Role of Caveolin-1 in the Modulation of Lipolysis and Lipid Droplet Formation

Diabetes

Volumn 53, Issue 5, 2004, Pages 1261-1270

  Cohen, Alex W ^a   Razani, Babak ^a   Schubert, William ^a   Williams, Terence M ^a   Wang, Xiao Bo ^a   Iyengar, Puneeth ^a   Brasaemle, Dawn L ^b   Scherer, Philipp E ^a   Lisanti, Michael P ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; CAVEOLIN 1; CELL PROTEIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; FAT DROPLET; PERILIPIN; UNCLASSIFIED DRUG;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOGENESIS; CELL SURFACE; CELL TYPE; CELLULAR DISTRIBUTION; COMPLEX FORMATION; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SUBUNIT; FIBROBLAST; FREEZE DRYING; GENE FUNCTION; GENETIC TRANSFECTION; HYPERBARISM; IMMUNOPRECIPITATION; IN VIVO STUDY; LIGAND BINDING; LIPID METABOLISM; LIPOLYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; WILD TYPE;

ADIPOCYTES; ADIPOSE TISSUE; ADRENERGIC BETA-AGONISTS; ANIMALS; CAVEOLIN 1; CAVEOLINS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DIOXOLES; FASTING; FATTY ACIDS, NONESTERIFIED; LIPID METABOLISM; LIPIDS; LIPOLYSIS; MICE; MICE, KNOCKOUT; MICROSCOPY, ELECTRON; PHOSPHOPROTEINS; PHOSPHORYLATION; RECEPTORS, ADRENERGIC, BETA-3; TIME FACTORS; UP-REGULATION;

EID: 2342510295     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.53.5.1261     Document Type: Article

References (50)

