6
  • 142
    • 33746959419 scopus 로고    scopus 로고
    • Identification and characterization of associated with lipid droplet protein 1: A novel membrane-associated protein that resides on hepatic lipid droplets
    • DOI 10.1111/j.1600-0854.2006.00465.x
    • S. Turro, M. Ingelmo-Torres, J.M. Estanyol, F. Tebar, M.A. Fernandez, and C.V. Albor et al. Identification and characterization of associated with lipid droplet protein 1: a novel membrane-associated protein that resides on hepatic lipid droplets Traffic 7 2006 1254 1269 (Pubitemid 44204000)
    • (2006) Traffic , vol.7 , Issue.9 , pp. 1254-1269
    • Turro, S.1    Ingelmo-Torres, M.2    Estanyol, J.M.3    Tebar, F.4    Fernandez, M.A.5    Albor, C.V.6    Gaus, K.7    Grewal, T.8    Enrich, C.9    Pol, A.10
  • 143
    • 84896963551 scopus 로고    scopus 로고
    • Rab GTPases associate with isolated lipid droplets (LDs) and show altered content after ethanol administration: Potential role in alcohol-impaired LD metabolism
    • K. Rasineni, B.L. McVicker, D.J. Tuma, M.A. McNiven, and C.A. Casey Rab GTPases associate with isolated lipid droplets (LDs) and show altered content after ethanol administration: potential role in alcohol-impaired LD metabolism Alcohol Clin Exp Res 2013
    • (2013) Alcohol Clin Exp Res
    • Rasineni, K.1    McVicker, B.L.2    Tuma, D.J.3    McNiven, M.A.4    Casey, C.A.5
  • 144
    • 84861742465 scopus 로고    scopus 로고
    • LSDP5 enhances triglyceride storage in hepatocytes by influencing lipolysis and fatty acid beta-oxidation of lipid droplets
    • H. Li, Y. Song, L.J. Zhang, Y. Gu, F.F. Li, and S.Y. Pan et al. LSDP5 enhances triglyceride storage in hepatocytes by influencing lipolysis and fatty acid beta-oxidation of lipid droplets PLoS One 7 2012 e36712
    • (2012) PLoS One , vol.7 , pp. 36712
    • Li, H.1    Song, Y.2    Zhang, L.J.3    Gu, Y.4    Li, F.F.5    Pan, S.Y.6
  • 145
    • 84862313783 scopus 로고    scopus 로고
    • The proteomics of lipid droplets: Structure, dynamics, and functions of the organelle conserved from bacteria to humans
    • L. Yang, Y. Ding, Y. Chen, S. Zhang, C. Huo, and Y. Wang et al. The proteomics of lipid droplets: structure, dynamics, and functions of the organelle conserved from bacteria to humans J Lipid Res 53 2012 1245 1253
    • (2012) J Lipid Res , vol.53 , pp. 1245-1253
    • Yang, L.1    Ding, Y.2    Chen, Y.3    Zhang, S.4    Huo, C.5    Wang, Y.6
  • 148
    • 0037113954 scopus 로고    scopus 로고
    • The surface of lipid droplets is a phospholipid monolayer with a unique fatty acid composition
    • DOI 10.1074/jbc.M207712200
    • K. Tauchi-Sato, S. Ozeki, T. Houjou, R. Taguchi, and T. Fujimoto The surface of lipid droplets is a phospholipid monolayer with a unique fatty acid composition J Biol Chem 277 2002 44507 44512 (Pubitemid 36157885)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.46 , pp. 44507-44512
    • Tauchi-Sato, K.1    Ozeki, S.2    Houjou, T.3    Taguchi, R.4    Fujimoto, T.5
  • 149
    • 0035810964 scopus 로고    scopus 로고
    • Lipid droplets: Proteins floating on a pool of fat
    • D.A. Brown Lipid droplets: proteins floating on a pool of fat Curr Biol 11 2001 R446 R449
    • (2001) Curr Biol , vol.11
    • Brown, D.A.1
  • 150
    • 38049184643 scopus 로고    scopus 로고
    • The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology
    • K.M. Szymanski, D. Binns, R. Bartz, N.V. Grishin, W.P. Li, and A.K. Agarwal et al. The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology Proc Natl Acad Sci USA 104 2007 20890 20895
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 20890-20895
    • Szymanski, K.M.1    Binns, D.2    Bartz, R.3    Grishin, N.V.4    Li, W.P.5    Agarwal, A.K.6
  • 152
    • 81855177041 scopus 로고    scopus 로고
    • Molecular characterization of seipin and its mutants: Implications for seipin in triacylglycerol synthesis
    • W. Fei, H. Li, G. Shui, T.S. Kapterian, C. Bielby, and X. Du et al. Molecular characterization of seipin and its mutants: implications for seipin in triacylglycerol synthesis J Lipid Res 52 2011 2136 2147
    • (2011) J Lipid Res , vol.52 , pp. 2136-2147
    • Fei, W.1    Li, H.2    Shui, G.3    Kapterian, T.S.4    Bielby, C.5    Du, X.6
  • 154
    • 79955629359 scopus 로고    scopus 로고
    • Tissue-autonomous function of Drosophila seipin in preventing ectopic lipid droplet formation
    • Y. Tian, J. Bi, G. Shui, Z. Liu, Y. Xiang, and Y. Liu et al. Tissue-autonomous function of Drosophila seipin in preventing ectopic lipid droplet formation PLoS Genet 7 2011 e1001364
    • (2011) PLoS Genet , vol.7 , pp. 1001364
    • Tian, Y.1    Bi, J.2    Shui, G.3    Liu, Z.4    Xiang, Y.5    Liu, Y.6
  • 155
    • 34547216748 scopus 로고    scopus 로고
    • A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum
    • DOI 10.1038/nature06004, PII NATURE06004
    • H.L. Ploegh A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum Nature 448 2007 435 438 (Pubitemid 47123517)
    • (2007) Nature , vol.448 , Issue.7152 , pp. 435-438
    • Ploegh, H.L.1
  • 159
    • 84867155451 scopus 로고    scopus 로고
    • Update on perilipin polymorphisms and obesity
    • C.E. Smith, and J.M. Ordovas Update on perilipin polymorphisms and obesity Nutr Rev 70 2012 611 621
    • (2012) Nutr Rev , vol.70 , pp. 611-621
    • Smith, C.E.1    Ordovas, J.M.2
  • 160
    • 80455135722 scopus 로고    scopus 로고
    • Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria
    • H. Wang, U. Sreenevasan, H. Hu, A. Saladino, B.M. Polster, and L.M. Lund et al. Perilipin 5, a lipid droplet-associated protein, provides physical and
    • (2011) J Lipid Res , vol.52 , pp. 2159-2168
    • Wang, H.1    Sreenevasan, U.2    Hu, H.3    Saladino, A.4    Polster, B.M.5    Lund, L.M.6
  • 161
    • 77950607704 scopus 로고    scopus 로고
    • Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins
    • A.R. Kimmel, D.L. Brasaemle, M. McAndrews-Hill, C. Sztalryd, and C. Londos Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins J Lipid Res 51 2010 468 471
    • (2010) J Lipid Res , vol.51 , pp. 468-471
    • Kimmel, A.R.1    Brasaemle, D.L.2    McAndrews-Hill, M.3    Sztalryd, C.4    Londos, C.5
  • 162
    • 84864862383 scopus 로고    scopus 로고
    • Opposing roles of cell death-inducing DFF45-like effector B and perilipin 2 in controlling hepatic VLDL lipidation
    • X. Li, J. Ye, L. Zhou, W. Gu, E.A. Fisher, and P. Li Opposing roles of cell death-inducing DFF45-like effector B and perilipin 2 in controlling hepatic VLDL lipidation J Lipid Res 53 2012 1877 1889
    • (2012) J Lipid Res , vol.53 , pp. 1877-1889
    • Li, X.1    Ye, J.2    Zhou, L.3    Gu, W.4    Fisher, E.A.5    Li, P.6
  • 164
    • 84873261154 scopus 로고    scopus 로고
    • Effects of perilipin 2 antisense oligonucleotide treatment on hepatic lipid metabolism and gene expression
    • Y. Imai, S. Boyle, G.M. Varela, E. Caron, X. Yin, and R. Dhir et al. Effects of perilipin 2 antisense oligonucleotide treatment on hepatic lipid metabolism and gene expression Physiol Genomics 44 2012 1125 1131
    • (2012) Physiol Genomics , vol.44 , pp. 1125-1131
    • Imai, Y.1    Boyle, S.2    Varela, G.M.3    Caron, E.4    Yin, X.5    Dhir, R.6
  • 166
    • 29644442801 scopus 로고    scopus 로고
    • Regulated localization of Rab18 to lipid droplets: Effects of lipolytic stimulation and inhibition of lipid droplet catabolism
    • DOI 10.1074/jbc.M506651200
