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Volumn 26, Issue 3, 2011, Pages 441-450

Molecular mechanisms of steatosis in nonalcoholic fatty liver disease;Mecanismos moleculares de la esteatosis en la patología de hígado graso no alcohólico

Author keywords

Fatty liver; N 3 polyunsatured fatty acids; Obesity; PPAR alfa; SREBP 1c

Indexed keywords

FATTY ACID; TRANSCRIPTION FACTOR;

EID: 79957943690     PISSN: 02121611     EISSN: 16995198     Source Type: Journal    
DOI: 10.3305/nh.2011.26.3.5119     Document Type: Article
Times cited : (62)

References (94)
  • 1
    • 33751193496 scopus 로고    scopus 로고
    • Insulin resistance and oxidative stress interdependency in non-alcoholic fatty liver disease
    • Videla LA, Rodrigo R, Araya J, Poniachik J. Insulin resistance and oxidative stress interdependency in non-alcoholic fatty liver disease. Trends Mol Med 2006; 12: 555-558.
    • (2006) Trends Mol Med , vol.12 , pp. 555-558
    • Videla, L.A.1    Rodrigo, R.2    Araya, J.3    Poniachik, J.4
  • 2
    • 24044536090 scopus 로고    scopus 로고
    • Recent concepts in non-alcoholic fatty liver disease
    • Adams LA, Angulo P. Recent concepts in non-alcoholic fatty liver disease. Diab Med 2005; 22: 1129-1133.
    • (2005) Diab Med , vol.22 , pp. 1129-1133
    • Adams, L.A.1    Angulo, P.2
  • 3
    • 74249123630 scopus 로고    scopus 로고
    • Oxidative stress and insulin resistance as interdependent pathogenic mechanisms in non-alcoholic fatty liver disease associated with obesity
    • In: S. Alvarez, P. Evelson (Eds.), Transworld Research Network, Kerala, India
    • Videla LA. 2008. Oxidative stress and insulin resistance as interdependent pathogenic mechanisms in non-alcoholic fatty liver disease associated with obesity. In: S. Alvarez, P. Evelson (Eds.), Free Radical Pathophysiology. pp. 369-385. Transworld Research Network, Kerala, India.
    • (2008) Free Radical Pathophysiology , pp. 369-385
    • Videla, L.A.1
  • 4
    • 0037129380 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Angulo P. Nonalcoholic fatty liver disease. N Eng J Med 2002; 346: 1221-1231.
    • (2002) N Eng J Med , vol.346 , pp. 1221-1231
    • Angulo, P.1
  • 5
    • 33645828659 scopus 로고    scopus 로고
    • Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidation
    • Reddy JK, Rao MS. Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidation. Am J Physiol Gastrointest Liver Physiol 2006; 290: 852-858.
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290 , pp. 852-858
    • Reddy, J.K.1    Rao, M.S.2
  • 6
    • 33645536593 scopus 로고    scopus 로고
    • Treatment of non-alcoholic fatty liver disease
    • Adams LA, Angulo P. Treatment of non-alcoholic fatty liver disease. Postgrad Med J 2006; 82: 315-322.
    • (2006) Postgrad Med J , vol.82 , pp. 315-322
    • Adams, L.A.1    Angulo, P.2
  • 8
    • 33644547706 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: From steatosis to cirrhosis
    • Farrell GC, Larter CZ. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology 2006; 43: 99-112.
    • (2006) Hepatology , vol.43 , pp. 99-112
    • Farrell, G.C.1    Larter, C.Z.2
  • 10
    • 54049150442 scopus 로고    scopus 로고
    • Molecular mechanisms and therapeutic targets in steatosis and steatohepatitis
    • Anderson N, Borlak J. Molecular mechanisms and therapeutic targets in steatosis and steatohepatitis. Pharmacol Rev 2008; 60: 311-357.
    • (2008) Pharmacol Rev , vol.60 , pp. 311-357
    • Anderson, N.1    Borlak, J.2
  • 13
    • 34547882082 scopus 로고    scopus 로고
    • Comparative review of diets for the metabolic syndrome: Implications for nonalcoholic fatty liver disease
    • Zivkovic AM, German JB, Sanyal AJ. Comparative review of diets for the metabolic syndrome: implications for nonalcoholic fatty liver disease. Am J Clin Nutr 2007; 86: 285-300.
    • (2007) Am J Clin Nutr , vol.86 , pp. 285-300
    • Zivkovic, A.M.1    German, J.B.2    Sanyal, A.J.3
  • 14
    • 34047192773 scopus 로고    scopus 로고
    • Current concepts in the pathogenesis of nonalcoholic fatty liver Disease
    • Méndez-Sánchez N, Arrese M, Zamora-Valdés D, Uribe M. Current concepts in the pathogenesis of nonalcoholic fatty liver Disease. Liver Int 2007; 27: 423-433.
