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1
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A current review of fatty acid transport proteins (SLC27)
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Stahl A. A current review of fatty acid transport proteins (SLC27). Pflugers Arch 2004; 447:722-727.
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Stahl, A.1
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3
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33746625148
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Protein-mediated fatty acid uptake: Novel insights from in vivo models
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Bethesda, This recent review focuses on the role of FATPs in fatty acid uptake
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Doege H, Stahl A. Protein-mediated fatty acid uptake: novel insights from in vivo models. Physiology (Bethesda) 2006; 21:259-268. This recent review focuses on the role of FATPs in fatty acid uptake.
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Physiology
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Doege, H.1
Stahl, A.2
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4
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0029828779
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Molecular cloning of cDNA encoding rat very long-chain acyl-CoA synthetase
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Uchiyama A, Aoyama T, Kamijo K, et al. Molecular cloning of cDNA encoding rat very long-chain acyl-CoA synthetase. J Biol Chem 1996; 271:30360-30365.
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Uchiyama, A.1
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5
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0036910989
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Molecular cloning and expression of rat liver bile acid CoA ligase
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Falany CN, Xie X, Wheeler JB, et al. Molecular cloning and expression of rat liver bile acid CoA ligase. J Lipid Res 2002; 43:2062-2071.
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Falany, C.N.1
Xie, X.2
Wheeler, J.B.3
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6
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0242384922
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Characterization of the Acyl-CoA synthetase activity of purified murine fatty acid transport protein 1
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Hall AM, Smith AJ, Bernlohr DA. Characterization of the Acyl-CoA synthetase activity of purified murine fatty acid transport protein 1. J Biol Chem 2003;278:43008-43013.
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Hall, A.M.1
Smith, A.J.2
Bernlohr, D.A.3
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7
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Enzymatic properties of purified murine fatty acid transport protein 4 and analysis of acyl-CoA synthetase activities in tissues from FATP4 null mice
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Hall AM, Wiczer BM, Herrmann T, et al. Enzymatic properties of purified murine fatty acid transport protein 4 and analysis of acyl-CoA synthetase activities in tissues from FATP4 null mice. J Biol Chem 2005; 280:11948-11954.
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Hall, A.M.1
Wiczer, B.M.2
Herrmann, T.3
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8
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33845709000
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Milger K, Herrmann T, Becker C, et al. Cellular uptake of fatty acids driven by the ER-localized acyl-CoA synthetase FATP4. J Cell Sci 2006; 119:4678-4688. The authors conduct a careful examination of the subcellular localization of FATP4 when overexpressed in cells and define an endoplasmic reticulum-localization domain in FATP4. They cannot detect FATP4 at the plasma membrane in intestinal cells, disagreeing with a previous report.
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Milger K, Herrmann T, Becker C, et al. Cellular uptake of fatty acids driven by the ER-localized acyl-CoA synthetase FATP4. J Cell Sci 2006; 119:4678-4688. The authors conduct a careful examination of the subcellular localization of FATP4 when overexpressed in cells and define an endoplasmic reticulum-localization domain in FATP4. They cannot detect FATP4 at the plasma membrane in intestinal cells, disagreeing with a previous report.
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9
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0037163035
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Fatty acid transport in Saccharomyces cerevisiae. Directed mutagenesis of FAT1 distinguishes the biochemical activities associated with Fat1p
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Zou Z, DiRusso CC, Ctrnacta V, Black PN. Fatty acid transport in Saccharomyces cerevisiae. Directed mutagenesis of FAT1 distinguishes the biochemical activities associated with Fat1p. J Biol Chem 2002; 277:31062-31071.
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Zou, Z.1
DiRusso, C.C.2
Ctrnacta, V.3
Black, P.N.4
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10
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23044498079
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Peroxisome proliferator-activated receptor-gamma and retinoid X receptor signaling regulate fatty acid uptake by primary human placental trophoblasts
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Schaiff WT, Bildirici I, Cheong M, et al. Peroxisome proliferator-activated receptor-gamma and retinoid X receptor signaling regulate fatty acid uptake by primary human placental trophoblasts. J Clin Endocrinol Metab 2005; 90:4267-4275.
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Schaiff, W.T.1
Bildirici, I.2
Cheong, M.3
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11
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20444484799
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Comparative biochemical studies of the murine fatty acid transport proteins (FATP) expressed in yeast
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DiRusso CC, Li H, Darwis D, et al. Comparative biochemical studies of the murine fatty acid transport proteins (FATP) expressed in yeast. J Biol Chem 2005; 280:16829-16837.
