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Volumn 7, Issue 4, 2011, Pages

Tissue-autonomous function of drosophila seipin in preventing ectopic lipid droplet formation

Author keywords

[No Author keywords available]

Indexed keywords

FAT DROPLET; GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA SUBUNIT; LIPID; PHOSPHATIDIC ACID;

EID: 79955629359     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1001364     Document Type: Article
Times cited : (122)

References (46)
  • 2
    • 0033826433 scopus 로고    scopus 로고
    • Physiological and nutritional regulation of enzymes of triacylglycerol synthesis
    • Coleman RA, Lewin TM, Muoio DM, (2000) Physiological and nutritional regulation of enzymes of triacylglycerol synthesis. Annu Rev Nutr 20: 77-103.
    • (2000) Annu Rev Nutr , vol.20 , pp. 77-103
    • Coleman, R.A.1    Lewin, T.M.2    Muoio, D.M.3
  • 3
    • 33750310241 scopus 로고    scopus 로고
    • Genetic disorders of adipose tissue development, differentiation, and death
    • Agarwal AK, Garg A, (2006) Genetic disorders of adipose tissue development, differentiation, and death. Annu Rev Genomics Hum Genet 7: 175-199.
    • (2006) Annu Rev Genomics Hum Genet , vol.7 , pp. 175-199
    • Agarwal, A.K.1    Garg, A.2
  • 4
    • 0036182137 scopus 로고    scopus 로고
    • Lipotoxic diseases
    • Unger RH, (2002) Lipotoxic diseases. Annu Rev Med 53: 319-336.
    • (2002) Annu Rev Med , vol.53 , pp. 319-336
    • Unger, R.H.1
  • 5
    • 42949116365 scopus 로고    scopus 로고
    • Lipid accumulation in non-adipose tissue and lipotoxicity
    • van Herpen NA, Schrauwen-Hinderling VB, (2008) Lipid accumulation in non-adipose tissue and lipotoxicity. Physiol Behav 94: 231-241.
    • (2008) Physiol Behav , vol.94 , pp. 231-241
    • van Herpen, N.A.1    Schrauwen-Hinderling, V.B.2
  • 6
    • 77953356804 scopus 로고    scopus 로고
    • Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity
    • Unger RH, Scherer PE, (2010) Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity. Trends Endocrinol Metab 21: 345-352.
    • (2010) Trends Endocrinol Metab , vol.21 , pp. 345-352
    • Unger, R.H.1    Scherer, P.E.2
  • 7
    • 58849088969 scopus 로고    scopus 로고
    • Ectopic lipids and organ function
    • Szendroedi J, Roden M, (2009) Ectopic lipids and organ function. Curr Opin Lipidol 20: 50-56.
    • (2009) Curr Opin Lipidol , vol.20 , pp. 50-56
    • Szendroedi, J.1    Roden, M.2
  • 8
    • 42449097289 scopus 로고    scopus 로고
    • Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes
    • Guilherme A, Virbasius JV, Puri V, Czech MP, (2008) Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat Rev Mol Cell Biol 9: 367-377.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 367-377
    • Guilherme, A.1    Virbasius, J.V.2    Puri, V.3    Czech, M.P.4
  • 9
    • 0033965557 scopus 로고    scopus 로고
    • Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice
    • Gavrilova O, Marcus-Samuels B, Graham D, Kim JK, Shulman GI, et al. (2000) Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice. J Clin Invest 105: 271-278.
    • (2000) J Clin Invest , vol.105 , pp. 271-278
    • Gavrilova, O.1    Marcus-Samuels, B.2    Graham, D.3    Kim, J.K.4    Shulman, G.I.5
  • 10
    • 9144262378 scopus 로고    scopus 로고
    • Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy
    • Cheng L, Ding G, Qin Q, Huang Y, Lewis W, et al. (2004) Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy. Nat Med 10: 1245-1250.
    • (2004) Nat Med , vol.10 , pp. 1245-1250
    • Cheng, L.1    Ding, G.2    Qin, Q.3    Huang, Y.4    Lewis, W.5
  • 11
    • 0036578783 scopus 로고    scopus 로고
    • AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34
    • Agarwal AK, Arioglu E, De Almeida S, Akkoc N, Taylor SI, et al. (2002) AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34. Nat Genet 31: 21-23.