    • (2007) Liver Int , vol.27 , pp. 423-433
    • Méndez-Sánchez, N.1    Arrese, M.2    Zamora-Valdés, D.3    Uribe, M.4
  • 15
    • 57649214103 scopus 로고    scopus 로고
    • Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD)
    • Musso G, Gambino R, Cassader M. Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD). Prog Lipid Res 2009; 48: 1-26.
    • (2009) Prog Lipid Res , vol.48 , pp. 1-26
    • Musso, G.1    Gambino, R.2    Cassader, M.3
  • 16
    • 15944425804 scopus 로고    scopus 로고
    • Mechanism underlying oxidative stress-mediated lipotoxicity: Exposure of J774.2 macrophages to triacylglycerols facilitates mitochondrial reactive oxygen species production and cellular necrosis
    • Aronis A, Madar Z, Tirosh O. Mechanism underlying oxidative stress-mediated lipotoxicity: exposure of J774.2 macrophages to triacylglycerols facilitates mitochondrial reactive oxygen species production and cellular necrosis. Free Radic Biol Med 2005; 38: 1221-1230.
    • (2005) Free Radic Biol Med , vol.38 , pp. 1221-1230
    • Aronis, A.1    Madar, Z.2    Tirosh, O.3
  • 19
    • 33747751924 scopus 로고    scopus 로고
    • Chotitriosidase gene expression in Kupffer cells from patients with non-alcoholic fatty liver disease
    • Malaguarnera L, Di Rosa M, Zambito AM, dell, Ombra N, Nicoletti F, Malaguarnera M. Chotitriosidase gene expression in Kupffer cells from patients with non-alcoholic fatty liver disease. Gut 2006; 55: 1313-1320.
    • (2006) Gut , vol.55 , pp. 1313-1320
    • Malaguarnera, L.1    di Rosa, M.2    Zambito, A.M.3    dell Ombra, N.4    Nicoletti, F.5    Malaguarnera, M.6
  • 20
    • 51449107605 scopus 로고    scopus 로고
    • Effects of weight loss on liver and erythrocyte polyunsaturated fatty acid pattern and oxidative stress status in obese patients with non-alcoholic fatty liver disease
    • Elizondo A, Araya J, Rodrigo R, Signorini C, Sgherri C, Comporti M, et al. Effects of weight loss on liver and erythrocyte polyunsaturated fatty acid pattern and oxidative stress status in obese patients with non-alcoholic fatty liver disease. Biol Res 2008; 41: 59-68.
    • (2008) Biol Res , vol.41 , pp. 59-68
    • Elizondo, A.1    Araya, J.2    Rodrigo, R.3    Signorini, C.4    Sgherri, C.5    Comporti, M.6
  • 21
    • 18344385579 scopus 로고    scopus 로고
    • Nutritional, dietary and postprandial oxidative stress
    • Sies H, Stahl W, Sevanian A. Nutritional, dietary and postprandial oxidative stress. J Nutr 2005; 135: 969-972.
    • (2005) J Nutr , vol.135 , pp. 969-972
    • Sies, H.1    Stahl, W.2    Sevanian, A.3
  • 22
    • 33645860825 scopus 로고    scopus 로고
    • Reactive oxygen species have a causal role in multiple forms of insulin resistance
    • Houstis N, Rosen ED, Lander ES. Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 2006; 440: 944-948.
    • (2006) Nature , vol.440 , pp. 944-948
    • Houstis, N.1    Rosen, E.D.2    Lander, E.S.3
  • 23
    • 77953587983 scopus 로고    scopus 로고
    • Oxidative stress signaling underlying liver disease and hepatoprotective mechanisms
    • Videla LA. Oxidative stress signaling underlying liver disease and hepatoprotective mechanisms. World J Hepatol 2009; 1: 73-79.
    • (2009) World J Hepatol , vol.1 , pp. 73-79
    • Videla, L.A.1
  • 24
    • 39649096642 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: Pathogenesis and potential for nuclear receptors as therapeutic targets
    • George J, Liddle C. Nonalcoholic fatty liver disease: pathogenesis and potential for nuclear receptors as therapeutic targets. Mol Pharm 2008; 5: 49-59.
    • (2008) Mol Pharm , vol.5 , pp. 49-59
    • George, J.1    Liddle, C.2
  • 26
    • 38649111018 scopus 로고    scopus 로고
    • Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease
    • Fabbrini E, Mohammed BS, Magkos F, Korenblat KM, Patterson BW, Klein S. Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease. Gastroenterology 2008; 134: 424-431.