    • S. Martin, K. Driessen, S.J. Nixon, M. Zerial, and R.G. Parton Regulated localization of Rab18 to lipid droplets: effects of lipolytic stimulation and inhibition of lipid droplet catabolism J Biol Chem 280 2005 42325 42335 (Pubitemid 43023204)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.51 , pp. 42325-42335
    • Martin, S.1    Driessen, K.2    Nixon, S.J.3    Zerial, M.4    Parton, R.G.5
  • 167
    • 57649116078 scopus 로고    scopus 로고
    • The gregarious lipid droplet
    • J.M. Goodman The gregarious lipid droplet J Biol Chem 283 2008 28005 28009
    • (2008) J Biol Chem , vol.283 , pp. 28005-28009
    • Goodman, J.M.1
  • 169
    • 21644459401 scopus 로고    scopus 로고
    • Rab18 localizes to lipid droplets and induces their close apposition to the endoplasmic reticulum-derived membrane
    • DOI 10.1242/jcs.02401
    • S. Ozeki, J. Cheng, K. Tauchi-Sato, N. Hatano, H. Taniguchi, and T. Fujimoto Rab18 localizes to lipid droplets and induces their close apposition to the endoplasmic reticulum-derived membrane J Cell Sci 118 2005 2601 2611 (Pubitemid 40932886)
    • (2005) Journal of Cell Science , vol.118 , Issue.12 , pp. 2601-2611
    • Ozeki, S.1    Cheng, J.2    Tauchi-Sato, K.3    Hatano, N.4    Taniguchi, H.5    Fujimoto, T.6
  • 170
    • 20444377641 scopus 로고    scopus 로고
    • A sixth sense for Rab5
    • A.M. van der Bliek A sixth sense for Rab5 Nat Cell Biol 7 2005 548 550
    • (2005) Nat Cell Biol , vol.7 , pp. 548-550
    • Van Der Bliek, A.M.1
  • 172
    • 84863157590 scopus 로고    scopus 로고
    • Rab32 is important for autophagy and lipid storage in Drosophila
    • C. Wang, Z. Liu, and X. Huang Rab32 is important for autophagy and lipid storage in Drosophila PLoS One 7 2012 e32086
    • (2012) PLoS One , vol.7 , pp. 32086
    • Wang, C.1    Liu, Z.2    Huang, X.3
  • 173
    • 84874054093 scopus 로고    scopus 로고
    • Fasting regulates FSP27 expression in the liver
    • V. Puri Fasting regulates FSP27 expression in the liver J Lipid Res 54 2013 569 570
    • (2013) J Lipid Res , vol.54 , pp. 569-570
    • Puri, V.1
  • 174
    • 84874050218 scopus 로고    scopus 로고
    • Fsp27/CIDEC is a CREB target gene induced during early fasting in liver and regulated by FA oxidation rate
    • A. Vila-Brau, A.L. De Sousa-Coelho, J.F. Goncalves, D. Haro, and P.F. Marrero Fsp27/CIDEC is a CREB target gene induced during early fasting in liver and regulated by FA oxidation rate J Lipid Res 54 2013 592 601
    • (2013) J Lipid Res , vol.54 , pp. 592-601
    • Vila-Brau, A.1    De Sousa-Coelho, A.L.2    Goncalves, J.F.3    Haro, D.4    Marrero, P.F.5
  • 175
    • 78649805641 scopus 로고    scopus 로고
    • Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1
    • T. Gimm, M. Wiese, B. Teschemacher, A. Deggerich, J. Schodel, and K.X. Knaup et al. Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1 FASEB J 24 2010 4443 4458
    • (2010) FASEB J , vol.24 , pp. 4443-4458
    • Gimm, T.1    Wiese, M.2    Teschemacher, B.3    Deggerich, A.4    Schodel, J.5    Knaup, K.X.6
  • 176
    • 73149109067 scopus 로고    scopus 로고
    • Hypoxia and non-alcoholic fatty liver disease
    • C.D. Byrne Hypoxia and non-alcoholic fatty liver disease Clin Sci (Lond) 118 2009 397 400
    • (2009) Clin Sci (Lond) , vol.118 , pp. 397-400
    • Byrne, C.D.1
  • 177
    • 51349133312 scopus 로고    scopus 로고
    • Murine cirrhosis induces hepatocyte epithelial mesenchymal transition and alterations in survival signaling pathways
    • T. Nitta, J.S. Kim, D. Mohuczy, and K.E. Behrns Murine cirrhosis induces hepatocyte epithelial mesenchymal transition and alterations in survival signaling pathways Hepatology 48 2008 909 919
    • (2008) Hepatology , vol.48 , pp. 909-919
    • Nitta, T.1    Kim, J.S.2    Mohuczy, D.3    Behrns, K.E.4
  • 178
    • 84896919536 scopus 로고    scopus 로고
    • The expression and secretion of vimentin in the progression of non-alcoholic steatohepatitis
    • S.J. Lee, S.Y. Choi, and O.S. Kwon The expression and secretion of vimentin in the progression of non-alcoholic steatohepatitis BMB Rep 2013
    • (2013) BMB Rep
    • Lee, S.J.1    Choi, S.Y.2    Kwon, O.S.3
  • 179
    • 79960147839 scopus 로고    scopus 로고
    • Seipin ablation in mice results in severe generalized lipodystrophy
    • X. Cui, Y. Wang, Y. Tang, Y. Liu, L. Zhao, and J. Deng et al. Seipin ablation in mice results in severe generalized lipodystrophy Hum Mol Genet 20 2011 3022 3030
    • (2011) Hum Mol Genet , vol.20 , pp. 3022-3030
    • Cui, X.1    Wang, Y.2    Tang, Y.3    Liu, Y.4    Zhao, L.5    Deng, J.6
  • 182
    • 84876899536 scopus 로고    scopus 로고
    • Seipin differentially regulates lipogenesis and adipogenesis through a conserved core sequence and an evolutionarily acquired C-terminus
    • W. Yang, S. Thein, X. Guo, F. Xu, B. Venkatesh, and S. Sugii et al. Seipin differentially regulates lipogenesis and adipogenesis through a conserved core sequence and an evolutionarily acquired C-terminus Biochem J 452 2013 37 44
    • (2013) Biochem J , vol.452 , pp. 37-44
    • Yang, W.1    Thein, S.2    Guo, X.3    Xu, F.4    Venkatesh, B.5    Sugii, S.6
  • 183
    • 83755183360 scopus 로고    scopus 로고
    • Direct binding of triglyceride to fat storage-inducing transmembrane proteins 1 and 2 is important for lipid droplet formation
    • D.A. Gross, C. Zhan, and D.L. Silver Direct binding of triglyceride to fat storage-inducing transmembrane proteins 1 and 2 is important for lipid droplet formation Proc Natl Acad Sci USA 108 2011 19581 19586
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 19581-19586
    • Gross, D.A.1    Zhan, C.2    Silver, D.L.3
  • 184
    • 77956509037 scopus 로고    scopus 로고
    • Structural insights into triglyceride storage mediated by fat storage-inducing transmembrane (FIT) protein 2
    • D.A. Gross, E.L. Snapp, and D.L. Silver Structural insights into triglyceride storage mediated by fat storage-inducing transmembrane (FIT) protein 2 PLoS One 5 2010 e10796
    • (2010) PLoS One , vol.5 , pp. 10796
    • Gross, D.A.1    Snapp, E.L.2    Silver, D.L.3
  • 185
    • 34548486955 scopus 로고    scopus 로고
    • The SPFH domain-containing proteins: More than lipid raft markers
    • DOI 10.1016/j.tcb.2007.06.005, PII S0962892407001584
    • D.T. Browman, M.B. Hoegg, and S.M. Robbins The SPFH domain-containing proteins: more than lipid raft markers Trends Cell Biol 17 2007 394 402 (Pubitemid 47375100)
    • (2007) Trends in Cell Biology , vol.17 , Issue.8 , pp. 394-402
    • Browman, D.T.1    Hoegg, M.B.2    Robbins, S.M.3
  • 186
    • 66349087046 scopus 로고    scopus 로고
    • The challenge of lipid rafts
    • L.J. Pike The challenge of lipid rafts J Lipid Res 50 Suppl 2009 S323 S328
    • (2009) J Lipid Res , vol.50 , Issue.SUPPL.
    • Pike, L.J.1
  • 187
    • 33847652195 scopus 로고    scopus 로고
    • Raft association and lipid droplet targeting of flotillins are independent of caveolin
    • DOI 10.1515/BC.2007.034
    • L. Rajendran, S. Le Lay, and H. Illges Raft association and lipid droplet targeting of flotillins are independent of caveolin Biol Chem 388 2007 307 314 (Pubitemid 46364470)
    • (2007) Biological Chemistry , vol.388 , Issue.3 , pp. 307-314
    • Rajendran, L.1    Le Lay, S.2    Illges, H.3
  • 188
    • 84896976460 scopus 로고    scopus 로고
    • The AOCS Lipid Library [Internet]; [cited 19.11.2013]
    • Kelly K, Jacobs RL. Phospholpid biosynthesis. The AOCS Lipid Library [Internet]; 2011. < http://lipidlibrary.aocs.org/animbio/phospholipids/index. htm > [cited 19.11.2013].