    • (2002) Nat Genet , vol.31 , pp. 21-23
    • Agarwal, A.K.1    Arioglu, E.2    de Almeida, S.3    Akkoc, N.4    Taylor, S.I.5
  • 12
    • 0034941121 scopus 로고    scopus 로고
    • Identification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13
    • Magre J, Delepine M, Khallouf E, Gedde-Dahl T Jr, Van Maldergem L, et al. (2001) Identification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13. Nat Genet 28: 365-370.
    • (2001) Nat Genet , vol.28 , pp. 365-370
    • Magre, J.1    Delepine, M.2    Khallouf, E.3    Gedde-Dahl Jr., T.4    van Maldergem, L.5
  • 13
    • 50949112676 scopus 로고    scopus 로고
    • The human lipodystrophy gene BSCL2/seipin may be essential for normal adipocyte differentiation
    • Payne VA, Grimsey N, Tuthill A, Virtue S, Gray SL, et al. (2008) The human lipodystrophy gene BSCL2/seipin may be essential for normal adipocyte differentiation. Diabetes 57: 2055-2060.
    • (2008) Diabetes , vol.57 , pp. 2055-2060
    • Payne, V.A.1    Grimsey, N.2    Tuthill, A.3    Virtue, S.4    Gray, S.L.5
  • 14
    • 70349323186 scopus 로고    scopus 로고
    • The human lipodystrophy gene product Berardinelli-Seip congenital lipodystrophy 2/seipin plays a key role in adipocyte differentiation
    • Chen W, Yechoor VK, Chang BH, Li MV, March KL, et al. (2009) The human lipodystrophy gene product Berardinelli-Seip congenital lipodystrophy 2/seipin plays a key role in adipocyte differentiation. Endocrinology 150: 4552-4561.
    • (2009) Endocrinology , vol.150 , pp. 4552-4561
    • Chen, W.1    Yechoor, V.K.2    Chang, B.H.3    Li, M.V.4    March, K.L.5
  • 15
    • 47149111389 scopus 로고    scopus 로고
    • Cell biology of lipid droplets
    • Thiele C, Spandl J, (2008) Cell biology of lipid droplets. Curr Opin Cell Biol 20: 378-385.
    • (2008) Curr Opin Cell Biol , vol.20 , pp. 378-385
    • Thiele, C.1    Spandl, J.2
  • 16
    • 33646168160 scopus 로고    scopus 로고
    • Lipid droplets: a unified view of a dynamic organelle
    • Martin S, Parton RG, (2006) Lipid droplets: a unified view of a dynamic organelle. Nat Rev Mol Cell Biol 7: 373-378.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 373-378
    • Martin, S.1    Parton, R.G.2
  • 17
    • 0034903123 scopus 로고    scopus 로고
    • The biogenesis and functions of lipid bodies in animals, plants and microorganisms
    • Murphy DJ, (2001) The biogenesis and functions of lipid bodies in animals, plants and microorganisms. Prog Lipid Res 40: 325-438.
    • (2001) Prog Lipid Res , vol.40 , pp. 325-438
    • Murphy, D.J.1
  • 18
    • 38049184643 scopus 로고    scopus 로고
    • The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology
    • Szymanski KM, Binns D, Bartz R, Grishin NV, Li WP, et al. (2007) The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology. Proc Natl Acad Sci U S A 104: 20890-20895.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 20890-20895
    • Szymanski, K.M.1    Binns, D.2    Bartz, R.3    Grishin, N.V.4    Li, W.P.5
  • 19
    • 39049151385 scopus 로고    scopus 로고
    • Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast
    • Fei W, Shui G, Gaeta B, Du X, Kuerschner L, et al. (2008) Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast. J Cell Biol 180: 473-482.
    • (2008) J Cell Biol , vol.180 , pp. 473-482
    • Fei, W.1    Shui, G.2    Gaeta, B.3    Du, X.4    Kuerschner, L.5
  • 20
    • 34548847172 scopus 로고    scopus 로고
    • Diabetic larvae and obese flies-emerging studies of metabolism in Drosophila
    • Baker KD, Thummel CS, (2007) Diabetic larvae and obese flies-emerging studies of metabolism in Drosophila. Cell Metab 6: 257-266.