    • (2008) Gastroenterology , vol.134 , pp. 424-431
    • Fabbrini, E.1    Mohammed, B.S.2    Magkos, F.3    Korenblat, K.M.4    Patterson, B.W.5    Klein, S.6
  • 27
    • 49649094683 scopus 로고    scopus 로고
    • Beyond insulin resistance: Innate immunity in nonalcoholic steatohepatitis
    • Maher JJ, Leon P, Ryan JC. Beyond insulin resistance: Innate immunity in nonalcoholic steatohepatitis. Hepatology 2008; 48: 670-678.
    • (2008) Hepatology , vol.48 , pp. 670-678
    • Maher, J.J.1    Leon, P.2    Ryan, J.C.3
  • 30
    • 0036251153 scopus 로고    scopus 로고
    • SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver
    • Horton JD, Goldstein JL, Brown MS. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 2002; 109: 1125-1131.
    • (2002) J Clin Invest , vol.109 , pp. 1125-1131
    • Horton, J.D.1    Goldstein, J.L.2    Brown, M.S.3
  • 31
    • 39849099238 scopus 로고    scopus 로고
    • Role of peroxisome proliferators-activated receptors in the pathogenesis and treatment of nonalcoholic fatty liver disease
    • Kallwitz ER, McLachlan A, Cotler SJ. Role of peroxisome proliferators-activated receptors in the pathogenesis and treatment of nonalcoholic fatty liver disease. World J Gastroenterol 2008; 14: 22-28.
    • (2008) World J Gastroenterol , vol.14 , pp. 22-28
    • Kallwitz, E.R.1    McLachlan, A.2    Cotler, S.J.3
  • 32
    • 4043077961 scopus 로고    scopus 로고
    • Molecular mediators of hepatic steatosis and liver injury
    • Browning JD, Horton JD. Molecular mediators of hepatic steatosis and liver injury. J Clin Invest 2004; 114:147-152.
    • (2004) J Clin Invest , vol.114 , pp. 147-152
    • Browning, J.D.1    Horton, J.D.2
  • 33
    • 0034791616 scopus 로고    scopus 로고
    • Nonalcoholic steatosis and steatohepatitis. I. Molecular mechanism for polyunsaturated fatty acid regulation of gene transcription
    • Clarke S.D. Nonalcoholic steatosis and steatohepatitis. I. Molecular mechanism for polyunsaturated fatty acid regulation of gene transcription. Am J Physiol Gastrointest Liver Physiol 2001; 281: 865-869.
    • (2001) Am J Physiol Gastrointest Liver Physiol , vol.281 , pp. 865-869
    • Clarke, S.D.1
  • 34
    • 73949159619 scopus 로고    scopus 로고
    • N-3 polyunsaturated fatty acids suppress insulin-induced SREBP-1c transcription via reduced trans-activating capacity of LXR alpha
    • Howell G. 3rd, Deng X, Yellaturu C, Park EA, Wilcox HG, Raghow R, Elam MB. N-3 polyunsaturated fatty acids suppress insulin-induced SREBP-1c transcription via reduced trans-activating capacity of LXR alpha. Biochim Biophys Acta 2009; 1791: 1190-1196.
    • (2009) Biochim Biophys Acta , vol.1791 , pp. 1190-1196
    • Howell III, G.1    Deng, X.2    Yellaturu, C.3    Park, E.A.4    Wilcox, H.G.5    Raghow, R.6    Elam, M.B.7
  • 35
    • 0037010478 scopus 로고    scopus 로고
    • Role of peroxisome proliferator-activated receptor gamma and retinoid X receptor heterodimer in hepatogastroenterological diseases
    • Dubuquoy L, Dharancy S, Nutten S, Pettersson S. Auwerx, J., Desreumaux, P. Role of peroxisome proliferator-activated receptor gamma and retinoid X receptor heterodimer in hepatogastroenterological diseases. Lancet 2002; 360: 1410-1418.
    • (2002) Lancet , vol.360 , pp. 1410-1418
    • Dubuquoy, L.1    Dharancy, S.2    Nutten, S.3    Pettersson, S.4    Auwerx, J.5    Desreumaux, P.6
  • 36
    • 0036709899 scopus 로고    scopus 로고
    • Is there a single mechanism for fatty acid regulation of gene transcription?
    • Duplus E, Forest C. Is there a single mechanism for fatty acid regulation of gene transcription?. Biochem Pharmacol 2002; 64: 893-901.