1. Razani B, Rubin CS, Lisanti MP: Regulation of cAMP-mediated signal transduction via interaction of caveolins with the catalytic subunit of protein kinase A. J Biol Chem 274:26353-26360, 1999.
2. Nystrom FH, Chen H, Cong LN, Li Y, Quon MJ: Caveolin-1 interacts with the insulin receptor and can differentially modulate insulin signaling in transfected Cos-7 cells and rat adipose cells. Mol Endocrinol 13:2013-2024, 1999
3. Fujimoto T, Kogo H, Ishiguro K, Tauchi K, Nomura R: Caveolin-2 is targeted to lipid droplets, a new "membrane domain" in the cell. J Cell Biol 152:1079-1085, 2001
4. Ostermeyer AG, Paci JM, Zeng Y, Lublin DM, Munro S, Brown DA: Accumulation of caveolin in the endoplasmic reticulum redirects the protein to lipid storage droplets. J Cell Biol 152:1071-1078, 2001
5. Pol A, Luetterforst R, Lindsay M, Heino S, Ikonen E, Parton RG: A caveolin dominant negative mutant associates with lipid bodies and induces intracellular cholesterol imbalance. J Cell Biol 152:1057-1070, 2001
6. Schwartz JH: The many dimensions of cAMP signaling. Proc Natl Acad Sci USA 98:13482-13484, 2001
7. Kalra P, Tigas S: Regulation of lipolysis: natriuretic peptides and the development of cachexia. Int J Cardiol 85:125-132, 2002
8. Tansey JT, Sztalryd C, Gruia-Gray J, Roush DL, Zee JV, Gavrilova O, Reitman ML, Deng CX, Li C, Kimmel AR, Londos C: Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity. Proc Natl Acad Sci USA 98:6494-6499, 2001
9. Martinez-Botas J, Anderson JB, Tessier D, Lapillonne A, Chang BH, Quast MJ, Gorenstein D, Chen KH, Chan L. Absence of perilipin results in leanness and reverses obesity in Lepr(db/db) mice. Nat Genet 26:474-479, 2000
10. Anthonsen MW, Ronnstrand L, Wernstedt C, Degerman E, Holm C: Identification of novel phosphorylation sites in hormone-sensitive lipase that are phosphorylated in response to isoproterenol and govern activation properties in vitro. J Biol Chem 273:215-221, 1998
11. Londos C, Brasaemle DL, Schultz CJ, Adler-Wailes DC, Levin DM, Kimmel AR, Rondinone CM: On the control of lipolysis in adipocytes. Ann N Y Acad Sci 892:155-168, 1999
12. Syu LJ, Saltiel AR: Lipotransin: a novel docking protein for hormone-sensitive lipase. Mol Cell 4:109-115, 1999
13. Egan JJ, Greenberg AS, Chang MK, Wek SA, Moos MC Jr, Londos C: Mechanism of hormone-stimulated lipolysis in adipocytes: translocation of hormone-sensitive lipase to the lipid storage droplet. Proc Natl Acad Sci USA 89:8537-8541, 1992
14. Brasaemle DL, Levin DM, Adler-Wailes DC, Londos C: The lipolytic stimulation of 3T3-L1 adipocytes promotes the translocation of hormone-sensitive lipase to the surfaces of lipid storage droplets. Biochim Biophys Acta 1483:251-262, 2000
15. Clifford GM, Londos C, Kraemer FB, Vernon RG, Yeaman SJ: Translocation of hormone-sensitive lipase and perilipin upon lipolytic stimulation of rat adipocytes. J Biol Chem 275:5011-5015, 2000
16. Su CL, Sztalryd C, Contreras JA, Holm C, Kimmel AR, Londos C: Mutational analysis of the hormone-sensitive lipase translocation reaction in adipocytes. J Biol Chem 278:43615-43619, 2003
17. Sztalryd C, Xu G, Dorward H, Tansey JT, Contreras JA, Kimmel AR, Londos C: Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activation. J Cell Biol 161:1093-1103, 2003
18. Garton AJ, Campbell DG, Carling D, Hardie DG, Colbran RJ, Yeaman SJ: Phosphorylation of bovine hormone-sensitive lipase by the AMP-activated protein kinase: a possible antilipolytic mechanism. Eur J Biochem 179: 249-254, 1989
19. Brasaemle DL, Rubin B, Harten IA, Gruia-Gray J, Kimmel AR, Londos C: Perilipin A increases triacylglycerol storage by decreasing the rate of triacylglycerol hydrolysis. J Biol Chem 275:38486-38493, 2000
20. Clifford GM, McCormick DK, Vernon RG, Yeaman SJ: Translocation of perilipin and hormone-sensitive lipase in response to lipolytic hormones (Abstract). Biochem Soc Trans 25:S672, 1997
21. Souza SC, Muliro KV, Liscum L, Lien P, Yamamoto MT, Schaffer JE, Dallal GE, Wang X, Kraemer FB, Obin M, Greenberg AS: Modulation of hormone-sensitive lipase and protein kinase A-mediated lipolysis by perilipin A in an adenoviral reconstituted system. J Biol Chem 277:8267-8272, 2002
22. Zhang HH, Souza SC, Muliro KV, Kraemer FB, Obin MS, Greenberg AS:. Lipase-selective functional domains of perilipin A differentially regulate constitutive and protein kinase A-stimulated lipolysis. J Biol Chem, 2003
23. Tansey JT, Huml AM, Vogt R, Davis KE, Jones JM, Fraser KA, Brasaemle DL, Kimmel AR, Londos C: Functional studies on native and mutated forms of perilipins: a role in protein kinase A-mediated lipolysis of triacylglycerols. J Biol Chem 278:8401-8406, 2003
24. Okazaki H, Osuga J, Tamura Y, Yahagi N, Tomita S, Shionoiri F, Iizuka Y, Ohaski K, Harada K, Kimura S, Gotoda T, Shimano H, Yamada N, Ishibashi S: Lipolysis in the absence of hormone-sensitive lipase: evidence for a common mechanism regulating distinct lipases. Diabetes 51:3368-3375, 2002