    • (2011) Phospholpid Biosynthesis
    • Kelly, K.1    Jacobs, R.L.2
  • 189
    • 34547939090 scopus 로고    scopus 로고
    • Lipids and lipid modifications in the regulation of membrane traffic
    • DOI 10.1016/j.ceb.2007.06.003, PII S095506740700097X
    • V. Haucke, and G. Di Paolo Lipids and lipid modifications in the regulation of membrane traffic Curr Opin Cell Biol 19 2007 426 435 (Pubitemid 47268765)
    • (2007) Current Opinion in Cell Biology , vol.19 , Issue.4 , pp. 426-435
    • Haucke, V.1    Di Paolo, G.2
  • 190
    • 0346099345 scopus 로고    scopus 로고
    • Dynamic and Regulated Association of Caveolin with Lipid Bodies: Modulation of Lipid Body Motility and Function by a Dominant Negative Mutant
    • DOI 10.1091/mbc.E03-06-0368
    • A. Pol, S. Martin, M.A. Fernandez, C. Ferguson, A. Carozzi, and R. Luetterforst et al. Dynamic and regulated association of caveolin with lipid bodies: modulation of lipid body motility and function by a dominant negative mutant Mol Biol Cell 15 2004 99 110 (Pubitemid 38044947)
    • (2004) Molecular Biology of the Cell , vol.15 , Issue.1 , pp. 99-110
    • Pol, A.1    Martin, S.2    Fernandez, M.A.3    Ferguson, C.4    Carozzi, A.5    Luetterforst, R.6    Enrich, C.7    Parton, R.G.8
  • 191
    • 79953741782 scopus 로고    scopus 로고
    • Alcohol and lipid traffic don't mix
    • M.A. McNiven, and C.A. Casey Alcohol and lipid traffic don't mix Hepatology 53 2011 1073 1075
    • (2011) Hepatology , vol.53 , pp. 1073-1075
    • McNiven, M.A.1    Casey, C.A.2
  • 193
    • 84866382121 scopus 로고    scopus 로고
    • The FATP1-DGAT2 complex facilitates lipid droplet expansion at the ER-lipid droplet interface
    • N. Xu, S.O. Zhang, R.A. Cole, S.A. McKinney, F. Guo, and J.T. Haas et al. The FATP1-DGAT2 complex facilitates lipid droplet expansion at the ER-lipid droplet interface J Cell Biol 198 2012 895 911
    • (2012) J Cell Biol , vol.198 , pp. 895-911
    • Xu, N.1    Zhang, S.O.2    Cole, R.A.3    McKinney, S.A.4    Guo, F.5    Haas, J.T.6
  • 194
    • 80054678271 scopus 로고    scopus 로고
    • Evidence that diacylglycerol acyltransferase 1 (DGAT1) has dual membrane topology in the endoplasmic reticulum of HepG2 cells
    • H.R. Wurie, L. Buckett, and V.A. Zammit Evidence that diacylglycerol acyltransferase 1 (DGAT1) has dual membrane topology in the endoplasmic reticulum of HepG2 cells J Biol Chem 286 2011 36238 36247
    • (2011) J Biol Chem , vol.286 , pp. 36238-36247
    • Wurie, H.R.1    Buckett, L.2    Zammit, V.A.3
  • 195
    • 84892543665 scopus 로고    scopus 로고
    • An ER protein functionally couples neutral lipid metabolism on lipid droplets to membrane lipid synthesis in the ER
    • D.F. Markgraf, R.W. Klemm, M. Junker, H.K. Hannibal-Bach, C.S. Ejsing, and T.A. Rapoport An ER protein functionally couples neutral lipid metabolism on lipid droplets to membrane lipid synthesis in the ER Cell Rep 6 2014 44 55
    • (2014) Cell Rep , vol.6 , pp. 44-55
    • Markgraf, D.F.1    Klemm, R.W.2    Junker, M.3    Hannibal-Bach, H.K.4    Ejsing, C.S.5    Rapoport, T.A.6
  • 196
    • 84872840929 scopus 로고    scopus 로고
    • Spatial regulation of UBXD8 and p97/VCP controls ATGL-mediated lipid droplet turnover
    • J.A. Olzmann, C.M. Richter, and R.R. Kopito Spatial regulation of UBXD8 and p97/VCP controls ATGL-mediated lipid droplet turnover Proc Natl Acad Sci USA 110 2013 1345 1350
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 1345-1350
    • Olzmann, J.A.1    Richter, C.M.2    Kopito, R.R.3
  • 198
    • 84862828272 scopus 로고    scopus 로고
    • Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice
    • C. Zhang, G. Wang, Z. Zheng, K.R. Maddipati, X. Zhang, and G. Dyson et al. Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice Hepatology 55 2012 1070 1082
    • (2012) Hepatology , vol.55 , pp. 1070-1082
    • Zhang, C.1    Wang, G.2    Zheng, Z.3    Maddipati, K.R.4    Zhang, X.5    Dyson, G.6
  • 199
    • 33847618703 scopus 로고    scopus 로고
    • MEK-ERK inhibition corrects the defect in VLDL assembly in HepG2 cells: Potential role of ERK in VLDL-apoB100 particle assembly
    • DOI 10.1161/01.ATV.0000249861.80471.96, PII 0004360520070100000032
    • J. Tsai, W. Qiu, R. Kohen-Avramoglu, and K. Adeli MEK-ERK inhibition corrects the defect in VLDL assembly in HepG2 cells: potential role of ERK in VLDL-ApoB100 particle assembly Arterioscler Thromb Vasc Biol 27 2007 211 218 (Pubitemid 46360401)
    • (2007) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.27 , Issue.1 , pp. 211-218
    • Tsai, J.1    Qiu, W.2    Kohen-Avramoglu, R.3    Adeli, K.4
  • 200
    • 84865523163 scopus 로고    scopus 로고
    • Selective hepatic insulin resistance, VLDL overproduction, and hypertriglyceridemia
    • J.D. Sparks, C.E. Sparks, and K. Adeli Selective hepatic insulin resistance, VLDL overproduction, and hypertriglyceridemia Arterioscler Thromb Vasc Biol 32 2012 2104 2112
    • (2012) Arterioscler Thromb Vasc Biol , vol.32 , pp. 2104-2112
    • Sparks, J.D.1    Sparks, C.E.2    Adeli, K.3
  • 201
    • 77953523654 scopus 로고    scopus 로고
    • Altered lipid droplet dynamics in hepatocytes lacking triacylglycerol hydrolase expression
    • H. Wang, E. Wei, A.D. Quiroga, X. Sun, N. Touret, and R. Lehner Altered lipid droplet dynamics in hepatocytes lacking triacylglycerol hydrolase expression Mol Biol Cell 21 2010 1991 2000
    • (2010) Mol Biol Cell , vol.21 , pp. 1991-2000
    • Wang, H.1    Wei, E.2    Quiroga, A.D.3    Sun, X.4    Touret, N.5    Lehner, R.6
  • 202
    • 84874918522 scopus 로고    scopus 로고
    • Insulin-stimulated degradation of apolipoprotein B100: Roles of class II phosphatidylinositol-3-kinase and autophagy
    • U. Andreo, L. Guo, D.V. Chirieac, A.C. Tuyama, E. Montenont, and J.L. Brodsky et al. Insulin-stimulated degradation of apolipoprotein B100: roles of class II phosphatidylinositol-3-kinase and autophagy PLoS One 8 2013 e57590
    • (2013) PLoS One , vol.8 , pp. 57590
    • Andreo, U.1    Guo, L.2    Chirieac, D.V.3    Tuyama, A.C.4    Montenont, E.5    Brodsky, J.L.6
  • 203
    • 38149136598 scopus 로고    scopus 로고
    • Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents
    • T. Ota, C. Gayet, and H.N. Ginsberg Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents J Clin Invest 118 2008 316 332
    • (2008) J Clin Invest , vol.118 , pp. 316-332
    • Ota, T.1    Gayet, C.2    Ginsberg, H.N.3
  • 204
    • 84876154662 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress induces hepatic steatosis via increased expression of the hepatic very low-density lipoprotein receptor
    • H. Jo, S.S. Choe, K.C. Shin, H. Jang, J.H. Lee, and J.K. Seong et al. Endoplasmic reticulum stress induces hepatic steatosis via increased expression of the hepatic very low-density lipoprotein receptor Hepatology 57 2013 1366 1377
    • (2013) Hepatology , vol.57 , pp. 1366-1377
    • Jo, H.1    Choe, S.S.2    Shin, K.C.3    Jang, H.4    Lee, J.H.5    Seong, J.K.6
  • 205
    • 84875326507 scopus 로고    scopus 로고
    • Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets
    • F. Wilfling, H. Wang, J.T. Haas, N. Krahmer, T.J. Gould, and A. Uchida et al. Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets Dev Cell 24 2013 384 399
    • (2013) Dev Cell , vol.24 , pp. 384-399
    • Wilfling, F.1    Wang, H.2    Haas, J.T.3    Krahmer, N.4    Gould, T.J.5    Uchida, A.6
  • 206
    • 41449098953 scopus 로고    scopus 로고
    • Hepatic Steatosis in Leptin-Deficient Mice Is Promoted by the PPARγ Target Gene Fsp27
    • DOI 10.1016/j.cmet.2008.03.003, PII S1550413108000740
    • K. Matsusue, T. Kusakabe, T. Noguchi, S. Takiguchi, T. Suzuki, and S. Yamano et al. Hepatic steatosis in leptin-deficient mice is promoted by the PPARgamma target gene Fsp27 Cell Metab 7 2008 302 311 (Pubitemid 351455219)
    • (2008) Cell Metabolism , vol.7 , Issue.4 , pp. 302-311
    • Matsusue, K.1    Kusakabe, T.2    Noguchi, T.3    Takiguchi, S.4    Suzuki, T.5    Yamano, S.6    Gonzalez, F.J.7
  • 207
    • 84900237792 scopus 로고    scopus 로고
    • The lipid droplet: A dynamic organelle, not only involved in the storage and turnover of lipids
    • C. Ehnholm, Springer-Verlag Berlin, Heidelberg
    • S.O. Olofsson, P. Bostrom, J. Lagerstedt, L. Andersson, M. Adiels, and J. Perman et al. The lipid droplet: a dynamic organelle, not only involved in the storage and turnover of lipids C. Ehnholm, Cellular lipid metabolism 2009 Springer-Verlag Berlin, Heidelberg 1 26
    • (2009) Cellular Lipid Metabolism , pp. 1-26
    • Olofsson, S.O.1    Bostrom, P.2    Lagerstedt, J.3    Andersson, L.4    Adiels, M.5    Perman, J.6
  • 209
    • 67649470529 scopus 로고    scopus 로고
    • Reconstitution of Rab- and SNARE-dependent membrane fusion by synthetic endosomes
    • T. Ohya, M. Miaczynska, U. Coskun, B. Lommer, A. Runge, and D. Drechsel et al. Reconstitution of Rab- and SNARE-dependent membrane fusion by synthetic endosomes Nature 459 2009 1091 1097
    • (2009) Nature , vol.459 , pp. 1091-1097
    • Ohya, T.1    Miaczynska, M.2    Coskun, U.3    Lommer, B.4    Runge, A.5    Drechsel, D.6
  • 212
    • 79959550724 scopus 로고    scopus 로고
    • Deficiency of liver adipose triglyceride lipase in mice causes progressive hepatic steatosis
    • J.W. Wu, S.P. Wang, F. Alvarez, S. Casavant, N. Gauthier, and L. Abed et al. Deficiency of liver adipose triglyceride lipase in mice causes progressive hepatic steatosis Hepatology 54 2011 122 132
    • (2011) Hepatology , vol.54 , pp. 122-132
    • Wu, J.W.1    Wang, S.P.2    Alvarez, F.3    Casavant, S.4    Gauthier, N.5    Abed, L.6
  • 213
    • 84871901684 scopus 로고    scopus 로고
    • Hepatic ATGL knockdown uncouples glucose intolerance from liver TAG accumulation
    • K.T. Ong, M.T. Mashek, S.Y. Bu, and D.G. Mashek Hepatic ATGL knockdown uncouples glucose intolerance from liver TAG accumulation FASEB J 27 2013 313 321
    • (2013) FASEB J , vol.27 , pp. 313-321
    • Ong, K.T.1    Mashek, M.T.2    Bu, S.Y.3    Mashek, D.G.4
  • 214
    • 84873178604 scopus 로고    scopus 로고
    • CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER- preventing diacylglycerol-mediated hepatic insulin resistance
    • J.L. Cantley, T. Yoshimura, J.P. Camporez, D. Zhang, F.R. Jornayvaz, and N. Kumashiro et al. CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance Proc Natl Acad Sci USA 110 2013 1869 1874
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 1869-1874
    • Cantley, J.L.1    Yoshimura, T.2    Camporez, J.P.3    Zhang, D.4    Jornayvaz, F.R.5    Kumashiro, N.6
  • 215
    • 78650718129 scopus 로고    scopus 로고
    • Identification of Ubxd8 protein as a sensor for unsaturated fatty acids and regulator of triglyceride synthesis
    • J.N. Lee, H. Kim, H. Yao, Y. Chen, K. Weng, and J. Ye Identification of Ubxd8 protein as a sensor for unsaturated fatty acids and regulator of triglyceride synthesis Proc Natl Acad Sci USA 107 2010 21424 21429
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 21424-21429
    • Lee, J.N.1    Kim, H.2    Yao, H.3    Chen, Y.4    Weng, K.5    Ye, J.6
  • 216
    • 33744755382 scopus 로고    scopus 로고
    • Cytoplasmic lipid droplets are sites of convergence of proteasomal and autophagic degradation of apolipoprotein B
    • DOI 10.1091/mbc.E05-07-0659
    • Y. Ohsaki, J. Cheng, A. Fujita, T. Tokumoto, and T. Fujimoto Cytoplasmic lipid droplets are sites of convergence of proteasomal and autophagic degradation of apolipoprotein B Mol Biol Cell 17 2006 2674 2683 (Pubitemid 43825504)
    • (2006) Molecular Biology of the Cell , vol.17 , Issue.6 , pp. 2674-2683
    • Ohsaki, Y.1    Cheng, J.2    Fujita, A.3    Tokumoto, T.4    Fujimoto, T.5
  • 217
    • 66349121084 scopus 로고    scopus 로고
    • Mammalian patatin domain containing proteins: A family with diverse lipolytic activities involved in multiple biological functions
    • P.C. Kienesberger, M. Oberer, A. Lass, and R. Zechner Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions J Lipid Res 50 Suppl 2009 S63 S68
    • (2009) J Lipid Res , vol.50 , Issue.SUPPL.