    • (2002) Biochem Pharmacol , vol.64 , pp. 893-901
    • Duplus, E.1    Forest, C.2
  • 37
    • 2942706241 scopus 로고    scopus 로고
    • Increase in long-chain polyunsaturated fatty acid n-6/n-3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease
    • Araya J, Rodrigo R, Videla LA, Thielemann L, Orellana M, Pettinelli P, Poniachik J. Increase in long-chain polyunsaturated fatty acid n-6/n-3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease. Clin Sci (Lond.) 2004; 106: 635-643.
    • (2004) Clin Sci (Lond.) , vol.106 , pp. 635-643
    • Araya, J.1    Rodrigo, R.2    Videla, L.A.3    Thielemann, L.4    Orellana, M.5    Pettinelli, P.6    Poniachik, J.7
  • 41
    • 4444360248 scopus 로고    scopus 로고
    • N-3 long chain polyunsaturated fatty acids: A nutritional tool to prevent insulin resistance associated to type 2 diabetes and obesity?
    • Delarue J, LeFoll C, Corporeau C, Lucas D. N-3 long chain polyunsaturated fatty acids: a nutritional tool to prevent insulin resistance associated to type 2 diabetes and obesity? Reprod Nutr Dev 2004; 44: 289-299.
    • (2004) Reprod Nutr Dev , vol.44 , pp. 289-299
    • Delarue, J.1    LeFoll, C.2    Corporeau, C.3    Lucas, D.4
  • 42
    • 77954143472 scopus 로고    scopus 로고
    • Decreased Liver Fatty Acid Delta-6 and Delta-5 Desaturase Activity in Obese Patients
    • Araya J, Rodrigo R, Pettinelli P, Araya AV, Poniachik J, Videla LA. Decreased Liver Fatty Acid Delta-6 and Delta-5 Desaturase Activity in Obese Patients. Obesity 2010; 18: 1460-1463.
    • (2010) Obesity , vol.18 , pp. 1460-1463
    • Araya, J.1    Rodrigo, R.2    Pettinelli, P.3    Araya, A.V.4    Poniachik, J.5    Videla, L.A.6
  • 46
    • 37349081571 scopus 로고    scopus 로고
    • Role of ChREBP in hepatic steatosis and insulin resistance
    • Denechaud PD, Dentin R, Girard J, Postic C. Role of ChREBP in hepatic steatosis and insulin resistance. FEBS Lett 2008; 582: 68-73.
    • (2008) FEBS Lett , vol.582 , pp. 68-73
    • Denechaud, P.D.1    Dentin, R.2    Girard, J.3    Postic, C.4
  • 47
    • 51449106076 scopus 로고    scopus 로고
    • ChREBP: A glucose-activated transcription factor involved in the development of metabolic syndrome
    • Iizuka K, Horikawa Y. ChREBP: a glucose-activated transcription factor involved in the development of metabolic syndrome. Endocr J 2008; 55: 617-624.
    • (2008) Endocr J , vol.55 , pp. 617-624
    • Iizuka, K.1    Horikawa, Y.2
  • 49
    • 70350459324 scopus 로고    scopus 로고
    • From sugar to fat: How the transcription factor XBP1 regulates hepatic lipogenesis
    • Glimcher LH, Lee AH. From sugar to fat: How the transcription factor XBP1 regulates hepatic lipogenesis. Ann NY Acad Sci 2009; 1173 (Suppl. 1): 2-9.
    • (2009) Ann NY Acad Sci , vol.1173 , Issue.SUPPL. 1 , pp. 2-9
    • Glimcher, L.H.1    Lee, A.H.2
  • 50
    • 34548392209 scopus 로고    scopus 로고
    • Modulation of sterol regulatory element binding proteins (SREBPs) as potential treatments for non-alcoholic fatty liver disease (NAFLD)
    • Ahmed MH, Byrne CD. Modulation of sterol regulatory element binding proteins (SREBPs) as potential treatments for non-alcoholic fatty liver disease (NAFLD). Drug Discov Today 2007; 12: 740-747.
    • (2007) Drug Discov Today , vol.12 , pp. 740-747
    • Ahmed, M.H.1    Byrne, C.D.2
  • 51
  • 52
    • 0033570119 scopus 로고    scopus 로고
    • Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus
    • Shimomura I, Bashmakov Y, Horton JD. Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus. J Biol Chem 1999; 274: 30028-30032.
    • (1999) J Biol Chem , vol.274 , pp. 30028-30032
    • Shimomura, I.1    Bashmakov, Y.2    Horton, J.D.3
  • 53
    • 0034693259 scopus 로고    scopus 로고
    • Sterol regulatory element-binding proteins (SREBPs): Key regulators of nutritional homeostasis and insulin action
    • Osborne TF. Sterol regulatory element-binding proteins (SREBPs): key regulators of nutritional homeostasis and insulin action. J Biol Chem 2000; 275: 32379-32382.