    • (2007) Cell Metab , vol.6 , pp. 257-266
    • Baker, K.D.1    Thummel, C.S.2
  • 21
    • 26944489689 scopus 로고    scopus 로고
    • Brummer lipase is an evolutionary conserved fat storage regulator in Drosophila
    • Gronke S, Mildner A, Fellert S, Tennagels N, Petry S, et al. (2005) Brummer lipase is an evolutionary conserved fat storage regulator in Drosophila. Cell Metab 1: 323-330.
    • (2005) Cell Metab , vol.1 , pp. 323-330
    • Gronke, S.1    Mildner, A.2    Fellert, S.3    Tennagels, N.4    Petry, S.5
  • 22
    • 56849110119 scopus 로고    scopus 로고
    • COPI complex is a regulator of lipid homeostasis
    • doi:10.1371/journal.pbio.0060292
    • Beller M, Sztalryd C, Southall N, Bell M, Jackle H, et al. (2008) COPI complex is a regulator of lipid homeostasis. PLoS Biol 6: e292 doi:10.1371/journal.pbio.0060292.
    • (2008) PLoS Biol , vol.6 , pp. 292
    • Beller, M.1    Sztalryd, C.2    Southall, N.3    Bell, M.4    Jackle, H.5
  • 23
    • 60649099790 scopus 로고    scopus 로고
    • Drosophila HNF4 regulates lipid mobilization and beta-oxidation
    • Palanker L, Tennessen JM, Lam G, Thummel CS, (2009) Drosophila HNF4 regulates lipid mobilization and beta-oxidation. Cell Metab 9: 228-239.
    • (2009) Cell Metab , vol.9 , pp. 228-239
    • Palanker, L.1    Tennessen, J.M.2    Lam, G.3    Thummel, C.S.4
  • 24
    • 33744544947 scopus 로고    scopus 로고
    • Fatty acid auxotrophy in Drosophila larvae lacking SREBP
    • Kunte AS, Matthews KA, Rawson RB, (2006) Fatty acid auxotrophy in Drosophila larvae lacking SREBP. Cell Metab 3: 439-448.
    • (2006) Cell Metab , vol.3 , pp. 439-448
    • Kunte, A.S.1    Matthews, K.A.2    Rawson, R.B.3
  • 25
    • 76049085521 scopus 로고    scopus 로고
    • Drosophila as a lipotoxicity model organism-more than a promise?
    • Kuhnlein RP, (2010) Drosophila as a lipotoxicity model organism-more than a promise? Biochim Biophys Acta 1801: 215-221.
    • (2010) Biochim Biophys Acta , vol.1801 , pp. 215-221
    • Kuhnlein, R.P.1
  • 27
    • 33846279755 scopus 로고    scopus 로고
    • Specialized hepatocyte-like cells regulate Drosophila lipid metabolism
    • Gutierrez E, Wiggins D, Fielding B, Gould AP, (2007) Specialized hepatocyte-like cells regulate Drosophila lipid metabolism. Nature 445: 275-280.
    • (2007) Nature , vol.445 , pp. 275-280
    • Gutierrez, E.1    Wiggins, D.2    Fielding, B.3    Gould, A.P.4
  • 30
    • 0036237635 scopus 로고    scopus 로고
    • Mutations in the midway gene disrupt a Drosophila acyl coenzyme A: diacylglycerol acyltransferase
    • Buszczak M, Lu X, Segraves WA, Chang TY, Cooley L, (2002) Mutations in the midway gene disrupt a Drosophila acyl coenzyme A: diacylglycerol acyltransferase. Genetics 160: 1511-1518.
    • (2002) Genetics , vol.160 , pp. 1511-1518
    • Buszczak, M.1    Lu, X.2    Segraves, W.A.3    Chang, T.Y.4    Cooley, L.5
  • 31
    • 33846481841 scopus 로고    scopus 로고
    • A role for the adult fat body in Drosophila male courtship behavior
    • doi:10.1371/journal.pgen.0030016
    • Lazareva AA, Roman G, Mattox W, Hardin PE, Dauwalder B, (2007) A role for the adult fat body in Drosophila male courtship behavior. PLoS Genet 3: e16 doi:10.1371/journal.pgen.0030016.