    • Kienesberger, P.C.1    Oberer, M.2    Lass, A.3    Zechner, R.4
  • 218
    • 77956625538 scopus 로고    scopus 로고
    • Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease
    • W. Chen, B. Chang, L. Li, and L. Chan Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease Hepatology 52 2010 1134 1142
    • (2010) Hepatology , vol.52 , pp. 1134-1142
    • Chen, W.1    Chang, B.2    Li, L.3    Chan, L.4
  • 219
    • 78751489992 scopus 로고    scopus 로고
    • Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome
    • M.K. Basantani, M.T. Sitnick, L. Cai, D.S. Brenner, N.P. Gardner, and J.Z. Li et al. Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome J Lipid Res 52 2011 318 329
    • (2011) J Lipid Res , vol.52 , pp. 318-329
    • Basantani, M.K.1    Sitnick, M.T.2    Cai, L.3    Brenner, D.S.4    Gardner, N.P.5    Li, J.Z.6
  • 220
    • 80054692396 scopus 로고    scopus 로고
    • Altered endocannabinoid signalling after a high-fat diet in Apoe(-/-) mice: Relevance to adipose tissue inflammation, hepatic steatosis and insulin resistance
    • A. Bartelt, P. Orlando, C. Mele, A. Ligresti, K. Toedter, and L. Scheja et al. Altered endocannabinoid signalling after a high-fat diet in Apoe(-/-) mice: relevance to adipose tissue inflammation, hepatic steatosis and insulin resistance Diabetologia 54 2011 2900 2910
    • (2011) Diabetologia , vol.54 , pp. 2900-2910
    • Bartelt, A.1    Orlando, P.2    Mele, C.3    Ligresti, A.4    Toedter, K.5    Scheja, L.6
  • 221
    • 84859768059 scopus 로고    scopus 로고
    • Lipophagy: Connecting autophagy and lipid metabolism
    • R. Singh, and A.M. Cuervo Lipophagy: connecting autophagy and lipid metabolism Int J Cell Biol 2012 2012 282041
    • (2012) Int J Cell Biol , vol.2012 , pp. 282041
    • Singh, R.1    Cuervo, A.M.2
  • 222
    • 84870995648 scopus 로고    scopus 로고
    • Regulation of lipid stores and metabolism by lipophagy
    • K. Liu, and M.J. Czaja Regulation of lipid stores and metabolism by lipophagy Cell Death Differ 20 2013 3 11
    • (2013) Cell Death Differ , vol.20 , pp. 3-11
    • Liu, K.1    Czaja, M.J.2
  • 223
    • 84873436219 scopus 로고    scopus 로고
    • Autophagy: Emerging roles in lipid homeostasis and metabolic control
    • P. Christian, J. Sacco, and K. Adeli Autophagy: emerging roles in lipid homeostasis and metabolic control Biochim Biophys Acta 1831 2013 819 824
    • (2013) Biochim Biophys Acta , vol.1831 , pp. 819-824
    • Christian, P.1    Sacco, J.2    Adeli, K.3
  • 224
    • 41849123475 scopus 로고    scopus 로고
    • Cytokines in the pathogenesis of fatty liver and disease progression to steatohepatitis: Implications for treatment
    • DOI 10.1111/j.1572-0241.2007.01709.x
    • C. Carter-Kent, N.N. Zein, and A.E. Feldstein Cytokines in the pathogenesis of fatty liver and disease progression to steatohepatitis: implications for treatment Am J Gastroenterol 103 2008 1036 1042 (Pubitemid 351501089)
    • (2008) American Journal of Gastroenterology , vol.103 , Issue.4 , pp. 1036-1042
    • Carter-Kent, C.1    Zein, N.N.2    Feldstein, A.E.3
  • 225
    • 80052617116 scopus 로고    scopus 로고
    • Hepatic steatosis inhibits autophagic proteolysis via impairment of autophagosomal acidification and cathepsin expression
    • Y. Inami, S. Yamashina, K. Izumi, T. Ueno, I. Tanida, and K. Ikejima et al. Hepatic steatosis inhibits autophagic proteolysis via impairment of autophagosomal acidification and cathepsin expression Biochem Biophys Res Commun 412 2011 618 625
    • (2011) Biochem Biophys Res Commun , vol.412 , pp. 618-625
    • Inami, Y.1    Yamashina, S.2    Izumi, K.3    Ueno, T.4    Tanida, I.5    Ikejima, K.6
  • 226
    • 79952541848 scopus 로고    scopus 로고
    • Qushi Huayu Decoction (QHD) inhibits protein and gene expression of cathepsin B in HepG2 cells induced by free fatty acids
    • Q. Feng, Y. Cheng, Y.Y. Hu, H. Zhang, J.H. Peng, and N. Zhang Qushi Huayu Decoction (QHD) inhibits protein and gene expression of cathepsin B in HepG2 cells induced by free fatty acids Chin J Integr Med 16 2010 518 524
    • (2010) Chin J Integr Med , vol.16 , pp. 518-524
    • Feng, Q.1    Cheng, Y.2    Hu, Y.Y.3    Zhang, H.4    Peng, J.H.5    Zhang, N.6
  • 228
    • 34548150017 scopus 로고    scopus 로고
    • Dynamic activity of lipid droplets: Protein phosphorylation and GTP-mediated protein translocation
    • DOI 10.1021/pr070158j
    • R. Bartz, J.K. Zehmer, M. Zhu, Y. Chen, G. Serrero, and Y. Zhao et al. Dynamic activity of lipid droplets: protein phosphorylation and GTP-mediated protein translocation J Proteome Res 6 2007 3256 3265 (Pubitemid 47310210)
    • (2007) Journal of Proteome Research , vol.6 , Issue.8 , pp. 3256-3265
    • Bartz, R.1    Zehmer, J.K.2    Zhu, M.3    Chen, Y.4    Serrero, G.5    Zhao, Y.6    Liu, P.7
  • 229
    • 77952954544 scopus 로고    scopus 로고
    • Lipid droplets: A dynamic organelle moves into focus
    • M. Beller, K. Thiel, P.J. Thul, and H. Jackle Lipid droplets: a dynamic organelle moves into focus FEBS Lett 584 2010 2176 2182
    • (2010) FEBS Lett , vol.584 , pp. 2176-2182
    • Beller, M.1    Thiel, K.2    Thul, P.J.3    Jackle, H.4
  • 230
    • 33646184680 scopus 로고    scopus 로고
    • ARF proteins: Roles in membrane traffic and beyond
    • C. D'Souza-Schorey, and P. Chavrier ARF proteins: roles in membrane traffic and beyond Nat Rev Mol Cell Biol 7 2006 347 358
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 347-358
    • D'Souza-Schorey, C.1    Chavrier, P.2
  • 231
    • 67349280293 scopus 로고    scopus 로고
    • Lipid droplet-organelle interactions; Sharing the fats
    • S. Murphy, S. Martin, and R.G. Parton Lipid droplet-organelle interactions; sharing the fats Biochim Biophys Acta 1791 2009 441 447
    • (2009) Biochim Biophys Acta , vol.1791 , pp. 441-447
    • Murphy, S.1    Martin, S.2    Parton, R.G.3
  • 232
    • 84861423416 scopus 로고    scopus 로고
    • Rab5 is necessary for the biogenesis of the endolysosomal system in vivo
    • A. Zeigerer, J. Gilleron, R.L. Bogorad, G. Marsico, H. Nonaka, and S. Seifert et al. Rab5 is necessary for the biogenesis of the endolysosomal system in vivo Nature 485 2012 465 470
    • (2012) Nature , vol.485 , pp. 465-470
    • Zeigerer, A.1    Gilleron, J.2    Bogorad, R.L.3    Marsico, G.4    Nonaka, H.5    Seifert, S.6
  • 233
    • 67249150119 scopus 로고    scopus 로고
    • Rab7: Roles in membrane trafficking and disease
    • M. Zhang, L. Chen, S. Wang, and T. Wang Rab7: roles in membrane trafficking and disease Biosci Rep 29 2009 193 209
    • (2009) Biosci Rep , vol.29 , pp. 193-209
    • Zhang, M.1    Chen, L.2    Wang, S.3    Wang, T.4
  • 235
    • 30344486984 scopus 로고    scopus 로고
    • Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells
    • DOI 10.1038/ncb1342, PII N1342
    • O.O. Glebov, N.A. Bright, and B.J. Nichols Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells Nat Cell Biol 8 2006 46 54 (Pubitemid 43064796)
    • (2006) Nature Cell Biology , vol.8 , Issue.1 , pp. 46-54
    • Glebov, O.O.1    Bright, N.A.2    Nichols, B.J.3
  • 238
    • 64149132208 scopus 로고    scopus 로고
    • The endoplasmic reticulum enzyme DGAT2 is found in mitochondria- associated membranes and has a mitochondrial targeting signal that promotes its association with mitochondria
    • S.J. Stone, M.C. Levin, P. Zhou, J. Han, T.C. Walther, and R.V. Farese Jr. The endoplasmic reticulum enzyme DGAT2 is found in mitochondria-associated membranes and has a mitochondrial targeting signal that promotes its association with mitochondria J Biol Chem 284 2009 5352 5361
    • (2009) J Biol Chem , vol.284 , pp. 5352-5361