    • (2000) J Biol Chem , vol.275 , pp. 32379-32382
    • Osborne, T.F.1
  • 54
    • 70450283986 scopus 로고    scopus 로고
    • Insulin enhances the biogenesis of nuclear sterol regulatory elementbinding protein (SREBP)-1c by posttranscriptional down-regulation of Insig-2A and its dissociation from SREBP cleavageactivating protein (SCAP). SREBP-1c complex
    • Yellaturu CR, Deng X, Park EA, Raghow R, Elam MB. Insulin enhances the biogenesis of nuclear sterol regulatory elementbinding protein (SREBP)-1c by posttranscriptional down-regulation of Insig-2A and its dissociation from SREBP cleavageactivating protein (SCAP). SREBP-1c complex. J Biol Chem 2009; 284: 31726-31734.
    • (2009) J Biol Chem , vol.284 , pp. 31726-31734
    • Yellaturu, C.R.1    Deng, X.2    Park, E.A.3    Raghow, R.4    Elam, M.B.5
  • 58
    • 33645027391 scopus 로고    scopus 로고
    • Altered hepatic expression of SREBP-1 and PPARgamma is associated with liver injury in insulin-resistant lipodystrophic HIV-infected patients
    • Lemoine M, Barbu V, Girard PM, Kim M, Bastard JP, Wendum D, Paye F, Housset C, Capeau J, Serfaty L. Altered hepatic expression of SREBP-1 and PPARgamma is associated with liver injury in insulin-resistant lipodystrophic HIV-infected patients. AIDS 2006; 20: 387-395.
    • (2006) AIDS , vol.20 , pp. 387-395
    • Lemoine, M.1    Barbu, V.2    Girard, P.M.3    Kim, M.4    Bastard, J.P.5    Wendum, D.6    Paye, F.7    Housset, C.8    Capeau, J.9    Serfaty, L.10
  • 61
    • 0037216466 scopus 로고    scopus 로고
    • Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects consuming high-fat, low-carbohydrate and low-fat, high-carbohydrate isoenergetic diets
    • Schwarz JM, Linfoot P, Dare D, Aghajanian K. Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects consuming high-fat, low-carbohydrate and low-fat, high-carbohydrate isoenergetic diets. Am J Clin Nutr 2003; 77: 43-50.
    • (2003) Am J Clin Nutr , vol.77 , pp. 43-50
    • Schwarz, J.M.1    Linfoot, P.2    Dare, D.3    Aghajanian, K.4
  • 62
    • 13744263104 scopus 로고    scopus 로고
    • Temporal pattern of de novo lipogenesis in the postprandial state in health men
    • Timlin MT, Parks EJ. Temporal pattern of de novo lipogenesis in the postprandial state in health men. Am J Clin Nutr 2005; 81: 35-42.
    • (2005) Am J Clin Nutr , vol.81 , pp. 35-42
    • Timlin, M.T.1    Parks, E.J.2
  • 63
    • 1942518840 scopus 로고    scopus 로고
    • PPARs and the complex journey to obesity
    • Evans RM, Barish GD, Wang YX. PPARs and the complex journey to obesity. Nat Med 2004; 10: 355-361.
    • (2004) Nat Med , vol.10 , pp. 355-361
    • Evans, R.M.1    Barish, G.D.2    Wang, Y.X.3
  • 65
    • 47949094965 scopus 로고    scopus 로고
    • Integration of metabolism and inflammation by lipid activated nuclear receptors
    • Bensinger SJ, Tontonoz P. Integration of metabolism and inflammation by lipid activated nuclear receptors. Nature 2008; 454: 470-477.
    • (2008) Nature , vol.454 , pp. 470-477
    • Bensinger, S.J.1    Tontonoz, P.2
  • 66
    • 0030977450 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids
    • Vidal-Puig AJ, Considine RV, Jimenez-Liñan M, Werman A, Pories WJ, Caro JF, Flier JS. Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids. J Clin Invest 1997; 99: 2416-2422.
    • (1997) J Clin Invest , vol.99 , pp. 2416-2422
    • Vidal-Puig, A.J.1    Considine, R.V.2    Jimenez-Liñan, M.3    Werman, A.4    Pories, W.J.5    Caro, J.F.6    Flier, J.S.7
  • 67
    • 33646572904 scopus 로고    scopus 로고
    • The metabolic syndrome and adipocytokines
    • Matsuzawa Y. The metabolic syndrome and adipocytokines. FEBS Lett 2006; 580: 2917-2921.