    • (2007) PLoS Genet , vol.3 , pp. 16
    • Lazareva, A.A.1    Roman, G.2    Mattox, W.3    Hardin, P.E.4    Dauwalder, B.5
  • 32
    • 0025054281 scopus 로고
    • Fine-structure mutational analysis of a stage- and tissue-specific promoter element of the Drosophila glue gene Sgs-3
    • Todo T, Roark M, Raghavan KV, Mayeda C, Meyerowitz E, (1990) Fine-structure mutational analysis of a stage- and tissue-specific promoter element of the Drosophila glue gene Sgs-3. Mol Cell Biol 10: 5991-6002.
    • (1990) Mol Cell Biol , vol.10 , pp. 5991-6002
    • Todo, T.1    Roark, M.2    Raghavan, K.V.3    Mayeda, C.4    Meyerowitz, E.5
  • 33
    • 0345171460 scopus 로고    scopus 로고
    • Enzymes of triacylglycerol synthesis and their regulation
    • Coleman RA, Lee DP, (2004) Enzymes of triacylglycerol synthesis and their regulation. Prog Lipid Res 43: 134-176.
    • (2004) Prog Lipid Res , vol.43 , pp. 134-176
    • Coleman, R.A.1    Lee, D.P.2
  • 34
    • 66849089697 scopus 로고    scopus 로고
    • Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis
    • Takeuchi K, Reue K, (2009) Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis. Am J Physiol Endocrinol Metab 296: E1195-1209.
    • (2009) Am J Physiol Endocrinol Metab , vol.296 , pp. 1195-1209
    • Takeuchi, K.1    Reue, K.2
  • 35
    • 44449095056 scopus 로고    scopus 로고
    • Functional genomic screen reveals genes involved in lipid-droplet formation and utilization
    • Guo Y, Walther TC, Rao M, Stuurman N, Goshima G, et al. (2008) Functional genomic screen reveals genes involved in lipid-droplet formation and utilization. Nature 453: 657-661.
    • (2008) Nature , vol.453 , pp. 657-661
    • Guo, Y.1    Walther, T.C.2    Rao, M.3    Stuurman, N.4    Goshima, G.5
  • 36
    • 65249141717 scopus 로고    scopus 로고
    • Rhabdomere biogenesis in Drosophila photoreceptors is acutely sensitive to phosphatidic acid levels
    • Raghu P, Coessens E, Manifava M, Georgiev P, Pettitt T, et al. (2009) Rhabdomere biogenesis in Drosophila photoreceptors is acutely sensitive to phosphatidic acid levels. J Cell Biol 185: 129-145.
    • (2009) J Cell Biol , vol.185 , pp. 129-145
    • Raghu, P.1    Coessens, E.2    Manifava, M.3    Georgiev, P.4    Pettitt, T.5
  • 37
    • 10744229057 scopus 로고    scopus 로고
    • Heterozygous missense mutations in BSCL2 are associated with distal hereditary motor neuropathy and Silver syndrome
    • Windpassinger C, Auer-Grumbach M, Irobi J, Patel H, Petek E, et al. (2004) Heterozygous missense mutations in BSCL2 are associated with distal hereditary motor neuropathy and Silver syndrome. Nat Genet 36: 271-276.
    • (2004) Nat Genet , vol.36 , pp. 271-276
    • Windpassinger, C.1    Auer-Grumbach, M.2    Irobi, J.3    Patel, H.4    Petek, E.5
  • 38
    • 0032763207 scopus 로고    scopus 로고
    • Transgenic mice lacking white fat: models for understanding human lipoatrophic diabetes
    • Reitman ML, Mason MM, Moitra J, Gavrilova O, Marcus-Samuels B, et al. (1999) Transgenic mice lacking white fat: models for understanding human lipoatrophic diabetes. Ann N Y Acad Sci 892: 289-296.
    • (1999) Ann N Y Acad Sci , vol.892 , pp. 289-296
    • Reitman, M.L.1    Mason, M.M.2    Moitra, J.3    Gavrilova, O.4    Marcus-Samuels, B.5
  • 39
    • 0032532152 scopus 로고    scopus 로고
    • Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy
    • Shimomura I, Hammer RE, Richardson JA, Ikemoto S, Bashmakov Y, et al. (1998) Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy. Genes Dev 12: 3182-3194.