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DiRusso, C.C.1
Li, H.2
Darwis, D.3
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33947122181
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Lobo S, Wiczer BM, Smith AJ, et al. Fatty acid metabolism in adipocytes: Functional analysis of fatty acid transport proteins 1 and 4. J Lipid Res 2006; 48:609-620. The authors use shRNA-mediated knockdown in 3T3-L1 adipocytes to examine the role of FATP1 and FATP4 in fatty acid uptake, lipolysis and lipid metabolism. They examine the subcellular localization of FATP1 and FATP4 in response to insulin.
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Lobo S, Wiczer BM, Smith AJ, et al. Fatty acid metabolism in adipocytes: Functional analysis of fatty acid transport proteins 1 and 4. J Lipid Res 2006; 48:609-620. The authors use shRNA-mediated knockdown in 3T3-L1 adipocytes to examine the role of FATP1 and FATP4 in fatty acid uptake, lipolysis and lipid metabolism. They examine the subcellular localization of FATP1 and FATP4 in response to insulin.
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13
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11144236852
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Mouse very long-chain Acyl-CoA synthetase 3/fatty acid transport protein 3 catalyzes fatty acid activation but not fatty acid transport in MA-10 cells
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Pei Z, Fraisl P, Berger J, et al. Mouse very long-chain Acyl-CoA synthetase 3/fatty acid transport protein 3 catalyzes fatty acid activation but not fatty acid transport in MA-10 cells. J Biol Chem 2004; 279:54454-54462.
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Pei, Z.1
Fraisl, P.2
Berger, J.3
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33644746164
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Richards MR, Harp JD, Ory DS, Schaffer JE. Fatty acid transport protein 1 and long-chain acyl coenzyme A synthetase 1 interact in adipocytes. J Lipid Res 2006; 47:665-672. This demonstrates coimmunoprecipitation of FATP1 and ACSL1 from 3T3-L1 adipocytes and examines the effects of insulin and isoproterenol on this interaction.
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Richards MR, Harp JD, Ory DS, Schaffer JE. Fatty acid transport protein 1 and long-chain acyl coenzyme A synthetase 1 interact in adipocytes. J Lipid Res 2006; 47:665-672. This demonstrates coimmunoprecipitation of FATP1 and ACSL1 from 3T3-L1 adipocytes and examines the effects of insulin and isoproterenol on this interaction.
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15
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33750495997
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Heather LC, Cole MA, Lygate CA, et al. Fatty acid transporter levels and palmitate oxidation rate correlate with ejection fraction in the infarcted rat heart. Cardiovasc Res 2006; 72:430-437. The authors examine the expression of FATP1, FATP6 and other fatty acid transporters in the infarcted rat heart
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Heather LC, Cole MA, Lygate CA, et al. Fatty acid transporter levels and palmitate oxidation rate correlate with ejection fraction in the infarcted rat heart. Cardiovasc Res 2006; 72:430-437. The authors examine the expression of FATP1, FATP6 and other fatty acid transporters in the infarcted rat heart
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33750604963
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Docosahexaenoic acid supply in pregnancy affects placental expression of fatty acid transport proteins
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Larque E, Krauss-Etschmann S, Campoy C, et al. Docosahexaenoic acid supply in pregnancy affects placental expression of fatty acid transport proteins. Am J Clin Nutr 2006; 84:853-861.
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Am J Clin Nutr
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Larque, E.1
Krauss-Etschmann, S.2
Campoy, C.3
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17
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3342919078
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Fiber type- and fatty acid composition-dependent effects of high-fat diets on rat muscle triacylglyceride and fatty acid transporter protein-1 content
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Marotta M, Ferrer-Martnez A, Parnau J, et al. Fiber type- and fatty acid composition-dependent effects of high-fat diets on rat muscle triacylglyceride and fatty acid transporter protein-1 content. Metabolism 2004; 53:1032-1036.
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Metabolism
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Marotta, M.1
Ferrer-Martnez, A.2
Parnau, J.3
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18
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33745727431
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Distinct effects of short- and longterm leptin treatment on glucose and fatty acid uptake and metabolism in HL-1 cardiomyocytes
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Palanivel R, Eguchi M, Shuralyova I, et al. Distinct effects of short- and longterm leptin treatment on glucose and fatty acid uptake and metabolism in HL-1 cardiomyocytes. Metabolism 2006; 55:1067-1075.
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Metabolism
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Palanivel, R.1
Eguchi, M.2
Shuralyova, I.3
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19
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Regulation of fatty acid uptake and metabolism in L6 skeletal muscle cells by resistin
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Palanivel R, Sweeney G. Regulation of fatty acid uptake and metabolism in L6 skeletal muscle cells by resistin. FEBS Lett 2005; 579:5049-5054.