    • Stone, S.J.1    Levin, M.C.2    Zhou, P.3    Han, J.4    Walther, T.C.5    Farese, Jr.R.V.6
  • 241
    • 84864029381 scopus 로고    scopus 로고
    • Genetics and molecular basis of human peroxisome biogenesis disorders
    • H.R. Waterham, and M.S. Ebberink Genetics and molecular basis of human peroxisome biogenesis disorders Biochim Biophys Acta 1822 2012 1430 1441
    • (2012) Biochim Biophys Acta , vol.1822 , pp. 1430-1441
    • Waterham, H.R.1    Ebberink, M.S.2
  • 242
  • 244
    • 84883612242 scopus 로고    scopus 로고
    • Plin2 inhibits cellular glucose uptake through interactions with SNAP23, a SNARE complex protein
    • S. Senthivinayagam, A.L. McIntosh, K.C. Moon, and B.P. Atshaves Plin2 inhibits cellular glucose uptake through interactions with SNAP23, a SNARE complex protein PLoS One 8 2013 e73696
    • (2013) PLoS One , vol.8 , pp. 73696
    • Senthivinayagam, S.1    McIntosh, A.L.2    Moon, K.C.3    Atshaves, B.P.4
  • 245
    • 35748940621 scopus 로고    scopus 로고
    • Lipid droplets highjack SNAREs
    • DOI 10.1038/ncb1107-1219, PII NCB1107-1219
    • T.H. Sollner Lipid droplets highjack SNAREs Nat Cell Biol 9 2007 1219 1220 (Pubitemid 350042349)
    • (2007) Nature Cell Biology , vol.9 , Issue.11 , pp. 1219-1220
    • Sollner, T.H.1
  • 246
    • 84863989487 scopus 로고    scopus 로고
    • The role of pathway-selective insulin resistance and responsiveness in diabetic dyslipoproteinemia
    • X. Wu, K. Chen, and K.J. Williams The role of pathway-selective insulin resistance and responsiveness in diabetic dyslipoproteinemia Curr Opin Lipidol 23 2012 334 344
    • (2012) Curr Opin Lipidol , vol.23 , pp. 334-344
    • Wu, X.1    Chen, K.2    Williams, K.J.3
  • 247
    • 37549022688 scopus 로고    scopus 로고
    • Inflammation and insulin resistance
    • DOI 10.1016/j.febslet.2007.11.057, PII S0014579307012082
    • C. de Luca, and J.M. Olefsky Inflammation and insulin resistance FEBS Lett 582 2008 97 105 (Pubitemid 50010731)
    • (2008) FEBS Letters , vol.582 , Issue.1 , pp. 97-105
    • De Luca, C.1    Olefsky, J.M.2
  • 249
  • 250
    • 80052005701 scopus 로고    scopus 로고
    • Inflammation-associated interleukin-6/signal transducer and activator of transcription 3 activation ameliorates alcoholic and nonalcoholic fatty liver diseases in interleukin-10-deficient mice
    • A.M. Miller, H. Wang, A. Bertola, O. Park, N. Horiguchi, and S.H. Ki et al. Inflammation-associated interleukin-6/signal transducer and activator of transcription 3 activation ameliorates alcoholic and nonalcoholic fatty liver diseases in interleukin-10-deficient mice Hepatology 54 2011 846 856
    • (2011) Hepatology , vol.54 , pp. 846-856
    • Miller, A.M.1    Wang, H.2    Bertola, A.3    Park, O.4    Horiguchi, N.5    Ki, S.H.6
  • 251
    • 84873804024 scopus 로고    scopus 로고
    • Direct control of hepatic glucose production by interleukin-13 in mice
    • K.J. Stanya, D. Jacobi, S. Liu, P. Bhargava, L. Dai, and M.R. Gangl et al. Direct control of hepatic glucose production by interleukin-13 in mice J Clin Invest 123 2013 261 271
    • (2013) J Clin Invest , vol.123 , pp. 261-271
    • Stanya, K.J.1    Jacobi, D.2    Liu, S.3    Bhargava, P.4    Dai, L.5    Gangl, M.R.6
  • 252
    • 84864269699 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress in nonalcoholic fatty liver disease
    • M.J. Pagliassotti Endoplasmic reticulum stress in nonalcoholic fatty liver disease Annu Rev Nutr 32 2012 17 33
    • (2012) Annu Rev Nutr , vol.32 , pp. 17-33
    • Pagliassotti, M.J.1
  • 253
    • 37349083834 scopus 로고    scopus 로고
    • PTEN Down-Regulation by Unsaturated Fatty Acids Triggers Hepatic Steatosis via an NF-κBp65/mTOR-Dependent Mechanism
    • DOI 10.1053/j.gastro.2007.10.010, PII S0016508507018094
    • M. Vinciguerra, C. Veyrat-Durebex, M.A. Moukil, L. Rubbia-Brandt, F. Rohner-Jeanrenaud, and M. Foti PTEN down-regulation by unsaturated fatty acids triggers hepatic steatosis via an NF-kappaBp65/mTOR-dependent mechanism Gastroenterology 134 2008 268 280 (Pubitemid 350309315)
    • (2008) Gastroenterology , vol.134 , Issue.1 , pp. 268-280
    • Vinciguerra, M.1    Veyrat-Durebex, C.2    Moukil, M.A.3    Rubbia-Brandt, L.4    Rohner-Jeanrenaud, F.5    Foti, M.6
  • 254
    • 32044453080 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response
    • DOI 10.1016/j.cell.2005.11.040, PII S0092867406000043
    • K. Zhang, X. Shen, J. Wu, K. Sakaki, T. Saunders, and D.T. Rutkowski et al. Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response Cell 124 2006 587 599 (Pubitemid 43199443)
    • (2006) Cell , vol.124 , Issue.3 , pp. 587-599
    • Zhang, K.1    Shen, X.2    Wu, J.3    Sakaki, K.4    Saunders, T.5    Rutkowski, D.T.6    Back, S.H.7    Kaufman, R.J.8
  • 255
    • 80052174716 scopus 로고    scopus 로고
    • Hepatic acyl-CoA:diacylglcyerol acyltransferase (DGAT) overexpression, diacylglycerol, and insulin sensitivity
    • [author reply E524]
    • M. Monetti, M.C. Levin, M.J. Watt, B.K. Hubbard, C. Newgard, and R.V.S. Farese et al. Hepatic acyl-CoA:diacylglcyerol acyltransferase (DGAT) overexpression, diacylglycerol, and insulin sensitivity Proc Natl Acad Sci USA 108 2011 E523 [author reply E524]
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 523
    • Monetti, M.1    Levin, M.C.2    Watt, M.J.3    Hubbard, B.K.4    Newgard, C.5    Farese, R.V.S.6
  • 257
    • 84870438208 scopus 로고    scopus 로고
    • Effects of dietary fat energy restriction and fish oil feeding on hepatic metabolic abnormalities and insulin resistance in KK mice with high-fat diet-induced obesity
    • T. Arai, H.J. Kim, S. Hirako, M. Nakasatomi, H. Chiba, and A. Matsumoto Effects of dietary fat energy restriction and fish oil feeding on hepatic metabolic abnormalities and insulin resistance in KK mice with high-fat diet-induced obesity J Nutr Biochem 24 2013 267 273
    • (2013) J Nutr Biochem , vol.24 , pp. 267-273
    • Arai, T.1    Kim, H.J.2    Hirako, S.3    Nakasatomi, M.4    Chiba, H.5    Matsumoto, A.6
  • 258
    • 33845263672 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase: A new therapeutic target of liver steatosis
    • P. Dobrzyn, and A. Dobrzyn Stearoyl-CoA desaturase: a new therapeutic target of liver steatosis Drug Dev Res 67 2006 643
    • (2006) Drug Dev Res , vol.67 , pp. 643
    • Dobrzyn, P.1    Dobrzyn, A.2
  • 260
    • 78049503712 scopus 로고    scopus 로고
    • Liver-specific suppressor of cytokine signaling-3 deletion in mice enhances hepatic insulin sensitivity and lipogenesis resulting in fatty liver and obesity
    • N. Sachithanandan, B.C. Fam, S. Fynch, N. Dzamko, M.J. Watt, and S. Wormald et al. Liver-specific suppressor of cytokine signaling-3 deletion in mice enhances hepatic insulin sensitivity and lipogenesis resulting in fatty liver and obesity Hepatology 52 2010 1632 1642
    • (2010) Hepatology , vol.52 , pp. 1632-1642
    • Sachithanandan, N.1    Fam, B.C.2    Fynch, S.3    Dzamko, N.4    Watt, M.J.5    Wormald, S.6
  • 261
  • 262
    • 84872223447 scopus 로고    scopus 로고
    • NF-kappaB1 deficiency stimulates the progression of non-alcoholic steatohepatitis (NASH) in mice by promoting NKT-cell-mediated responses
    • I. Locatelli, S. Sutti, M. Vacchiano, C. Bozzola, and E. Albano NF-kappaB1 deficiency stimulates the progression of non-alcoholic steatohepatitis (NASH) in mice by promoting NKT-cell-mediated responses Clin Sci (Lond) 124 2013 279 287
    • (2013) Clin Sci (Lond) , vol.124 , pp. 279-287
    • Locatelli, I.1    Sutti, S.2    Vacchiano, M.3    Bozzola, C.4    Albano, E.5
  • 263
    • 84868549057 scopus 로고    scopus 로고
    • Drug sensitivity and sphingolipid metabolism in CLL