    • (1998) Genes Dev , vol.12 , pp. 3182-3194
    • Shimomura, I.1    Hammer, R.E.2    Richardson, J.A.3    Ikemoto, S.4    Bashmakov, Y.5
  • 40
    • 58749091644 scopus 로고    scopus 로고
    • Molecular mechanisms of hepatic steatosis and insulin resistance in the AGPAT2-deficient mouse model of congenital generalized lipodystrophy
    • Cortes VA, Curtis DE, Sukumaran S, Shao X, Parameswara V, et al. (2009) Molecular mechanisms of hepatic steatosis and insulin resistance in the AGPAT2-deficient mouse model of congenital generalized lipodystrophy. Cell Metab 9: 165-176.
    • (2009) Cell Metab , vol.9 , pp. 165-176
    • Cortes, V.A.1    Curtis, D.E.2    Sukumaran, S.3    Shao, X.4    Parameswara, V.5
  • 41
    • 0035163850 scopus 로고    scopus 로고
    • Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin
    • Peterfy M, Phan J, Xu P, Reue K, (2001) Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin. Nat Genet 27: 121-124.
    • (2001) Nat Genet , vol.27 , pp. 121-124
    • Peterfy, M.1    Phan, J.2    Xu, P.3    Reue, K.4
  • 42
    • 67349097875 scopus 로고    scopus 로고
    • Seipin deficiency alters fatty acid Delta9 desaturation and lipid droplet formation in Berardinelli-Seip congenital lipodystrophy
    • Boutet E, El Mourabit H, Prot M, Nemani M, Khallouf E, et al. (2009) Seipin deficiency alters fatty acid Delta9 desaturation and lipid droplet formation in Berardinelli-Seip congenital lipodystrophy. Biochimie 91: 796-803.
    • (2009) Biochimie , vol.91 , pp. 796-803
    • Boutet, E.1    El Mourabit, H.2    Prot, M.3    Nemani, M.4    Khallouf, E.5
  • 43
    • 0037418177 scopus 로고    scopus 로고
    • Ends-out, or replacement, gene targeting in Drosophila
    • Gong WJ, Golic KG, (2003) Ends-out, or replacement, gene targeting in Drosophila. Proc Natl Acad Sci U S A 100: 2556-2561.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 2556-2561
    • Gong, W.J.1    Golic, K.G.2
  • 44
    • 66149111805 scopus 로고    scopus 로고
    • Case studies of ends-out gene targeting in Drosophila
    • Chen H, Ma Z, Liu Z, Tian Y, Xiang Y, et al. (2009) Case studies of ends-out gene targeting in Drosophila. Genesis 47: 305-308.
    • (2009) Genesis , vol.47 , pp. 305-308
    • Chen, H.1    Ma, Z.2    Liu, Z.3    Tian, Y.4    Xiang, Y.5
  • 45
    • 77957814983 scopus 로고    scopus 로고
    • Characterization of substrate preference for Slc1p and Cst26p in Saccharomyces cerevisiae using lipidomic approaches and an LPAAT activity assay
    • doi:10.1371/journal.pone.0011956
    • Shui G, Guan XL, Gopalakrishnan P, Xue Y, Goh JS, et al. (2010) Characterization of substrate preference for Slc1p and Cst26p in Saccharomyces cerevisiae using lipidomic approaches ity assay. PLoS ONE 5: e11956 doi:10.1371/journal.pone.0011956.
    • (2010) PLoS ONE , vol.5 , pp. 11956
    • Shui, G.1    Guan, X.L.2    Gopalakrishnan, P.3    Xue, Y.4    Goh, J.S.5
  • 46
    • 77952512222 scopus 로고    scopus 로고
    • Toward one step analysis of cellular lipidomes using liquid chromatography coupled with mass spectrometry: application to Saccharomyces cerevisiae and Schizosaccharomyces pombe lipidomics
    • Shui G, Guan XL, Low CP, Chua GH, Goh JS, et al. (2010) Toward one step analysis of cellular lipidomes using liquid chromatography coupled with mass spectrometry: application to Saccharomyces cerevisiae and Schizosaccharomyces pombe lipidomics. Mol Biosyst 6: 1008-1017.
    • (2010) Mol Biosyst , vol.6 , pp. 1008-1017
    • Shui, G.1    Guan, X.L.2    Low, C.P.3    Chua, G.H.4    Goh, J.S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.