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Palanivel, R.1
Sweeney, G.2
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33644876109
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Differences in transport of fatty acids and expression of fatty acid transporting proteins in adipose tissue of obese black and white women
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Bower JF, Davis JM, Hao E, Barakat HA. Differences in transport of fatty acids and expression of fatty acid transporting proteins in adipose tissue of obese black and white women. Am J Physiol Endocrinol Metab 2006; 290:E87-E91.
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Am J Physiol Endocrinol Metab
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Bower, J.F.1
Davis, J.M.2
Hao, E.3
Barakat, H.A.4
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21
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0036228690
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Insulin causes fatty acid transport protein translocation and enhanced fatty acid uptake in adipocytes
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Stahl A, Evans JG, Pattel S, et al. Insulin causes fatty acid transport protein translocation and enhanced fatty acid uptake in adipocytes. Dev Cell 2002; 2:477-488.
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Stahl, A.1
Evans, J.G.2
Pattel, S.3
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Wu Q, Ortegon AM, Tsang B, et al. FATP1 is an insulin-sensitive fatty acid transporter involved in diet-induced obesity. Mol Cell Biol 2006; 26:3455-3467. The authors use FATP1 knockout mice to show an important role for FATP1 in regulated fatty acid uptake in white adipose tissue and muscle. They demonstrate insulin-mediated relocalization of FATP1 to the plasma membrane in muscle and show that FATP1 deletion mice are protected from diet-induced obesity and insulin resistance.
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Wu Q, Ortegon AM, Tsang B, et al. FATP1 is an insulin-sensitive fatty acid transporter involved in diet-induced obesity. Mol Cell Biol 2006; 26:3455-3467. The authors use FATP1 knockout mice to show an important role for FATP1 in regulated fatty acid uptake in white adipose tissue and muscle. They demonstrate insulin-mediated relocalization of FATP1 to the plasma membrane in muscle and show that FATP1 deletion mice are protected from diet-induced obesity and insulin resistance.
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Impact on fatty acid metabolism and differential localization of FATP1 and FAT/CD36 proteins delivered in cultured human muscle cells
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Garcia-Martinez C, Marotta M, Moore-Carrasco R, et al. Impact on fatty acid metabolism and differential localization of FATP1 and FAT/CD36 proteins delivered in cultured human muscle cells. Am J Physiol Cell Physiol 2005; 288:C1264-C1272.
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Am J Physiol Cell Physiol
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Garcia-Martinez, C.1
Marotta, M.2
Moore-Carrasco, R.3
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The subcellular compartmentation of fatty acid transporters is regulated differently by insulin and by AICAR
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Chabowski A, Coort SL, Calles-Escandon J, et al. The subcellular compartmentation of fatty acid transporters is regulated differently by insulin and by AICAR. FEBS Lett 2005; 579:2428-2432.
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Chabowski, A.1
Coort, S.L.2
Calles-Escandon, J.3
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25
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11144355563
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Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle
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Kim JK, Gimeno RE, Higashimori T, et al. Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle. J Clin Invest 2004; 113:756-763.
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Kim, J.K.1
Gimeno, R.E.2
Higashimori, T.3
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Wu Q, Kazantzis M, Doege H, et al. Fatty acid transport protein 1 is required for nonshivering thermogenesis in brown adipose tissue. Diabetes 2006; 55:3229-3237. This is the first examination of the role of FATPs in brown adipose tissue function. It uses FATP1 knockout mice to demonstrate that FATP1 has an important role in nonshivering thermogenesis
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Wu Q, Kazantzis M, Doege H, et al. Fatty acid transport protein 1 is required for nonshivering thermogenesis in brown adipose tissue. Diabetes 2006; 55:3229-3237. This is the first examination of the role of FATPs in brown adipose tissue function. It uses FATP1 knockout mice to demonstrate that FATP1 has an important role in nonshivering thermogenesis
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Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy
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Chiu HC, Kovacs A, Blanton RM, et al. Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy. Circ Res 2005; 96:225-233.
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Chiu, H.C.1
Kovacs, A.2
Blanton, R.M.3
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0037025401
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Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling
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Mihalik SJ, Steinberg SJ, Pei Z, et al. Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling. J Biol Chem 2002; 277:24771-24779.
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Mihalik, S.J.1
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Pei, Z.3
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A very long-chain acyl-CoA synthetasedeficient mouse and its relevance to X-linked adrenoleukodystrophy
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Heinzer AK, Watkins PA, Lu JF, et al. A very long-chain acyl-CoA synthetasedeficient mouse and its relevance to X-linked adrenoleukodystrophy. Hum Mol Genet 2003; 12:1145-1154.