    • U. Jaeger Drug sensitivity and sphingolipid metabolism in CLL Blood 120 2012 3865 3866
    • (2012) Blood , vol.120 , pp. 3865-3866
    • Jaeger, U.1
  • 264
    • 80052266598 scopus 로고    scopus 로고
    • Type 2 deiodinase at the crossroads of thyroid hormone action
    • E. Arrojo, R. Drigo, and A.C. Bianco Type 2 deiodinase at the crossroads of thyroid hormone action Int J Biochem Cell Biol 43 2011 1432 1441
    • (2011) Int J Biochem Cell Biol , vol.43 , pp. 1432-1441
    • Arrojo, E.1    Drigo, R.2    Bianco, A.C.3
  • 265
    • 84922685920 scopus 로고    scopus 로고
    • Novel mechanism for hepatic lipid accumulation: A physiological role for hepatic PPARgamma-fsp27 signal
    • K. Matsusue Novel mechanism for hepatic lipid accumulation: a physiological role for hepatic PPARgamma-fsp27 signal Yakugaku Zasshi 132 2012 823 829
    • (2012) Yakugaku Zasshi , vol.132 , pp. 823-829
    • Matsusue, K.1
  • 266
    • 0942287191 scopus 로고    scopus 로고
    • Chinese Hamster Ovary K2 Cell Lipid Droplets Appear to be Metabolic Organelles Involved in Membrane Traffic
    • DOI 10.1074/jbc.M311945200
    • P. Liu, Y. Ying, Y. Zhao, D.I. Mundy, M. Zhu, and R.G. Anderson Chinese hamster ovary K2 cell lipid droplets appear to be metabolic organelles involved in membrane traffic J Biol Chem 279 2004 3787 3792 (Pubitemid 38140623)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.5 , pp. 3787-3792
    • Liu, P.1    Ying, Y.2    Zhao, Y.3    Mundy, D.I.4    Zhu, M.5    Anderson, R.G.W.6
  • 268
    • 62149086225 scopus 로고    scopus 로고
    • Bayesian model averaging in meta-analysis: Vitamin e supplementation and mortality
    • D. Berry, J.K. Wathen, and M. Newell Bayesian model averaging in meta-analysis: vitamin E supplementation and mortality Clin Trials 6 2009 28 41
    • (2009) Clin Trials , vol.6 , pp. 28-41
    • Berry, D.1    Wathen, J.K.2    Newell, M.3
  • 269
    • 80055028155 scopus 로고    scopus 로고
    • Pentoxifylline improves nonalcoholic steatohepatitis: A randomized placebo-controlled trial
    • C.O. Zein, L.M. Yerian, P. Gogate, R. Lopez, J.P. Kirwan, and A.E. Feldstein et al. Pentoxifylline improves nonalcoholic steatohepatitis: a randomized placebo-controlled trial Hepatology 54 2011 1610 1619
    • (2011) Hepatology , vol.54 , pp. 1610-1619
    • Zein, C.O.1    Yerian, L.M.2    Gogate, P.3    Lopez, R.4    Kirwan, J.P.5    Feldstein, A.E.6
  • 270
    • 84867165316 scopus 로고    scopus 로고
    • Pentoxifylline decreases oxidized lipid products in nonalcoholic steatohepatitis: New evidence on the potential therapeutic mechanism
    • C.O. Zein, R. Lopez, X. Fu, J.P. Kirwan, L.M. Yerian, and A.J. McCullough et al. Pentoxifylline decreases oxidized lipid products in nonalcoholic steatohepatitis: new evidence on the potential therapeutic mechanism Hepatology 56 2012 1291 1299
    • (2012) Hepatology , vol.56 , pp. 1291-1299
    • Zein, C.O.1    Lopez, R.2    Fu, X.3    Kirwan, J.P.4    Yerian, L.M.5    McCullough, A.J.6
  • 271
    • 84886906559 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease and the renin-angiotensin system: Implications for treatment
    • P. Paschos, and K. Tziomalos Nonalcoholic fatty liver disease and the renin-angiotensin system: implications for treatment World J Hepatol 4 2012 327 331
    • (2012) World J Hepatol , vol.4 , pp. 327-331
    • Paschos, P.1    Tziomalos, K.2
  • 272
    • 84878646607 scopus 로고    scopus 로고
    • Mitochondrial triglyceride transfer protein inhibition: New achievements in the treatment of dyslipidemias
    • M.S. Kostapanos, E.C. Rizos, N. Papanas, E. Maltezos, and M.S. Elisaf Mitochondrial triglyceride transfer protein inhibition: new achievements in the treatment of dyslipidemias Curr Pharm Des 19 2013 3150 3160
    • (2013) Curr Pharm des , vol.19 , pp. 3150-3160
    • Kostapanos, M.S.1    Rizos, E.C.2    Papanas, N.3    Maltezos, E.4    Elisaf, M.S.5
  • 273
    • 84856429876 scopus 로고    scopus 로고
    • Obesity, inflammation, and liver cancer
    • B. Sun, and M. Karin Obesity, inflammation, and liver cancer J Hepatol 56 2012 704 713
    • (2012) J Hepatol , vol.56 , pp. 704-713
    • Sun, B.1    Karin, M.2
  • 275
    • 84870877532 scopus 로고    scopus 로고
    • Functional role of monocytes and macrophages for the inflammatory response in acute liver injury
    • H.W. Zimmermann, C. Trautwein, and F. Tacke Functional role of monocytes and macrophages for the inflammatory response in acute liver injury Front Physiol 3 2012 56
    • (2012) Front Physiol , vol.3 , pp. 56
    • Zimmermann, H.W.1    Trautwein, C.2    Tacke, F.3
  • 277
    • 33745216724 scopus 로고    scopus 로고
    • MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity
    • H. Kanda, S. Tateya, Y. Tamori, K. Kotani, K. Hiasa, and R. Kitazawa et al. MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity J Clin Invest 116 2006 1494 1505
    • (2006) J Clin Invest , vol.116 , pp. 1494-1505
    • Kanda, H.1    Tateya, S.2    Tamori, Y.3    Kotani, K.4    Hiasa, K.5    Kitazawa, R.6
  • 278
    • 84864198388 scopus 로고    scopus 로고
    • A liver full of JNK: Signaling in regulation of cell function and disease pathogenesis, and clinical approaches
    • E. Seki, D.A. Brenner, and M. Karin A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches Gastroenterology 143 2012 307 320
    • (2012) Gastroenterology , vol.143 , pp. 307-320
    • Seki, E.1    Brenner, D.A.2    Karin, M.3
  • 280
    • 0035059634 scopus 로고    scopus 로고
    • A selective ROCK inhibitor, Y27632, prevents dimethylnitrosamine-induced hepatic fibrosis in rats
    • DOI 10.1016/S0168-8278(00)00059-3, PII S0168827800000593
    • S. Tada, H. Iwamoto, M. Nakamuta, R. Sugimoto, M. Enjoji, and Y. Nakashima et al. A selective ROCK inhibitor, Y27632, prevents dimethylnitrosamine-induced hepatic fibrosis in rats J Hepatol 34 2001 529 536 (Pubitemid 32328509)
    • (2001) Journal of Hepatology , vol.34 , Issue.4 , pp. 529-536
    • Tada, S.1    Iwamoto, H.2    Nakamuta, M.3    Sugimoto, R.4    Enjoji, M.5    Nakashima, Y.6    Nawata, H.7
  • 281
    • 79954452300 scopus 로고    scopus 로고
    • Inflammatory stress exacerbates hepatic cholesterol accumulation via increasing cholesterol uptake and de novo synthesis
    • L. Zhao, Y. Chen, R. Tang, Y. Chen, Q. Li, and J. Gong et al. Inflammatory stress exacerbates hepatic cholesterol accumulation via increasing cholesterol uptake and de novo synthesis J Gastroenterol Hepatol 26 2011 875 883
    • (2011) J Gastroenterol Hepatol , vol.26 , pp. 875-883
    • Zhao, L.1    Chen, Y.2    Tang, R.3    Chen, Y.4    Li, Q.5    Gong, J.6
  • 282
    • 84860243404 scopus 로고    scopus 로고
    • Inflammatory stress exacerbates hepatic cholesterol accumulation via disrupting cellular cholesterol export
    • Y. Chen, Y. Chen, L. Zhao, Y. Chen, M. Mei, and Q. Li et al. Inflammatory stress exacerbates hepatic cholesterol accumulation via disrupting cellular cholesterol export J Gastroenterol Hepatol 27 2012 974 984
    • (2012) J Gastroenterol Hepatol , vol.27 , pp. 974-984
    • Chen, Y.1    Chen, Y.2    Zhao, L.3    Chen, Y.4    Mei, M.5    Li, Q.6
  • 283
    • 84856297712 scopus 로고    scopus 로고
    • LDL receptor knock-out mice are a physiological model particularly vulnerable to study the onset of inflammation in non-alcoholic fatty liver disease
    • V. Bieghs, P.J. Van Gorp, K. Wouters, T. Hendrikx, M.J. Gijbels, and M. van Bilsen et al. LDL receptor knock-out mice are a physiological model particularly vulnerable to study the onset of inflammation in non-alcoholic fatty liver disease PLoS One 7 2012 e30668
    • (2012) PLoS One , vol.7 , pp. 30668
    • Bieghs, V.1    Van Gorp, P.J.2    Wouters, K.3    Hendrikx, T.4    Gijbels, M.J.5    Van Bilsen, M.6