25. Servetnick DA, Brasaemle DL, Gruia-Gray J, Kimmel AR, Wolff J, Londos C: Perilipins are associated with cholesteryl ester droplets in steroidogenic adrenal cortical and Leydig cells. J Biol Chem 270:16970-16973, 1995
26. Razani B, Engelman JA, Wang XB, Schubert W, Zhang XL, Marks CB, Macaluso F, Russell RG, Li M, Pestell RG, Di Vizio D, Hou H Jr, Kneitz B, Lagaud G, Christ GJ, Edelmann W, Lisanti MP: Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities. J Biol Chem 276:38121-38138, 2001
27. Razani B, Wang XB, Engelman JA, Battista M, Lagaud G, Zhang XL, Kneitz B, Hou H Jr, Christ GJ, Edelmann W, Lisanti MP: Caveolin-2-deficient mice show evidence of severe pulmonary dysfunction without disruption of caveolae. Mol Cell Biol 22:2329-2344, 2002
28. Razani B, Combs TP, Wang XB, Frank PG, Park DS, Russell RG, Li M, Tang B, Jelicks LA, Scherer PE, Lisanti MP: Caveolin-1 deficient mice are lean, resistant to diet-induced obesity, and show hyper-triglyceridemia with adipocyte abnormalities. J Biol Chem 277:8635-8647, 2002
29. Carpéné C: Adipose tissue protocols. In Methods in Molecular Biology. Ailhaud G, Ed. Totowa, NJ, Humana Press, 2001, p. 129-140
30. Cohen AW, Razani B, Wang XB, Combs TP, Williams TM, Scherer PE, Lisanti MP: Caveolin-1-deficient mice show insulin resistance and defective insulin receptor protein expression in adipose tissue. Am J Physiol Cell Physiol 285:C222-C235, 2003
31. Schlegel A, Wang C, Pestell RG, Lisanti MP: Ligand-independent activation of oestrogen receptor alpha by caveolin-1. Biochem J 359:203-210, 2001
32. Scherer PE, Lisanti MP, Baldini G, Sargiacomo M, Corley-Mastick C, Lodish HF: Induction of caveolin during adipogenesis and association of GLUT4 with caveolin-rich vesicles. J Cell Biol 127:1233-1243, 1994
33. Shaywitz AJ, Greenberg ME: CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu Rev Biochem 68:821-861, 1999
34. Greenberg AS, Egan JJ, Wek SA, Garty NB, Blanchette-Mackie EJ, Londos C: Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets. J Biol Chem 266:11341-11346, 1991
35. Brown DA: Lipid droplets: proteins floating on a pool of fat. Curr Biol 11:R446-449, 2001
36. Blanchette-Mackie EJ, Dwyer NK, Barber T, Coxey RA, Takeda T, Rondinone CM, Theodorakis JL, Greenberg AS, Londos C: Perilipin is located on the surface layer of intracellular lipid droplets in adipocytes. J Lipid Res 36:1211-1226, 1995
37. Tauchi-Sato K, Ozeki S, Houjou T, Taguchi R, Fujimoto T: The surface of lipid droplets is a phospholipid monolayer with a unique fatty acid composition. J Biol Chem 277:44507-44512, 2002
38. Wolins NE, Skinner JR, Schoenfish MJ, Tzekov A, Bensch KG, Bickel PE: Adipocyte protein S3-12 coats nascent lipid droplets. J Biol Chem 278:37713-37721, 2003
39. Miura S, Gan JW, Brzostowski J, Parisi MJ, Schultz CJ, Londos C, Oliver B, Kimmel AR: Functional conservation for lipid storage droplet association among Perilipin, ADRP, and TIP47 (PAT)-related proteins in mammals, Drosophila, and Dictyostelium. J Biol Chem 277:32253-32257, 2002
40. Wolins NE, Rubin B, Brasaemle DL: TIP47 associates with lipid droplets. J Biol Chem 276:5101-5108, 2001
41. Brasaemle DL, Barber T, Wolins NE, Serrero G, Blanchette-Mackie FJ, Londos C: Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein. J Lipid Res 38:2249-2263, 1997
42. Londos C, Brasaemle DL, Gruia-Gray J, Servetnick DA, Schultz CJ, Levin DM, Kimmel AR: Perilipin: unique proteins associated with intracellular neutral lipid droplets in adipocytes and steroidogenic cells. Biochem Soc Trans 23:611-615, 1995
43. Ohashi M, Mizushima N, Kabeya Y, Yoshimori T: Localization of mammalian NAD(P)H steroid dehydrogenase-like protein on lipid droplets. J Biol Chem 278:30319-36829, 2003
44. Franke WW, Hergt M, Grund C: Rearrangement of the vimentin cytoskeleton during adipose conversion: formation of an intermediate filament cage around lipid globules. Cell 49:131-141, 1987
45. Greenberg AS, Egan JJ, Wek SA, Moos MC Jr, Londos C, Kimmel AR: Isolation of cDNAs for perilipins A and B: sequence and expression of lipid droplet-associated proteins of adipocytes. Proc Natl Acad Sci USA 90:12035-12039, 1993
46. Fulton D, Gratton JP, Sessa WC: Post-translational control of endothelial nitric oxide synthase: why isn't calcium/calmodulin enough? J Pharmacol Exp Ther 299:818-824, 2001
47. Garcia-Cardena G, Martasek P, Masters BS, Skidd PM, Couet J, Li S, Lisanti MP, Sessa WC: Dissecting the interaction between nitric oxide synthase (NOS) and caveolin: functional significance of the NOS caveolin binding domain in vivo. J Biol Chem 272:25437-25440, 1997
48. Solomonson LP, Flam BR, Pendleton LC, Goodwin BL, Eichler DC: The caveolar nitric oxide synthase/arginine regeneration system for NO production in endothelial cells. J Exp Biol 206:2083-2087, 2003
49. Shaul PW: Regulation of endothelial nitric oxide synthase: location, location, location. Annu Rev Physiol 64:749-774, 2002
50. Shaul PW, Smart FJ, Robinson LJ, German Z, Yuhanna IS, Ying Y, Anderson RG, Michel T: Acylation targets endothelial nitric-oxide synthase to plasmalemmal caveolae. J Biol Chem 271:6518-6522, 1996