    • (2006) FEBS Lett , vol.580 , pp. 2917-2921
    • Matsuzawa, Y.1
  • 69
    • 56649085036 scopus 로고    scopus 로고
    • Abnormalities of lipid metabolism in nonalcoholic fatty liver disease
    • Cheung O, Sanyal AJ. Abnormalities of lipid metabolism in nonalcoholic fatty liver disease. Sem Liver Dis 2008; 28: 351-359.
    • (2008) Sem Liver Dis , vol.28 , pp. 351-359
    • Cheung, O.1    Sanyal, A.J.2
  • 70
    • 0034796418 scopus 로고    scopus 로고
    • Hepatic over-expression of peroxisome proliferator activated receptor gamma2 in the ob/ob mouse model of non-insulin dependent diabetes mellitus
    • Rahimian R, Masih-Khan E, Lo M, van Breemen C, McManus BM, Dubé GP. Hepatic over-expression of peroxisome proliferator activated receptor gamma2 in the ob/ob mouse model of non-insulin dependent diabetes mellitus. Mol Cell Biochem 2001; 224: 29-37.
    • (2001) Mol Cell Biochem , vol.224 , pp. 29-37
    • Rahimian, R.1    Masih-Khan, E.2    Lo, M.3    van Breemen, C.4    McManus, B.M.5    Dubé, G.P.6
  • 71
  • 73
    • 69249229453 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A protein increases hepatic lipid accumulation via induction of activation and expression of PPARgamma
    • Kim K, Kim KH, Ha E, Park JY, Sakamoto N, Cheong J. Hepatitis C virus NS5A protein increases hepatic lipid accumulation via induction of activation and expression of PPARgamma. FEBS Lett 2009; 583: 2720-2726.
    • (2009) FEBS Lett , vol.583 , pp. 2720-2726
    • Kim, K.1    Kim, K.H.2    Ha, E.3    Park, J.Y.4    Sakamoto, N.5    Cheong, J.6
  • 74
    • 79955650290 scopus 로고    scopus 로고
    • Up-Regulation of PPAR-{gamma} mRNA Expression in the Liver of Obese Patients: An Additional Reinforcing Lipogenic Mechanism to SREBP-1c Induction
    • [Epub ahead of print]
    • Pettinelli P, Videla LA. Up-Regulation of PPAR-{gamma} mRNA Expression in the Liver of Obese Patients: an Additional Reinforcing Lipogenic Mechanism to SREBP-1c Induction. J Clin Endocrinol Metab. [Epub ahead of print].
    • J Clin Endocrinol Metab.
    • Pettinelli, P.1    Videla, L.A.2
  • 75
    • 35748972366 scopus 로고    scopus 로고
    • Genes involved in fatty acid partitioning and binding, lipolysis, monocyte/macrophage recruitment, and inflammation are overexpressed in the human fatty liver of insulin-resistant subjects
    • Westerbacka J, Kolak M, Kiviluoto T, Arkkila P, Sirén J, Hamsten A, Fisher RM, Yki-Järvinen H. Genes involved in fatty acid partitioning and binding, lipolysis, monocyte/macrophage recruitment, and inflammation are overexpressed in the human fatty liver of insulin-resistant subjects. Diabetes 2007; 56: 2759-2765.
    • (2007) Diabetes , vol.56 , pp. 2759-2765
    • Westerbacka, J.1    Kolak, M.2    Kiviluoto, T.3    Arkkila, P.4    Sirén, J.5    Hamsten, A.6    Fisher, R.M.7    Yki-Järvinen, H.8
  • 76
    • 0030877565 scopus 로고    scopus 로고
    • Ligand-independent activation domain in the N terminus of peroxisome proliferator activated receptor gamma (PPARgamma): Differential activity of PPARgamma1 and-2 isoforms and influence of insulin
    • Werman A, Hollenberg A, Solanes G, Bjorbaek C, Vidal-Puig AJ, Flier JS. Ligand-independent activation domain in the N terminus of peroxisome proliferator activated receptor gamma (PPARgamma): differential activity of PPARgamma1 and-2 isoforms and influence of insulin. J Biol Chem 1997; 272: 20230-20235.