  • 286
    • 84867590025 scopus 로고    scopus 로고
    • Attenuation of early liver fibrosis by pharmacological inhibition of smoothened receptor signaling
    • A. Pratap, S. Singh, V. Mundra, N. Yang, R. Panakanti, and J.D. Eason et al. Attenuation of early liver fibrosis by pharmacological inhibition of smoothened receptor signaling J Drug Target 20 2012 770 782
    • (2012) J Drug Target , vol.20 , pp. 770-782
    • Pratap, A.1    Singh, S.2    Mundra, V.3    Yang, N.4    Panakanti, R.5    Eason, J.D.6
  • 287
    • 4043170647 scopus 로고    scopus 로고
    • Hepatic microvascular dysfunction during evolution of dietary steatohepatitis in mice
    • DOI 10.1002/hep.20302
    • R.S. McCuskey, Y. Ito, G.R. Robertson, M.K. McCuskey, M. Perry, and G.C. Farrell Hepatic microvascular dysfunction during evolution of dietary steatohepatitis in mice Hepatology 40 2004 386 393 (Pubitemid 39062856)
    • (2004) Hepatology , vol.40 , Issue.2 , pp. 386-393
    • McCuskey, R.S.1    Ito, Y.2    Robertson, G.R.3    McCuskey, M.K.4    Perry, M.5    Farrell, G.C.6
  • 288
    • 84878626950 scopus 로고    scopus 로고
    • Activated hepatic stellate cells mediate the differentiation of macrophages
    • J. Chang, T. Hisamatsu, K. Shimamura, K. Yoneno, M. Adachi, and H. Naruse et al. Activated hepatic stellate cells mediate the differentiation of macrophages Hepatol Res 43 2013 658 669
    • (2013) Hepatol Res , vol.43 , pp. 658-669
    • Chang, J.1    Hisamatsu, T.2    Shimamura, K.3    Yoneno, K.4    Adachi, M.5    Naruse, H.6
  • 289
    • 43249111258 scopus 로고    scopus 로고
    • Advanced glycation end products enhance the proliferation and activation of hepatic stellate cells
    • DOI 10.1007/s00535-007-2152-7
    • K. Iwamoto, K. Kanno, H. Hyogo, S. Yamagishi, M. Takeuchi, and S. Tazuma et al. Advanced glycation end products enhance the proliferation and activation of hepatic stellate cells J Gastroenterol 43 2008 298 304 (Pubitemid 351650040)
    • (2008) Journal of Gastroenterology , vol.43 , Issue.4 , pp. 298-304
    • Iwamoto, K.1    Kanno, K.2    Hyogo, H.3    Yamagishi, S.-I.4    Takeuchi, M.5    Tazuma, S.6    Chayama, K.7
  • 290
    • 76049128362 scopus 로고    scopus 로고
    • Advanced glycation end products enhance monocyte activation during human mixed lymphocyte reaction
    • K. Ohashi, H.K. Takahashi, S. Mori, K. Liu, H. Wake, and H. Sadamori et al. Advanced glycation end products enhance monocyte activation during human mixed lymphocyte reaction Clin Immunol 134 2010 345 353
    • (2010) Clin Immunol , vol.134 , pp. 345-353
    • Ohashi, K.1    Takahashi, H.K.2    Mori, S.3    Liu, K.4    Wake, H.5    Sadamori, H.6
  • 291
    • 84857055199 scopus 로고    scopus 로고
    • Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury
    • C. Baeck, A. Wehr, K.R. Karlmark, F. Heymann, M. Vucur, and N. Gassler et al. Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury Gut 61 2012 416 426
    • (2012) Gut , vol.61 , pp. 416-426
    • Baeck, C.1    Wehr, A.2    Karlmark, K.R.3    Heymann, F.4    Vucur, M.5    Gassler, N.6
  • 293
    • 68349146412 scopus 로고    scopus 로고
    • The effect of consecutively larger doses of l-arginine on hepatic microcirculation and tissue oxygenation in hepatic steatosis
    • S. Ijaz, M.C. Winslet, and A.M. Seifalian The effect of consecutively larger doses of l-arginine on hepatic microcirculation and tissue oxygenation in hepatic steatosis Microvasc Res 78 2009 206 211
    • (2009) Microvasc Res , vol.78 , pp. 206-211
    • Ijaz, S.1    Winslet, M.C.2    Seifalian, A.M.3
  • 294
  • 295
    • 80455174348 scopus 로고    scopus 로고
    • Type of steatosis influences microcirculation and fibrogenesis in different rat strains
    • S. Rosenstengel, S. Stoeppeler, R. Bahde, H.U. Spiegel, and D. Palmes Type of steatosis influences microcirculation and fibrogenesis in different rat strains J Invest Surg 24 2011 273 282
    • (2011) J Invest Surg , vol.24 , pp. 273-282
    • Rosenstengel, S.1    Stoeppeler, S.2    Bahde, R.3    Spiegel, H.U.4    Palmes, D.5
  • 296
    • 67349205002 scopus 로고    scopus 로고
    • Kupffer cells in non-alcoholic fatty liver disease: The emerging view
    • G. Baffy Kupffer cells in non-alcoholic fatty liver disease: the emerging view J Hepatol 51 2009 212 223
    • (2009) J Hepatol , vol.51 , pp. 212-223
    • Baffy, G.1
  • 297
    • 84870042853 scopus 로고    scopus 로고
    • Kuppfer cells trigger nonalcoholic steatohepatitis development in diet-induced mouse model through tumor necrosis factor-alpha production
    • A.C. Tosello-Trampont, S.G. Landes, V. Nguyen, T.I. Novobrantseva, and Y.S. Hahn Kuppfer cells trigger nonalcoholic steatohepatitis development in diet-induced mouse model through tumor necrosis factor-alpha production J Biol Chem 287 2012 40161 40172
    • (2012) J Biol Chem , vol.287 , pp. 40161-40172
    • Tosello-Trampont, A.C.1    Landes, S.G.2    Nguyen, V.3    Novobrantseva, T.I.4    Hahn, Y.S.5
  • 298
    • 77449117735 scopus 로고    scopus 로고
    • Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance
    • W. Huang, A. Metlakunta, N. Dedousis, P. Zhang, I. Sipula, and J.J. Dube et al. Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance Diabetes 59 2010 347 357
    • (2010) Diabetes , vol.59 , pp. 347-357
    • Huang, W.1    Metlakunta, A.2    Dedousis, N.3    Zhang, P.4    Sipula, I.5    Dube, J.J.6
  • 299
    • 77956321989 scopus 로고    scopus 로고
    • The relationship of omental and subcutaneous adipocyte size to metabolic disease in severe obesity
    • J. O'Connell, L. Lynch, T.J. Cawood, A. Kwasnik, N. Nolan, and J. Geoghegan et al. The relationship of omental and subcutaneous adipocyte size to metabolic disease in severe obesity PLoS One 5 2010 e9997
    • (2010) PLoS One , vol.5 , pp. 9997
    • O'Connell, J.1    Lynch, L.2    Cawood, T.J.3    Kwasnik, A.4    Nolan, N.5    Geoghegan, J.6
  • 301
    • 79959473762 scopus 로고    scopus 로고
    • O-GlcNAcylation increases ChREBP protein content and transcriptional activity in the liver
    • C. Guinez, G. Filhoulaud, F. Rayah-Benhamed, S. Marmier, C. Dubuquoy, and R. Dentin et al. O-GlcNAcylation increases ChREBP protein content and transcriptional activity in the liver Diabetes 60 2011 1399 1413
    • (2011) Diabetes , vol.60 , pp. 1399-1413
    • Guinez, C.1    Filhoulaud, G.2    Rayah-Benhamed, F.3    Marmier, S.4    Dubuquoy, C.5    Dentin, R.6
  • 302
    • 80052782148 scopus 로고    scopus 로고
    • Adiponectin suppresses endoplasmic reticulum stress in nonalcoholic steatohepatitis
    • T. Ueno, A. Nakamura, H. Nakayama, S. Otabe, X. Yuan, and T. Fukutani et al. Adiponectin suppresses endoplasmic reticulum stress in nonalcoholic steatohepatitis Exp Ther Med 2 2011 1035 1040
    • (2011) Exp Ther Med , vol.2 , pp. 1035-1040
    • Ueno, T.1    Nakamura, A.2    Nakayama, H.3    Otabe, S.4    Yuan, X.5    Fukutani, T.6
  • 303
    • 84870452496 scopus 로고    scopus 로고
    • Adiponectin: Key player in the adipose tissue-liver crosstalk
    • A.R. Moschen, V. Wieser, and H. Tilg Adiponectin: key player in the adipose tissue-liver crosstalk Curr Med Chem 19 2012 5467 5473
    • (2012) Curr Med Chem , vol.19 , pp. 5467-5473
    • Moschen, A.R.1    Wieser, V.2    Tilg, H.3
  • 304
    • 67650484317 scopus 로고    scopus 로고
    • Visceral and subcutaneous adipose tissue diacylglycerol acyltransferase activity in humans
    • X.G. Hou, S. Moser, M.G. Sarr, G.B. Thompson, F.G. Que, and M.D. Jensen Visceral and subcutaneous adipose tissue diacylglycerol acyltransferase activity in humans Obesity (Silver Spring) 17 2009 1129 1134
    • (2009) Obesity (Silver Spring) , vol.17 , pp. 1129-1134