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Heinzer, A.K.1
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Lu, J.F.3
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Triglyceride accumulation in injured renal tubular cells: Alterations in both synthetic and catabolic pathways
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Johnson AC, Stahl A, Zager RA. Triglyceride accumulation in injured renal tubular cells: alterations in both synthetic and catabolic pathways. Kidney Int 2005; 67:2196-2209.
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Johnson, A.C.1
Stahl, A.2
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Identification of the major intestinal fatty acid transport protein
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Stahl A, Hirsch DJ, Gimeno RE, et al. Identification of the major intestinal fatty acid transport protein. Mol Cell 1999; 4:299-308.
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Disturbed epidermal structure in mice with temporally controlled fatp4 deficiency
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Herrmann T, Grone HJ, Langbein L, et al. Disturbed epidermal structure in mice with temporally controlled fatp4 deficiency. J Invest Dermatol 2005; 125:1228-1235.
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Herrmann, T.1
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Langbein, L.3
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Differential expression of fatty acid transport proteins in epidermis and skin appendages
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Schmuth M, Ortegon AM, Mao-Qiang M, et al. Differential expression of fatty acid transport proteins in epidermis and skin appendages. J Invest Dermatol 2005; 125:1174-1181.
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Mao-Qiang, M.3
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Fatty acid handling protein expression in adipose tissue, fatty acid composition of adipose tissue and serum, and markers of insulin resistance
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Gertow K, Rosell M, Sjogren P, et al. Fatty acid handling protein expression in adipose tissue, fatty acid composition of adipose tissue and serum, and markers of insulin resistance. Eur J Clin Nutr 2006; 60: 1406-1413.
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Sjogren, P.3
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Targeted deletion of fatty acid transport protein-4 results in early embryonic lethality
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Gimeno RE, Hirsch DJ, Punreddy S, et al. Targeted deletion of fatty acid transport protein-4 results in early embryonic lethality. J Biol Chem 2003; 278:49512-49516.
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, vol.278
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Gimeno, R.E.1
Hirsch, D.J.2
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Blackburn C, Guan B, Brown J, et al. Identification and characterization of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones as inhibitors of the fatty acid transporter FATP4. Bioorg Med Chem Lett 2006; 16:3504-3509. This is the first report of small molecule inhibitors targeting a member of the FATP family.
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Blackburn C, Guan B, Brown J, et al. Identification and characterization of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones as inhibitors of the fatty acid transporter FATP4. Bioorg Med Chem Lett 2006; 16:3504-3509. This is the first report of small molecule inhibitors targeting a member of the FATP family.
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Doege H, Baillie RA, Ortegon AM, et al. Targeted deletion of FATP5 reveals multiple functions in liver metabolism: alterations in hepatic lipid homeostasis. Gastroenterology 2006; 130:1245-1258. This is the first report demonstrating an important function for FATP5 in hepatic fatty acid uptake in vivo. It describes a careful subcellular localization study of endogenous FATP5 in hepatocytes.
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Doege H, Baillie RA, Ortegon AM, et al. Targeted deletion of FATP5 reveals multiple functions in liver metabolism: alterations in hepatic lipid homeostasis. Gastroenterology 2006; 130:1245-1258. This is the first report demonstrating an important function for FATP5 in hepatic fatty acid uptake in vivo. It describes a careful subcellular localization study of endogenous FATP5 in hepatocytes.
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Hubbard B, Doege H, Punreddy S, et al. Mice deleted for fatty acid transport protein 5 have defective bile acid conjugation and are protected from obesity. Gastroenterology 2006; 130:1259-1269. This is the first report demonstrating an important function for FATP5 in bile acid conjugation in vivo. It demonstrates that FATP5 deletion mice have no overt defect in fat absorption, but are protected from diet-induced obesity and insulin resistance.
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Hubbard B, Doege H, Punreddy S, et al. Mice deleted for fatty acid transport protein 5 have defective bile acid conjugation and are protected from obesity. Gastroenterology 2006; 130:1259-1269. This is the first report demonstrating an important function for FATP5 in bile acid conjugation in vivo. It demonstrates that FATP5 deletion mice have no overt defect in fat absorption, but are protected from diet-induced obesity and insulin resistance.
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Characterization of a heart-specific fatty acid transport protein
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Gimeno RE, Ortegon AM, Patel S, et al. Characterization of a heart-specific fatty acid transport protein. J Biol Chem 2003; 278:16039-16044.
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Gimeno, R.E.1
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