    • (1997) J Biol Chem , vol.272 , pp. 20230-20235
    • Werman, A.1    Hollenberg, A.2    Solanes, G.3    Bjorbaek, C.4    Vidal-Puig, A.J.5    Flier, J.S.6
  • 77
    • 39549113664 scopus 로고    scopus 로고
    • Effect of peroxisome proliferatoractivated receptors-gamma and co-activator-1alpha genetic polymorphisms on plasma adiponectin levels and susceptibility of non-alcoholic fatty liver disease in Chinese people
    • Hui Y, Yu-Yuan L, Yu-Qiang N, Wei-Hong S, Yan-Lei D, Xiao-Bo L, Yong-Jian Z. Effect of peroxisome proliferatoractivated receptors-gamma and co-activator-1alpha genetic polymorphisms on plasma adiponectin levels and susceptibility of non-alcoholic fatty liver disease in Chinese people. Liver Int 2008; 28: 385-392.
    • (2008) Liver Int , vol.28 , pp. 385-392
    • Hui, Y.1    Yu-Yuan, L.2    Yu-Qiang, N.3    Wei-Hong, S.4    Yan-Lei, D.5    Xiao-Bo, L.6    Yong-Jian, Z.7
  • 79
    • 0032502704 scopus 로고    scopus 로고
    • Control of human muscle-type carnitine palmitoyltransferase I gene transcription by peroxisome proliferator-activated receptor
    • Mascaró C, Acosta E, Ortiz JA, Marrero PF, Hegardt FG, Haro D. Control of human muscle-type carnitine palmitoyltransferase I gene transcription by peroxisome proliferator-activated receptor. J Biol Chem 1998; 273: 8560-8563.
    • (1998) J Biol Chem , vol.273 , pp. 8560-8563
    • Mascaró, C.1    Acosta, E.2    Ortiz, J.A.3    Marrero, P.F.4    Hegardt, F.G.5    Haro, D.6
  • 80
    • 0035865496 scopus 로고    scopus 로고
    • Long-chain fatty acids regulate liver carnitine palmitoyltransferase I gene (L-CPT I) expression through a peroxisome-proliferator-activated receptor alpha (PPARalpha)-independent pathway
    • Louet JF, Chatelain F, Decaux JF, Park EA, Kohl C, Pineau T, Girard J, Pegorier JP. Long-chain fatty acids regulate liver carnitine palmitoyltransferase I gene (L-CPT I) expression through a peroxisome-proliferator-activated receptor alpha (PPARalpha)-independent pathway. Biochem J 2001; 354: 189-197.
    • (2001) Biochem J , vol.354 , pp. 189-197
    • Louet, J.F.1    Chatelain, F.2    Decaux, J.F.3    Park, E.A.4    Kohl, C.5    Pineau, T.6    Girard, J.7    Pegorier, J.P.8
  • 81
    • 67651003144 scopus 로고    scopus 로고
    • Structural insight into function and regulation of carnitine palmitoyltransferase
    • Rufer AC, Thoma R, Hennig M. Structural insight into function and regulation of carnitine palmitoyltransferase. Cell Mol Life Sci 2009; 66: 2489-2501.
    • (2009) Cell Mol Life Sci , vol.66 , pp. 2489-2501
    • Rufer, A.C.1    Thoma, R.2    Hennig, M.3
  • 82
    • 0032546929 scopus 로고    scopus 로고
    • Steatohepatitis, spontaneous peroxisome proliferation and liver tumors in mice lacking peroxisomal fatty acyl-CoA oxidase. Implications for peroxisome proliferator-activated receptor alpha natural ligand metabolism
    • Fan CY, Pan J, Usuda N, Yeldandi AV, Rao MS, Reddy JK. Steatohepatitis, spontaneous peroxisome proliferation and liver tumors in mice lacking peroxisomal fatty acyl-CoA oxidase. Implications for peroxisome proliferator-activated receptor alpha natural ligand metabolism. J Biol Chem 1998; 273: 15639-15645.
    • (1998) J Biol Chem , vol.273 , pp. 15639-15645
    • Fan, C.Y.1    Pan, J.2    Usuda, N.3    Yeldandi, A.V.4    Rao, M.S.5    Reddy, J.K.6
  • 83
    • 0034666132 scopus 로고    scopus 로고
    • Defect in peroxisome proliferator-activated receptor alpha-inducible fatty acid oxidation determines the severity of hepatic steatosis in response to fasting
    • Hashimoto T, Cook WS, Qi C, Yeldandi AV, Reddy JK, Rao MS. Defect in peroxisome proliferator-activated receptor alpha-inducible fatty acid oxidation determines the severity of hepatic steatosis in response to fasting. J Biol Chem 2000; 275: 28918-28928.