    • Hou, X.G.1    Moser, S.2    Sarr, M.G.3    Thompson, G.B.4    Que, F.G.5    Jensen, M.D.6
  • 305
    • 79953297691 scopus 로고    scopus 로고
    • DGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytes
    • C.A. Harris, J.T. Haas, R.S. Streeper, S.J. Stone, M. Kumari, and K. Yang et al. DGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytes J Lipid Res 52 2011 657 667
    • (2011) J Lipid Res , vol.52 , pp. 657-667
    • Harris, C.A.1    Haas, J.T.2    Streeper, R.S.3    Stone, S.J.4    Kumari, M.5    Yang, K.6
  • 306
    • 12344332455 scopus 로고    scopus 로고
    • Cytokines and the pathogenesis of non-alcoholic steatohepatitis
    • DOI 10.1136/gut.2003.024935
    • A.M. Diehl, Z.P. Li, H.Z. Lin, and S.Q. Yang Cytokines and the pathogenesis of non-alcoholic steatohepatitis Gut 54 2005 303 306 (Pubitemid 40139250)
    • (2005) Gut , vol.54 , Issue.2 , pp. 303-306
    • Diehl, A.M.1    Li, Z.P.2    Lin, H.Z.3    Yang, S.Q.4
  • 307
    • 84862500687 scopus 로고    scopus 로고
    • Hepatic steatosis in type 1 diabetes
    • S.E. Regnell, and A. Lernmark Hepatic steatosis in type 1 diabetes Rev Diabet Stud 8 2011 454 467
    • (2011) Rev Diabet Stud , vol.8 , pp. 454-467
    • Regnell, S.E.1    Lernmark, A.2
  • 308
    • 79960555502 scopus 로고    scopus 로고
    • Metabolic factors in the development of hepatic steatosis and altered mitochondrial gene expression in vivo
    • S. Wang, A. Kamat, P. Pergola, A. Swamy, F. Tio, and K. Cusi Metabolic factors in the development of hepatic steatosis and altered mitochondrial gene expression in vivo Metabolism 60 2011 1090 1099
    • (2011) Metabolism , vol.60 , pp. 1090-1099
    • Wang, S.1    Kamat, A.2    Pergola, P.3    Swamy, A.4    Tio, F.5    Cusi, K.6
  • 310
    • 80455125921 scopus 로고    scopus 로고
    • Unmasking differential effects of rosiglitazone and pioglitazone in the combination treatment with n-3 fatty acids in mice fed a high-fat diet
    • V. Kus, P. Flachs, O. Kuda, K. Bardova, P. Janovska, and M. Svobodova et al. Unmasking differential effects of rosiglitazone and pioglitazone in the combination treatment with n-3 fatty acids in mice fed a high-fat diet PLoS One 6 2011 e27126
    • (2011) PLoS One , vol.6 , pp. 27126
    • Kus, V.1    Flachs, P.2    Kuda, O.3    Bardova, K.4    Janovska, P.5    Svobodova, M.6
  • 311
    • 83555164835 scopus 로고    scopus 로고
    • Meta-analysis: Pioglitazone improves liver histology and fibrosis in patients with non-alcoholic steatohepatitis
    • E. Boettcher, G. Csako, F. Pucino, R. Wesley, and R. Loomba Meta-analysis: pioglitazone improves liver histology and fibrosis in patients with non-alcoholic steatohepatitis Aliment Pharmacol Ther 35 2012 66 75
    • (2012) Aliment Pharmacol Ther , vol.35 , pp. 66-75
    • Boettcher, E.1    Csako, G.2    Pucino, F.3    Wesley, R.4    Loomba, R.5
  • 312
    • 84862300888 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease and vascular risk
    • L.S. Bhatia, N.P. Curzen, and C.D. Byrne Nonalcoholic fatty liver disease and vascular risk Curr Opin Cardiol 27 2012 420 428
    • (2012) Curr Opin Cardiol , vol.27 , pp. 420-428
    • Bhatia, L.S.1    Curzen, N.P.2    Byrne, C.D.3
  • 313
    • 84861417701 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease: A new and important cardiovascular risk factor?
    • L.S. Bhatia, N.P. Curzen, P.C. Calder, and C.D. Byrne Non-alcoholic fatty liver disease: a new and important cardiovascular risk factor? Eur Heart J 33 2012 1190 1200
    • (2012) Eur Heart J , vol.33 , pp. 1190-1200
    • Bhatia, L.S.1    Curzen, N.P.2    Calder, P.C.3    Byrne, C.D.4
  • 315
    • 84877854022 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease (NAFLD) and its connection with insulin resistance, dyslipidemia, atherosclerosis and coronary heart disease
    • M. Gaggini, M. Morelli, E. Buzzigoli, R.A. DeFronzo, E. Bugianesi, and A. Gastaldelli Non-alcoholic fatty liver disease (NAFLD) and its connection with insulin resistance, dyslipidemia, atherosclerosis and coronary heart disease Nutrients 5 2013 1544 1560
    • (2013) Nutrients , vol.5 , pp. 1544-1560
    • Gaggini, M.1    Morelli, M.2    Buzzigoli, E.3    Defronzo, R.A.4    Bugianesi, E.5    Gastaldelli, A.6
  • 317
    • 79958148945 scopus 로고    scopus 로고
    • Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: Evidence and guidance for management
    • M.J. Chapman, H.N. Ginsberg, P. Amarenco, F. Andreotti, J. Boren, and A.L. Catapano et al. Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management Eur Heart J 32 2011 1345 1361
    • (2011) Eur Heart J , vol.32 , pp. 1345-1361
    • Chapman, M.J.1    Ginsberg, H.N.2    Amarenco, P.3    Andreotti, F.4    Boren, J.5    Catapano, A.L.6
  • 318
    • 84855171923 scopus 로고    scopus 로고
    • Diagnosis and evaluation of nonalcoholic fatty liver disease
    • M. Obika, and H. Noguchi Diagnosis and evaluation of nonalcoholic fatty liver disease Exp Diabetes Res 2012 2012 145754
    • (2012) Exp Diabetes Res , vol.2012 , pp. 145754
    • Obika, M.1    Noguchi, H.2
  • 320
    • 84885124263 scopus 로고    scopus 로고
    • Diagnosing Fatty liver disease: A comparative evaluation of metabolic markers, phenotypes, genotypes and established biomarkers
    • S. Siegert, Z. Yu, R. Wang-Sattler, T. Illig, J. Adamski, and J. Hampe et al. Diagnosing Fatty liver disease: a comparative evaluation of metabolic markers, phenotypes, genotypes and established biomarkers PLoS One 8 2013 e76813
    • (2013) PLoS One , vol.8 , pp. 76813
    • Siegert, S.1    Yu, Z.2    Wang-Sattler, R.3    Illig, T.4    Adamski, J.5    Hampe, J.6
  • 321
    • 78149477200 scopus 로고    scopus 로고
    • Changes in hepatic gene expression upon oral administration of taurine-conjugated ursodeoxycholic acid in ob/ob mice
    • J.S. Yang, J.T. Kim, J. Jeon, H.S. Park, G.H. Kang, and K.S. Park et al. Changes in hepatic gene expression upon oral administration of taurine-conjugated ursodeoxycholic acid in ob/ob mice PLoS One 5 2010 e13858
    • (2010) PLoS One , vol.5 , pp. 13858
    • Yang, J.S.1    Kim, J.T.2    Jeon, J.3    Park, H.S.4    Kang, G.H.5    Park, K.S.6
  • 322
  • 323
    • 83455201680 scopus 로고    scopus 로고
    • Effect of spironolactone and vitamin e on serum metabolic parameters and insulin resistance in patients with nonalcoholic fatty liver disease
    • S.A. Polyzos, J. Kountouras, E. Zafeiriadou, K. Patsiaoura, E. Katsiki, and G. Deretzi et al. Effect of spironolactone and vitamin E on serum metabolic parameters and insulin resistance in patients with nonalcoholic fatty liver disease J Renin Angiotensin Aldosterone Syst 12 2011 498 503
    • (2011) J Renin Angiotensin Aldosterone Syst , vol.12 , pp. 498-503
    • Polyzos, S.A.1    Kountouras, J.2    Zafeiriadou, E.3    Patsiaoura, K.4    Katsiki, E.5    Deretzi, G.6
  • 324
    • 78650969341 scopus 로고    scopus 로고
    • Effect of atorvastatin, vitamin e and C on nonalcoholic fatty liver disease: Is the combination required?
    • B.M. Arendt, and J.P. Allard Effect of atorvastatin, vitamin E and C on nonalcoholic fatty liver disease: is the combination required? Am J Gastroenterol 106 2011 78 80
    • (2011) Am J Gastroenterol , vol.106 , pp. 78-80
    • Arendt, B.M.1    Allard, J.P.2
  • 325
    • 33747622293 scopus 로고    scopus 로고
    • SNAREs - Engines for membrane fusion
    • DOI 10.1038/nrm2002, PII NRM2002
    • R. Jahn, and R.H. Scheller SNAREs - engines for membrane fusion Nat Rev Mol Cell Biol 7 2006 631 643 (Pubitemid 44268209)
    • (2006) Nature Reviews Molecular Cell Biology , vol.7 , Issue.9 , pp. 631-643
    • Jahn, R.1    Scheller, R.H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.