    • (2000) J Biol Chem , vol.275 , pp. 28918-28928
    • Hashimoto, T.1    Cook, W.S.2    Qi, C.3    Yeldandi, A.V.4    Reddy, J.K.5    Rao, M.S.6
  • 84
    • 11144226736 scopus 로고    scopus 로고
    • Peroxisomal fatty acid metabolism, peroxisomal proliferator-activated receptors and non-alcoholic fatty liver disease
    • Macdonald GA, Prins JB. Peroxisomal fatty acid metabolism, peroxisomal proliferator-activated receptors and non-alcoholic fatty liver disease. J Gastroenterol Hepatol 2004; 19: 1335-1337.
    • (2004) J Gastroenterol Hepatol , vol.19 , pp. 1335-1337
    • Macdonald, G.A.1    Prins, J.B.2
  • 85
    • 31644451456 scopus 로고    scopus 로고
    • Hepatitis C virus infection down-regulates the expression of peroxisome proliferator-activated receptor alpha and carnitine palmitoyl acyl-CoA transferase 1A
    • Cheng Y, Dharancy S, Malapel M, Desreumaux P. Hepatitis C virus infection down-regulates the expression of peroxisome proliferator-activated receptor alpha and carnitine palmitoyl acyl-CoA transferase 1A. World J Gastroenterol 2005; 11: 7591-7596.
    • (2005) World J Gastroenterol , vol.11 , pp. 7591-7596
    • Cheng, Y.1    Dharancy, S.2    Malapel, M.3    Desreumaux, P.4
  • 86
    • 65349175993 scopus 로고    scopus 로고
    • Peroxisome Proliferator-Activated Receptors in HCV-Related Infection
    • Dharancy S, Lemoine M, Mathurin P, Serfaty L, Dubuquoy L. Peroxisome Proliferator-Activated Receptors in HCV-Related Infection. PPAR Res 2009;2009:357204.
    • (2009) PPAR Res , vol.2009 , pp. 357204
    • Dharancy, S.1    Lemoine, M.2    Mathurin, P.3    Serfaty, L.4    Dubuquoy, L.5
  • 87
    • 0033554001 scopus 로고    scopus 로고
    • Evidence for direct binding of fatty acids and eicosanoids to human peroxisome proliferatorsactivated receptor alpha
    • Murakami K, Ide T, Suzuki M, Mochizuki T, Kadowaki T. Evidence for direct binding of fatty acids and eicosanoids to human peroxisome proliferatorsactivated receptor alpha. Biochem Biophys Res Commun 1999; 260: 609-613.
    • (1999) Biochem Biophys Res Commun , vol.260 , pp. 609-613
    • Murakami, K.1    Ide, T.2    Suzuki, M.3    Mochizuki, T.4    Kadowaki, T.5
  • 89
    • 0035066651 scopus 로고    scopus 로고
    • Polyunsaturated fatty acid regulation of gene transcription: A molecular mechanism to improve the metabolic syndrome
    • Clarke SD. Polyunsaturated fatty acid regulation of gene transcription: a molecular mechanism to improve the metabolic syndrome. J Nutr 2001; 131: 1129-1132.
    • (2001) J Nutr , vol.131 , pp. 1129-1132
    • Clarke, S.D.1
  • 90
    • 77957362125 scopus 로고    scopus 로고
    • Liver NF-9B and AP-1 activation and PPAR-B expression are negatively correlated in obese patients: Proinflammaroty implications
    • Videla LA. Liver NF-9B and AP-1 activation and PPAR-B expression are negatively correlated in obese patients: proinflammaroty implications. Clin Nutr 2010; 29: 687-688.
    • (2010) Clin Nutr , vol.29 , pp. 687-688
    • Videla, L.A.1
  • 91
    • 23944435868 scopus 로고    scopus 로고
    • Polyunsaturated fatty acid regulation of genes of lipid metabolism
    • Sampath H, Ntambi JM. Polyunsaturated fatty acid regulation of genes of lipid metabolism. Annu Rev Nutr 2005; 25: 317-340.
    • (2005) Annu Rev Nutr , vol.25 , pp. 317-340
    • Sampath, H.1    Ntambi, J.M.2
  • 92
    • 58449110344 scopus 로고    scopus 로고
    • SREBPs: Protein interaction and SREBPs
    • Sato R. SREBPs: protein interaction and SREBPs. FEBS J 2009; 276: 622-627.
    • (2009) FEBS J , vol.276 , pp. 622-627
    • Sato, R.1
  • 93
    • 34347406521 scopus 로고    scopus 로고
    • SREBP-1c transcription factor and lipid homeostasis: Clinical perspective
    • Ferré P, Foufelle F. SREBP-1c transcription factor and lipid homeostasis: clinical perspective. Horm Res 2007; 68: 72-82.
    • (2007) Horm Res , vol.68 , pp. 72-82
    • Ferré, P.1    Foufelle, F.2


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